Incidental Mutation 'IGL00481:Frem3'
ID 5010
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Frem3
Ensembl Gene ENSMUSG00000042353
Gene Name Fras1 related extracellular matrix protein 3
Synonyms LOC333315
Accession Numbers
Essential gene? Probably non essential (E-score: 0.152) question?
Stock # IGL00481
Quality Score
Status
Chromosome 8
Chromosomal Location 80611080-80695356 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 80668810 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 1822 (Q1822R)
Ref Sequence ENSEMBL: ENSMUSP00000038015 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039695]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000039695
AA Change: Q1822R

PolyPhen 2 Score 0.748 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000038015
Gene: ENSMUSG00000042353
AA Change: Q1822R

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
Pfam:Cadherin_3 369 515 9.5e-31 PFAM
Pfam:Cadherin_3 495 596 9.4e-20 PFAM
Pfam:Cadherin_3 637 786 4.2e-20 PFAM
Pfam:Cadherin_3 788 913 5.5e-23 PFAM
Pfam:Cadherin_3 998 1163 1.8e-20 PFAM
Pfam:Cadherin_3 1129 1254 1.3e-19 PFAM
Pfam:Cadherin_3 1250 1395 9.5e-34 PFAM
Pfam:Cadherin_3 1397 1508 2.7e-21 PFAM
Pfam:Cadherin_3 1493 1617 1.2e-27 PFAM
Pfam:Cadherin_3 1622 1748 4.8e-17 PFAM
Calx_beta 1754 1853 1.45e-7 SMART
Calx_beta 1866 1977 3.35e-12 SMART
Calx_beta 1991 2098 1.61e-5 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The protein belongs to the family of FRAS1/FREM extracellular matrix proteins and may play a role cell adhesion. [provided by RefSeq, Feb 2017]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931440F15Rik A G 11: 29,824,755 L234P probably damaging Het
9230110C19Rik T C 9: 8,042,431 Y57C probably damaging Het
Abca13 T C 11: 9,290,969 L944P probably damaging Het
Akap13 A G 7: 75,723,895 S1885G probably damaging Het
Aqp3 A G 4: 41,093,632 Y261H probably damaging Het
Arap2 A T 5: 62,635,962 N1380K probably damaging Het
Arntl2 T A 6: 146,809,666 M56K probably benign Het
Barx2 T C 9: 31,846,845 I266V unknown Het
BC034090 C T 1: 155,232,521 R360H probably benign Het
Ccnb2 T C 9: 70,418,907 K52E probably damaging Het
Ccp110 G A 7: 118,729,997 V868I possibly damaging Het
Cyld G T 8: 88,707,290 V236F probably damaging Het
Dst T C 1: 34,169,329 probably benign Het
Ehmt1 G T 2: 24,838,818 A637E possibly damaging Het
Erlin1 G T 19: 44,069,319 Y22* probably null Het
Ezh1 A T 11: 101,199,302 M539K possibly damaging Het
Fam160b1 A G 19: 57,381,345 E440G probably benign Het
Fancc A T 13: 63,400,245 I80N probably damaging Het
Fat1 G A 8: 45,050,940 S4447N probably benign Het
Iqgap1 C T 7: 80,759,844 V248I probably benign Het
Itch T C 2: 155,213,023 I749T probably damaging Het
Kcna10 T A 3: 107,195,514 M487K probably benign Het
Krt83 A T 15: 101,488,211 L223Q probably benign Het
Mtmr2 T C 9: 13,785,916 I84T probably benign Het
Myocd G A 11: 65,187,154 T477M probably damaging Het
Nfic A T 10: 81,408,220 V240E possibly damaging Het
Olfr463 A G 11: 87,893,621 I101T possibly damaging Het
Prkdc A T 16: 15,790,466 Y3044F probably benign Het
Prkg1 A G 19: 30,571,622 I636T probably benign Het
Ptpru A G 4: 131,808,235 V477A probably benign Het
Rab7b T A 1: 131,698,591 M119K possibly damaging Het
Sec61a1 T C 6: 88,506,940 probably benign Het
Sectm1b A G 11: 121,055,973 V32A probably benign Het
Shroom2 A G X: 152,623,223 S1034P probably benign Het
Sipa1l3 A T 7: 29,386,108 I688N probably damaging Het
Slc24a1 T C 9: 64,928,019 Y942C probably damaging Het
Smg1 C T 7: 118,210,794 R139K possibly damaging Het
Stt3b G A 9: 115,251,847 T574I probably benign Het
Thoc2 A G X: 41,879,891 I76T possibly damaging Het
Tpm3 C T 3: 90,087,717 T180M probably damaging Het
Uqcrfs1 C A 13: 30,540,925 V211F probably benign Het
Usp47 A G 7: 112,074,783 S418G probably benign Het
Usp5 T C 6: 124,829,353 T15A probably benign Het
Vps13c T C 9: 67,860,865 L122P probably damaging Het
Zfp677 A T 17: 21,397,668 E329V probably benign Het
Zfyve16 A T 13: 92,516,538 N846K possibly damaging Het
Zp1 G T 19: 10,918,777 P195T probably damaging Het
Other mutations in Frem3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Frem3 APN 8 80,615,134 (GRCm38) missense probably benign 0.02
IGL01470:Frem3 APN 8 80,614,315 (GRCm38) missense probably damaging 1.00
IGL01609:Frem3 APN 8 80,612,704 (GRCm38) missense probably benign 0.00
IGL01622:Frem3 APN 8 80,613,915 (GRCm38) missense probably benign 0.01
IGL01623:Frem3 APN 8 80,613,915 (GRCm38) missense probably benign 0.01
IGL01751:Frem3 APN 8 80,615,743 (GRCm38) missense probably benign 0.33
IGL02037:Frem3 APN 8 80,611,489 (GRCm38) missense probably benign 0.31
IGL02039:Frem3 APN 8 80,612,971 (GRCm38) missense probably damaging 1.00
IGL02084:Frem3 APN 8 80,612,443 (GRCm38) missense possibly damaging 0.95
IGL02124:Frem3 APN 8 80,613,094 (GRCm38) missense probably damaging 0.99
IGL02140:Frem3 APN 8 80,614,107 (GRCm38) missense possibly damaging 0.84
IGL02836:Frem3 APN 8 80,614,381 (GRCm38) missense probably benign
IGL03090:Frem3 APN 8 80,618,229 (GRCm38) missense probably benign 0.01
IGL03102:Frem3 APN 8 80,613,032 (GRCm38) missense possibly damaging 0.92
IGL03116:Frem3 APN 8 80,612,806 (GRCm38) missense possibly damaging 0.84
IGL03165:Frem3 APN 8 80,612,529 (GRCm38) missense probably benign 0.26
IGL03224:Frem3 APN 8 80,613,463 (GRCm38) missense probably damaging 1.00
IGL03401:Frem3 APN 8 80,614,541 (GRCm38) missense probably damaging 1.00
IGL03403:Frem3 APN 8 80,611,090 (GRCm38) missense probably benign 0.04
FR4340:Frem3 UTSW 8 80,615,241 (GRCm38) small insertion probably benign
FR4976:Frem3 UTSW 8 80,615,241 (GRCm38) small insertion probably benign
IGL02991:Frem3 UTSW 8 80,668,882 (GRCm38) missense probably damaging 1.00
IGL03052:Frem3 UTSW 8 80,614,530 (GRCm38) missense probably damaging 1.00
R0089:Frem3 UTSW 8 80,615,878 (GRCm38) missense possibly damaging 0.94
R0647:Frem3 UTSW 8 80,615,185 (GRCm38) missense probably damaging 1.00
R0690:Frem3 UTSW 8 80,613,952 (GRCm38) missense possibly damaging 0.84
R0766:Frem3 UTSW 8 80,615,322 (GRCm38) missense probably benign
R0834:Frem3 UTSW 8 80,687,008 (GRCm38) missense probably damaging 1.00
R0909:Frem3 UTSW 8 80,663,406 (GRCm38) missense probably benign 0.45
R1033:Frem3 UTSW 8 80,695,157 (GRCm38) missense probably benign 0.00
R1144:Frem3 UTSW 8 80,611,884 (GRCm38) missense probably benign 0.01
R1312:Frem3 UTSW 8 80,615,322 (GRCm38) missense probably benign
R1330:Frem3 UTSW 8 80,668,839 (GRCm38) missense probably damaging 0.99
R1355:Frem3 UTSW 8 80,690,702 (GRCm38) missense probably damaging 1.00
R1390:Frem3 UTSW 8 80,690,773 (GRCm38) missense probably damaging 0.99
R1413:Frem3 UTSW 8 80,668,801 (GRCm38) missense probably benign
R1470:Frem3 UTSW 8 80,611,191 (GRCm38) missense probably benign 0.05
R1470:Frem3 UTSW 8 80,611,191 (GRCm38) missense probably benign 0.05
R1503:Frem3 UTSW 8 80,687,018 (GRCm38) missense probably damaging 0.99
R1538:Frem3 UTSW 8 80,613,135 (GRCm38) missense probably benign 0.00
R1538:Frem3 UTSW 8 80,612,710 (GRCm38) missense probably damaging 1.00
R1612:Frem3 UTSW 8 80,614,861 (GRCm38) missense probably damaging 1.00
R1793:Frem3 UTSW 8 80,613,112 (GRCm38) missense probably benign 0.03
R1872:Frem3 UTSW 8 80,612,576 (GRCm38) missense probably damaging 1.00
R1879:Frem3 UTSW 8 80,611,938 (GRCm38) nonsense probably null
R1886:Frem3 UTSW 8 80,613,885 (GRCm38) missense probably benign 0.00
R1933:Frem3 UTSW 8 80,612,890 (GRCm38) missense probably benign 0.00
R2027:Frem3 UTSW 8 80,695,337 (GRCm38) missense possibly damaging 0.75
R2040:Frem3 UTSW 8 80,615,826 (GRCm38) missense possibly damaging 0.92
R2050:Frem3 UTSW 8 80,614,891 (GRCm38) missense probably damaging 1.00
R2079:Frem3 UTSW 8 80,615,103 (GRCm38) missense probably benign 0.03
R2099:Frem3 UTSW 8 80,615,859 (GRCm38) missense probably benign 0.06
R2120:Frem3 UTSW 8 80,615,457 (GRCm38) missense probably benign 0.20
R2842:Frem3 UTSW 8 80,669,349 (GRCm38) splice site probably null
R2845:Frem3 UTSW 8 80,613,220 (GRCm38) missense probably damaging 1.00
R3015:Frem3 UTSW 8 80,690,773 (GRCm38) missense probably damaging 0.99
R3442:Frem3 UTSW 8 80,613,040 (GRCm38) missense probably damaging 1.00
R3724:Frem3 UTSW 8 80,615,271 (GRCm38) missense probably benign 0.06
R3730:Frem3 UTSW 8 80,615,916 (GRCm38) missense probably damaging 0.99
R3939:Frem3 UTSW 8 80,615,020 (GRCm38) missense possibly damaging 0.84
R3940:Frem3 UTSW 8 80,615,020 (GRCm38) missense possibly damaging 0.84
R3941:Frem3 UTSW 8 80,615,020 (GRCm38) missense possibly damaging 0.84
R4089:Frem3 UTSW 8 80,615,173 (GRCm38) missense probably damaging 1.00
R4282:Frem3 UTSW 8 80,614,141 (GRCm38) missense probably benign 0.00
R4437:Frem3 UTSW 8 80,612,607 (GRCm38) missense probably benign 0.30
R4480:Frem3 UTSW 8 80,611,357 (GRCm38) missense probably benign 0.10
R4575:Frem3 UTSW 8 80,616,075 (GRCm38) missense probably benign 0.17
R4583:Frem3 UTSW 8 80,613,514 (GRCm38) missense probably benign 0.03
R4620:Frem3 UTSW 8 80,668,957 (GRCm38) missense possibly damaging 0.82
R4621:Frem3 UTSW 8 80,669,191 (GRCm38) splice site probably null
R4644:Frem3 UTSW 8 80,613,727 (GRCm38) missense probably benign 0.33
R4667:Frem3 UTSW 8 80,663,420 (GRCm38) missense probably damaging 0.97
R4748:Frem3 UTSW 8 80,611,459 (GRCm38) missense probably damaging 1.00
R4823:Frem3 UTSW 8 80,613,958 (GRCm38) missense probably benign 0.25
R4836:Frem3 UTSW 8 80,663,397 (GRCm38) missense probably damaging 0.99
R4867:Frem3 UTSW 8 80,613,283 (GRCm38) missense probably damaging 1.00
R4921:Frem3 UTSW 8 80,613,136 (GRCm38) missense possibly damaging 0.83
R5030:Frem3 UTSW 8 80,613,247 (GRCm38) missense possibly damaging 0.89
R5035:Frem3 UTSW 8 80,615,914 (GRCm38) missense probably damaging 0.97
R5172:Frem3 UTSW 8 80,612,566 (GRCm38) missense probably benign 0.44
R5289:Frem3 UTSW 8 80,612,319 (GRCm38) missense probably benign 0.00
R5492:Frem3 UTSW 8 80,612,677 (GRCm38) missense probably damaging 1.00
R5655:Frem3 UTSW 8 80,612,694 (GRCm38) missense probably benign 0.00
R5685:Frem3 UTSW 8 80,695,303 (GRCm38) missense probably damaging 1.00
R5723:Frem3 UTSW 8 80,613,397 (GRCm38) missense probably benign 0.02
R5743:Frem3 UTSW 8 80,615,778 (GRCm38) missense probably damaging 0.98
R5889:Frem3 UTSW 8 80,614,288 (GRCm38) missense probably damaging 1.00
R6048:Frem3 UTSW 8 80,613,433 (GRCm38) missense probably benign 0.03
R6057:Frem3 UTSW 8 80,615,587 (GRCm38) missense probably damaging 0.99
R6137:Frem3 UTSW 8 80,615,047 (GRCm38) missense probably benign
R6264:Frem3 UTSW 8 80,615,203 (GRCm38) missense probably damaging 1.00
R6339:Frem3 UTSW 8 80,613,015 (GRCm38) missense possibly damaging 0.84
R6418:Frem3 UTSW 8 80,611,152 (GRCm38) missense probably benign 0.08
R6680:Frem3 UTSW 8 80,669,320 (GRCm38) missense probably damaging 1.00
R6773:Frem3 UTSW 8 80,611,815 (GRCm38) missense probably damaging 1.00
R6838:Frem3 UTSW 8 80,612,031 (GRCm38) missense probably damaging 1.00
R6928:Frem3 UTSW 8 80,611,282 (GRCm38) missense possibly damaging 0.48
R6939:Frem3 UTSW 8 80,615,145 (GRCm38) missense probably benign 0.23
R6995:Frem3 UTSW 8 80,612,579 (GRCm38) missense probably damaging 0.98
R7112:Frem3 UTSW 8 80,612,031 (GRCm38) missense probably damaging 1.00
R7155:Frem3 UTSW 8 80,616,039 (GRCm38) missense probably benign 0.01
R7235:Frem3 UTSW 8 80,690,725 (GRCm38) missense probably benign 0.00
R7282:Frem3 UTSW 8 80,612,031 (GRCm38) missense probably damaging 1.00
R7403:Frem3 UTSW 8 80,616,145 (GRCm38) missense probably damaging 1.00
R7422:Frem3 UTSW 8 80,615,763 (GRCm38) missense probably benign 0.00
R7485:Frem3 UTSW 8 80,613,336 (GRCm38) missense probably damaging 1.00
R7516:Frem3 UTSW 8 80,612,083 (GRCm38) missense probably damaging 0.99
R7858:Frem3 UTSW 8 80,611,721 (GRCm38) nonsense probably null
R7976:Frem3 UTSW 8 80,611,602 (GRCm38) nonsense probably null
R8171:Frem3 UTSW 8 80,615,240 (GRCm38) missense probably damaging 1.00
R8185:Frem3 UTSW 8 80,612,304 (GRCm38) nonsense probably null
R8306:Frem3 UTSW 8 80,612,211 (GRCm38) missense possibly damaging 0.95
R8478:Frem3 UTSW 8 80,611,558 (GRCm38) missense probably damaging 1.00
R8518:Frem3 UTSW 8 80,612,595 (GRCm38) missense probably damaging 1.00
R8794:Frem3 UTSW 8 80,616,222 (GRCm38) missense probably benign 0.02
R8794:Frem3 UTSW 8 80,612,278 (GRCm38) missense probably damaging 1.00
R8806:Frem3 UTSW 8 80,663,435 (GRCm38) missense probably benign 0.30
R8833:Frem3 UTSW 8 80,612,772 (GRCm38) missense probably benign 0.29
R8879:Frem3 UTSW 8 80,613,148 (GRCm38) missense probably damaging 0.98
R8897:Frem3 UTSW 8 80,612,790 (GRCm38) missense probably damaging 1.00
R8983:Frem3 UTSW 8 80,669,246 (GRCm38) missense probably damaging 1.00
R9207:Frem3 UTSW 8 80,613,442 (GRCm38) missense possibly damaging 0.73
R9277:Frem3 UTSW 8 80,690,773 (GRCm38) missense probably damaging 0.96
R9536:Frem3 UTSW 8 80,615,419 (GRCm38) missense probably benign 0.00
R9596:Frem3 UTSW 8 80,615,322 (GRCm38) missense probably benign
R9649:Frem3 UTSW 8 80,614,516 (GRCm38) missense probably damaging 1.00
R9671:Frem3 UTSW 8 80,612,505 (GRCm38) missense probably benign 0.00
R9723:Frem3 UTSW 8 80,614,723 (GRCm38) missense probably benign
R9790:Frem3 UTSW 8 80,613,261 (GRCm38) missense probably benign 0.01
R9791:Frem3 UTSW 8 80,613,261 (GRCm38) missense probably benign 0.01
RF030:Frem3 UTSW 8 80,615,238 (GRCm38) small insertion probably benign
RF034:Frem3 UTSW 8 80,615,238 (GRCm38) small insertion probably benign
RF042:Frem3 UTSW 8 80,615,238 (GRCm38) small insertion probably benign
X0024:Frem3 UTSW 8 80,613,081 (GRCm38) missense possibly damaging 0.76
X0027:Frem3 UTSW 8 80,612,388 (GRCm38) nonsense probably null
Z1088:Frem3 UTSW 8 80,615,426 (GRCm38) missense probably benign 0.04
Z1176:Frem3 UTSW 8 80,615,431 (GRCm38) missense probably benign 0.03
Z1176:Frem3 UTSW 8 80,611,503 (GRCm38) missense probably damaging 0.99
Z1177:Frem3 UTSW 8 80,616,129 (GRCm38) missense possibly damaging 0.81
Posted On 2012-04-20