Incidental Mutation 'R5627:Kremen1'
ID 501342
Institutional Source Beutler Lab
Gene Symbol Kremen1
Ensembl Gene ENSMUSG00000020393
Gene Name kringle containing transmembrane protein 1
Synonyms Krm1
MMRRC Submission 043166-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R5627 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 5141552-5211558 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 5149709 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 321 (T321A)
Ref Sequence ENSEMBL: ENSMUSP00000020662 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020662]
AlphaFold Q99N43
Predicted Effect probably benign
Transcript: ENSMUST00000020662
AA Change: T321A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000020662
Gene: ENSMUSG00000020393
AA Change: T321A

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
KR 30 116 9.81e-23 SMART
Pfam:WSC 119 200 3.7e-21 PFAM
CUB 214 321 4.27e-19 SMART
transmembrane domain 391 413 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb8 C T 5: 24,605,137 (GRCm39) R108C possibly damaging Het
Abl1 T C 2: 31,690,595 (GRCm39) W705R probably benign Het
Alpk1 A T 3: 127,474,296 (GRCm39) V569D probably damaging Het
Ano3 T C 2: 110,587,298 (GRCm39) N425S possibly damaging Het
Atad2b A G 12: 4,967,911 (GRCm39) D68G probably benign Het
Cacna1e A G 1: 154,511,604 (GRCm39) I173T probably damaging Het
Cenpe G T 3: 134,941,234 (GRCm39) L716F possibly damaging Het
Cep85 A T 4: 133,861,408 (GRCm39) L622Q probably damaging Het
Cep97 A G 16: 55,745,330 (GRCm39) probably null Het
Ces1f A T 8: 94,006,327 (GRCm39) M1K probably null Het
Chil5 A G 3: 105,926,951 (GRCm39) L228P probably damaging Het
Col22a1 T C 15: 71,853,767 (GRCm39) E265G probably damaging Het
Col3a1 T C 1: 45,370,720 (GRCm39) probably benign Het
Cyp3a59 T A 5: 146,049,664 (GRCm39) D497E probably benign Het
Egfem1 G T 3: 29,722,548 (GRCm39) E175* probably null Het
Eif4g2 A G 7: 110,673,446 (GRCm39) Y778H probably benign Het
Fam98b T C 2: 117,098,414 (GRCm39) C295R probably damaging Het
Gm3149 A T 14: 15,702,790 (GRCm39) I246L probably benign Het
Gm5134 A G 10: 75,821,942 (GRCm39) T259A possibly damaging Het
Gm5150 A G 3: 16,017,564 (GRCm39) Y236H probably damaging Het
Golga2 C A 2: 32,196,059 (GRCm39) Y864* probably null Het
Inpp4a A G 1: 37,406,854 (GRCm39) D199G probably damaging Het
Inpp4b T C 8: 82,470,445 (GRCm39) probably benign Het
Map3k3 A G 11: 106,039,428 (GRCm39) S250G probably benign Het
Mtmr10 A T 7: 63,986,500 (GRCm39) K526M probably damaging Het
Nbea C T 3: 55,899,766 (GRCm39) C1461Y probably damaging Het
Nckap5l A T 15: 99,325,587 (GRCm39) N305K possibly damaging Het
Nup210l A T 3: 90,051,557 (GRCm39) Y567F probably damaging Het
Or11g26 A G 14: 50,753,257 (GRCm39) M199V probably benign Het
Or14c39 G T 7: 86,344,347 (GRCm39) V228F possibly damaging Het
Or4a70 A T 2: 89,324,388 (GRCm39) N89K probably benign Het
Or56b2 G A 7: 104,337,377 (GRCm39) V52M probably benign Het
Or5b96 T A 19: 12,867,663 (GRCm39) I93F probably damaging Het
Or5g25 T A 2: 85,477,991 (GRCm39) I225F probably damaging Het
Rcc1 T C 4: 132,065,454 (GRCm39) R57G probably damaging Het
Rfx7 C T 9: 72,440,066 (GRCm39) probably benign Het
Saraf T A 8: 34,621,799 (GRCm39) M1K probably null Het
Serpinb9d C T 13: 33,386,676 (GRCm39) T248I probably damaging Het
Slc38a6 A G 12: 73,390,457 (GRCm39) I254M possibly damaging Het
Slc6a5 A G 7: 49,561,522 (GRCm39) D18G possibly damaging Het
Supt20 A G 3: 54,620,611 (GRCm39) D389G possibly damaging Het
Tecpr2 T A 12: 110,907,916 (GRCm39) I1001K probably damaging Het
Vcan CAAAA CAA 13: 89,839,254 (GRCm39) probably null Het
Wdr36 T A 18: 32,994,691 (GRCm39) D717E possibly damaging Het
Zfp318 T C 17: 46,724,062 (GRCm39) S2022P probably damaging Het
Other mutations in Kremen1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01813:Kremen1 APN 11 5,149,667 (GRCm39) missense probably benign 0.00
R0038:Kremen1 UTSW 11 5,157,703 (GRCm39) splice site probably benign
R0511:Kremen1 UTSW 11 5,165,447 (GRCm39) missense probably damaging 1.00
R1557:Kremen1 UTSW 11 5,165,373 (GRCm39) splice site probably null
R1579:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R1729:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R1784:Kremen1 UTSW 11 5,151,792 (GRCm39) unclassified probably benign
R1800:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2079:Kremen1 UTSW 11 5,151,794 (GRCm39) frame shift probably null
R2100:Kremen1 UTSW 11 5,151,788 (GRCm39) unclassified probably benign
R2286:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2298:Kremen1 UTSW 11 5,151,788 (GRCm39) unclassified probably benign
R2352:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2512:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2761:Kremen1 UTSW 11 5,151,792 (GRCm39) unclassified probably benign
R2846:Kremen1 UTSW 11 5,151,793 (GRCm39) unclassified probably benign
R2882:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2944:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R2980:Kremen1 UTSW 11 5,151,794 (GRCm39) unclassified probably benign
R3151:Kremen1 UTSW 11 5,145,012 (GRCm39) missense probably damaging 0.99
R3610:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R3831:Kremen1 UTSW 11 5,151,794 (GRCm39) unclassified probably benign
R3957:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
R4231:Kremen1 UTSW 11 5,193,881 (GRCm39) nonsense probably null
R4397:Kremen1 UTSW 11 5,149,610 (GRCm39) missense probably benign 0.36
R6818:Kremen1 UTSW 11 5,145,051 (GRCm39) missense probably benign 0.02
R7584:Kremen1 UTSW 11 5,144,964 (GRCm39) missense possibly damaging 0.95
R8803:Kremen1 UTSW 11 5,144,981 (GRCm39) missense probably benign 0.01
T0975:Kremen1 UTSW 11 5,145,105 (GRCm39) missense probably benign 0.02
Y4339:Kremen1 UTSW 11 5,151,791 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- AATATCCCAACATGTGTCTGCAGG -3'
(R):5'- TGAGTCCCACATGTGCTTCC -3'

Sequencing Primer
(F):5'- TGAAAGAACTACCTTCCACTCTGTG -3'
(R):5'- CGCATTTCCATGTTCCCCACG -3'
Posted On 2017-12-01