Mutagenetix > Incidental Mutation

Incidental Mutation 'R5809:Or11g24'

501571

Institutional Source

Beutler Lab

Gene Symbol

Or11g24

Ensembl Gene

ENSMUSG00000057903

Gene Name

olfactory receptor family 11 subfamily G member 24

Synonyms

GA_x6K02T2PMLR-6121675-6122604, MOR106-2, Olfr739

MMRRC Submission

043394-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

R5809 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

50661978-50662907 bp(+) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

T to C at 50662905 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Glutamine at position 310 (*310Q)

Ref Sequence

ENSEMBL: ENSMUSP00000150559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075261] [ENSMUST00000216949]

AlphaFold

E9Q1P0

Predicted Effect

probably null
Transcript: ENSMUST00000075261
AA Change: *310Q

SMART Domains

Protein: ENSMUSP00000074740
Gene: ENSMUSG00000057903
AA Change: *310Q

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	309	1.1e-53	PFAM
Pfam:7tm_1	43	292	1.9e-22	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000216949
AA Change: *310Q

Meta Mutation Damage Score

0.8532

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.5%
20x: 95.9%

Validation Efficiency

99% (77/78)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A230072I06Rik	A	G	8: 12,329,556 (GRCm39)	S4G	unknown	Het
AA623943	T	C	11: 94,703,828 (GRCm39)		noncoding transcript	Het
Abca13	T	A	11: 9,243,692 (GRCm39)	S1852T	probably damaging	Het
Ackr2	G	A	9: 121,738,540 (GRCm39)	C305Y	probably damaging	Het
Aebp1	T	C	11: 5,820,257 (GRCm39)	V411A	probably benign	Het
Akp3	G	A	1: 87,054,270 (GRCm39)	R269H	probably benign	Het
Alox15	C	A	11: 70,241,708 (GRCm39)	G58W	probably damaging	Het
Ankle2	A	G	5: 110,385,856 (GRCm39)	N369S	probably damaging	Het
Ankrd28	T	A	14: 31,465,311 (GRCm39)	I289L	probably benign	Het
Atp13a4	T	A	16: 29,252,805 (GRCm39)	T714S	possibly damaging	Het
Birc6	A	C	17: 74,977,369 (GRCm39)	N4388T	probably damaging	Het
Blm	A	T	7: 80,114,592 (GRCm39)	L1159Q	probably damaging	Het
Caskin1	G	A	17: 24,723,521 (GRCm39)	V770I	probably benign	Het
Ccdc148	T	A	2: 58,713,657 (GRCm39)	H498L	probably damaging	Het
Cdh26	T	A	2: 178,101,919 (GRCm39)	Y179*	probably null	Het
Cela2a	T	A	4: 141,552,864 (GRCm39)	T38S	probably benign	Het
Cep350	A	T	1: 155,809,087 (GRCm39)	N496K	probably damaging	Het
Cep89	A	G	7: 35,117,151 (GRCm39)	Y251C	probably damaging	Het
Cluh	T	C	11: 74,552,526 (GRCm39)	S524P	probably damaging	Het
Cpeb4	T	C	11: 31,822,801 (GRCm39)	S172P	probably damaging	Het
Ctnnd2	T	C	15: 30,847,523 (GRCm39)	S705P	probably damaging	Het
Dock2	T	G	11: 34,212,445 (GRCm39)	D1232A	probably benign	Het
Donson	T	C	16: 91,484,738 (GRCm39)	N9S	possibly damaging	Het
Gdf9	T	C	11: 53,324,381 (GRCm39)	L50P	probably benign	Het
Gm10300	C	T	4: 131,802,458 (GRCm39)		probably benign	Het
Gm8369	A	G	19: 11,482,248 (GRCm39)		probably benign	Het
Gm8674	T	A	13: 50,055,924 (GRCm39)		noncoding transcript	Het
Hepacam	T	A	9: 37,296,101 (GRCm39)	S417R	possibly damaging	Het
Hibch	T	A	1: 52,892,859 (GRCm39)	L23Q	probably benign	Het
Hmcn1	G	A	1: 150,525,358 (GRCm39)	R3389C	probably damaging	Het
Hsp90ab1	G	T	17: 45,881,575 (GRCm39)		probably benign	Het
Hunk	C	A	16: 90,272,791 (GRCm39)	T365K	probably damaging	Het
Il12a	A	T	3: 68,602,595 (GRCm39)		probably benign	Het
Ints13	A	G	6: 146,477,847 (GRCm39)	V34A	probably benign	Het
Intu	A	C	3: 40,634,020 (GRCm39)	M418L	probably damaging	Het
Khdc4	A	G	3: 88,616,192 (GRCm39)	R460G	probably damaging	Het
Klra9	A	G	6: 130,156,036 (GRCm39)	S240P	probably damaging	Het
Mtpn	C	T	6: 35,489,225 (GRCm39)	D100N	probably benign	Het
Ndrg1	A	G	15: 66,802,699 (GRCm39)		probably benign	Het
Or5k17	T	C	16: 58,746,860 (GRCm39)	T25A	probably benign	Het
Pate6	C	T	9: 35,700,297 (GRCm39)	C96Y	probably damaging	Het
Pax7	A	G	4: 139,557,682 (GRCm39)	S30P	probably damaging	Het
Pdcd11	A	T	19: 47,082,247 (GRCm39)	T54S	probably benign	Het
Pex19	T	C	1: 171,958,306 (GRCm39)	V95A	probably damaging	Het
Pkhd1l1	A	G	15: 44,383,103 (GRCm39)	I1121V	probably benign	Het
Pklr	A	T	3: 89,049,091 (GRCm39)	I146F	probably benign	Het
Plcb1	T	C	2: 135,104,164 (GRCm39)	Y278H	possibly damaging	Het
Plcl1	T	A	1: 55,735,160 (GRCm39)	I167N	probably damaging	Het
Plekhh1	A	T	12: 79,125,461 (GRCm39)	I1241F	probably benign	Het
Plxnb2	G	T	15: 89,051,774 (GRCm39)	D148E	possibly damaging	Het
Pthlh	T	C	6: 147,158,745 (GRCm39)	I72V	probably damaging	Het
Ptpru	C	T	4: 131,513,067 (GRCm39)	R880Q	probably benign	Het
Rrp36	T	C	17: 46,978,932 (GRCm39)	K209E	probably damaging	Het
Scarb1	A	G	5: 125,381,286 (GRCm39)	V86A	probably damaging	Het
Sh2d7	A	C	9: 54,446,860 (GRCm39)	S37R	probably benign	Het
Slc13a2	A	T	11: 78,288,647 (GRCm39)	V543E	probably damaging	Het
Smarcal1	A	G	1: 72,630,296 (GRCm39)	T117A	probably benign	Het
Smok2a	A	G	17: 13,445,865 (GRCm39)	R481G	possibly damaging	Het
Smr2	G	A	5: 88,256,699 (GRCm39)	A126T	probably benign	Het
Sspo	G	T	6: 48,436,979 (GRCm39)	W1304C	possibly damaging	Het
Svep1	A	G	4: 58,116,524 (GRCm39)	S909P	possibly damaging	Het
Tchh	A	T	3: 93,352,880 (GRCm39)	K773N	unknown	Het
Tmem156	T	C	5: 65,232,950 (GRCm39)	N140S	possibly damaging	Het
Tmem213	T	C	6: 38,092,589 (GRCm39)	I107T	possibly damaging	Het
Tpd52l2	A	G	2: 181,153,372 (GRCm39)	Y161C	probably damaging	Het
Trappc8	C	T	18: 20,951,139 (GRCm39)	A1436T	probably benign	Het
Ubr3	A	G	2: 69,795,855 (GRCm39)	Y933C	possibly damaging	Het
Ufm1	A	T	3: 53,765,303 (GRCm39)		probably benign	Het
Wdr27	A	T	17: 15,103,931 (GRCm39)	L725Q	probably damaging	Het
Zdbf2	A	G	1: 63,345,035 (GRCm39)	D1138G	possibly damaging	Het
Zkscan16	G	A	4: 58,946,481 (GRCm39)	V119M	probably damaging	Het
Zmat5	A	G	11: 4,672,431 (GRCm39)	D16G	probably damaging	Het

Other mutations in Or11g24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01719:Or11g24	APN	14	50,662,018 (GRCm39)	missense	possibly damaging	0.88
IGL02430:Or11g24	APN	14	50,662,608 (GRCm39)	missense	probably benign
IGL02603:Or11g24	APN	14	50,662,657 (GRCm39)	missense	probably damaging	1.00
IGL02959:Or11g24	APN	14	50,662,389 (GRCm39)	missense	possibly damaging	0.76
IGL03154:Or11g24	APN	14	50,662,080 (GRCm39)	missense	probably benign	0.00
R0455:Or11g24	UTSW	14	50,662,359 (GRCm39)	missense	possibly damaging	0.45
R1984:Or11g24	UTSW	14	50,662,848 (GRCm39)	missense	possibly damaging	0.93
R3160:Or11g24	UTSW	14	50,662,488 (GRCm39)	missense	probably damaging	0.99
R3161:Or11g24	UTSW	14	50,662,488 (GRCm39)	missense	probably damaging	0.99
R3162:Or11g24	UTSW	14	50,662,488 (GRCm39)	missense	probably damaging	0.99
R4821:Or11g24	UTSW	14	50,662,206 (GRCm39)	missense	possibly damaging	0.96
R4880:Or11g24	UTSW	14	50,662,758 (GRCm39)	missense	possibly damaging	0.90
R5047:Or11g24	UTSW	14	50,662,696 (GRCm39)	missense	probably damaging	1.00
R5384:Or11g24	UTSW	14	50,662,846 (GRCm39)	missense	possibly damaging	0.77
R5385:Or11g24	UTSW	14	50,662,846 (GRCm39)	missense	possibly damaging	0.77
R5386:Or11g24	UTSW	14	50,662,846 (GRCm39)	missense	possibly damaging	0.77
R5640:Or11g24	UTSW	14	50,662,111 (GRCm39)	missense	probably benign	0.18
R6035:Or11g24	UTSW	14	50,661,984 (GRCm39)	missense	probably benign
R6035:Or11g24	UTSW	14	50,661,984 (GRCm39)	missense	probably benign
R6229:Or11g24	UTSW	14	50,662,662 (GRCm39)	missense	probably benign	0.38
R6614:Or11g24	UTSW	14	50,662,546 (GRCm39)	missense	probably benign	0.00
R7308:Or11g24	UTSW	14	50,662,722 (GRCm39)	missense	possibly damaging	0.57
R7443:Or11g24	UTSW	14	50,662,507 (GRCm39)	missense	probably damaging	1.00
R7699:Or11g24	UTSW	14	50,662,792 (GRCm39)	missense	probably benign
R7700:Or11g24	UTSW	14	50,662,792 (GRCm39)	missense	probably benign
R7851:Or11g24	UTSW	14	50,662,827 (GRCm39)	missense	probably damaging	0.99
R8397:Or11g24	UTSW	14	50,662,137 (GRCm39)	missense	probably damaging	1.00
R8906:Or11g24	UTSW	14	50,662,291 (GRCm39)	missense	probably damaging	1.00
R9393:Or11g24	UTSW	14	50,662,255 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TTCACTATTTTATGGCTCAGTGATG -3'
(R):5'- AGTCTCTGACAACTATTGCCC -3'

Sequencing Primer
(F):5'- CAGTGATGATAATGTATCTGAGCCC -3'
(R):5'- GGGATGTCTACAGCTTCATCTGAAAG -3'

Posted On

2017-12-01