Incidental Mutation 'R5970:St13'
ID 501659
Institutional Source Beutler Lab
Gene Symbol St13
Ensembl Gene ENSMUSG00000022403
Gene Name suppression of tumorigenicity 13
Synonyms 3110002K08Rik, HSPABP1, PRO0786, SNC6, 1110007I03Rik, p48, Hsp70 interacting protein
MMRRC Submission 044153-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.294) question?
Stock # R5970 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 81247870-81284278 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 81261999 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 146 (S146R)
Ref Sequence ENSEMBL: ENSMUSP00000023039 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023039] [ENSMUST00000165582] [ENSMUST00000172107]
AlphaFold Q99L47
Predicted Effect probably damaging
Transcript: ENSMUST00000023039
AA Change: S146R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000023039
Gene: ENSMUSG00000022403
AA Change: S146R

DomainStartEndE-ValueType
PDB:4J8C|B 1 44 6e-25 PDB
low complexity region 52 72 N/A INTRINSIC
TPR 104 137 1.2e1 SMART
TPR 138 171 6.95e-4 SMART
TPR 172 205 4.8e1 SMART
coiled coil region 225 264 N/A INTRINSIC
low complexity region 271 305 N/A INTRINSIC
STI1 312 351 3.37e-10 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000165582
AA Change: S118R

PolyPhen 2 Score 0.928 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000129966
Gene: ENSMUSG00000022403
AA Change: S118R

DomainStartEndE-ValueType
low complexity region 15 29 N/A INTRINSIC
low complexity region 34 44 N/A INTRINSIC
Pfam:TPR_11 74 129 6.8e-10 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000172107
AA Change: S155R

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000130195
Gene: ENSMUSG00000022403
AA Change: S155R

DomainStartEndE-ValueType
PDB:4J8C|B 1 44 6e-25 PDB
low complexity region 52 66 N/A INTRINSIC
low complexity region 71 81 N/A INTRINSIC
TPR 113 146 1.2e1 SMART
TPR 147 180 6.95e-4 SMART
TPR 181 214 4.8e1 SMART
coiled coil region 234 273 N/A INTRINSIC
low complexity region 280 314 N/A INTRINSIC
STI1 321 360 3.37e-10 SMART
Meta Mutation Damage Score 0.7363 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.4%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1l1 G A 6: 90,574,028 (GRCm39) probably benign Het
Ambn T C 5: 88,615,810 (GRCm39) V413A possibly damaging Het
Amotl1 T A 9: 14,507,824 (GRCm39) D41V probably damaging Het
Arhgef26 T C 3: 62,247,468 (GRCm39) V184A probably benign Het
Birc6 G T 17: 74,925,497 (GRCm39) G936V possibly damaging Het
Ccser1 T A 6: 61,288,226 (GRCm39) S130T possibly damaging Het
Cecr2 A G 6: 120,697,868 (GRCm39) I56V probably damaging Het
Cfap52 A G 11: 67,821,570 (GRCm39) I486T probably damaging Het
Col4a3 A G 1: 82,694,050 (GRCm39) I1557V possibly damaging Het
Col6a5 T A 9: 105,823,046 (GRCm39) I104F unknown Het
Cry2 A G 2: 92,243,312 (GRCm39) S510P probably benign Het
Csmd2 G C 4: 128,439,944 (GRCm39) A3133P probably benign Het
Cyld G T 8: 89,459,621 (GRCm39) A611S probably damaging Het
Dennd4c G A 4: 86,743,749 (GRCm39) G1197E probably damaging Het
Dnah10 T C 5: 124,885,793 (GRCm39) F2969L probably benign Het
Dnai1 A G 4: 41,625,281 (GRCm39) K415R probably benign Het
Dnmbp T A 19: 43,842,610 (GRCm39) T1253S probably benign Het
Dsp T C 13: 38,379,678 (GRCm39) L1542P possibly damaging Het
Duox1 T A 2: 122,170,682 (GRCm39) L1234Q probably damaging Het
Efr3b T A 12: 4,018,590 (GRCm39) R585S possibly damaging Het
Gpt A G 15: 76,583,552 (GRCm39) probably null Het
Heatr6 G A 11: 83,644,544 (GRCm39) probably benign Het
Kcns2 A G 15: 34,839,930 (GRCm39) D431G probably benign Het
Kdm3b A G 18: 34,962,342 (GRCm39) N1543D probably damaging Het
Man2a1 A G 17: 64,932,375 (GRCm39) K154R probably benign Het
Mical3 G A 6: 120,935,232 (GRCm39) Q893* probably null Het
Morc3 C T 16: 93,663,341 (GRCm39) H515Y possibly damaging Het
Mprip A T 11: 59,648,547 (GRCm39) R750S probably damaging Het
Mroh1 G A 15: 76,335,691 (GRCm39) V1436M probably benign Het
Muc5ac C T 7: 141,344,406 (GRCm39) R69* probably null Het
Muc5b A T 7: 141,410,449 (GRCm39) Y1274F unknown Het
Mybpc1 A G 10: 88,378,318 (GRCm39) L674P probably damaging Het
Mypn A G 10: 62,966,802 (GRCm39) V958A probably benign Het
Nipbl T C 15: 8,326,302 (GRCm39) T2436A probably benign Het
Or7g20 A G 9: 18,946,443 (GRCm39) D8G probably benign Het
Pcdhb5 T A 18: 37,454,826 (GRCm39) L402Q probably damaging Het
Pigp T A 16: 94,171,053 (GRCm39) probably null Het
Rp1 A G 1: 4,418,685 (GRCm39) L809P probably benign Het
Scn3a T A 2: 65,325,125 (GRCm39) probably benign Het
Sdf2 A T 11: 78,136,906 (GRCm39) M29L probably benign Het
Serpina3b T G 12: 104,100,350 (GRCm39) L311V possibly damaging Het
Snx31 A T 15: 36,523,634 (GRCm39) Y349* probably null Het
Spidr A C 16: 15,932,733 (GRCm39) C182W probably damaging Het
St8sia4 A G 1: 95,581,307 (GRCm39) V145A probably damaging Het
Stradb T C 1: 59,019,175 (GRCm39) probably null Het
Tcp11l2 T A 10: 84,430,661 (GRCm39) probably benign Het
Tfdp2 C T 9: 96,199,627 (GRCm39) P74S unknown Het
Tmprss15 C T 16: 78,854,547 (GRCm39) R287H probably benign Het
Trav10d T C 14: 53,048,779 (GRCm39) Y57H probably damaging Het
Vmn2r104 A G 17: 20,249,733 (GRCm39) I846T probably benign Het
Ywhah T A 5: 33,184,292 (GRCm39) M165K possibly damaging Het
Zfp324 C A 7: 12,703,293 (GRCm39) P72T probably benign Het
Other mutations in St13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01647:St13 APN 15 81,255,708 (GRCm39) missense probably damaging 0.99
IGL01933:St13 APN 15 81,273,899 (GRCm39) critical splice acceptor site probably null
IGL02152:St13 APN 15 81,250,583 (GRCm39) missense probably damaging 1.00
R0714:St13 UTSW 15 81,267,228 (GRCm39) missense probably benign 0.16
R3417:St13 UTSW 15 81,253,651 (GRCm39) splice site probably benign
R4845:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R4925:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R4934:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R5029:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R5042:St13 UTSW 15 81,249,693 (GRCm39) missense probably damaging 1.00
R5048:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R5139:St13 UTSW 15 81,283,786 (GRCm39) missense probably benign 0.09
R6158:St13 UTSW 15 81,283,802 (GRCm39) splice site probably null
R6175:St13 UTSW 15 81,283,506 (GRCm39) critical splice donor site probably null
R6872:St13 UTSW 15 81,250,547 (GRCm39) critical splice donor site probably null
R7320:St13 UTSW 15 81,273,854 (GRCm39) missense probably damaging 0.99
R7912:St13 UTSW 15 81,283,719 (GRCm39) missense possibly damaging 0.52
R9258:St13 UTSW 15 81,272,569 (GRCm39) missense probably benign 0.01
R9281:St13 UTSW 15 81,261,927 (GRCm39) missense probably damaging 0.99
R9442:St13 UTSW 15 81,272,575 (GRCm39) missense possibly damaging 0.88
R9483:St13 UTSW 15 81,250,587 (GRCm39) missense probably damaging 0.99
R9549:St13 UTSW 15 81,259,063 (GRCm39) missense possibly damaging 0.64
X0065:St13 UTSW 15 81,250,637 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TTCTAGCCTCCATAGCACCACG -3'
(R):5'- TGTTCACAGACGCCATCAAG -3'

Sequencing Primer
(F):5'- AAGGTGTGTGCCATCACTAC -3'
(R):5'- ACTGGAGCACAAAGTCCT -3'
Posted On 2017-12-01