Mutagenetix > Incidental Mutation

Incidental Mutation 'R6038:Coro7'

501759

Institutional Source

Beutler Lab

Gene Symbol

Coro7

Ensembl Gene

ENSMUSG00000039637

Gene Name

coronin 7

Synonyms

0610011B16Rik

MMRRC Submission

044208-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R6038 (G1)

Quality Score

138.008

Status

Not validated

Chromosome

Chromosomal Location

4626133-4679777 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to T at 4679550 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000087966 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038552] [ENSMUST00000060067] [ENSMUST00000090480] [ENSMUST00000115854] [ENSMUST00000135823] [ENSMUST00000229529]

AlphaFold

Q9D2V7

Predicted Effect

probably null
Transcript: ENSMUST00000038552

SMART Domains

Protein: ENSMUSP00000048489
Gene: ENSMUSG00000039637

Domain	Start	End	E-Value	Type
DUF1899	3	64	6.41e-15	SMART
WD40	66	106	1.83e-7	SMART
WD40	115	154	4.13e0	SMART
WD40	157	196	1.78e-5	SMART
DUF1900	251	385	4.49e-60	SMART
low complexity region	427	456	N/A	INTRINSIC
DUF1899	463	528	1.2e-19	SMART
WD40	531	570	3.64e-2	SMART
WD40	580	620	8.55e-8	SMART
WD40	623	662	1.16e-9	SMART
low complexity region	667	679	N/A	INTRINSIC
DUF1900	718	854	6.69e-68	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000060067

SMART Domains

Protein: ENSMUSP00000053842
Gene: ENSMUSG00000004069

Domain	Start	End	E-Value	Type
low complexity region	20	36	N/A	INTRINSIC
DnaJ	92	150	4.57e-31	SMART
Pfam:DnaJ_C	209	413	4.4e-23	PFAM
Pfam:DnaJ_CXXCXGXG	236	296	2.4e-12	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000090480

SMART Domains

Protein: ENSMUSP00000087966
Gene: ENSMUSG00000039637

Domain	Start	End	E-Value	Type
DUF1899	3	64	6.41e-15	SMART
WD40	66	106	1.83e-7	SMART
WD40	115	154	4.13e0	SMART
WD40	157	196	1.78e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000115854

SMART Domains

Protein: ENSMUSP00000111520
Gene: ENSMUSG00000004069

Domain	Start	End	E-Value	Type
low complexity region	20	36	N/A	INTRINSIC
DnaJ	92	150	4.57e-31	SMART
Pfam:DnaJ_CXXCXGXG	236	296	3.9e-14	PFAM
Pfam:CTDII	345	423	1.5e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123031

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127850

Predicted Effect

probably benign
Transcript: ENSMUST00000135823

SMART Domains

Protein: ENSMUSP00000118310
Gene: ENSMUSG00000039637

Domain	Start	End	E-Value	Type
DUF1899	3	64	6.41e-15	SMART
WD40	66	106	1.83e-7	SMART
WD40	115	154	4.13e0	SMART
WD40	157	196	1.78e-5	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138495

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144815

Predicted Effect

probably benign
Transcript: ENSMUST00000229529

Meta Mutation Damage Score

0.9389

Coding Region Coverage

1x: 99.8%
3x: 99.1%
10x: 93.7%
20x: 76.5%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele are viable and overtly normal but exhibit disruption of the Golgi apparatus. Mutant fibroblasts show increased cell spreading and cellular F-actin content, increased cell polarization and migration, and enhanced wound healing in a scratch-wound assay. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc10	A	G	17: 46,304,360	C1327R	probably damaging	Het
Adcy7	A	G	8: 88,322,980	T704A	probably benign	Het
Adgra3	A	T	5: 49,999,145	Y414*	probably null	Het
Adgrf1	T	C	17: 43,295,209	S75P	probably benign	Het
Antxr1	C	A	6: 87,287,000		probably null	Het
Arid1b	A	T	17: 5,336,682	Y1470F	probably benign	Het
Baiap3	T	C	17: 25,246,334	D649G	probably damaging	Het
BC067074	G	A	13: 113,318,619	V400M	possibly damaging	Het
Cabin1	A	G	10: 75,739,366	V615A	probably benign	Het
Cntnap1	G	A	11: 101,184,636	R880Q	probably benign	Het
Col28a1	T	C	6: 8,013,140	T971A	probably benign	Het
Defb19	T	G	2: 152,576,267		probably null	Het
Dnah17	T	C	11: 118,055,889	D3045G	probably benign	Het
Dock4	A	T	12: 40,733,351		probably null	Het
Egln3	A	G	12: 54,181,690	V210A	probably damaging	Het
Epb41l4a	T	C	18: 33,854,335	S330G	probably benign	Het
Epha7	G	A	4: 28,821,521	E229K	probably damaging	Het
Fam71a	C	T	1: 191,162,722	E575K	probably damaging	Het
Fam71e1	C	T	7: 44,500,295	R147W	probably damaging	Het
Fam71e2	T	C	7: 4,753,595		probably null	Het
Fetub	C	T	16: 22,932,331	R143C	probably damaging	Het
Gxylt2	T	A	6: 100,804,594	L410Q	probably damaging	Het
H2-M10.3	C	A	17: 36,368,395	C6F	probably benign	Het
Hecw1	G	T	13: 14,346,062	Q197K	probably benign	Het
Hk3	T	C	13: 55,006,560	M778V	probably benign	Het
Hydin	A	G	8: 110,599,031	T4691A	probably benign	Het
Kndc1	CT	C	7: 139,923,775		probably null	Het
Larp1	A	G	11: 58,041,605	E204G	possibly damaging	Het
Lrp12	A	C	15: 39,872,380	W738G	probably damaging	Het
March10	A	G	11: 105,402,051	S72P	probably damaging	Het
Mdga2	A	T	12: 66,630,053	D488E	probably damaging	Het
Mrc1	G	C	2: 14,257,071	W290C	probably damaging	Het
Nhp2	T	C	11: 51,620,085	V55A	probably benign	Het
Olfr1116	T	A	2: 87,269,267	I141N	possibly damaging	Het
Olfr58	A	G	9: 19,783,562	Y143C	probably benign	Het
Olfr741	T	C	14: 50,486,220	L254P	probably damaging	Het
Osbpl7	C	T	11: 97,050,716	P22S	probably benign	Het
Pebp1	A	T	5: 117,284,105	L124Q	probably benign	Het
Pfkp	G	T	13: 6,597,969	H524N	probably benign	Het
Pnmt	G	A	11: 98,387,768	D187N	probably damaging	Het
Ppl	A	T	16: 5,102,581	I355K	possibly damaging	Het
Prom1	A	T	5: 44,001,793	Y836N	probably damaging	Het
Rubcnl	T	C	14: 75,031,970	S23P	probably benign	Het
Sap130	T	A	18: 31,680,486	I532N	probably damaging	Het
Serpina1e	A	T	12: 103,946,836		probably null	Het
Skiv2l2	A	T	13: 112,891,290	S679T	probably benign	Het
Slc12a3	T	G	8: 94,330,472	S124R	probably benign	Het
Slc24a5	A	G	2: 125,085,731	T317A	probably benign	Het
Smarcad1	T	C	6: 65,073,248	S284P	possibly damaging	Het
Spag9	C	G	11: 94,112,092	R724G	probably damaging	Het
Speg	T	C	1: 75,418,459		probably null	Het
Steap3	A	G	1: 120,241,641	Y271H	probably damaging	Het
Syne2	C	T	12: 75,878,384	Q44*	probably null	Het
Syt16	G	A	12: 74,222,535		probably null	Het
Tas2r114	A	T	6: 131,689,481	C195S	possibly damaging	Het
Tcl1b4	T	C	12: 105,202,507	M10T	possibly damaging	Het
Tln1	G	C	4: 43,555,052	F259L	probably damaging	Het
Vmn2r60	C	A	7: 42,194,962	A583D	probably benign	Het
Wdhd1	T	C	14: 47,263,580	Q455R	possibly damaging	Het
Wdr17	A	G	8: 54,632,311		probably null	Het
Xbp1	T	C	11: 5,524,798	L233P	probably benign	Het
Zbtb17	A	G	4: 141,464,441	E288G	probably benign	Het

Other mutations in Coro7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00428:Coro7	APN	16	4634636	missense	possibly damaging	0.83
IGL00885:Coro7	APN	16	4635026	missense	probably benign	0.00
IGL02944:Coro7	APN	16	4635412	missense	probably benign	0.14
IGL03104:Coro7	APN	16	4629126	missense	probably damaging	1.00
IGL03153:Coro7	APN	16	4635382	critical splice donor site	probably null
R0022:Coro7	UTSW	16	4633304	missense	probably benign	0.01
R0022:Coro7	UTSW	16	4633304	missense	probably benign	0.01
R0071:Coro7	UTSW	16	4670527	missense	probably damaging	1.00
R0071:Coro7	UTSW	16	4670527	missense	probably damaging	1.00
R0080:Coro7	UTSW	16	4630464	missense	probably damaging	1.00
R0193:Coro7	UTSW	16	4627504	unclassified	probably benign
R0242:Coro7	UTSW	16	4630178	splice site	probably benign
R0318:Coro7	UTSW	16	4675807	missense	probably benign	0.09
R0554:Coro7	UTSW	16	4632257	missense	possibly damaging	0.63
R0666:Coro7	UTSW	16	4631911	missense	possibly damaging	0.70
R0835:Coro7	UTSW	16	4632254	missense	probably benign	0.12
R0968:Coro7	UTSW	16	4670055	splice site	probably benign
R1670:Coro7	UTSW	16	4628233	missense	possibly damaging	0.76
R1709:Coro7	UTSW	16	4634441	splice site	probably null
R1848:Coro7	UTSW	16	4630434	missense	probably damaging	0.99
R1884:Coro7	UTSW	16	4628819	unclassified	probably benign
R1935:Coro7	UTSW	16	4628732	missense	probably benign
R1937:Coro7	UTSW	16	4628732	missense	probably benign
R1939:Coro7	UTSW	16	4628732	missense	probably benign
R1967:Coro7	UTSW	16	4634889	missense	probably damaging	1.00
R1969:Coro7	UTSW	16	4633756	missense	probably benign	0.19
R1970:Coro7	UTSW	16	4633756	missense	probably benign	0.19
R3034:Coro7	UTSW	16	4632291	missense	probably damaging	0.99
R4638:Coro7	UTSW	16	4632287	missense	probably damaging	0.96
R4710:Coro7	UTSW	16	4634933	intron	probably benign
R4723:Coro7	UTSW	16	4631994	missense	probably benign	0.00
R4789:Coro7	UTSW	16	4628221	missense	probably damaging	1.00
R5493:Coro7	UTSW	16	4632487	missense	probably damaging	0.99
R5619:Coro7	UTSW	16	4676935	critical splice donor site	probably null
R5756:Coro7	UTSW	16	4632284	missense	probably damaging	0.97
R5974:Coro7	UTSW	16	4631889	missense	possibly damaging	0.83
R6010:Coro7	UTSW	16	4669956	missense	possibly damaging	0.68
R6038:Coro7	UTSW	16	4679550	critical splice donor site	probably null
R6906:Coro7	UTSW	16	4633304	missense	probably benign	0.00
R6925:Coro7	UTSW	16	4628674	critical splice donor site	probably null
R7069:Coro7	UTSW	16	4679611	start codon destroyed	probably damaging	0.99
R7326:Coro7	UTSW	16	4632048	missense	probably damaging	0.96
R7421:Coro7	UTSW	16	4668751	missense	probably benign	0.19
R7521:Coro7	UTSW	16	4631482	missense	probably benign	0.00
R7773:Coro7	UTSW	16	4632006	missense	probably damaging	1.00
R7846:Coro7	UTSW	16	4670536	missense	probably damaging	1.00
R8240:Coro7	UTSW	16	4668796	missense	probably damaging	0.96
R8726:Coro7	UTSW	16	4668755	missense	possibly damaging	0.95
R8762:Coro7	UTSW	16	4634339	missense	probably benign
R9383:Coro7	UTSW	16	4635024	missense	probably damaging	1.00
R9451:Coro7	UTSW	16	4670538	missense	probably damaging	1.00
R9553:Coro7	UTSW	16	4668760	missense	possibly damaging	0.55

Predicted Primers

Posted On

2017-12-01