Incidental Mutation 'R6131:Mmp10'
ID 501814
Institutional Source Beutler Lab
Gene Symbol Mmp10
Ensembl Gene ENSMUSG00000047562
Gene Name matrix metallopeptidase 10
Synonyms stromelysin 2
MMRRC Submission 044278-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.192) question?
Stock # R6131 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 7502353-7510241 bp(+) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) A to G at 7503633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000034488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034488] [ENSMUST00000034488]
AlphaFold O55123
Predicted Effect probably null
Transcript: ENSMUST00000034488
SMART Domains Protein: ENSMUSP00000034488
Gene: ENSMUSG00000047562

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:PG_binding_1 27 87 3.2e-12 PFAM
ZnMc 105 265 1.81e-61 SMART
HX 295 337 2.03e-6 SMART
HX 339 382 9.11e-9 SMART
HX 387 434 8.49e-18 SMART
HX 436 476 3.88e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000034488
SMART Domains Protein: ENSMUSP00000034488
Gene: ENSMUSG00000047562

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:PG_binding_1 27 87 3.2e-12 PFAM
ZnMc 105 265 1.81e-61 SMART
HX 295 337 2.03e-6 SMART
HX 339 382 9.11e-9 SMART
HX 387 434 8.49e-18 SMART
HX 436 476 3.88e-3 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency 96% (50/52)
MGI Phenotype FUNCTION: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. The lack of encoded protein in mice promotes experimental lung cancer formation, exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031439G07Rik A T 15: 84,844,793 (GRCm39) W75R probably damaging Het
Aadacl2fm3 A G 3: 59,776,324 (GRCm39) K165R possibly damaging Het
Abca15 T C 7: 119,939,428 (GRCm39) V274A probably benign Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Ap1m2 T C 9: 21,207,797 (GRCm39) Y396C probably damaging Het
Apob T C 12: 8,065,874 (GRCm39) S405P probably benign Het
Arhgap26 G T 18: 39,419,638 (GRCm39) G533* probably null Het
Atxn2l T C 7: 126,102,337 (GRCm39) probably benign Het
Ccdc88c A T 12: 100,907,387 (GRCm39) L995H probably damaging Het
Ccn3 A G 15: 54,612,756 (GRCm39) D255G probably benign Het
Cep192 A G 18: 67,971,068 (GRCm39) H1023R possibly damaging Het
Cog5 T A 12: 31,936,220 (GRCm39) M589K possibly damaging Het
Col25a1 C A 3: 130,329,114 (GRCm39) P337Q probably damaging Het
Cyfip1 T G 7: 55,523,228 (GRCm39) V51G possibly damaging Het
Dnah7b A T 1: 46,292,626 (GRCm39) I3004F probably damaging Het
Dsg3 A T 18: 20,671,569 (GRCm39) D758V probably damaging Het
Dsg3 A G 18: 20,653,534 (GRCm39) probably null Het
Eml5 A T 12: 98,827,510 (GRCm39) H573Q probably damaging Het
Erp27 T C 6: 136,885,201 (GRCm39) D199G probably damaging Het
Flnb A G 14: 7,894,635 (GRCm38) Y811C possibly damaging Het
G6pd2 A T 5: 61,966,593 (GRCm39) S123C probably benign Het
Gm1818 T A 12: 48,602,319 (GRCm39) noncoding transcript Het
Gm29340 C T 2: 116,798,519 (GRCm39) noncoding transcript Het
H2bc7 C A 13: 23,758,310 (GRCm39) probably benign Het
Hcn2 G T 10: 79,569,742 (GRCm39) G581W probably damaging Het
Kidins220 T C 12: 25,042,313 (GRCm39) probably null Het
Lonp1 T C 17: 56,921,457 (GRCm39) E926G probably benign Het
Lrp1 T C 10: 127,396,026 (GRCm39) I2415V probably benign Het
Mmel1 C T 4: 154,979,475 (GRCm39) H728Y probably damaging Het
Myo16 T A 8: 10,619,877 (GRCm39) I1476N probably benign Het
Nectin3 G T 16: 46,215,515 (GRCm39) H76N probably damaging Het
Nphs2 G A 1: 156,153,521 (GRCm39) R204Q probably damaging Het
Or5ac15 T C 16: 58,940,256 (GRCm39) Y59C probably damaging Het
Or8b36 ATTGCTGTTT ATTGCTGTTTGCTGTTT 9: 37,937,836 (GRCm39) probably null Het
Or8b53 T A 9: 38,667,362 (GRCm39) I126N probably damaging Het
Otx1 A T 11: 21,949,406 (GRCm39) L24H probably damaging Het
Pate10 T A 9: 35,652,840 (GRCm39) C27* probably null Het
Psme2b T C 11: 48,836,752 (GRCm39) D65G probably damaging Het
Rlf T C 4: 121,012,172 (GRCm39) K214E probably damaging Het
Rnasel A T 1: 153,630,206 (GRCm39) T241S probably damaging Het
Samd9l C G 6: 3,377,252 (GRCm39) G3A probably benign Het
Smg7 A G 1: 152,720,962 (GRCm39) probably null Het
Spag16 A G 1: 70,764,242 (GRCm39) probably null Het
Spata31d1c T A 13: 65,183,485 (GRCm39) D342E probably benign Het
Stab2 A G 10: 86,719,642 (GRCm39) probably null Het
Taar7b A T 10: 23,876,615 (GRCm39) Y260F probably benign Het
Vcpip1 T C 1: 9,817,517 (GRCm39) I289V probably damaging Het
Vmn2r130 C T 17: 23,282,629 (GRCm39) A103V probably benign Het
Vmn2r39 A G 7: 9,017,963 (GRCm39) V791A probably damaging Het
Vmn2r66 T A 7: 84,644,224 (GRCm39) I729F probably damaging Het
Zfp536 T A 7: 37,269,137 (GRCm39) D93V probably damaging Het
Other mutations in Mmp10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01084:Mmp10 APN 9 7,505,651 (GRCm39) missense possibly damaging 0.77
Disco UTSW 9 7,504,170 (GRCm39) nonsense probably null
steel UTSW 9 7,506,513 (GRCm39) missense probably benign 0.01
Strobe UTSW 9 7,508,199 (GRCm39) missense probably benign
R0240:Mmp10 UTSW 9 7,506,544 (GRCm39) missense probably damaging 1.00
R0240:Mmp10 UTSW 9 7,506,544 (GRCm39) missense probably damaging 1.00
R0503:Mmp10 UTSW 9 7,507,340 (GRCm39) missense probably damaging 1.00
R0595:Mmp10 UTSW 9 7,508,199 (GRCm39) missense probably benign
R1222:Mmp10 UTSW 9 7,505,682 (GRCm39) splice site probably benign
R1487:Mmp10 UTSW 9 7,509,978 (GRCm39) missense probably damaging 0.98
R1622:Mmp10 UTSW 9 7,504,996 (GRCm39) nonsense probably null
R1669:Mmp10 UTSW 9 7,505,526 (GRCm39) critical splice acceptor site probably null
R1806:Mmp10 UTSW 9 7,506,502 (GRCm39) missense probably benign 0.01
R1880:Mmp10 UTSW 9 7,505,575 (GRCm39) missense probably benign 0.00
R4749:Mmp10 UTSW 9 7,508,169 (GRCm39) missense probably damaging 1.00
R4866:Mmp10 UTSW 9 7,508,190 (GRCm39) missense probably damaging 1.00
R5231:Mmp10 UTSW 9 7,502,501 (GRCm39) critical splice donor site probably null
R5367:Mmp10 UTSW 9 7,505,603 (GRCm39) missense probably damaging 1.00
R5814:Mmp10 UTSW 9 7,503,621 (GRCm39) missense possibly damaging 0.91
R6542:Mmp10 UTSW 9 7,506,513 (GRCm39) missense probably benign 0.01
R6997:Mmp10 UTSW 9 7,503,531 (GRCm39) missense probably benign 0.08
R7400:Mmp10 UTSW 9 7,503,301 (GRCm39) missense probably damaging 1.00
R7513:Mmp10 UTSW 9 7,508,128 (GRCm39) missense probably damaging 1.00
R7593:Mmp10 UTSW 9 7,503,154 (GRCm39) missense probably damaging 1.00
R7676:Mmp10 UTSW 9 7,503,550 (GRCm39) missense probably damaging 1.00
R7830:Mmp10 UTSW 9 7,507,284 (GRCm39) missense probably benign 0.00
R7967:Mmp10 UTSW 9 7,504,116 (GRCm39) missense probably damaging 1.00
R8353:Mmp10 UTSW 9 7,508,203 (GRCm39) missense probably damaging 1.00
R8453:Mmp10 UTSW 9 7,508,203 (GRCm39) missense probably damaging 1.00
R8728:Mmp10 UTSW 9 7,502,480 (GRCm39) missense probably benign
R8788:Mmp10 UTSW 9 7,502,687 (GRCm39) intron probably benign
R9023:Mmp10 UTSW 9 7,504,913 (GRCm39) missense probably damaging 1.00
R9386:Mmp10 UTSW 9 7,503,388 (GRCm39) missense probably damaging 1.00
R9388:Mmp10 UTSW 9 7,504,170 (GRCm39) nonsense probably null
R9414:Mmp10 UTSW 9 7,502,489 (GRCm39) missense probably benign 0.16
Z1176:Mmp10 UTSW 9 7,508,206 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CAGCGTTATAAATGTGTCAGGAGC -3'
(R):5'- GCTGCTTTTGCCATAGGAGG -3'

Sequencing Primer
(F):5'- CGTTATAAATGTGTCAGGAGCATCAC -3'
(R):5'- CTGCTTTTGCCATAGGAGGTAACAC -3'
Posted On 2017-12-04