Incidental Mutation 'R6131:Mmp10'
ID501814
Institutional Source Beutler Lab
Gene Symbol Mmp10
Ensembl Gene ENSMUSG00000047562
Gene Namematrix metallopeptidase 10
Synonymsstromelysin 2
MMRRC Submission 044278-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.090) question?
Stock #R6131 (G1)
Quality Score225.009
Status Validated
Chromosome9
Chromosomal Location7502352-7510240 bp(+) (GRCm38)
Type of Mutationsplice site (3 bp from exon)
DNA Base Change (assembly) A to G at 7503632 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000034488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034488] [ENSMUST00000034488]
Predicted Effect probably null
Transcript: ENSMUST00000034488
SMART Domains Protein: ENSMUSP00000034488
Gene: ENSMUSG00000047562

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:PG_binding_1 27 87 3.2e-12 PFAM
ZnMc 105 265 1.81e-61 SMART
HX 295 337 2.03e-6 SMART
HX 339 382 9.11e-9 SMART
HX 387 434 8.49e-18 SMART
HX 436 476 3.88e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000034488
SMART Domains Protein: ENSMUSP00000034488
Gene: ENSMUSG00000047562

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:PG_binding_1 27 87 3.2e-12 PFAM
ZnMc 105 265 1.81e-61 SMART
HX 295 337 2.03e-6 SMART
HX 339 382 9.11e-9 SMART
HX 387 434 8.49e-18 SMART
HX 436 476 3.88e-3 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency 96% (50/52)
MGI Phenotype FUNCTION: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. The lack of encoded protein in mice promotes experimental lung cancer formation, exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031439G07Rik A T 15: 84,960,592 W75R probably damaging Het
Abca15 T C 7: 120,340,205 V274A probably benign Het
Afg3l2 G T 18: 67,421,259 L458M probably damaging Het
Ap1m2 T C 9: 21,296,501 Y396C probably damaging Het
Apob T C 12: 8,015,874 S405P probably benign Het
Arhgap26 G T 18: 39,286,585 G533* probably null Het
Atxn2l T C 7: 126,503,165 probably benign Het
Ccdc88c A T 12: 100,941,128 L995H probably damaging Het
Cep192 A G 18: 67,837,997 H1023R possibly damaging Het
Cog5 T A 12: 31,886,221 M589K possibly damaging Het
Col25a1 C A 3: 130,535,465 P337Q probably damaging Het
Cyfip1 T G 7: 55,873,480 V51G possibly damaging Het
Dnah7b A T 1: 46,253,466 I3004F probably damaging Het
Dsg3 A T 18: 20,538,512 D758V probably damaging Het
Dsg3 A G 18: 20,520,477 probably null Het
Eml5 A T 12: 98,861,251 H573Q probably damaging Het
Erp27 T C 6: 136,908,203 D199G probably damaging Het
Flnb A G 14: 7,894,635 Y811C possibly damaging Het
G6pd2 A T 5: 61,809,250 S123C probably benign Het
Gm17677 T A 9: 35,741,544 C27* probably null Het
Gm1818 T A 12: 48,555,536 noncoding transcript Het
Gm29340 C T 2: 116,968,038 noncoding transcript Het
Gm8298 A G 3: 59,868,903 K165R possibly damaging Het
Hcn2 G T 10: 79,733,908 G581W probably damaging Het
Hist1h2bf C A 13: 23,574,136 probably benign Het
Kidins220 T C 12: 24,992,314 probably null Het
Lonp1 T C 17: 56,614,457 E926G probably benign Het
Lrp1 T C 10: 127,560,157 I2415V probably benign Het
Mmel1 C T 4: 154,895,018 H728Y probably damaging Het
Myo16 T A 8: 10,569,877 I1476N probably benign Het
Nectin3 G T 16: 46,395,152 H76N probably damaging Het
Nov A G 15: 54,749,360 D255G probably benign Het
Nphs2 G A 1: 156,325,951 R204Q probably damaging Het
Olfr194 T C 16: 59,119,893 Y59C probably damaging Het
Olfr883 ATTGCTGTTT ATTGCTGTTTGCTGTTT 9: 38,026,540 probably null Het
Olfr920 T A 9: 38,756,066 I126N probably damaging Het
Otx1 A T 11: 21,999,406 L24H probably damaging Het
Psme2b T C 11: 48,945,925 D65G probably damaging Het
Rlf T C 4: 121,154,975 K214E probably damaging Het
Rnasel A T 1: 153,754,460 T241S probably damaging Het
Samd9l C G 6: 3,377,252 G3A probably benign Het
Smg7 A G 1: 152,845,211 probably null Het
Spag16 A G 1: 70,725,083 probably null Het
Spata31d1c T A 13: 65,035,671 D342E probably benign Het
Stab2 A G 10: 86,883,778 probably null Het
Taar7b A T 10: 24,000,717 Y260F probably benign Het
Vcpip1 T C 1: 9,747,292 I289V probably damaging Het
Vmn2r39 A G 7: 9,014,964 V791A probably damaging Het
Vmn2r66 T A 7: 84,995,016 I729F probably damaging Het
Vmn2r-ps130 C T 17: 23,063,655 A103V probably benign Het
Zfp536 T A 7: 37,569,712 D93V probably damaging Het
Other mutations in Mmp10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01084:Mmp10 APN 9 7505650 missense possibly damaging 0.77
steel UTSW 9 7506512 missense probably benign 0.01
R0240:Mmp10 UTSW 9 7506543 missense probably damaging 1.00
R0240:Mmp10 UTSW 9 7506543 missense probably damaging 1.00
R0503:Mmp10 UTSW 9 7507339 missense probably damaging 1.00
R0595:Mmp10 UTSW 9 7508198 missense probably benign
R1222:Mmp10 UTSW 9 7505681 splice site probably benign
R1487:Mmp10 UTSW 9 7509977 missense probably damaging 0.98
R1622:Mmp10 UTSW 9 7504995 nonsense probably null
R1669:Mmp10 UTSW 9 7505525 critical splice acceptor site probably null
R1806:Mmp10 UTSW 9 7506501 missense probably benign 0.01
R1880:Mmp10 UTSW 9 7505574 missense probably benign 0.00
R4749:Mmp10 UTSW 9 7508168 missense probably damaging 1.00
R4866:Mmp10 UTSW 9 7508189 missense probably damaging 1.00
R5231:Mmp10 UTSW 9 7502500 critical splice donor site probably null
R5367:Mmp10 UTSW 9 7505602 missense probably damaging 1.00
R5814:Mmp10 UTSW 9 7503620 missense possibly damaging 0.91
R6542:Mmp10 UTSW 9 7506512 missense probably benign 0.01
R6997:Mmp10 UTSW 9 7503530 missense probably benign 0.08
R7400:Mmp10 UTSW 9 7503300 missense probably damaging 1.00
R7513:Mmp10 UTSW 9 7508127 missense probably damaging 1.00
R7593:Mmp10 UTSW 9 7503153 missense probably damaging 1.00
R7676:Mmp10 UTSW 9 7503549 missense probably damaging 1.00
R7830:Mmp10 UTSW 9 7507283 missense probably benign 0.00
R7967:Mmp10 UTSW 9 7504115 missense probably damaging 1.00
R8353:Mmp10 UTSW 9 7508202 missense probably damaging 1.00
R8453:Mmp10 UTSW 9 7508202 missense probably damaging 1.00
Z1176:Mmp10 UTSW 9 7508205 critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CAGCGTTATAAATGTGTCAGGAGC -3'
(R):5'- GCTGCTTTTGCCATAGGAGG -3'

Sequencing Primer
(F):5'- CGTTATAAATGTGTCAGGAGCATCAC -3'
(R):5'- CTGCTTTTGCCATAGGAGGTAACAC -3'
Posted On2017-12-04