Incidental Mutation 'R5748:Tcfl5'
ID 501918
Institutional Source Beutler Lab
Gene Symbol Tcfl5
Ensembl Gene ENSMUSG00000038932
Gene Name transcription factor-like 5 (basic helix-loop-helix)
Synonyms FIG beta, Figlb
MMRRC Submission 043355-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.189) question?
Stock # R5748 (G1)
Quality Score 44
Status Validated
Chromosome 2
Chromosomal Location 180263749-180284501 bp(-) (GRCm39)
Type of Mutation synonymous
DNA Base Change (assembly) G to A at 180284050 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125945 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037877] [ENSMUST00000161425]
AlphaFold Q32NY8
Predicted Effect silent
Transcript: ENSMUST00000037877
SMART Domains Protein: ENSMUSP00000040611
Gene: ENSMUSG00000038932

DomainStartEndE-ValueType
low complexity region 3 36 N/A INTRINSIC
low complexity region 76 110 N/A INTRINSIC
low complexity region 152 167 N/A INTRINSIC
low complexity region 185 198 N/A INTRINSIC
low complexity region 355 373 N/A INTRINSIC
HLH 395 445 2.13e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131881
Predicted Effect silent
Transcript: ENSMUST00000161425
SMART Domains Protein: ENSMUSP00000125945
Gene: ENSMUSG00000038932

DomainStartEndE-ValueType
low complexity region 3 36 N/A INTRINSIC
low complexity region 76 110 N/A INTRINSIC
low complexity region 152 167 N/A INTRINSIC
low complexity region 185 198 N/A INTRINSIC
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 96.0%
Validation Efficiency 98% (58/59)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan A G 7: 78,739,447 (GRCm39) Q285R probably damaging Het
Acy1 T A 9: 106,313,926 (GRCm39) N78I probably damaging Het
Anln T C 9: 22,249,230 (GRCm39) K166E probably damaging Het
C1qtnf4 A G 2: 90,719,877 (GRCm39) D50G probably damaging Het
Cntnap2 A G 6: 45,692,818 (GRCm39) T100A probably damaging Het
Cxcr6 C T 9: 123,639,406 (GRCm39) R143C probably damaging Het
Dhx16 T C 17: 36,194,206 (GRCm39) L439P probably damaging Het
Dlk1 T C 12: 109,425,898 (GRCm39) V257A probably benign Het
Ebpl A T 14: 61,597,793 (GRCm39) L16Q probably null Het
Eml5 T A 12: 98,791,814 (GRCm39) Y1234F probably damaging Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Gria1 A G 11: 57,200,702 (GRCm39) D793G probably benign Het
Gtse1 T C 15: 85,751,778 (GRCm39) Y324H probably benign Het
Hcn1 A T 13: 118,112,591 (GRCm39) S852C probably damaging Het
Invs A G 4: 48,307,823 (GRCm39) T83A probably damaging Het
Iqgap3 T C 3: 88,016,677 (GRCm39) L155P probably damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Lrrc14b T A 13: 74,511,759 (GRCm39) D107V probably damaging Het
Mcm9 A T 10: 53,501,825 (GRCm39) H253Q probably damaging Het
Mcmdc2 A G 1: 9,982,032 (GRCm39) Y30C probably damaging Het
Mdga1 C T 17: 30,069,525 (GRCm39) D174N probably benign Het
Med13l G A 5: 118,731,510 (GRCm39) R62H probably damaging Het
Mrgpra2b A G 7: 47,152,280 (GRCm39) probably benign Het
Nacad T A 11: 6,548,370 (GRCm39) K1426* probably null Het
Ndufb6 A G 4: 40,279,234 (GRCm39) L35S probably damaging Het
Niban2 A T 2: 32,809,581 (GRCm39) K260M probably damaging Het
Nkapl A G 13: 21,651,779 (GRCm39) I278T probably benign Het
Nrbp2 T C 15: 75,961,332 (GRCm39) E263G probably damaging Het
Nup85 T A 11: 115,471,338 (GRCm39) L110Q probably damaging Het
Or14c40 A G 7: 86,313,293 (GRCm39) N141S possibly damaging Het
Or1e35 A G 11: 73,797,721 (GRCm39) I199T probably damaging Het
Or2t6 T C 14: 14,175,314 (GRCm38) Y256C probably damaging Het
Or4a78 A T 2: 89,498,146 (GRCm39) M28K possibly damaging Het
Or5b12 T A 19: 12,897,379 (GRCm39) Q98L probably damaging Het
Or6b2b T A 1: 92,418,815 (GRCm39) I221F probably damaging Het
Polr2m C T 9: 71,390,918 (GRCm39) D95N probably benign Het
Popdc2 A T 16: 38,194,665 (GRCm39) D362V probably damaging Het
Pot1a A T 6: 25,758,855 (GRCm39) I308N possibly damaging Het
Rsf1 GCGGCGGC GCGGCGGCGTCGGCGGC 7: 97,229,135 (GRCm39) probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Rundc3a G A 11: 102,290,225 (GRCm39) E189K possibly damaging Het
Scaf1 A C 7: 44,662,230 (GRCm39) probably null Het
Scaper T C 9: 55,766,360 (GRCm39) probably null Het
Sh3glb1 C T 3: 144,418,410 (GRCm39) C51Y probably damaging Het
Slc10a5 T C 3: 10,400,391 (GRCm39) T90A probably benign Het
Slc17a3 T A 13: 24,040,449 (GRCm39) S336T probably damaging Het
Slc41a2 C A 10: 83,133,023 (GRCm39) C341F probably benign Het
Spata31 A G 13: 65,068,127 (GRCm39) *67W probably null Het
Stap2 C T 17: 56,307,475 (GRCm39) probably null Het
Stt3a A T 9: 36,663,696 (GRCm39) M182K probably benign Het
Tmx3 T C 18: 90,555,225 (GRCm39) V314A probably benign Het
Upf1 A G 8: 70,791,167 (GRCm39) L525P probably damaging Het
Wdr6 T C 9: 108,452,981 (GRCm39) I301V possibly damaging Het
Ylpm1 T A 12: 85,107,025 (GRCm39) probably null Het
Zfp273 T C 13: 67,973,450 (GRCm39) Y160H probably damaging Het
Other mutations in Tcfl5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02799:Tcfl5 UTSW 2 180,280,419 (GRCm39) missense possibly damaging 0.94
R1238:Tcfl5 UTSW 2 180,264,440 (GRCm39) missense probably benign 0.29
R6679:Tcfl5 UTSW 2 180,277,055 (GRCm39) missense probably damaging 1.00
R6694:Tcfl5 UTSW 2 180,264,447 (GRCm39) missense probably damaging 1.00
R7293:Tcfl5 UTSW 2 180,283,958 (GRCm39) missense probably benign 0.08
R8284:Tcfl5 UTSW 2 180,280,330 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACACCAGCTCTGCAATCAGG -3'
(R):5'- AGCTGCAGCACATCCTCTAC -3'

Sequencing Primer
(F):5'- ATACTGTTGAAGCGGTCCTCCAG -3'
(R):5'- ATCCTCTACTCGCACATGGAGG -3'
Posted On 2017-12-20