Incidental Mutation 'R6187:Eif2ak4'
| ID |
502217 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Eif2ak4
|
| Ensembl Gene |
ENSMUSG00000005102 |
| Gene Name |
eukaryotic translation initiation factor 2 alpha kinase 4 |
| Synonyms |
GCN2 |
| MMRRC Submission |
044327-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6187 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
118219099-118305715 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 118287638 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Methionine
at position 1081
(T1081M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106496
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005233]
[ENSMUST00000102527]
[ENSMUST00000110869]
[ENSMUST00000110870]
[ENSMUST00000110872]
[ENSMUST00000110874]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000005233
AA Change: T1202M
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000005233
Gene: ENSMUSG00000005102
AA Change: T1202M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
13 |
N/A |
INTRINSIC |
|
RWD
|
25 |
137 |
3.42e-38 |
SMART |
|
coiled coil region
|
146 |
205 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
323 |
538 |
4.6e-27 |
PFAM |
|
Pfam:Pkinase_Tyr
|
326 |
535 |
5.5e-18 |
PFAM |
|
Pfam:Pkinase
|
589 |
663 |
1.7e-11 |
PFAM |
|
Pfam:Pkinase_Tyr
|
589 |
663 |
1.2e-5 |
PFAM |
|
low complexity region
|
728 |
738 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
781 |
1000 |
2.6e-38 |
PFAM |
|
Pfam:Pkinase_Tyr
|
786 |
998 |
1.8e-18 |
PFAM |
|
Pfam:tRNA-synt_His
|
1054 |
1380 |
5.7e-18 |
PFAM |
|
Pfam:HGTP_anticodon2
|
1392 |
1647 |
5.8e-17 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000102527
AA Change: T1090M
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000099586
Gene: ENSMUSG00000005102
AA Change: T1090M
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
34 |
93 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
211 |
426 |
1.6e-22 |
PFAM |
|
Pfam:Pkinase_Tyr
|
215 |
423 |
6.8e-18 |
PFAM |
|
Pfam:Pkinase_Tyr
|
477 |
551 |
1.2e-5 |
PFAM |
|
Pfam:Pkinase
|
477 |
552 |
3.9e-11 |
PFAM |
|
low complexity region
|
616 |
626 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
647 |
888 |
9.4e-42 |
PFAM |
|
Pfam:Pkinase_Tyr
|
672 |
886 |
1.4e-19 |
PFAM |
|
Pfam:tRNA-synt_His
|
941 |
1268 |
4.8e-19 |
PFAM |
|
Pfam:HGTP_anticodon2
|
1280 |
1535 |
1e-16 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110869
|
| SMART Domains |
Protein: ENSMUSP00000106493
Gene: ENSMUSG00000005102
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
15 |
199 |
2.3e-32 |
PFAM |
|
Pfam:Pkinase_Tyr
|
16 |
198 |
3.1e-13 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000110870
AA Change: T924M
PolyPhen 2
Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000106494
Gene: ENSMUSG00000005102
AA Change: T924M
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
45 |
260 |
3.3e-22 |
PFAM |
|
Pfam:Pkinase_Tyr
|
47 |
257 |
1.3e-17 |
PFAM |
|
Pfam:Pkinase_Tyr
|
311 |
385 |
2.5e-5 |
PFAM |
|
Pfam:Pkinase
|
311 |
386 |
8e-11 |
PFAM |
|
low complexity region
|
450 |
460 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
481 |
722 |
1.9e-41 |
PFAM |
|
Pfam:Pkinase_Tyr
|
506 |
720 |
2.8e-19 |
PFAM |
|
Pfam:tRNA-synt_His
|
775 |
1102 |
8.7e-19 |
PFAM |
|
Pfam:HGTP_anticodon2
|
1114 |
1369 |
1.9e-16 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000110872
AA Change: T1081M
PolyPhen 2
Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000106496
Gene: ENSMUSG00000005102
AA Change: T1081M
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
25 |
84 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
202 |
417 |
3.8e-22 |
PFAM |
|
Pfam:Pkinase_Tyr
|
206 |
414 |
1.6e-17 |
PFAM |
|
Pfam:Pkinase_Tyr
|
468 |
542 |
2.8e-5 |
PFAM |
|
Pfam:Pkinase
|
468 |
543 |
9.1e-11 |
PFAM |
|
low complexity region
|
607 |
617 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
638 |
879 |
2.2e-41 |
PFAM |
|
Pfam:Pkinase_Tyr
|
663 |
877 |
3.3e-19 |
PFAM |
|
Pfam:tRNA-synt_His
|
932 |
1259 |
1.1e-18 |
PFAM |
|
Pfam:HGTP_anticodon2
|
1271 |
1526 |
2.2e-16 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110874
AA Change: T1124M
PolyPhen 2
Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000106498
Gene: ENSMUSG00000005102
AA Change: T1124M
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RWD
|
8 |
56 |
6.4e-8 |
PFAM |
|
coiled coil region
|
68 |
127 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
245 |
460 |
1.1e-22 |
PFAM |
|
Pfam:Pkinase_Tyr
|
247 |
457 |
4.2e-18 |
PFAM |
|
Pfam:Pkinase_Tyr
|
511 |
585 |
7.8e-6 |
PFAM |
|
Pfam:Pkinase
|
511 |
586 |
2.5e-11 |
PFAM |
|
low complexity region
|
650 |
660 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
681 |
922 |
6.2e-42 |
PFAM |
|
Pfam:Pkinase_Tyr
|
706 |
920 |
9.3e-20 |
PFAM |
|
Pfam:tRNA-synt_His
|
975 |
1302 |
3.8e-19 |
PFAM |
|
Pfam:HGTP_anticodon2
|
1314 |
1569 |
5.4e-17 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125281
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
99% (79/80) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
PHENOTYPE: Homozygotes for a null allele have altered feeding behavior, synaptic plasticity and dendritic cell function. Homozygotes for another null allele show enhanced muscle loss and morbidity after amino acid deprivation. Homozygotes for an ENU-induced allele show higher susceptibility to viral infection. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(8) : Targeted(3) Gene trapped(4) Chemically induced(1)
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
A |
11: 9,259,085 (GRCm39) |
L2937H |
probably damaging |
Het |
| Abca3 |
A |
G |
17: 24,627,141 (GRCm39) |
I1281V |
possibly damaging |
Het |
| Adam2 |
A |
T |
14: 66,306,068 (GRCm39) |
S138T |
possibly damaging |
Het |
| Adamts4 |
C |
T |
1: 171,078,562 (GRCm39) |
P61S |
probably damaging |
Het |
| Adamts6 |
C |
T |
13: 104,433,933 (GRCm39) |
P121S |
probably damaging |
Het |
| Afg3l2 |
G |
T |
18: 67,554,329 (GRCm39) |
L458M |
probably damaging |
Het |
| Ak1 |
G |
A |
2: 32,523,489 (GRCm39) |
V186M |
probably damaging |
Het |
| Alpk1 |
T |
C |
3: 127,466,991 (GRCm39) |
Y1096C |
probably damaging |
Het |
| Ankrd29 |
A |
C |
18: 12,412,747 (GRCm39) |
Y73* |
probably null |
Het |
| Asah2 |
A |
T |
19: 32,002,267 (GRCm39) |
S292R |
probably damaging |
Het |
| Atp6v1b1 |
A |
T |
6: 83,729,377 (GRCm39) |
T105S |
probably damaging |
Het |
| Axdnd1 |
T |
A |
1: 156,193,182 (GRCm39) |
|
probably null |
Het |
| Bub1b |
T |
G |
2: 118,461,481 (GRCm39) |
S678A |
probably damaging |
Het |
| Cdcp3 |
G |
A |
7: 130,872,328 (GRCm39) |
|
probably benign |
Het |
| Cenpq |
T |
A |
17: 41,238,089 (GRCm39) |
M142L |
probably benign |
Het |
| Ciz1 |
T |
A |
2: 32,260,063 (GRCm39) |
V203E |
possibly damaging |
Het |
| Cmklr2 |
T |
C |
1: 63,222,434 (GRCm39) |
E267G |
probably damaging |
Het |
| Col2a1 |
G |
T |
15: 97,886,671 (GRCm39) |
T378N |
unknown |
Het |
| Cyp2c68 |
A |
T |
19: 39,729,452 (GRCm39) |
S12T |
probably benign |
Het |
| Cyp4f18 |
C |
A |
8: 72,747,030 (GRCm39) |
A322S |
probably damaging |
Het |
| Disp2 |
A |
G |
2: 118,622,624 (GRCm39) |
S1119G |
probably damaging |
Het |
| Faxc |
A |
G |
4: 21,958,445 (GRCm39) |
T201A |
possibly damaging |
Het |
| Fbxw14 |
A |
G |
9: 109,105,332 (GRCm39) |
S278P |
probably damaging |
Het |
| Fpr1 |
G |
T |
17: 18,097,190 (GRCm39) |
C266* |
probably null |
Het |
| Fsip2 |
T |
C |
2: 82,812,798 (GRCm39) |
I3039T |
probably benign |
Het |
| Gas1 |
G |
T |
13: 60,324,186 (GRCm39) |
S190R |
possibly damaging |
Het |
| Gemin2 |
A |
G |
12: 59,060,371 (GRCm39) |
T37A |
probably damaging |
Het |
| Gm21370 |
T |
C |
13: 120,488,403 (GRCm39) |
I49V |
probably benign |
Het |
| Gm8444 |
T |
C |
15: 81,727,807 (GRCm39) |
|
probably benign |
Het |
| Gria1 |
A |
G |
11: 57,128,936 (GRCm39) |
D401G |
possibly damaging |
Het |
| Gstk1 |
G |
A |
6: 42,226,794 (GRCm39) |
V187I |
possibly damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,506,479 (GRCm39) |
D3776G |
probably damaging |
Het |
| Itfg1 |
A |
C |
8: 86,563,094 (GRCm39) |
V102G |
probably damaging |
Het |
| Kidins220 |
A |
G |
12: 25,101,307 (GRCm39) |
|
probably null |
Het |
| Kif13b |
A |
C |
14: 64,973,664 (GRCm39) |
D338A |
probably damaging |
Het |
| Mab21l2 |
T |
C |
3: 86,454,565 (GRCm39) |
Y145C |
probably damaging |
Het |
| Magel2 |
A |
G |
7: 62,027,389 (GRCm39) |
M98V |
unknown |
Het |
| Mdfic |
T |
C |
6: 15,721,196 (GRCm39) |
|
probably benign |
Het |
| Minar1 |
A |
G |
9: 89,473,220 (GRCm39) |
I897T |
probably damaging |
Het |
| Mlip |
G |
A |
9: 77,137,764 (GRCm39) |
S381L |
probably damaging |
Het |
| Mycbp2 |
A |
G |
14: 103,384,453 (GRCm39) |
L3475P |
probably damaging |
Het |
| Myh14 |
G |
A |
7: 44,276,457 (GRCm39) |
T1216I |
probably damaging |
Het |
| Nfatc2 |
T |
A |
2: 168,322,158 (GRCm39) |
I914F |
probably benign |
Het |
| Nup58 |
T |
C |
14: 60,478,256 (GRCm39) |
|
probably null |
Het |
| Or10ag53 |
T |
A |
2: 87,083,042 (GRCm39) |
S254T |
probably damaging |
Het |
| Or10al4 |
T |
C |
17: 38,037,032 (GRCm39) |
L48P |
probably damaging |
Het |
| Or13a22 |
A |
G |
7: 140,072,529 (GRCm39) |
|
probably benign |
Het |
| Or2y13 |
G |
T |
11: 49,414,338 (GRCm39) |
|
probably benign |
Het |
| Or4l15 |
A |
G |
14: 50,198,526 (GRCm39) |
M1T |
probably null |
Het |
| Or5p50 |
A |
T |
7: 107,421,781 (GRCm39) |
N298K |
probably benign |
Het |
| Or7g20 |
A |
C |
9: 18,946,689 (GRCm39) |
Q90P |
probably benign |
Het |
| Otx1 |
A |
T |
11: 21,949,406 (GRCm39) |
L24H |
probably damaging |
Het |
| Oxr1 |
A |
G |
15: 41,689,315 (GRCm39) |
Q513R |
probably damaging |
Het |
| Padi1 |
C |
T |
4: 140,554,276 (GRCm39) |
V310M |
probably damaging |
Het |
| Pard3 |
T |
C |
8: 127,800,023 (GRCm39) |
L11S |
probably benign |
Het |
| Pcdhb14 |
A |
T |
18: 37,581,497 (GRCm39) |
D201V |
probably damaging |
Het |
| Pcdhb7 |
A |
G |
18: 37,475,622 (GRCm39) |
R253G |
probably benign |
Het |
| Plxnb2 |
C |
T |
15: 89,051,461 (GRCm39) |
D253N |
probably damaging |
Het |
| Ppp2cb |
T |
C |
8: 34,105,502 (GRCm39) |
S171P |
probably damaging |
Het |
| Prr5 |
C |
T |
15: 84,577,973 (GRCm39) |
T94M |
probably damaging |
Het |
| Rp1 |
A |
G |
1: 4,420,092 (GRCm39) |
F340S |
probably damaging |
Het |
| Rpa1 |
C |
G |
11: 75,201,062 (GRCm39) |
G433A |
probably benign |
Het |
| Smg1 |
A |
T |
7: 117,788,386 (GRCm39) |
|
probably benign |
Het |
| Sry |
C |
G |
Y: 2,662,975 (GRCm39) |
Q228H |
unknown |
Homo |
| Svep1 |
C |
T |
4: 58,072,872 (GRCm39) |
G2146R |
probably damaging |
Het |
| Tas2r106 |
A |
G |
6: 131,655,173 (GRCm39) |
M226T |
probably damaging |
Het |
| Tbk1 |
T |
C |
10: 121,420,148 (GRCm39) |
I14V |
probably benign |
Het |
| Tekt4 |
G |
C |
17: 25,691,197 (GRCm39) |
V168L |
probably damaging |
Het |
| Tnfaip1 |
T |
A |
11: 78,418,372 (GRCm39) |
T232S |
probably damaging |
Het |
| Trio |
C |
T |
15: 27,744,038 (GRCm39) |
|
probably null |
Het |
| Ttn |
T |
A |
2: 76,774,781 (GRCm39) |
Y2133F |
unknown |
Het |
| Uap1l1 |
C |
T |
2: 25,252,741 (GRCm39) |
R433H |
probably damaging |
Het |
| Ugt2b35 |
T |
C |
5: 87,155,181 (GRCm39) |
F339L |
probably damaging |
Het |
| Unc5b |
T |
C |
10: 60,608,003 (GRCm39) |
Y699C |
probably damaging |
Het |
| Vcpip1 |
T |
C |
1: 9,795,005 (GRCm39) |
H1122R |
probably damaging |
Het |
| Vmn2r91 |
T |
C |
17: 18,326,888 (GRCm39) |
V391A |
probably benign |
Het |
| Vps13c |
C |
T |
9: 67,822,939 (GRCm39) |
R1327W |
probably damaging |
Het |
| Yes1 |
A |
G |
5: 32,802,385 (GRCm39) |
Y100C |
probably damaging |
Het |
| Zfp407 |
A |
T |
18: 84,577,134 (GRCm39) |
N1326K |
possibly damaging |
Het |
| Zfp518a |
G |
A |
19: 40,903,890 (GRCm39) |
C1273Y |
probably benign |
Het |
| Zfr |
AGCAGCAGCAGCAGCTGCTGCTGCAGCAGCA |
AGCAGCAGCA |
15: 12,146,317 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Eif2ak4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00233:Eif2ak4
|
APN |
2 |
118,294,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00806:Eif2ak4
|
APN |
2 |
118,271,647 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01343:Eif2ak4
|
APN |
2 |
118,252,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01796:Eif2ak4
|
APN |
2 |
118,276,785 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02263:Eif2ak4
|
APN |
2 |
118,292,259 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02391:Eif2ak4
|
APN |
2 |
118,251,272 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02516:Eif2ak4
|
APN |
2 |
118,266,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02603:Eif2ak4
|
APN |
2 |
118,280,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02731:Eif2ak4
|
APN |
2 |
118,219,295 (GRCm39) |
missense |
probably benign |
|
|
IGL02928:Eif2ak4
|
APN |
2 |
118,303,168 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02947:Eif2ak4
|
APN |
2 |
118,261,514 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03191:Eif2ak4
|
APN |
2 |
118,252,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03202:Eif2ak4
|
APN |
2 |
118,231,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03235:Eif2ak4
|
APN |
2 |
118,273,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03375:Eif2ak4
|
APN |
2 |
118,252,799 (GRCm39) |
missense |
probably benign |
0.08 |
|
absurdum
|
UTSW |
2 |
118,251,291 (GRCm39) |
nonsense |
probably null |
|
|
Ad
|
UTSW |
2 |
118,266,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
atchoum
|
UTSW |
2 |
118,231,134 (GRCm39) |
splice site |
probably benign |
|
|
reductio
|
UTSW |
2 |
118,266,639 (GRCm39) |
splice site |
probably null |
|
|
PIT4520001:Eif2ak4
|
UTSW |
2 |
118,292,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0023:Eif2ak4
|
UTSW |
2 |
118,293,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0358:Eif2ak4
|
UTSW |
2 |
118,294,410 (GRCm39) |
splice site |
probably null |
|
|
R0482:Eif2ak4
|
UTSW |
2 |
118,292,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Eif2ak4
|
UTSW |
2 |
118,261,517 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0523:Eif2ak4
|
UTSW |
2 |
118,272,577 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0578:Eif2ak4
|
UTSW |
2 |
118,305,472 (GRCm39) |
splice site |
probably benign |
|
|
R0615:Eif2ak4
|
UTSW |
2 |
118,266,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1300:Eif2ak4
|
UTSW |
2 |
118,294,464 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1531:Eif2ak4
|
UTSW |
2 |
118,273,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1777:Eif2ak4
|
UTSW |
2 |
118,261,320 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1866:Eif2ak4
|
UTSW |
2 |
118,303,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1932:Eif2ak4
|
UTSW |
2 |
118,278,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1977:Eif2ak4
|
UTSW |
2 |
118,292,238 (GRCm39) |
nonsense |
probably null |
|
|
R2011:Eif2ak4
|
UTSW |
2 |
118,261,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2046:Eif2ak4
|
UTSW |
2 |
118,281,889 (GRCm39) |
splice site |
probably benign |
|
|
R2122:Eif2ak4
|
UTSW |
2 |
118,286,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2125:Eif2ak4
|
UTSW |
2 |
118,252,604 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2126:Eif2ak4
|
UTSW |
2 |
118,252,604 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2193:Eif2ak4
|
UTSW |
2 |
118,252,747 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2259:Eif2ak4
|
UTSW |
2 |
118,286,264 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2513:Eif2ak4
|
UTSW |
2 |
118,257,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3798:Eif2ak4
|
UTSW |
2 |
118,304,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3898:Eif2ak4
|
UTSW |
2 |
118,261,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3900:Eif2ak4
|
UTSW |
2 |
118,305,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4375:Eif2ak4
|
UTSW |
2 |
118,258,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4423:Eif2ak4
|
UTSW |
2 |
118,269,547 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4589:Eif2ak4
|
UTSW |
2 |
118,247,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4734:Eif2ak4
|
UTSW |
2 |
118,252,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5173:Eif2ak4
|
UTSW |
2 |
118,238,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5367:Eif2ak4
|
UTSW |
2 |
118,266,639 (GRCm39) |
splice site |
probably null |
|
|
R5471:Eif2ak4
|
UTSW |
2 |
118,304,613 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5528:Eif2ak4
|
UTSW |
2 |
118,258,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5634:Eif2ak4
|
UTSW |
2 |
118,292,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Eif2ak4
|
UTSW |
2 |
118,273,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5756:Eif2ak4
|
UTSW |
2 |
118,293,221 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5779:Eif2ak4
|
UTSW |
2 |
118,243,444 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5807:Eif2ak4
|
UTSW |
2 |
118,219,332 (GRCm39) |
missense |
probably benign |
|
|
R6045:Eif2ak4
|
UTSW |
2 |
118,219,296 (GRCm39) |
nonsense |
probably null |
|
|
R6193:Eif2ak4
|
UTSW |
2 |
118,231,081 (GRCm39) |
start gained |
probably benign |
|
|
R6468:Eif2ak4
|
UTSW |
2 |
118,266,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6555:Eif2ak4
|
UTSW |
2 |
118,258,350 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6616:Eif2ak4
|
UTSW |
2 |
118,285,326 (GRCm39) |
nonsense |
probably null |
|
|
R6737:Eif2ak4
|
UTSW |
2 |
118,292,749 (GRCm39) |
frame shift |
probably null |
|
|
R6956:Eif2ak4
|
UTSW |
2 |
118,252,748 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7075:Eif2ak4
|
UTSW |
2 |
118,251,291 (GRCm39) |
nonsense |
probably null |
|
|
R7109:Eif2ak4
|
UTSW |
2 |
118,235,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7228:Eif2ak4
|
UTSW |
2 |
118,287,638 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7441:Eif2ak4
|
UTSW |
2 |
118,302,377 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7555:Eif2ak4
|
UTSW |
2 |
118,247,764 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7567:Eif2ak4
|
UTSW |
2 |
118,280,795 (GRCm39) |
missense |
probably benign |
|
|
R8004:Eif2ak4
|
UTSW |
2 |
118,247,775 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8063:Eif2ak4
|
UTSW |
2 |
118,241,382 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8092:Eif2ak4
|
UTSW |
2 |
118,272,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8195:Eif2ak4
|
UTSW |
2 |
118,280,819 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8306:Eif2ak4
|
UTSW |
2 |
118,287,656 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8470:Eif2ak4
|
UTSW |
2 |
118,293,207 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8671:Eif2ak4
|
UTSW |
2 |
118,252,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8693:Eif2ak4
|
UTSW |
2 |
118,262,718 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8714:Eif2ak4
|
UTSW |
2 |
118,292,765 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8744:Eif2ak4
|
UTSW |
2 |
118,261,474 (GRCm39) |
nonsense |
probably null |
|
|
R8813:Eif2ak4
|
UTSW |
2 |
118,278,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8917:Eif2ak4
|
UTSW |
2 |
118,287,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8924:Eif2ak4
|
UTSW |
2 |
118,258,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9177:Eif2ak4
|
UTSW |
2 |
118,271,701 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9189:Eif2ak4
|
UTSW |
2 |
118,258,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9231:Eif2ak4
|
UTSW |
2 |
118,271,662 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9268:Eif2ak4
|
UTSW |
2 |
118,271,701 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9321:Eif2ak4
|
UTSW |
2 |
118,292,798 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9512:Eif2ak4
|
UTSW |
2 |
118,293,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9569:Eif2ak4
|
UTSW |
2 |
118,251,316 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9658:Eif2ak4
|
UTSW |
2 |
118,269,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9748:Eif2ak4
|
UTSW |
2 |
118,247,730 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9757:Eif2ak4
|
UTSW |
2 |
118,269,398 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9766:Eif2ak4
|
UTSW |
2 |
118,261,313 (GRCm39) |
nonsense |
probably null |
|
|
X0061:Eif2ak4
|
UTSW |
2 |
118,298,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGCCAGTCGGTTACCACTG -3'
(R):5'- TGCTTGTGTCACAGTAGAGC -3'
Sequencing Primer
(F):5'- GAAACCCTGTCTCAGTAGATAGATG -3'
(R):5'- CTTGTGTCACAGTAGAGCAAAGATG -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation