|Institutional Source||Beutler Lab|
|Gene Name||protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6187 (G1)|
|Chromosomal Location||33599625-33619441 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 33615474 bp|
|Amino Acid Change||Serine to Proline at position 171 (S171P)|
|Ref Sequence||ENSEMBL: ENSMUSP00000009774 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000009774] [ENSMUST00000095349]|
|Predicted Effect||probably damaging
AA Change: S171P
PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
AA Change: S171P
|Predicted Effect||probably benign
|Meta Mutation Damage Score||0.578|
|Coding Region Coverage||
|Validation Efficiency||99% (79/80)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ppp2cb||
(F):5'- GCTTTGCATTGTAGTTCACAGATC -3'
(R):5'- CAGCACCACGTGGAGAAATG -3'
(F):5'- GCATTGTAGTTCACAGATCTTTCAGC -3'
(R):5'- TCACACATTGGGCCCTGGATAAG -3'