Incidental Mutation 'IGL01086:Cmklr2'
ID 50224
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cmklr2
Ensembl Gene ENSMUSG00000046856
Gene Name chemerin chemokine-like receptor 2
Synonyms Gpr1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01086
Quality Score
Status
Chromosome 1
Chromosomal Location 63221850-63253702 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 63222650 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 195 (E195G)
Ref Sequence ENSEMBL: ENSMUSP00000051417 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027108] [ENSMUST00000050536] [ENSMUST00000129339] [ENSMUST00000142062] [ENSMUST00000135877] [ENSMUST00000174890] [ENSMUST00000188524]
AlphaFold Q8K087
Predicted Effect probably benign
Transcript: ENSMUST00000027108
Predicted Effect probably benign
Transcript: ENSMUST00000050536
AA Change: E195G

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000051417
Gene: ENSMUSG00000046856
AA Change: E195G

DomainStartEndE-ValueType
Pfam:7tm_1 55 302 3.9e-40 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082668
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082678
Predicted Effect probably benign
Transcript: ENSMUST00000126795
SMART Domains Protein: ENSMUSP00000134341
Gene: ENSMUSG00000025967

DomainStartEndE-ValueType
SCOP:d1aw9_1 4 62 8e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129339
SMART Domains Protein: ENSMUSP00000116492
Gene: ENSMUSG00000025967

DomainStartEndE-ValueType
EF-1_beta_acid 103 130 2.53e-4 SMART
EF1_GNE 139 225 3.86e-44 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148553
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199062
Predicted Effect probably benign
Transcript: ENSMUST00000142062
Predicted Effect probably benign
Transcript: ENSMUST00000135877
SMART Domains Protein: ENSMUSP00000137671
Gene: ENSMUSG00000025967

DomainStartEndE-ValueType
transmembrane domain 38 57 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000174890
SMART Domains Protein: ENSMUSP00000133545
Gene: ENSMUSG00000025967

DomainStartEndE-ValueType
Blast:WHEP 3 64 3e-6 BLAST
SCOP:d1aw9_1 7 65 2e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000188524
SMART Domains Protein: ENSMUSP00000140895
Gene: ENSMUSG00000025967

DomainStartEndE-ValueType
EF-1_beta_acid 62 89 1.2e-8 SMART
EF1_GNE 98 184 2.9e-48 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016H13Rik T A 5: 103,796,729 (GRCm39) R104S probably damaging Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Aim2 A G 1: 173,282,999 (GRCm39) Y27C probably damaging Het
Apol7b T C 15: 77,308,114 (GRCm39) E127G probably damaging Het
Atp10a T C 7: 58,474,066 (GRCm39) F1118L probably damaging Het
Cacna1e T C 1: 154,347,347 (GRCm39) D940G probably benign Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Clip4 G A 17: 72,131,789 (GRCm39) V376I probably benign Het
Coro6 C A 11: 77,357,374 (GRCm39) C194* probably null Het
Crebbp T C 16: 3,997,416 (GRCm39) M223V probably benign Het
Dkk4 T A 8: 23,116,857 (GRCm39) C157S probably damaging Het
Dnah14 T C 1: 181,579,611 (GRCm39) L3048S probably benign Het
Dscaml1 T C 9: 45,613,960 (GRCm39) probably benign Het
Gria2 T C 3: 80,599,688 (GRCm39) Y732C probably damaging Het
Igkv4-59 T C 6: 69,415,707 (GRCm39) I7V probably benign Het
Lamc3 T C 2: 31,788,488 (GRCm39) F216S probably damaging Het
Lcn6 T C 2: 25,570,792 (GRCm39) F61L probably benign Het
Nup205 T A 6: 35,185,871 (GRCm39) probably benign Het
Or5w18 T A 2: 87,633,544 (GRCm39) Y266* probably null Het
Otof C T 5: 30,533,617 (GRCm39) probably null Het
Pik3c2b T C 1: 133,019,356 (GRCm39) C1035R probably damaging Het
Pla1a T C 16: 38,227,984 (GRCm39) N298D probably benign Het
Poteg T A 8: 27,963,648 (GRCm39) probably benign Het
Pwp1 T C 10: 85,715,757 (GRCm39) probably null Het
Scel A G 14: 103,849,827 (GRCm39) I631V probably benign Het
Scn3a T A 2: 65,300,503 (GRCm39) M1288L probably benign Het
Serpina11 T A 12: 103,952,329 (GRCm39) D147V probably damaging Het
Shroom3 T A 5: 93,096,311 (GRCm39) C1266S probably benign Het
Slc12a7 A G 13: 73,962,962 (GRCm39) Y1054C probably damaging Het
Srms A G 2: 180,854,216 (GRCm39) V117A probably damaging Het
Tmem161b T C 13: 84,370,541 (GRCm39) probably benign Het
Tmem94 A T 11: 115,681,110 (GRCm39) T158S probably benign Het
Tomm40l T C 1: 171,047,878 (GRCm39) probably null Het
Traf6 A G 2: 101,515,128 (GRCm39) I95V probably benign Het
Ttc13 A G 8: 125,402,085 (GRCm39) I686T probably damaging Het
Zmat2 C T 18: 36,929,163 (GRCm39) H104Y probably damaging Het
Other mutations in Cmklr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00427:Cmklr2 APN 1 63,222,497 (GRCm39) missense probably damaging 0.99
IGL01490:Cmklr2 APN 1 63,222,455 (GRCm39) missense probably damaging 0.99
IGL02409:Cmklr2 APN 1 63,222,875 (GRCm39) missense probably damaging 1.00
IGL02426:Cmklr2 APN 1 63,222,827 (GRCm39) missense probably damaging 0.97
R0218:Cmklr2 UTSW 1 63,222,690 (GRCm39) missense probably benign 0.25
R2088:Cmklr2 UTSW 1 63,222,811 (GRCm39) splice site probably null
R2166:Cmklr2 UTSW 1 63,223,107 (GRCm39) missense probably benign
R2895:Cmklr2 UTSW 1 63,222,321 (GRCm39) missense probably benign 0.24
R2896:Cmklr2 UTSW 1 63,222,321 (GRCm39) missense probably benign 0.24
R5102:Cmklr2 UTSW 1 63,222,326 (GRCm39) missense probably damaging 0.99
R5131:Cmklr2 UTSW 1 63,222,840 (GRCm39) missense probably damaging 1.00
R5471:Cmklr2 UTSW 1 63,223,058 (GRCm39) missense probably damaging 1.00
R5652:Cmklr2 UTSW 1 63,222,626 (GRCm39) missense probably benign 0.00
R6187:Cmklr2 UTSW 1 63,222,434 (GRCm39) missense probably damaging 1.00
R7956:Cmklr2 UTSW 1 63,222,665 (GRCm39) missense probably damaging 0.99
R8953:Cmklr2 UTSW 1 63,222,272 (GRCm39) missense probably damaging 1.00
R9031:Cmklr2 UTSW 1 63,223,145 (GRCm39) missense probably benign 0.03
X0060:Cmklr2 UTSW 1 63,222,218 (GRCm39) missense probably benign 0.02
Z1177:Cmklr2 UTSW 1 63,222,798 (GRCm39) missense probably benign 0.00
Posted On 2013-06-21