Incidental Mutation 'IGL01089:Usp37'
ID50235
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Usp37
Ensembl Gene ENSMUSG00000033364
Gene Nameubiquitin specific peptidase 37
SynonymsC330008N13Rik, 4932415L06Rik
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL01089
Quality Score
Status
Chromosome1
Chromosomal Location74435511-74544284 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 74493046 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 63 (R63*)
Ref Sequence ENSEMBL: ENSMUSP00000140670 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044260] [ENSMUST00000186282] [ENSMUST00000189257]
Predicted Effect probably null
Transcript: ENSMUST00000044260
AA Change: R63*
SMART Domains Protein: ENSMUSP00000035445
Gene: ENSMUSG00000033364
AA Change: R63*

DomainStartEndE-ValueType
Pfam:UCH_N 1 105 5.1e-47 PFAM
low complexity region 182 200 N/A INTRINSIC
Pfam:UCH_1 341 645 3.4e-16 PFAM
UIM 704 723 1.33e1 SMART
UIM 806 825 1.04e-1 SMART
UIM 828 847 2.11e-2 SMART
low complexity region 893 909 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000186282
Predicted Effect probably null
Transcript: ENSMUST00000189257
AA Change: R63*
SMART Domains Protein: ENSMUSP00000140670
Gene: ENSMUSG00000033364
AA Change: R63*

DomainStartEndE-ValueType
PDB:3U12|B 4 125 2e-71 PDB
low complexity region 182 200 N/A INTRINSIC
Pfam:UCH_1 341 608 4.3e-19 PFAM
low complexity region 628 646 N/A INTRINSIC
UIM 704 723 1.33e1 SMART
UIM 806 825 1.04e-1 SMART
UIM 828 847 2.11e-2 SMART
low complexity region 893 909 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191058
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit complete embryonic lethality. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016K19Rik A G 11: 76,003,337 E180G possibly damaging Het
Actr8 T C 14: 29,988,335 L353S probably damaging Het
Adgrf2 G A 17: 42,710,158 P592S probably damaging Het
Aen G A 7: 78,907,302 M299I probably damaging Het
Afap1l2 A C 19: 56,913,411 probably null Het
Asnsd1 G A 1: 53,348,277 P64S probably damaging Het
Bmt2 A G 6: 13,663,271 M76T probably damaging Het
Clca3b A T 3: 144,823,522 V797D probably benign Het
Cog2 T C 8: 124,545,243 S499P probably benign Het
Cyp27a1 A T 1: 74,731,938 Y94F possibly damaging Het
D430042O09Rik A G 7: 125,795,313 E187G probably damaging Het
D630045J12Rik A G 6: 38,136,963 S1765P probably benign Het
Fam149a A G 8: 45,348,527 L519P possibly damaging Het
Fam171a2 G A 11: 102,437,848 A695V possibly damaging Het
Fat1 T A 8: 45,017,857 V1566E probably damaging Het
Flvcr1 T G 1: 191,013,390 N361H probably damaging Het
Gm1110 T C 9: 26,881,860 N540S probably benign Het
Kcns3 T A 12: 11,091,571 T376S possibly damaging Het
Krt32 A G 11: 100,087,779 S150P probably benign Het
Lrtm2 C T 6: 119,320,792 R96Q possibly damaging Het
Mctp1 A G 13: 77,020,798 E838G probably damaging Het
Mios T C 6: 8,234,363 probably null Het
Olfr338 A T 2: 36,377,166 Y130F probably damaging Het
Phldb1 T A 9: 44,707,887 K167* probably null Het
Pkhd1l1 A G 15: 44,483,869 probably benign Het
Plaa A G 4: 94,574,047 V531A probably benign Het
Psmb2 A G 4: 126,684,206 Y59C probably damaging Het
Ptprg A G 14: 12,215,286 H1091R probably damaging Het
Rbm44 T A 1: 91,168,697 V926D possibly damaging Het
Rgma G T 7: 73,409,714 V189L possibly damaging Het
Sbf2 A T 7: 110,348,962 I1227K probably damaging Het
Slc8a1 T C 17: 81,648,281 T443A probably damaging Het
Slc8a1 A G 17: 81,388,881 V896A probably damaging Het
Taf2 T C 15: 55,016,581 M1120V probably benign Het
Ugt2b34 C T 5: 86,906,326 V199I probably benign Het
Unc5c C A 3: 141,818,202 probably benign Het
Other mutations in Usp37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00929:Usp37 APN 1 74490154 missense probably benign 0.05
IGL00961:Usp37 APN 1 74490155 missense probably benign
IGL01348:Usp37 APN 1 74461702 missense probably damaging 0.98
IGL01609:Usp37 APN 1 74475040 missense probably benign 0.02
PIT4544001:Usp37 UTSW 1 74470579 missense possibly damaging 0.65
R0331:Usp37 UTSW 1 74454064 nonsense probably null
R0332:Usp37 UTSW 1 74495710 missense possibly damaging 0.47
R0418:Usp37 UTSW 1 74490107 missense probably benign 0.01
R0456:Usp37 UTSW 1 74468348 missense probably damaging 1.00
R1605:Usp37 UTSW 1 74493004 missense possibly damaging 0.59
R1756:Usp37 UTSW 1 74479655 missense probably benign 0.20
R1971:Usp37 UTSW 1 74439968 nonsense probably null
R2061:Usp37 UTSW 1 74468272 missense probably damaging 1.00
R2130:Usp37 UTSW 1 74461656 missense probably damaging 1.00
R2215:Usp37 UTSW 1 74444526 missense probably damaging 1.00
R2867:Usp37 UTSW 1 74450532 missense probably damaging 1.00
R2867:Usp37 UTSW 1 74450532 missense probably damaging 1.00
R3716:Usp37 UTSW 1 74492986 missense possibly damaging 0.93
R5077:Usp37 UTSW 1 74441561 missense probably damaging 0.99
R5635:Usp37 UTSW 1 74495811 start gained probably benign
R5826:Usp37 UTSW 1 74470626 missense probably damaging 0.99
R5933:Usp37 UTSW 1 74485982 missense probably damaging 0.98
R6048:Usp37 UTSW 1 74478136 splice site probably null
R6169:Usp37 UTSW 1 74495751 missense probably damaging 0.99
R6193:Usp37 UTSW 1 74492928 missense probably damaging 1.00
R6235:Usp37 UTSW 1 74475133 nonsense probably null
R6361:Usp37 UTSW 1 74453893 missense probably benign 0.06
R6572:Usp37 UTSW 1 74495782 missense possibly damaging 0.95
R6759:Usp37 UTSW 1 74495749 nonsense probably null
R6997:Usp37 UTSW 1 74453959 missense probably benign 0.01
R7471:Usp37 UTSW 1 74495628 critical splice donor site probably null
R7632:Usp37 UTSW 1 74468374 missense probably benign 0.04
R7691:Usp37 UTSW 1 74486760 frame shift probably null
RF017:Usp37 UTSW 1 74470690 missense probably damaging 1.00
X0058:Usp37 UTSW 1 74453923 missense probably damaging 1.00
Posted On2013-06-21