Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01090:Fmo4'

50241

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fmo4

Ensembl Gene

ENSMUSG00000026692

Gene Name

flavin containing monooxygenase 4

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.108) question?

Stock #

IGL01090

Quality Score

Status

Chromosome

Chromosomal Location

162793188-162813972 bp(-) (GRCm38)

Type of Mutation

splice site (5 bp from exon)

DNA Base Change (assembly)

C to A at 162809785 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000118476 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028014] [ENSMUST00000111525] [ENSMUST00000140274] [ENSMUST00000144916]

AlphaFold

Q8VHG0

Predicted Effect

probably null
Transcript: ENSMUST00000028014

SMART Domains

Protein: ENSMUSP00000028014
Gene: ENSMUSG00000026692

Domain	Start	End	E-Value	Type
Pfam:FMO-like	2	531	9.4e-272	PFAM
Pfam:Pyr_redox_2	4	430	1e-8	PFAM
Pfam:Pyr_redox_3	6	220	5.1e-16	PFAM
Pfam:K_oxygenase	68	227	1.7e-11	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000111525

SMART Domains

Protein: ENSMUSP00000107150
Gene: ENSMUSG00000026692

Domain	Start	End	E-Value	Type
Pfam:FMO-like	2	531	9.4e-272	PFAM
Pfam:Pyr_redox_2	3	225	1.7e-11	PFAM
Pfam:Pyr_redox_3	6	220	2.5e-9	PFAM
Pfam:K_oxygenase	67	227	6e-12	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000140031

Predicted Effect

probably null
Transcript: ENSMUST00000140274

SMART Domains

Protein: ENSMUSP00000118476
Gene: ENSMUSG00000026692

Domain	Start	End	E-Value	Type
Pfam:FMO-like	2	99	1.5e-57	PFAM
Pfam:NAD_binding_8	7	94	1.6e-7	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000144916

SMART Domains

Protein: ENSMUSP00000119389
Gene: ENSMUSG00000026692

Domain	Start	End	E-Value	Type
Pfam:FMO-like	1	114	2.6e-63	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193508

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930590J08Rik	T	C	6: 91,919,118	S316P	possibly damaging	Het
Actn1	A	T	12: 80,199,072		probably null	Het
Agbl3	T	C	6: 34,799,887	Y443H	probably benign	Het
Akap13	T	A	7: 75,666,531	D578E	probably benign	Het
Aldoa	A	T	7: 126,796,035	H292Q	probably benign	Het
Als2	T	C	1: 59,215,616	K194R	possibly damaging	Het
Bivm	C	A	1: 44,129,291	H244N	probably damaging	Het
Cabp5	G	A	7: 13,405,487	E146K	probably damaging	Het
Cfap206	C	T	4: 34,721,562	S162N	probably damaging	Het
Clcn4	A	G	7: 7,294,036	V129A	probably benign	Het
Clec4g	A	G	8: 3,719,482	S54P	probably damaging	Het
Crim1	G	T	17: 78,347,229	V645L	probably damaging	Het
Csta1	T	C	16: 36,125,051	T31A	probably damaging	Het
D930048N14Rik	T	C	11: 51,653,783		probably benign	Het
Dhx34	G	T	7: 16,216,256	P329Q	probably damaging	Het
Dusp16	T	C	6: 134,725,949	N193S	probably benign	Het
Fbn1	A	G	2: 125,394,776		probably benign	Het
Fbxo46	A	G	7: 19,136,803	Y449C	probably damaging	Het
Foxi3	C	A	6: 70,960,745	N320K	probably damaging	Het
Gm9964	A	G	11: 79,296,384	L79P	unknown	Het
Gpr161	T	C	1: 165,306,580	I137T	probably damaging	Het
Herc1	C	T	9: 66,469,175	Q3426*	probably null	Het
Hps5	C	T	7: 46,788,327	R108H	probably benign	Het
Itch	T	A	2: 155,206,336	V540E	probably damaging	Het
L3mbtl1	C	A	2: 162,966,005	P520H	probably damaging	Het
Mvp	A	G	7: 126,989,687	V636A	probably benign	Het
Odf4	A	G	11: 68,921,952		probably benign	Het
Olfr830	A	G	9: 18,876,242	K305R	probably benign	Het
Pld1	T	C	3: 28,088,667	S675P	probably benign	Het
Plod3	A	G	5: 136,990,236	D325G	probably benign	Het
Prss12	T	C	3: 123,482,739	V339A	possibly damaging	Het
Ptpn13	T	A	5: 103,541,314	L991Q	probably null	Het
Ptpn3	T	A	4: 57,240,833	I261F	probably damaging	Het
Rab3gap1	T	C	1: 127,930,387		probably benign	Het
Rasa4	A	G	5: 136,101,993	R373G	possibly damaging	Het
Rmi1	T	C	13: 58,409,394	S486P	probably damaging	Het
Slc25a23	A	G	17: 57,047,233	I139T	probably benign	Het
Sspo	T	A	6: 48,490,125	S4017T	probably benign	Het
Tcaf1	C	A	6: 42,686,622	C108F	probably benign	Het
Tnc	T	C	4: 64,000,080	Q1198R	probably damaging	Het
Tnni3k	G	T	3: 154,939,683	Q522K	possibly damaging	Het
Trio	T	A	15: 27,773,007	E713V	probably damaging	Het
Ugt2b34	C	A	5: 86,893,820	V338F	probably damaging	Het
Usp40	T	A	1: 87,962,465	M892L	probably benign	Het
Usp54	A	T	14: 20,586,157		probably benign	Het
Vmn2r53	T	C	7: 12,600,908	E275G	possibly damaging	Het
Vmn2r87	A	G	10: 130,497,378	M1T	probably null	Het
Wdr66	A	C	5: 123,279,989		probably benign	Het
Wdr83os	A	T	8: 85,081,847	D76V	probably damaging	Het

Other mutations in Fmo4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00933:Fmo4	APN	1	162794023	missense	probably benign	0.00
IGL01295:Fmo4	APN	1	162799124	missense	probably damaging	1.00
IGL02089:Fmo4	APN	1	162799080	missense	probably benign	0.04
IGL02483:Fmo4	APN	1	162808421	missense	possibly damaging	0.60
R0608:Fmo4	UTSW	1	162803651	missense	possibly damaging	0.95
R0660:Fmo4	UTSW	1	162809848	missense	probably benign	0.05
R0737:Fmo4	UTSW	1	162808392	nonsense	probably null
R1117:Fmo4	UTSW	1	162803663	missense	probably benign	0.03
R1464:Fmo4	UTSW	1	162794355	missense	possibly damaging	0.54
R1464:Fmo4	UTSW	1	162794355	missense	possibly damaging	0.54
R1577:Fmo4	UTSW	1	162803700	missense	possibly damaging	0.50
R1792:Fmo4	UTSW	1	162794290	missense	probably benign
R1875:Fmo4	UTSW	1	162803618	missense	possibly damaging	0.95
R1929:Fmo4	UTSW	1	162799047	missense	possibly damaging	0.95
R1956:Fmo4	UTSW	1	162803690	missense	probably benign	0.01
R1957:Fmo4	UTSW	1	162803690	missense	probably benign	0.01
R1958:Fmo4	UTSW	1	162803690	missense	probably benign	0.01
R2011:Fmo4	UTSW	1	162798889	missense	probably damaging	1.00
R2030:Fmo4	UTSW	1	162794172	missense	probably damaging	1.00
R2072:Fmo4	UTSW	1	162809887	missense	probably benign	0.20
R2272:Fmo4	UTSW	1	162799047	missense	possibly damaging	0.95
R3890:Fmo4	UTSW	1	162794055	missense	probably benign	0.39
R4255:Fmo4	UTSW	1	162794326	missense	probably benign	0.00
R4273:Fmo4	UTSW	1	162805179	missense	probably damaging	0.97
R4760:Fmo4	UTSW	1	162809827	missense	probably damaging	1.00
R5445:Fmo4	UTSW	1	162805273	missense	probably benign	0.24
R5726:Fmo4	UTSW	1	162808259	critical splice donor site	probably null
R5786:Fmo4	UTSW	1	162803717	missense	probably benign	0.00
R6391:Fmo4	UTSW	1	162793969	nonsense	probably null
R6826:Fmo4	UTSW	1	162803769	missense	probably damaging	1.00
R7457:Fmo4	UTSW	1	162794103	missense	probably benign	0.00
R7913:Fmo4	UTSW	1	162794172	missense	possibly damaging	0.69
R8031:Fmo4	UTSW	1	162798852	nonsense	probably null
R8055:Fmo4	UTSW	1	162808446	missense	probably benign
R8234:Fmo4	UTSW	1	162805188	missense	probably damaging	1.00
R8346:Fmo4	UTSW	1	162794223	missense	probably benign	0.01
R8706:Fmo4	UTSW	1	162794023	nonsense	probably null
R9050:Fmo4	UTSW	1	162807530	missense	probably benign	0.15
R9467:Fmo4	UTSW	1	162803669	missense	probably benign
R9488:Fmo4	UTSW	1	162803768	missense	probably damaging	1.00
R9633:Fmo4	UTSW	1	162803622	missense	probably benign	0.00
X0020:Fmo4	UTSW	1	162794378	missense	probably benign	0.02
Z1177:Fmo4	UTSW	1	162803720	missense	probably benign	0.00

Posted On

2013-06-21