Incidental Mutation 'R6191:Mtcl1'
| ID |
502603 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mtcl1
|
| Ensembl Gene |
ENSMUSG00000052105 |
| Gene Name |
microtubule crosslinking factor 1 |
| Synonyms |
1110012J17Rik, Soga2, t8219b25 |
| MMRRC Submission |
044331-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.154)
|
| Stock # |
R6191 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
66643977-66756745 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 66650521 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Histidine
at position 1345
(R1345H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135690
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086693]
[ENSMUST00000097291]
[ENSMUST00000145347]
[ENSMUST00000177034]
|
| AlphaFold |
Q3UHU5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000086693
AA Change: R1648H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000083899
Gene: ENSMUSG00000052105
AA Change: R1648H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
493 |
587 |
1.8e-34 |
PFAM |
|
Pfam:DUF3166
|
622 |
714 |
3.8e-39 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1344 |
3e-40 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
low complexity region
|
1912 |
1924 |
N/A |
INTRINSIC |
|
low complexity region
|
1931 |
1943 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000097291
AA Change: R1648H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000094894
Gene: ENSMUSG00000052105
AA Change: R1648H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
492 |
588 |
1.8e-43 |
PFAM |
|
Pfam:DUF3166
|
621 |
716 |
5e-19 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1392 |
3.9e-49 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129525
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134139
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000145347
AA Change: R1199H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000121387
Gene: ENSMUSG00000052105
AA Change: R1199H
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3166
|
43 |
139 |
9.1e-44 |
PFAM |
|
Pfam:DUF3166
|
172 |
267 |
2.5e-19 |
PFAM |
|
low complexity region
|
394 |
410 |
N/A |
INTRINSIC |
|
low complexity region
|
447 |
461 |
N/A |
INTRINSIC |
|
low complexity region
|
513 |
524 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
613 |
N/A |
INTRINSIC |
|
coiled coil region
|
671 |
710 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
771 |
910 |
4.6e-49 |
PFAM |
|
low complexity region
|
1015 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1232 |
N/A |
INTRINSIC |
|
low complexity region
|
1463 |
1475 |
N/A |
INTRINSIC |
|
low complexity region
|
1482 |
1494 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177034
AA Change: R1345H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135690
Gene: ENSMUSG00000052105
AA Change: R1345H
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3166
|
140 |
236 |
1.5e-43 |
PFAM |
|
Pfam:DUF3166
|
269 |
364 |
4e-19 |
PFAM |
|
low complexity region
|
491 |
507 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
558 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
coiled coil region
|
642 |
674 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
751 |
N/A |
INTRINSIC |
|
coiled coil region
|
809 |
848 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
909 |
1042 |
4e-49 |
PFAM |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
low complexity region
|
1369 |
1378 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
99% (84/85) |
| MGI Phenotype |
PHENOTYPE: Global or Purkinje cell-specific homozygous knockout affects Purkinje cell axon and dendrite morphology, resulting in abnormal motor function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930563M21Rik |
A |
C |
9: 55,909,807 (GRCm39) |
D144E |
possibly damaging |
Het |
| Amigo2 |
T |
A |
15: 97,143,419 (GRCm39) |
K334N |
probably benign |
Het |
| Ano6 |
T |
C |
15: 95,846,380 (GRCm39) |
|
probably null |
Het |
| Ap1m2 |
C |
A |
9: 21,210,601 (GRCm39) |
V343F |
probably benign |
Het |
| Apol6 |
T |
C |
15: 76,940,098 (GRCm39) |
V307A |
probably benign |
Het |
| Arsi |
C |
A |
18: 61,045,544 (GRCm39) |
A78E |
probably damaging |
Het |
| B2m |
A |
T |
2: 121,981,396 (GRCm39) |
N37I |
possibly damaging |
Het |
| Bltp3b |
G |
T |
10: 89,641,180 (GRCm39) |
G784C |
possibly damaging |
Het |
| C8a |
T |
C |
4: 104,703,100 (GRCm39) |
K363R |
probably benign |
Het |
| Ccdc117 |
C |
A |
11: 5,484,242 (GRCm39) |
|
probably null |
Het |
| Ccdc154 |
C |
A |
17: 25,386,945 (GRCm39) |
Q325K |
probably damaging |
Het |
| Cd300e |
A |
T |
11: 114,945,359 (GRCm39) |
V145E |
possibly damaging |
Het |
| Col19a1 |
G |
T |
1: 24,356,474 (GRCm39) |
P673Q |
probably damaging |
Het |
| Csn2 |
A |
G |
5: 87,843,885 (GRCm39) |
|
probably null |
Het |
| Ctnna1 |
T |
C |
18: 35,307,408 (GRCm39) |
V135A |
probably damaging |
Het |
| Dnah11 |
T |
A |
12: 118,154,632 (GRCm39) |
D216V |
probably benign |
Het |
| Dnah12 |
A |
G |
14: 26,431,412 (GRCm39) |
H410R |
probably benign |
Het |
| Dock2 |
C |
T |
11: 34,181,652 (GRCm39) |
R1637H |
possibly damaging |
Het |
| Dspp |
A |
G |
5: 104,325,214 (GRCm39) |
N526D |
unknown |
Het |
| Frem2 |
T |
C |
3: 53,562,701 (GRCm39) |
H602R |
probably benign |
Het |
| Galc |
A |
T |
12: 98,218,293 (GRCm39) |
H186Q |
probably damaging |
Het |
| Grina |
T |
C |
15: 76,133,218 (GRCm39) |
V262A |
probably damaging |
Het |
| Gse1 |
G |
A |
8: 121,280,542 (GRCm39) |
|
probably null |
Het |
| H2-Oa |
C |
A |
17: 34,312,842 (GRCm39) |
Q40K |
probably damaging |
Het |
| Hfm1 |
C |
A |
5: 107,034,419 (GRCm39) |
D763Y |
possibly damaging |
Het |
| Hmcn2 |
T |
A |
2: 31,348,758 (GRCm39) |
Y4925N |
probably damaging |
Het |
| Hs3st3b1 |
C |
A |
11: 63,780,029 (GRCm39) |
R366L |
probably benign |
Het |
| Idh2 |
TCCCAGG |
T |
7: 79,748,079 (GRCm39) |
|
probably benign |
Het |
| Iqank1 |
T |
C |
15: 75,918,218 (GRCm39) |
|
probably null |
Het |
| Itpr2 |
A |
G |
6: 146,229,833 (GRCm39) |
V1221A |
probably benign |
Het |
| Kdm6b |
T |
C |
11: 69,297,584 (GRCm39) |
N285S |
probably benign |
Het |
| Klk1b1 |
T |
A |
7: 43,620,081 (GRCm39) |
N181K |
probably damaging |
Het |
| Kmt2a |
C |
A |
9: 44,738,125 (GRCm39) |
|
probably benign |
Het |
| Lama5 |
T |
C |
2: 179,827,752 (GRCm39) |
D2170G |
probably damaging |
Het |
| Lama5 |
T |
A |
2: 179,822,404 (GRCm39) |
T2890S |
probably damaging |
Het |
| Lsm2 |
T |
A |
17: 35,201,131 (GRCm39) |
|
probably benign |
Het |
| Map3k5 |
G |
T |
10: 19,899,415 (GRCm39) |
C232F |
probably damaging |
Het |
| Mapk9 |
T |
G |
11: 49,754,383 (GRCm39) |
D45E |
probably damaging |
Het |
| Mpnd |
T |
C |
17: 56,319,482 (GRCm39) |
V315A |
possibly damaging |
Het |
| Msh2 |
A |
G |
17: 88,030,900 (GRCm39) |
I926V |
probably benign |
Het |
| Nbeal2 |
A |
G |
9: 110,457,058 (GRCm39) |
|
probably null |
Het |
| Neo1 |
T |
C |
9: 58,796,312 (GRCm39) |
D1205G |
probably damaging |
Het |
| Nhlrc2 |
A |
G |
19: 56,559,291 (GRCm39) |
S259G |
probably benign |
Het |
| Nkain4 |
G |
A |
2: 180,577,796 (GRCm39) |
P186L |
probably damaging |
Het |
| Nkain4 |
G |
A |
2: 180,577,797 (GRCm39) |
P186S |
probably damaging |
Het |
| Nlrp1b |
T |
A |
11: 71,109,283 (GRCm39) |
R73* |
probably null |
Het |
| Nr5a2 |
T |
C |
1: 136,818,536 (GRCm39) |
D330G |
probably damaging |
Het |
| Nup54 |
A |
G |
5: 92,572,153 (GRCm39) |
L299P |
probably damaging |
Het |
| Or2v1 |
T |
C |
11: 49,025,877 (GRCm39) |
L286P |
probably damaging |
Het |
| Or5aq7 |
A |
G |
2: 86,938,296 (GRCm39) |
V145A |
probably damaging |
Het |
| Pcdhb8 |
T |
A |
18: 37,489,279 (GRCm39) |
V319E |
probably benign |
Het |
| Pcsk6 |
T |
A |
7: 65,578,875 (GRCm39) |
D129E |
probably benign |
Het |
| Pld5 |
G |
A |
1: 175,798,100 (GRCm39) |
T433I |
probably benign |
Het |
| Plin1 |
A |
T |
7: 79,371,347 (GRCm39) |
L459H |
probably benign |
Het |
| Psd4 |
T |
C |
2: 24,284,499 (GRCm39) |
V121A |
probably damaging |
Het |
| Pxdn |
A |
T |
12: 30,032,716 (GRCm39) |
I167F |
possibly damaging |
Het |
| R3hdm2 |
T |
C |
10: 127,320,384 (GRCm39) |
S569P |
probably damaging |
Het |
| Rfng |
T |
A |
11: 120,673,516 (GRCm39) |
T202S |
probably damaging |
Het |
| Robo1 |
T |
C |
16: 72,730,696 (GRCm39) |
S266P |
probably benign |
Het |
| Sema3c |
G |
T |
5: 17,858,804 (GRCm39) |
V68L |
probably damaging |
Het |
| Slco6c1 |
C |
T |
1: 96,993,808 (GRCm39) |
R645H |
possibly damaging |
Het |
| Slfn8 |
A |
G |
11: 82,907,626 (GRCm39) |
Y306H |
possibly damaging |
Het |
| Snap91 |
T |
C |
9: 86,720,105 (GRCm39) |
D144G |
probably damaging |
Het |
| St7l |
T |
G |
3: 104,775,349 (GRCm39) |
F75C |
probably damaging |
Het |
| Stard10 |
A |
G |
7: 100,992,468 (GRCm39) |
I145V |
probably damaging |
Het |
| Tekt3 |
C |
T |
11: 62,968,999 (GRCm39) |
A242V |
probably damaging |
Het |
| Tex44 |
A |
G |
1: 86,354,306 (GRCm39) |
|
probably benign |
Het |
| Thg1l |
T |
C |
11: 45,844,988 (GRCm39) |
Q88R |
probably benign |
Het |
| Trav8n-2 |
T |
A |
14: 53,583,744 (GRCm39) |
I67N |
probably damaging |
Het |
| Ttn |
G |
A |
2: 76,677,770 (GRCm39) |
|
probably benign |
Het |
| Ube4a |
A |
T |
9: 44,861,051 (GRCm39) |
L253* |
probably null |
Het |
| Uggt1 |
A |
T |
1: 36,201,289 (GRCm39) |
N1150K |
probably damaging |
Het |
| Ush2a |
T |
A |
1: 187,995,298 (GRCm39) |
L23* |
probably null |
Het |
| Usp22 |
T |
A |
11: 61,065,602 (GRCm39) |
N37I |
probably benign |
Het |
| Usp53 |
T |
A |
3: 122,743,390 (GRCm39) |
K515N |
probably damaging |
Het |
| Vmn2r4 |
T |
C |
3: 64,322,702 (GRCm39) |
K6E |
probably benign |
Het |
| Vps13d |
C |
T |
4: 144,875,918 (GRCm39) |
V1530M |
probably damaging |
Het |
| Vwa3b |
A |
G |
1: 37,153,612 (GRCm39) |
I485V |
possibly damaging |
Het |
| Wnk4 |
T |
C |
11: 101,155,156 (GRCm39) |
Y356H |
probably damaging |
Het |
| Zcchc2 |
A |
G |
1: 105,917,900 (GRCm39) |
|
probably benign |
Het |
| Zfp345 |
A |
C |
2: 150,315,010 (GRCm39) |
Y176D |
probably benign |
Het |
| Zfp598 |
T |
C |
17: 24,896,850 (GRCm39) |
F238S |
possibly damaging |
Het |
| Zkscan17 |
T |
C |
11: 59,393,820 (GRCm39) |
D10G |
probably damaging |
Het |
| Zmat4 |
T |
G |
8: 24,392,083 (GRCm39) |
M13R |
probably damaging |
Het |
|
| Other mutations in Mtcl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Mtcl1
|
APN |
17 |
66,651,314 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01774:Mtcl1
|
APN |
17 |
66,692,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01918:Mtcl1
|
APN |
17 |
66,675,263 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL02000:Mtcl1
|
APN |
17 |
66,661,185 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02074:Mtcl1
|
APN |
17 |
66,673,463 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02338:Mtcl1
|
APN |
17 |
66,686,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02597:Mtcl1
|
APN |
17 |
66,645,016 (GRCm39) |
missense |
probably benign |
|
|
IGL03034:Mtcl1
|
APN |
17 |
66,651,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Mtcl1
|
APN |
17 |
66,686,378 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03184:Mtcl1
|
APN |
17 |
66,661,209 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03240:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03294:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Mtcl1
|
UTSW |
17 |
66,745,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4520001:Mtcl1
|
UTSW |
17 |
66,692,907 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R0110:Mtcl1
|
UTSW |
17 |
66,665,109 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R0113:Mtcl1
|
UTSW |
17 |
66,661,237 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0321:Mtcl1
|
UTSW |
17 |
66,686,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Mtcl1
|
UTSW |
17 |
66,645,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0629:Mtcl1
|
UTSW |
17 |
66,645,137 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Mtcl1
|
UTSW |
17 |
66,686,143 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1650:Mtcl1
|
UTSW |
17 |
66,692,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1754:Mtcl1
|
UTSW |
17 |
66,687,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Mtcl1
|
UTSW |
17 |
66,686,509 (GRCm39) |
missense |
probably benign |
|
|
R1882:Mtcl1
|
UTSW |
17 |
66,686,315 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1935:Mtcl1
|
UTSW |
17 |
66,686,409 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2063:Mtcl1
|
UTSW |
17 |
66,653,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Mtcl1
|
UTSW |
17 |
66,650,618 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2197:Mtcl1
|
UTSW |
17 |
66,673,427 (GRCm39) |
missense |
probably benign |
|
|
R3196:Mtcl1
|
UTSW |
17 |
66,650,829 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3877:Mtcl1
|
UTSW |
17 |
66,649,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4116:Mtcl1
|
UTSW |
17 |
66,673,476 (GRCm39) |
missense |
probably benign |
|
|
R4204:Mtcl1
|
UTSW |
17 |
66,745,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4373:Mtcl1
|
UTSW |
17 |
66,687,074 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4396:Mtcl1
|
UTSW |
17 |
66,651,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4591:Mtcl1
|
UTSW |
17 |
66,655,506 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4610:Mtcl1
|
UTSW |
17 |
66,684,882 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4681:Mtcl1
|
UTSW |
17 |
66,756,139 (GRCm39) |
missense |
unknown |
|
|
R4922:Mtcl1
|
UTSW |
17 |
66,655,474 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4992:Mtcl1
|
UTSW |
17 |
66,649,834 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5169:Mtcl1
|
UTSW |
17 |
66,650,818 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5542:Mtcl1
|
UTSW |
17 |
66,691,354 (GRCm39) |
intron |
probably benign |
|
|
R5804:Mtcl1
|
UTSW |
17 |
66,650,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5998:Mtcl1
|
UTSW |
17 |
66,675,275 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6163:Mtcl1
|
UTSW |
17 |
66,686,326 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6254:Mtcl1
|
UTSW |
17 |
66,665,129 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6260:Mtcl1
|
UTSW |
17 |
66,650,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6524:Mtcl1
|
UTSW |
17 |
66,655,280 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6884:Mtcl1
|
UTSW |
17 |
66,745,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7199:Mtcl1
|
UTSW |
17 |
66,647,534 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7431:Mtcl1
|
UTSW |
17 |
66,649,901 (GRCm39) |
nonsense |
probably null |
|
|
R7479:Mtcl1
|
UTSW |
17 |
66,686,485 (GRCm39) |
missense |
probably benign |
|
|
R7564:Mtcl1
|
UTSW |
17 |
66,678,322 (GRCm39) |
missense |
probably benign |
|
|
R7608:Mtcl1
|
UTSW |
17 |
66,650,300 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7691:Mtcl1
|
UTSW |
17 |
66,687,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7847:Mtcl1
|
UTSW |
17 |
66,651,328 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Mtcl1
|
UTSW |
17 |
66,678,325 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8262:Mtcl1
|
UTSW |
17 |
66,650,653 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8324:Mtcl1
|
UTSW |
17 |
66,743,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8477:Mtcl1
|
UTSW |
17 |
66,684,942 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8927:Mtcl1
|
UTSW |
17 |
66,755,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8928:Mtcl1
|
UTSW |
17 |
66,755,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9016:Mtcl1
|
UTSW |
17 |
66,651,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9048:Mtcl1
|
UTSW |
17 |
66,678,331 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9059:Mtcl1
|
UTSW |
17 |
66,650,606 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Mtcl1
|
UTSW |
17 |
66,650,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9327:Mtcl1
|
UTSW |
17 |
66,645,130 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9398:Mtcl1
|
UTSW |
17 |
66,755,462 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9762:Mtcl1
|
UTSW |
17 |
66,673,347 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0065:Mtcl1
|
UTSW |
17 |
66,686,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Mtcl1
|
UTSW |
17 |
66,650,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
Z1176:Mtcl1
|
UTSW |
17 |
66,686,455 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Mtcl1
|
UTSW |
17 |
66,651,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTGCTATTTGGCTGGTCAG -3'
(R):5'- GTCTAAGAACATGAGTGATGACATG -3'
Sequencing Primer
(F):5'- CTCTGAAGTTTGGGAGAACCGTAC -3'
(R):5'- ACATGAAGGAGGTGGCTTTTTC -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation