Incidental Mutation 'R6192:Vmn2r4'
| ID |
502625 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r4
|
| Ensembl Gene |
ENSMUSG00000092049 |
| Gene Name |
vomeronasal 2, receptor 4 |
| Synonyms |
EG637053 |
| MMRRC Submission |
044332-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
R6192 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
64295982-64322741 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 64322699 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 7
(C7S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135228
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000175724]
|
| AlphaFold |
K7N784 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175724
AA Change: C7S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000135228
Gene: ENSMUSG00000092049
AA Change: C7S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
88 |
505 |
2.3e-75 |
PFAM |
|
Pfam:NCD3G
|
547 |
600 |
4.7e-17 |
PFAM |
|
Pfam:7tm_3
|
633 |
867 |
8.2e-47 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
100% (75/75) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts9 |
T |
C |
6: 92,774,002 (GRCm39) |
E1137G |
probably damaging |
Het |
| Adcy9 |
T |
C |
16: 4,105,818 (GRCm39) |
I1099V |
probably benign |
Het |
| Angptl4 |
A |
T |
17: 33,996,015 (GRCm39) |
N320K |
probably benign |
Het |
| Atp6v0a2 |
G |
A |
5: 124,767,268 (GRCm39) |
M10I |
probably benign |
Het |
| Bltp1 |
C |
T |
3: 37,042,318 (GRCm39) |
T2768I |
probably benign |
Het |
| Cbfa2t3 |
A |
G |
8: 123,361,135 (GRCm39) |
S395P |
probably benign |
Het |
| Cenpe |
C |
T |
3: 134,954,291 (GRCm39) |
T1716I |
possibly damaging |
Het |
| Chsy1 |
T |
C |
7: 65,820,625 (GRCm39) |
Y287H |
probably benign |
Het |
| Col4a4 |
G |
T |
1: 82,462,151 (GRCm39) |
P1075T |
probably damaging |
Het |
| Cryab |
T |
A |
9: 50,665,813 (GRCm39) |
M68K |
probably damaging |
Het |
| Cybrd1 |
T |
A |
2: 70,967,858 (GRCm39) |
L143Q |
probably null |
Het |
| Dcaf7 |
T |
C |
11: 105,942,584 (GRCm39) |
V177A |
probably damaging |
Het |
| Dclk2 |
T |
C |
3: 86,722,457 (GRCm39) |
Y392C |
probably damaging |
Het |
| Ddx20 |
T |
C |
3: 105,586,036 (GRCm39) |
T770A |
probably benign |
Het |
| Dennd1b |
T |
A |
1: 139,095,456 (GRCm39) |
D501E |
probably benign |
Het |
| Dgkh |
A |
T |
14: 78,865,504 (GRCm39) |
Y26* |
probably null |
Het |
| Dnajc2 |
A |
G |
5: 21,973,646 (GRCm39) |
V196A |
probably damaging |
Het |
| Etl4 |
A |
G |
2: 20,806,362 (GRCm39) |
K827E |
probably damaging |
Het |
| Fam8a1 |
C |
T |
13: 46,823,099 (GRCm39) |
P13L |
probably damaging |
Het |
| Gfra3 |
T |
C |
18: 34,837,582 (GRCm39) |
S139G |
possibly damaging |
Het |
| Ggnbp1 |
G |
A |
17: 27,248,847 (GRCm39) |
V139I |
possibly damaging |
Het |
| Gja1 |
T |
A |
10: 56,264,330 (GRCm39) |
Y230N |
probably damaging |
Het |
| Gldc |
A |
G |
19: 30,111,172 (GRCm39) |
S535P |
probably damaging |
Het |
| Gm45871 |
A |
G |
18: 90,610,357 (GRCm39) |
T532A |
probably benign |
Het |
| Gm5431 |
T |
A |
11: 48,785,220 (GRCm39) |
D107V |
probably benign |
Het |
| Herc2 |
C |
T |
7: 55,857,510 (GRCm39) |
T4031M |
probably damaging |
Het |
| Iffo2 |
G |
A |
4: 139,333,769 (GRCm39) |
A282T |
probably damaging |
Het |
| Ifi44 |
T |
G |
3: 151,451,276 (GRCm39) |
|
probably null |
Het |
| Igkv4-53 |
C |
T |
6: 69,625,915 (GRCm39) |
R62H |
possibly damaging |
Het |
| Lrp11 |
A |
C |
10: 7,474,454 (GRCm39) |
|
probably null |
Het |
| Lrp4 |
A |
G |
2: 91,338,833 (GRCm39) |
T1755A |
probably benign |
Het |
| Mcm3ap |
A |
T |
10: 76,336,934 (GRCm39) |
K1316M |
probably damaging |
Het |
| Mctp1 |
T |
G |
13: 76,971,082 (GRCm39) |
|
probably null |
Het |
| Mroh5 |
A |
T |
15: 73,662,630 (GRCm39) |
I396N |
probably damaging |
Het |
| Mrps5 |
T |
A |
2: 127,443,305 (GRCm39) |
H294Q |
probably damaging |
Het |
| Muc16 |
A |
T |
9: 18,569,985 (GRCm39) |
S845T |
unknown |
Het |
| Mycbpap |
A |
T |
11: 94,398,557 (GRCm39) |
V474E |
probably damaging |
Het |
| Mzt2 |
G |
C |
16: 15,666,551 (GRCm39) |
S122W |
probably benign |
Het |
| Neb |
T |
C |
2: 52,146,802 (GRCm39) |
I2821V |
probably benign |
Het |
| Ngef |
A |
T |
1: 87,415,622 (GRCm39) |
D347E |
probably damaging |
Het |
| Nlrp14 |
T |
C |
7: 106,781,646 (GRCm39) |
V281A |
probably benign |
Het |
| Obscn |
A |
T |
11: 58,888,864 (GRCm39) |
Y7597N |
unknown |
Het |
| Or4k47 |
T |
C |
2: 111,451,520 (GRCm39) |
R300G |
possibly damaging |
Het |
| Patj |
G |
T |
4: 98,344,394 (GRCm39) |
G569W |
probably damaging |
Het |
| Pdzrn4 |
A |
T |
15: 92,655,562 (GRCm39) |
E485V |
probably damaging |
Het |
| Phf2 |
T |
A |
13: 48,973,583 (GRCm39) |
T361S |
unknown |
Het |
| Pik3r6 |
A |
G |
11: 68,434,455 (GRCm39) |
E552G |
probably damaging |
Het |
| Pitx2 |
A |
G |
3: 129,009,521 (GRCm39) |
T147A |
probably benign |
Het |
| Pkmyt1 |
G |
A |
17: 23,953,167 (GRCm39) |
G241D |
probably damaging |
Het |
| Pola2 |
A |
T |
19: 6,003,802 (GRCm39) |
V191D |
possibly damaging |
Het |
| Ralgapb |
T |
A |
2: 158,291,367 (GRCm39) |
|
probably null |
Het |
| Rapgef4 |
T |
C |
2: 71,811,661 (GRCm39) |
S11P |
probably benign |
Het |
| Rnf10 |
G |
A |
5: 115,395,136 (GRCm39) |
R151C |
probably damaging |
Het |
| Rpl34 |
G |
A |
3: 130,522,716 (GRCm39) |
P50L |
probably benign |
Het |
| Rptn |
C |
G |
3: 93,305,437 (GRCm39) |
H923Q |
possibly damaging |
Het |
| Sbno2 |
A |
T |
10: 79,895,850 (GRCm39) |
L977Q |
probably damaging |
Het |
| Sec14l3 |
G |
A |
11: 4,025,566 (GRCm39) |
|
probably null |
Het |
| Serping1 |
A |
T |
2: 84,600,612 (GRCm39) |
N243K |
possibly damaging |
Het |
| Slco2b1 |
T |
A |
7: 99,334,779 (GRCm39) |
I231F |
probably damaging |
Het |
| Spag8 |
A |
G |
4: 43,652,458 (GRCm39) |
F294S |
probably damaging |
Het |
| Speer4f1 |
G |
A |
5: 17,684,493 (GRCm39) |
A174T |
probably damaging |
Het |
| Spred3 |
T |
C |
7: 28,862,402 (GRCm39) |
D147G |
probably benign |
Het |
| Stard9 |
A |
G |
2: 120,527,241 (GRCm39) |
D1166G |
probably damaging |
Het |
| Svep1 |
G |
T |
4: 58,104,536 (GRCm39) |
T1229K |
possibly damaging |
Het |
| Tanc1 |
T |
A |
2: 59,669,305 (GRCm39) |
|
probably null |
Het |
| Tmem232 |
T |
C |
17: 65,737,800 (GRCm39) |
Y420C |
probably damaging |
Het |
| Tubd1 |
A |
T |
11: 86,448,619 (GRCm39) |
M311L |
probably benign |
Het |
| Tulp3 |
G |
A |
6: 128,332,703 (GRCm39) |
|
probably null |
Het |
| Usp42 |
T |
C |
5: 143,702,942 (GRCm39) |
T560A |
possibly damaging |
Het |
| Vmn1r170 |
A |
T |
7: 23,305,934 (GRCm39) |
Y112F |
probably damaging |
Het |
| Wrn |
A |
G |
8: 33,774,682 (GRCm39) |
M652T |
probably benign |
Het |
| Wsb1 |
G |
A |
11: 79,139,336 (GRCm39) |
P120L |
possibly damaging |
Het |
| Zfp142 |
T |
C |
1: 74,609,667 (GRCm39) |
E1376G |
probably damaging |
Het |
| Zfp709 |
TCGACG |
TCG |
8: 72,644,552 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Vmn2r4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01310:Vmn2r4
|
APN |
3 |
64,317,200 (GRCm39) |
splice site |
probably null |
|
|
IGL01448:Vmn2r4
|
APN |
3 |
64,313,816 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01452:Vmn2r4
|
APN |
3 |
64,313,816 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01454:Vmn2r4
|
APN |
3 |
64,313,816 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01456:Vmn2r4
|
APN |
3 |
64,313,816 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01463:Vmn2r4
|
APN |
3 |
64,313,816 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01467:Vmn2r4
|
APN |
3 |
64,313,816 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01468:Vmn2r4
|
APN |
3 |
64,313,816 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01470:Vmn2r4
|
APN |
3 |
64,313,816 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01476:Vmn2r4
|
APN |
3 |
64,313,816 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01481:Vmn2r4
|
APN |
3 |
64,313,816 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01534:Vmn2r4
|
APN |
3 |
64,313,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01636:Vmn2r4
|
APN |
3 |
64,313,657 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01879:Vmn2r4
|
APN |
3 |
64,298,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02147:Vmn2r4
|
APN |
3 |
64,305,782 (GRCm39) |
splice site |
probably benign |
|
|
IGL02276:Vmn2r4
|
APN |
3 |
64,313,877 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02432:Vmn2r4
|
APN |
3 |
64,313,821 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02533:Vmn2r4
|
APN |
3 |
64,305,840 (GRCm39) |
nonsense |
probably null |
|
|
IGL02655:Vmn2r4
|
APN |
3 |
64,305,886 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02666:Vmn2r4
|
APN |
3 |
64,296,433 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02902:Vmn2r4
|
APN |
3 |
64,314,337 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL03189:Vmn2r4
|
APN |
3 |
64,296,589 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03250:Vmn2r4
|
APN |
3 |
64,314,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03271:Vmn2r4
|
APN |
3 |
64,305,850 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0310:Vmn2r4
|
UTSW |
3 |
64,296,855 (GRCm39) |
nonsense |
probably null |
|
|
R0504:Vmn2r4
|
UTSW |
3 |
64,296,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1546:Vmn2r4
|
UTSW |
3 |
64,314,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1562:Vmn2r4
|
UTSW |
3 |
64,296,865 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1863:Vmn2r4
|
UTSW |
3 |
64,314,410 (GRCm39) |
missense |
probably benign |
0.33 |
|
R1873:Vmn2r4
|
UTSW |
3 |
64,298,479 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1939:Vmn2r4
|
UTSW |
3 |
64,305,976 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2103:Vmn2r4
|
UTSW |
3 |
64,322,704 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R3083:Vmn2r4
|
UTSW |
3 |
64,296,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3687:Vmn2r4
|
UTSW |
3 |
64,296,896 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3707:Vmn2r4
|
UTSW |
3 |
64,296,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3963:Vmn2r4
|
UTSW |
3 |
64,322,572 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4428:Vmn2r4
|
UTSW |
3 |
64,322,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4710:Vmn2r4
|
UTSW |
3 |
64,317,201 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4737:Vmn2r4
|
UTSW |
3 |
64,317,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4767:Vmn2r4
|
UTSW |
3 |
64,298,397 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4776:Vmn2r4
|
UTSW |
3 |
64,296,082 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4834:Vmn2r4
|
UTSW |
3 |
64,317,484 (GRCm39) |
missense |
probably benign |
0.40 |
|
R4893:Vmn2r4
|
UTSW |
3 |
64,313,676 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4908:Vmn2r4
|
UTSW |
3 |
64,296,476 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R5049:Vmn2r4
|
UTSW |
3 |
64,306,019 (GRCm39) |
splice site |
probably null |
|
|
R5092:Vmn2r4
|
UTSW |
3 |
64,298,373 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5234:Vmn2r4
|
UTSW |
3 |
64,305,878 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5240:Vmn2r4
|
UTSW |
3 |
64,314,358 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5704:Vmn2r4
|
UTSW |
3 |
64,317,370 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5897:Vmn2r4
|
UTSW |
3 |
64,322,687 (GRCm39) |
nonsense |
probably null |
|
|
R5907:Vmn2r4
|
UTSW |
3 |
64,298,487 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5924:Vmn2r4
|
UTSW |
3 |
64,296,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6145:Vmn2r4
|
UTSW |
3 |
64,314,364 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6191:Vmn2r4
|
UTSW |
3 |
64,322,702 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6207:Vmn2r4
|
UTSW |
3 |
64,313,926 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6457:Vmn2r4
|
UTSW |
3 |
64,317,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6533:Vmn2r4
|
UTSW |
3 |
64,322,519 (GRCm39) |
missense |
probably benign |
|
|
R6545:Vmn2r4
|
UTSW |
3 |
64,313,777 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6594:Vmn2r4
|
UTSW |
3 |
64,296,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7049:Vmn2r4
|
UTSW |
3 |
64,296,550 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7150:Vmn2r4
|
UTSW |
3 |
64,305,898 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7187:Vmn2r4
|
UTSW |
3 |
64,322,681 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7363:Vmn2r4
|
UTSW |
3 |
64,314,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7477:Vmn2r4
|
UTSW |
3 |
64,305,850 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7675:Vmn2r4
|
UTSW |
3 |
64,322,657 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7858:Vmn2r4
|
UTSW |
3 |
64,317,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7888:Vmn2r4
|
UTSW |
3 |
64,313,943 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8678:Vmn2r4
|
UTSW |
3 |
64,314,391 (GRCm39) |
missense |
probably benign |
|
|
R8743:Vmn2r4
|
UTSW |
3 |
64,317,247 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8841:Vmn2r4
|
UTSW |
3 |
64,314,058 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9671:Vmn2r4
|
UTSW |
3 |
64,317,271 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9778:Vmn2r4
|
UTSW |
3 |
64,322,497 (GRCm39) |
missense |
probably benign |
0.15 |
|
X0019:Vmn2r4
|
UTSW |
3 |
64,314,057 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCACTTGTTGGCATGGTCC -3'
(R):5'- CTAAAAGTGTTGCTCAGCTCC -3'
Sequencing Primer
(F):5'- GTTGGCATGGTCCTATAATGAACAG -3'
(R):5'- AAAAGTGTTGCTCAGCTCCTATTC -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation