Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01107:Tmem131'

50280

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem131

Ensembl Gene

ENSMUSG00000026116

Gene Name

transmembrane protein 131

Synonyms

2610524E03Rik, D1Bwg0491e, CC28, Neg, Rw1, YR-23

Accession Numbers

Essential gene?

Probably essential (E-score: 0.866) question?

Stock #

IGL01107

Quality Score

Status

Chromosome

Chromosomal Location

36792191-36943666 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 36829581 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Glycine at position 388 (S388G)

Ref Sequence

ENSEMBL: ENSMUSP00000142307 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027290] [ENSMUST00000186486] [ENSMUST00000194563]

AlphaFold

O70472

Predicted Effect

probably damaging
Transcript: ENSMUST00000027290
AA Change: S388G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000027290
Gene: ENSMUSG00000026116
AA Change: S388G

Domain	Start	End	E-Value	Type
low complexity region	5	44	N/A	INTRINSIC
low complexity region	77	89	N/A	INTRINSIC
Pfam:TMEM131_like	106	189	1.7e-32	PFAM
transmembrane domain	1081	1103	N/A	INTRINSIC
transmembrane domain	1116	1138	N/A	INTRINSIC
low complexity region	1232	1258	N/A	INTRINSIC
low complexity region	1283	1315	N/A	INTRINSIC
low complexity region	1369	1382	N/A	INTRINSIC
low complexity region	1384	1433	N/A	INTRINSIC
low complexity region	1460	1471	N/A	INTRINSIC
low complexity region	1595	1610	N/A	INTRINSIC
low complexity region	1613	1626	N/A	INTRINSIC
low complexity region	1628	1646	N/A	INTRINSIC
low complexity region	1675	1684	N/A	INTRINSIC
low complexity region	1693	1701	N/A	INTRINSIC
low complexity region	1738	1748	N/A	INTRINSIC
low complexity region	1760	1779	N/A	INTRINSIC
low complexity region	1799	1810	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000186486

SMART Domains

Protein: ENSMUSP00000142080
Gene: ENSMUSG00000026116

Domain	Start	End	E-Value	Type
low complexity region	31	48	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000194563
AA Change: S388G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000142307
Gene: ENSMUSG00000026116
AA Change: S388G

Domain	Start	End	E-Value	Type
low complexity region	5	44	N/A	INTRINSIC
low complexity region	77	89	N/A	INTRINSIC
Pfam:DUF3651	170	243	1.9e-27	PFAM
Pfam:DUF3651	500	580	4.5e-16	PFAM
Pfam:DUF3651	631	706	5.2e-15	PFAM
transmembrane domain	1081	1103	N/A	INTRINSIC
transmembrane domain	1116	1138	N/A	INTRINSIC
low complexity region	1232	1258	N/A	INTRINSIC
low complexity region	1283	1315	N/A	INTRINSIC
low complexity region	1369	1382	N/A	INTRINSIC
low complexity region	1384	1433	N/A	INTRINSIC
low complexity region	1460	1471	N/A	INTRINSIC
low complexity region	1595	1610	N/A	INTRINSIC
low complexity region	1613	1626	N/A	INTRINSIC
low complexity region	1628	1646	N/A	INTRINSIC
low complexity region	1675	1684	N/A	INTRINSIC
low complexity region	1693	1701	N/A	INTRINSIC
low complexity region	1738	1748	N/A	INTRINSIC
low complexity region	1760	1779	N/A	INTRINSIC
low complexity region	1799	1810	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001O22Rik	A	T	2: 30,797,936 (GRCm38)	F215Y	probably damaging	Het
2700049A03Rik	T	C	12: 71,194,468 (GRCm38)		probably null	Het
Akip1	C	T	7: 109,711,838 (GRCm38)	T195M	probably damaging	Het
Arhgef16	T	C	4: 154,280,244 (GRCm38)	N631S	probably benign	Het
Brat1	C	T	5: 140,717,177 (GRCm38)	S544L	probably damaging	Het
Cfap65	C	T	1: 74,919,183 (GRCm38)		probably null	Het
Defa22	T	A	8: 21,163,037 (GRCm38)		probably null	Het
Dnajc4	C	T	19: 6,989,501 (GRCm38)	R153H	probably benign	Het
Dusp11	A	G	6: 85,952,370 (GRCm38)		probably benign	Het
E2f4	T	A	8: 105,304,177 (GRCm38)		probably benign	Het
Ece1	T	A	4: 137,938,658 (GRCm38)	L271Q	probably damaging	Het
Fcgrt	T	C	7: 45,093,328 (GRCm38)	D343G	probably damaging	Het
Igsf10	T	C	3: 59,331,524 (GRCm38)	E412G	probably damaging	Het
Il4ra	G	T	7: 125,575,914 (GRCm38)	L431F	possibly damaging	Het
Ilrun	A	T	17: 27,786,069 (GRCm38)		probably null	Het
Krt86	T	A	15: 101,475,425 (GRCm38)	L200Q	probably damaging	Het
Lpcat1	T	A	13: 73,494,828 (GRCm38)	F126I	probably damaging	Het
Prag1	A	G	8: 36,099,931 (GRCm38)	T79A	probably benign	Het
Pramel13	A	T	4: 144,393,094 (GRCm38)	I301N	probably benign	Het
Psg29	G	T	7: 17,204,925 (GRCm38)	L41F	probably benign	Het
Rai14	C	T	15: 10,599,711 (GRCm38)		probably benign	Het
Reg3a	A	G	6: 78,383,245 (GRCm38)	D136G	probably benign	Het
Rif1	A	G	2: 52,111,303 (GRCm38)	T1590A	probably benign	Het
Rorb	A	T	19: 18,957,328 (GRCm38)	L300*	probably null	Het
Sin3b	T	C	8: 72,731,105 (GRCm38)	C150R	possibly damaging	Het
Smarcc1	C	A	9: 110,221,937 (GRCm38)	H942N	probably damaging	Het
Tas2r105	A	G	6: 131,687,111 (GRCm38)	V118A	probably benign	Het
Ttll9	C	A	2: 153,002,889 (GRCm38)		probably benign	Het
Ush1c	A	G	7: 46,209,901 (GRCm38)	L498P	probably damaging	Het
Vmn2r100	A	G	17: 19,521,356 (GRCm38)	Y110C	probably damaging	Het
Zbtb11	T	C	16: 56,006,007 (GRCm38)	Y800H	probably damaging	Het
Zdhhc20	T	A	14: 57,865,589 (GRCm38)	E101V	probably damaging	Het

Other mutations in Tmem131

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00561:Tmem131	APN	1	36,811,427 (GRCm38)	missense	probably damaging	1.00
IGL00945:Tmem131	APN	1	36,827,005 (GRCm38)	splice site	probably benign
IGL01401:Tmem131	APN	1	36,799,387 (GRCm38)	missense	probably damaging	1.00
IGL01533:Tmem131	APN	1	36,818,722 (GRCm38)	missense	probably damaging	1.00
IGL01701:Tmem131	APN	1	36,808,237 (GRCm38)	missense	probably benign	0.02
IGL01784:Tmem131	APN	1	36,815,483 (GRCm38)	missense	probably damaging	1.00
IGL01890:Tmem131	APN	1	36,823,156 (GRCm38)	splice site	probably benign
IGL01969:Tmem131	APN	1	36,825,460 (GRCm38)	missense	possibly damaging	0.85
IGL02327:Tmem131	APN	1	36,799,022 (GRCm38)	missense	probably damaging	1.00
IGL02707:Tmem131	APN	1	36,825,479 (GRCm38)	missense	probably benign	0.03
IGL02743:Tmem131	APN	1	36,793,151 (GRCm38)	missense	probably benign	0.00
IGL03111:Tmem131	APN	1	36,828,144 (GRCm38)	missense	probably damaging	1.00
R0063:Tmem131	UTSW	1	36,819,128 (GRCm38)	missense	probably benign	0.09
R0063:Tmem131	UTSW	1	36,819,128 (GRCm38)	missense	probably benign	0.09
R0238:Tmem131	UTSW	1	36,828,050 (GRCm38)	splice site	probably benign
R0239:Tmem131	UTSW	1	36,828,050 (GRCm38)	splice site	probably benign
R0499:Tmem131	UTSW	1	36,841,673 (GRCm38)	missense	probably damaging	1.00
R0548:Tmem131	UTSW	1	36,838,038 (GRCm38)	missense	probably damaging	1.00
R0845:Tmem131	UTSW	1	36,816,222 (GRCm38)	missense	probably damaging	1.00
R0975:Tmem131	UTSW	1	36,854,885 (GRCm38)	missense	probably damaging	1.00
R1018:Tmem131	UTSW	1	36,794,819 (GRCm38)	missense	probably damaging	0.98
R1170:Tmem131	UTSW	1	36,834,898 (GRCm38)	nonsense	probably null
R1443:Tmem131	UTSW	1	36,825,478 (GRCm38)	missense	probably damaging	0.98
R1448:Tmem131	UTSW	1	36,827,358 (GRCm38)	missense	probably benign	0.16
R1472:Tmem131	UTSW	1	36,816,241 (GRCm38)	missense	possibly damaging	0.68
R1530:Tmem131	UTSW	1	36,827,009 (GRCm38)	critical splice donor site	probably null
R1672:Tmem131	UTSW	1	36,824,759 (GRCm38)	missense	probably damaging	1.00
R1872:Tmem131	UTSW	1	36,807,927 (GRCm38)	missense	probably benign	0.05
R1914:Tmem131	UTSW	1	36,796,266 (GRCm38)	missense	probably damaging	1.00
R1915:Tmem131	UTSW	1	36,796,266 (GRCm38)	missense	probably damaging	1.00
R1929:Tmem131	UTSW	1	36,812,271 (GRCm38)	missense	possibly damaging	0.50
R1971:Tmem131	UTSW	1	36,804,599 (GRCm38)	nonsense	probably null
R2146:Tmem131	UTSW	1	36,812,609 (GRCm38)	missense	probably benign	0.13
R2148:Tmem131	UTSW	1	36,812,609 (GRCm38)	missense	probably benign	0.13
R2149:Tmem131	UTSW	1	36,812,609 (GRCm38)	missense	probably benign	0.13
R2150:Tmem131	UTSW	1	36,812,609 (GRCm38)	missense	probably benign	0.13
R2386:Tmem131	UTSW	1	36,829,635 (GRCm38)	missense	probably benign	0.00
R2879:Tmem131	UTSW	1	36,841,707 (GRCm38)	missense	possibly damaging	0.76
R2903:Tmem131	UTSW	1	36,825,297 (GRCm38)	missense	probably damaging	1.00
R3430:Tmem131	UTSW	1	36,808,821 (GRCm38)	splice site	probably benign
R3821:Tmem131	UTSW	1	36,808,396 (GRCm38)	missense	probably damaging	0.99
R3961:Tmem131	UTSW	1	36,818,950 (GRCm38)	missense	probably damaging	1.00
R4153:Tmem131	UTSW	1	36,808,793 (GRCm38)	intron	probably benign
R4154:Tmem131	UTSW	1	36,808,793 (GRCm38)	intron	probably benign
R4502:Tmem131	UTSW	1	36,825,479 (GRCm38)	missense	probably benign	0.03
R4503:Tmem131	UTSW	1	36,825,479 (GRCm38)	missense	probably benign	0.03
R4795:Tmem131	UTSW	1	36,841,676 (GRCm38)	missense	probably damaging	1.00
R5030:Tmem131	UTSW	1	36,827,174 (GRCm38)	missense	possibly damaging	0.78
R5068:Tmem131	UTSW	1	36,854,905 (GRCm38)	missense	probably damaging	1.00
R5070:Tmem131	UTSW	1	36,854,905 (GRCm38)	missense	probably damaging	1.00
R5386:Tmem131	UTSW	1	36,872,558 (GRCm38)	missense	possibly damaging	0.47
R5507:Tmem131	UTSW	1	36,889,280 (GRCm38)	missense	probably damaging	1.00
R5569:Tmem131	UTSW	1	36,799,338 (GRCm38)	missense	probably benign	0.02
R5913:Tmem131	UTSW	1	36,819,128 (GRCm38)	missense	probably benign	0.01
R6044:Tmem131	UTSW	1	36,881,341 (GRCm38)	nonsense	probably null
R6125:Tmem131	UTSW	1	36,808,306 (GRCm38)	missense	possibly damaging	0.95
R6259:Tmem131	UTSW	1	36,819,128 (GRCm38)	missense	probably benign	0.09
R6392:Tmem131	UTSW	1	36,881,342 (GRCm38)	missense	probably benign	0.10
R6704:Tmem131	UTSW	1	36,796,180 (GRCm38)	missense	possibly damaging	0.77
R6828:Tmem131	UTSW	1	36,804,643 (GRCm38)	missense	possibly damaging	0.46
R6964:Tmem131	UTSW	1	36,796,292 (GRCm38)	missense	probably damaging	0.99
R7034:Tmem131	UTSW	1	36,792,973 (GRCm38)	missense	possibly damaging	0.80
R7036:Tmem131	UTSW	1	36,792,973 (GRCm38)	missense	possibly damaging	0.80
R7081:Tmem131	UTSW	1	36,889,295 (GRCm38)	missense	possibly damaging	0.94
R7278:Tmem131	UTSW	1	36,796,301 (GRCm38)	missense	probably damaging	0.99
R7282:Tmem131	UTSW	1	36,841,604 (GRCm38)	missense	probably damaging	1.00
R7294:Tmem131	UTSW	1	36,854,847 (GRCm38)	missense	possibly damaging	0.88
R7635:Tmem131	UTSW	1	36,872,548 (GRCm38)	missense	probably damaging	1.00
R7916:Tmem131	UTSW	1	36,823,086 (GRCm38)	missense	probably benign	0.00
R7948:Tmem131	UTSW	1	36,794,148 (GRCm38)	missense	probably damaging	1.00
R8012:Tmem131	UTSW	1	36,807,964 (GRCm38)	missense	probably damaging	1.00
R8244:Tmem131	UTSW	1	36,808,893 (GRCm38)	missense	probably benign	0.08
R8461:Tmem131	UTSW	1	36,794,821 (GRCm38)	missense	probably damaging	1.00
R8770:Tmem131	UTSW	1	36,799,105 (GRCm38)	splice site	probably benign
R8902:Tmem131	UTSW	1	36,808,965 (GRCm38)	missense	probably damaging	1.00
R8915:Tmem131	UTSW	1	36,829,577 (GRCm38)	missense	probably damaging	1.00
R8984:Tmem131	UTSW	1	36,828,147 (GRCm38)	missense	probably benign	0.05
R8994:Tmem131	UTSW	1	36,815,457 (GRCm38)	missense	probably benign	0.29
R9105:Tmem131	UTSW	1	36,815,510 (GRCm38)	missense	probably benign	0.44
R9156:Tmem131	UTSW	1	36,841,686 (GRCm38)	missense	possibly damaging	0.88
R9328:Tmem131	UTSW	1	36,819,155 (GRCm38)	nonsense	probably null
R9501:Tmem131	UTSW	1	36,819,184 (GRCm38)	missense	possibly damaging	0.73
R9633:Tmem131	UTSW	1	36,807,988 (GRCm38)	missense	probably damaging	0.99
Z1176:Tmem131	UTSW	1	36,796,257 (GRCm38)	missense	probably damaging	1.00

Posted On

2013-06-21