Incidental Mutation 'IGL01107:Tmem131'
ID 50280
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem131
Ensembl Gene ENSMUSG00000026116
Gene Name transmembrane protein 131
Synonyms 2610524E03Rik, D1Bwg0491e, CC28, Neg, Rw1, YR-23
Accession Numbers
Essential gene? Probably essential (E-score: 0.866) question?
Stock # IGL01107
Quality Score
Status
Chromosome 1
Chromosomal Location 36792191-36943666 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 36829581 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 388 (S388G)
Ref Sequence ENSEMBL: ENSMUSP00000142307 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027290] [ENSMUST00000186486] [ENSMUST00000194563]
AlphaFold O70472
Predicted Effect probably damaging
Transcript: ENSMUST00000027290
AA Change: S388G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000027290
Gene: ENSMUSG00000026116
AA Change: S388G

DomainStartEndE-ValueType
low complexity region 5 44 N/A INTRINSIC
low complexity region 77 89 N/A INTRINSIC
Pfam:TMEM131_like 106 189 1.7e-32 PFAM
transmembrane domain 1081 1103 N/A INTRINSIC
transmembrane domain 1116 1138 N/A INTRINSIC
low complexity region 1232 1258 N/A INTRINSIC
low complexity region 1283 1315 N/A INTRINSIC
low complexity region 1369 1382 N/A INTRINSIC
low complexity region 1384 1433 N/A INTRINSIC
low complexity region 1460 1471 N/A INTRINSIC
low complexity region 1595 1610 N/A INTRINSIC
low complexity region 1613 1626 N/A INTRINSIC
low complexity region 1628 1646 N/A INTRINSIC
low complexity region 1675 1684 N/A INTRINSIC
low complexity region 1693 1701 N/A INTRINSIC
low complexity region 1738 1748 N/A INTRINSIC
low complexity region 1760 1779 N/A INTRINSIC
low complexity region 1799 1810 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000186486
SMART Domains Protein: ENSMUSP00000142080
Gene: ENSMUSG00000026116

DomainStartEndE-ValueType
low complexity region 31 48 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000194563
AA Change: S388G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000142307
Gene: ENSMUSG00000026116
AA Change: S388G

DomainStartEndE-ValueType
low complexity region 5 44 N/A INTRINSIC
low complexity region 77 89 N/A INTRINSIC
Pfam:DUF3651 170 243 1.9e-27 PFAM
Pfam:DUF3651 500 580 4.5e-16 PFAM
Pfam:DUF3651 631 706 5.2e-15 PFAM
transmembrane domain 1081 1103 N/A INTRINSIC
transmembrane domain 1116 1138 N/A INTRINSIC
low complexity region 1232 1258 N/A INTRINSIC
low complexity region 1283 1315 N/A INTRINSIC
low complexity region 1369 1382 N/A INTRINSIC
low complexity region 1384 1433 N/A INTRINSIC
low complexity region 1460 1471 N/A INTRINSIC
low complexity region 1595 1610 N/A INTRINSIC
low complexity region 1613 1626 N/A INTRINSIC
low complexity region 1628 1646 N/A INTRINSIC
low complexity region 1675 1684 N/A INTRINSIC
low complexity region 1693 1701 N/A INTRINSIC
low complexity region 1738 1748 N/A INTRINSIC
low complexity region 1760 1779 N/A INTRINSIC
low complexity region 1799 1810 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001O22Rik A T 2: 30,797,936 (GRCm38) F215Y probably damaging Het
2700049A03Rik T C 12: 71,194,468 (GRCm38) probably null Het
Akip1 C T 7: 109,711,838 (GRCm38) T195M probably damaging Het
Arhgef16 T C 4: 154,280,244 (GRCm38) N631S probably benign Het
Brat1 C T 5: 140,717,177 (GRCm38) S544L probably damaging Het
Cfap65 C T 1: 74,919,183 (GRCm38) probably null Het
Defa22 T A 8: 21,163,037 (GRCm38) probably null Het
Dnajc4 C T 19: 6,989,501 (GRCm38) R153H probably benign Het
Dusp11 A G 6: 85,952,370 (GRCm38) probably benign Het
E2f4 T A 8: 105,304,177 (GRCm38) probably benign Het
Ece1 T A 4: 137,938,658 (GRCm38) L271Q probably damaging Het
Fcgrt T C 7: 45,093,328 (GRCm38) D343G probably damaging Het
Igsf10 T C 3: 59,331,524 (GRCm38) E412G probably damaging Het
Il4ra G T 7: 125,575,914 (GRCm38) L431F possibly damaging Het
Ilrun A T 17: 27,786,069 (GRCm38) probably null Het
Krt86 T A 15: 101,475,425 (GRCm38) L200Q probably damaging Het
Lpcat1 T A 13: 73,494,828 (GRCm38) F126I probably damaging Het
Prag1 A G 8: 36,099,931 (GRCm38) T79A probably benign Het
Pramel13 A T 4: 144,393,094 (GRCm38) I301N probably benign Het
Psg29 G T 7: 17,204,925 (GRCm38) L41F probably benign Het
Rai14 C T 15: 10,599,711 (GRCm38) probably benign Het
Reg3a A G 6: 78,383,245 (GRCm38) D136G probably benign Het
Rif1 A G 2: 52,111,303 (GRCm38) T1590A probably benign Het
Rorb A T 19: 18,957,328 (GRCm38) L300* probably null Het
Sin3b T C 8: 72,731,105 (GRCm38) C150R possibly damaging Het
Smarcc1 C A 9: 110,221,937 (GRCm38) H942N probably damaging Het
Tas2r105 A G 6: 131,687,111 (GRCm38) V118A probably benign Het
Ttll9 C A 2: 153,002,889 (GRCm38) probably benign Het
Ush1c A G 7: 46,209,901 (GRCm38) L498P probably damaging Het
Vmn2r100 A G 17: 19,521,356 (GRCm38) Y110C probably damaging Het
Zbtb11 T C 16: 56,006,007 (GRCm38) Y800H probably damaging Het
Zdhhc20 T A 14: 57,865,589 (GRCm38) E101V probably damaging Het
Other mutations in Tmem131
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00561:Tmem131 APN 1 36,811,427 (GRCm38) missense probably damaging 1.00
IGL00945:Tmem131 APN 1 36,827,005 (GRCm38) splice site probably benign
IGL01401:Tmem131 APN 1 36,799,387 (GRCm38) missense probably damaging 1.00
IGL01533:Tmem131 APN 1 36,818,722 (GRCm38) missense probably damaging 1.00
IGL01701:Tmem131 APN 1 36,808,237 (GRCm38) missense probably benign 0.02
IGL01784:Tmem131 APN 1 36,815,483 (GRCm38) missense probably damaging 1.00
IGL01890:Tmem131 APN 1 36,823,156 (GRCm38) splice site probably benign
IGL01969:Tmem131 APN 1 36,825,460 (GRCm38) missense possibly damaging 0.85
IGL02327:Tmem131 APN 1 36,799,022 (GRCm38) missense probably damaging 1.00
IGL02707:Tmem131 APN 1 36,825,479 (GRCm38) missense probably benign 0.03
IGL02743:Tmem131 APN 1 36,793,151 (GRCm38) missense probably benign 0.00
IGL03111:Tmem131 APN 1 36,828,144 (GRCm38) missense probably damaging 1.00
R0063:Tmem131 UTSW 1 36,819,128 (GRCm38) missense probably benign 0.09
R0063:Tmem131 UTSW 1 36,819,128 (GRCm38) missense probably benign 0.09
R0238:Tmem131 UTSW 1 36,828,050 (GRCm38) splice site probably benign
R0239:Tmem131 UTSW 1 36,828,050 (GRCm38) splice site probably benign
R0499:Tmem131 UTSW 1 36,841,673 (GRCm38) missense probably damaging 1.00
R0548:Tmem131 UTSW 1 36,838,038 (GRCm38) missense probably damaging 1.00
R0845:Tmem131 UTSW 1 36,816,222 (GRCm38) missense probably damaging 1.00
R0975:Tmem131 UTSW 1 36,854,885 (GRCm38) missense probably damaging 1.00
R1018:Tmem131 UTSW 1 36,794,819 (GRCm38) missense probably damaging 0.98
R1170:Tmem131 UTSW 1 36,834,898 (GRCm38) nonsense probably null
R1443:Tmem131 UTSW 1 36,825,478 (GRCm38) missense probably damaging 0.98
R1448:Tmem131 UTSW 1 36,827,358 (GRCm38) missense probably benign 0.16
R1472:Tmem131 UTSW 1 36,816,241 (GRCm38) missense possibly damaging 0.68
R1530:Tmem131 UTSW 1 36,827,009 (GRCm38) critical splice donor site probably null
R1672:Tmem131 UTSW 1 36,824,759 (GRCm38) missense probably damaging 1.00
R1872:Tmem131 UTSW 1 36,807,927 (GRCm38) missense probably benign 0.05
R1914:Tmem131 UTSW 1 36,796,266 (GRCm38) missense probably damaging 1.00
R1915:Tmem131 UTSW 1 36,796,266 (GRCm38) missense probably damaging 1.00
R1929:Tmem131 UTSW 1 36,812,271 (GRCm38) missense possibly damaging 0.50
R1971:Tmem131 UTSW 1 36,804,599 (GRCm38) nonsense probably null
R2146:Tmem131 UTSW 1 36,812,609 (GRCm38) missense probably benign 0.13
R2148:Tmem131 UTSW 1 36,812,609 (GRCm38) missense probably benign 0.13
R2149:Tmem131 UTSW 1 36,812,609 (GRCm38) missense probably benign 0.13
R2150:Tmem131 UTSW 1 36,812,609 (GRCm38) missense probably benign 0.13
R2386:Tmem131 UTSW 1 36,829,635 (GRCm38) missense probably benign 0.00
R2879:Tmem131 UTSW 1 36,841,707 (GRCm38) missense possibly damaging 0.76
R2903:Tmem131 UTSW 1 36,825,297 (GRCm38) missense probably damaging 1.00
R3430:Tmem131 UTSW 1 36,808,821 (GRCm38) splice site probably benign
R3821:Tmem131 UTSW 1 36,808,396 (GRCm38) missense probably damaging 0.99
R3961:Tmem131 UTSW 1 36,818,950 (GRCm38) missense probably damaging 1.00
R4153:Tmem131 UTSW 1 36,808,793 (GRCm38) intron probably benign
R4154:Tmem131 UTSW 1 36,808,793 (GRCm38) intron probably benign
R4502:Tmem131 UTSW 1 36,825,479 (GRCm38) missense probably benign 0.03
R4503:Tmem131 UTSW 1 36,825,479 (GRCm38) missense probably benign 0.03
R4795:Tmem131 UTSW 1 36,841,676 (GRCm38) missense probably damaging 1.00
R5030:Tmem131 UTSW 1 36,827,174 (GRCm38) missense possibly damaging 0.78
R5068:Tmem131 UTSW 1 36,854,905 (GRCm38) missense probably damaging 1.00
R5070:Tmem131 UTSW 1 36,854,905 (GRCm38) missense probably damaging 1.00
R5386:Tmem131 UTSW 1 36,872,558 (GRCm38) missense possibly damaging 0.47
R5507:Tmem131 UTSW 1 36,889,280 (GRCm38) missense probably damaging 1.00
R5569:Tmem131 UTSW 1 36,799,338 (GRCm38) missense probably benign 0.02
R5913:Tmem131 UTSW 1 36,819,128 (GRCm38) missense probably benign 0.01
R6044:Tmem131 UTSW 1 36,881,341 (GRCm38) nonsense probably null
R6125:Tmem131 UTSW 1 36,808,306 (GRCm38) missense possibly damaging 0.95
R6259:Tmem131 UTSW 1 36,819,128 (GRCm38) missense probably benign 0.09
R6392:Tmem131 UTSW 1 36,881,342 (GRCm38) missense probably benign 0.10
R6704:Tmem131 UTSW 1 36,796,180 (GRCm38) missense possibly damaging 0.77
R6828:Tmem131 UTSW 1 36,804,643 (GRCm38) missense possibly damaging 0.46
R6964:Tmem131 UTSW 1 36,796,292 (GRCm38) missense probably damaging 0.99
R7034:Tmem131 UTSW 1 36,792,973 (GRCm38) missense possibly damaging 0.80
R7036:Tmem131 UTSW 1 36,792,973 (GRCm38) missense possibly damaging 0.80
R7081:Tmem131 UTSW 1 36,889,295 (GRCm38) missense possibly damaging 0.94
R7278:Tmem131 UTSW 1 36,796,301 (GRCm38) missense probably damaging 0.99
R7282:Tmem131 UTSW 1 36,841,604 (GRCm38) missense probably damaging 1.00
R7294:Tmem131 UTSW 1 36,854,847 (GRCm38) missense possibly damaging 0.88
R7635:Tmem131 UTSW 1 36,872,548 (GRCm38) missense probably damaging 1.00
R7916:Tmem131 UTSW 1 36,823,086 (GRCm38) missense probably benign 0.00
R7948:Tmem131 UTSW 1 36,794,148 (GRCm38) missense probably damaging 1.00
R8012:Tmem131 UTSW 1 36,807,964 (GRCm38) missense probably damaging 1.00
R8244:Tmem131 UTSW 1 36,808,893 (GRCm38) missense probably benign 0.08
R8461:Tmem131 UTSW 1 36,794,821 (GRCm38) missense probably damaging 1.00
R8770:Tmem131 UTSW 1 36,799,105 (GRCm38) splice site probably benign
R8902:Tmem131 UTSW 1 36,808,965 (GRCm38) missense probably damaging 1.00
R8915:Tmem131 UTSW 1 36,829,577 (GRCm38) missense probably damaging 1.00
R8984:Tmem131 UTSW 1 36,828,147 (GRCm38) missense probably benign 0.05
R8994:Tmem131 UTSW 1 36,815,457 (GRCm38) missense probably benign 0.29
R9105:Tmem131 UTSW 1 36,815,510 (GRCm38) missense probably benign 0.44
R9156:Tmem131 UTSW 1 36,841,686 (GRCm38) missense possibly damaging 0.88
R9328:Tmem131 UTSW 1 36,819,155 (GRCm38) nonsense probably null
R9501:Tmem131 UTSW 1 36,819,184 (GRCm38) missense possibly damaging 0.73
R9633:Tmem131 UTSW 1 36,807,988 (GRCm38) missense probably damaging 0.99
Z1176:Tmem131 UTSW 1 36,796,257 (GRCm38) missense probably damaging 1.00
Posted On 2013-06-21