Incidental Mutation 'R6197:Ces1g'
ID 502985
Institutional Source Beutler Lab
Gene Symbol Ces1g
Ensembl Gene ENSMUSG00000057074
Gene Name carboxylesterase 1G
Synonyms Ses-1, Ces-1, Ces1
MMRRC Submission 044337-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R6197 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 94028997-94063837 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 94063764 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 7 (S7G)
Ref Sequence ENSEMBL: ENSMUSP00000037555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044602]
AlphaFold Q8VCC2
Predicted Effect probably benign
Transcript: ENSMUST00000044602
AA Change: S7G

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000037555
Gene: ENSMUSG00000057074
AA Change: S7G

DomainStartEndE-ValueType
Pfam:COesterase 1 545 3.6e-168 PFAM
Pfam:Abhydrolase_3 136 295 5.7e-11 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 92% (49/53)
MGI Phenotype FUNCTION: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700109H08Rik T A 5: 3,630,442 (GRCm39) Y119* probably null Het
Abcb9 C A 5: 124,209,812 (GRCm39) E664* probably null Het
Adgrl2 T C 3: 148,564,578 (GRCm39) D334G probably damaging Het
Ak9 T G 10: 41,193,826 (GRCm39) C57G probably damaging Het
Als2cl A G 9: 110,724,952 (GRCm39) K809E probably damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atp11a A G 8: 12,896,099 (GRCm39) I223V probably benign Het
Cacna2d3 A T 14: 28,630,278 (GRCm39) V1022E probably benign Het
Cc2d1b C T 4: 108,490,422 (GRCm39) R825W probably damaging Het
Cd37 A G 7: 44,886,598 (GRCm39) C85R probably damaging Het
Cltc T C 11: 86,611,188 (GRCm39) N561S probably benign Het
Cnbd2 A G 2: 156,217,494 (GRCm39) E661G possibly damaging Het
Col6a3 A T 1: 90,750,063 (GRCm39) F257Y probably damaging Het
Cpt1b T C 15: 89,309,037 (GRCm39) Y55C possibly damaging Het
Csmd1 A G 8: 15,976,611 (GRCm39) V2869A probably benign Het
Dnah11 T C 12: 118,143,482 (GRCm39) E387G probably benign Het
Eny2 T A 15: 44,292,949 (GRCm39) probably null Het
Fbxo10 G T 4: 45,043,857 (GRCm39) H655Q probably benign Het
Gm14403 AAACCCTA AA 2: 177,201,448 (GRCm39) probably benign Het
Gpx2 C T 12: 76,842,068 (GRCm39) G28S probably damaging Het
H2-Q5 G T 17: 35,613,918 (GRCm39) A156S probably benign Het
Hoxd4 A G 2: 74,558,807 (GRCm39) D210G possibly damaging Het
Hoxd9 A G 2: 74,529,166 (GRCm39) Q256R probably damaging Het
Macf1 A G 4: 123,346,085 (GRCm39) V2571A probably damaging Het
Mtus1 A G 8: 41,537,074 (GRCm39) V214A possibly damaging Het
Myh1 C T 11: 67,111,793 (GRCm39) A1716V probably benign Het
Nbeal1 A G 1: 60,261,287 (GRCm39) D249G probably damaging Het
Nup54 TCTGCTGCTGCTGCTGCTGCTGCTG TCTGCTGCTGCTGCTGCTGCTG 5: 92,578,663 (GRCm39) probably benign Het
Or10v9 G T 19: 11,833,148 (GRCm39) H56Q probably damaging Het
Or4c124 A T 2: 89,155,677 (GRCm39) N282K probably damaging Het
Or5w17 C T 2: 87,583,696 (GRCm39) V214I probably benign Het
Or7a37 T G 10: 78,805,974 (GRCm39) L164V probably damaging Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Pramel23 T C 4: 143,423,886 (GRCm39) Y301C possibly damaging Het
Prss59 A G 6: 40,897,939 (GRCm39) I248T probably benign Het
Pwwp2a A G 11: 43,595,423 (GRCm39) D196G probably benign Het
Rarg A T 15: 102,150,327 (GRCm39) C93S possibly damaging Het
Rcc1 T C 4: 132,065,073 (GRCm39) D150G possibly damaging Het
Ripk2 A G 4: 16,163,330 (GRCm39) Y23H probably damaging Het
Rragc A G 4: 123,811,340 (GRCm39) Y5C possibly damaging Het
Rubcnl G A 14: 75,269,369 (GRCm39) G9D probably damaging Het
Sephs2 A T 7: 126,872,073 (GRCm39) V340E probably damaging Het
Slc22a3 C T 17: 12,677,438 (GRCm39) M243I probably benign Het
Slco6c1 A G 1: 97,000,518 (GRCm39) probably null Het
Sncaip T G 18: 53,039,966 (GRCm39) I308R probably damaging Het
Supt16 G A 14: 52,408,338 (GRCm39) T869M probably damaging Het
Tanc1 G A 2: 59,674,366 (GRCm39) E1817K possibly damaging Het
Usp4 C A 9: 108,248,154 (GRCm39) Q395K probably damaging Het
Usp49 T A 17: 47,984,272 (GRCm39) S210T possibly damaging Het
Virma A G 4: 11,505,498 (GRCm39) I124M probably damaging Het
Vmn1r234 G A 17: 21,449,589 (GRCm39) V168I probably benign Het
Vnn3 T A 10: 23,732,187 (GRCm39) C146S probably damaging Het
Ylpm1 A G 12: 85,088,953 (GRCm39) D1234G probably damaging Het
Zfp617 T A 8: 72,687,098 (GRCm39) V476E probably benign Het
Other mutations in Ces1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00841:Ces1g APN 8 94,029,615 (GRCm39) missense possibly damaging 0.61
IGL00971:Ces1g APN 8 94,029,660 (GRCm39) missense probably damaging 1.00
IGL01583:Ces1g APN 8 94,033,587 (GRCm39) missense probably damaging 1.00
IGL02993:Ces1g APN 8 94,043,707 (GRCm39) missense probably benign 0.00
IGL03386:Ces1g APN 8 94,052,440 (GRCm39) missense probably benign 0.00
R0359:Ces1g UTSW 8 94,055,163 (GRCm39) splice site probably benign
R0373:Ces1g UTSW 8 94,057,821 (GRCm39) missense probably benign 0.06
R0499:Ces1g UTSW 8 94,060,317 (GRCm39) missense probably benign 0.01
R0689:Ces1g UTSW 8 94,055,035 (GRCm39) missense probably damaging 1.00
R1756:Ces1g UTSW 8 94,033,582 (GRCm39) missense probably benign 0.03
R3052:Ces1g UTSW 8 94,061,676 (GRCm39) missense possibly damaging 0.50
R3150:Ces1g UTSW 8 94,052,444 (GRCm39) missense probably benign 0.45
R3899:Ces1g UTSW 8 94,029,678 (GRCm39) missense probably damaging 1.00
R3966:Ces1g UTSW 8 94,055,139 (GRCm39) missense possibly damaging 0.50
R4134:Ces1g UTSW 8 94,046,500 (GRCm39) missense probably benign 0.00
R4198:Ces1g UTSW 8 94,032,496 (GRCm39) missense probably benign 0.11
R4332:Ces1g UTSW 8 94,046,446 (GRCm39) missense probably benign 0.01
R4719:Ces1g UTSW 8 94,043,718 (GRCm39) missense possibly damaging 0.59
R4841:Ces1g UTSW 8 94,060,323 (GRCm39) missense probably benign 0.01
R4842:Ces1g UTSW 8 94,060,323 (GRCm39) missense probably benign 0.01
R4843:Ces1g UTSW 8 94,057,893 (GRCm39) missense probably damaging 1.00
R5344:Ces1g UTSW 8 94,063,821 (GRCm39) start gained probably benign
R5405:Ces1g UTSW 8 94,032,496 (GRCm39) missense probably benign 0.29
R5425:Ces1g UTSW 8 94,052,428 (GRCm39) missense probably benign 0.20
R5884:Ces1g UTSW 8 94,033,558 (GRCm39) missense probably benign 0.24
R6022:Ces1g UTSW 8 94,055,085 (GRCm39) missense probably damaging 1.00
R6183:Ces1g UTSW 8 94,057,867 (GRCm39) missense possibly damaging 0.48
R6307:Ces1g UTSW 8 94,057,820 (GRCm39) missense possibly damaging 0.60
R6688:Ces1g UTSW 8 94,033,600 (GRCm39) missense possibly damaging 0.92
R6863:Ces1g UTSW 8 94,043,647 (GRCm39) missense possibly damaging 0.92
R7097:Ces1g UTSW 8 94,043,665 (GRCm39) missense possibly damaging 0.89
R7122:Ces1g UTSW 8 94,043,665 (GRCm39) missense possibly damaging 0.89
R7180:Ces1g UTSW 8 94,029,576 (GRCm39) missense probably benign 0.04
R7202:Ces1g UTSW 8 94,029,595 (GRCm39) missense probably benign 0.01
R7361:Ces1g UTSW 8 94,060,307 (GRCm39) missense not run
R7537:Ces1g UTSW 8 94,046,455 (GRCm39) missense probably benign 0.01
R7621:Ces1g UTSW 8 94,055,094 (GRCm39) missense probably damaging 1.00
R8200:Ces1g UTSW 8 94,055,085 (GRCm39) missense probably damaging 1.00
R8895:Ces1g UTSW 8 94,046,512 (GRCm39) missense possibly damaging 0.83
R9248:Ces1g UTSW 8 94,060,319 (GRCm39) missense possibly damaging 0.62
R9290:Ces1g UTSW 8 94,029,545 (GRCm39) missense probably benign 0.07
R9324:Ces1g UTSW 8 94,055,118 (GRCm39) missense probably damaging 1.00
R9361:Ces1g UTSW 8 94,061,646 (GRCm39) critical splice donor site probably null
R9565:Ces1g UTSW 8 94,061,792 (GRCm39) missense probably benign 0.06
R9615:Ces1g UTSW 8 94,061,807 (GRCm39) missense probably damaging 1.00
Z1176:Ces1g UTSW 8 94,052,439 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GGCACGGCAAAATTAAATTCCTC -3'
(R):5'- TAAGAAGTCCCATTAGGCGC -3'

Sequencing Primer
(F):5'- CCCTCAGCTTAGAGTAACTGGTG -3'
(R):5'- CCCAGAGAGCTCTCAGTCAG -3'
Posted On 2018-02-27