Mutagenetix > Incidental Mutation

Incidental Mutation 'R6197:Or7a37'

502990

Institutional Source

Beutler Lab

Gene Symbol

Or7a37

Ensembl Gene

ENSMUSG00000042774

Gene Name

olfactory receptor family 7 subfamily A member 37

Synonyms

GA_x6K02T2QGN0-2842591-2841662, Olfr1353, MOR139-2

MMRRC Submission

044337-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R6197 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

78799143-78806446 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 78805974 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Valine at position 164 (L164V)

Ref Sequence

ENSEMBL: ENSMUSP00000145073 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039718] [ENSMUST00000204849] [ENSMUST00000205193]

AlphaFold

Q8VGU8

Predicted Effect

probably damaging
Transcript: ENSMUST00000039718
AA Change: L164V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000038992
Gene: ENSMUSG00000042774
AA Change: L164V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.2e-48	PFAM
Pfam:7TM_GPCR_Srsx	35	305	2.9e-6	PFAM
Pfam:7tm_1	41	290	9.3e-27	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000204849
AA Change: L164V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000145454
Gene: ENSMUSG00000042774
AA Change: L164V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.2e-48	PFAM
Pfam:7TM_GPCR_Srsx	35	305	2.9e-6	PFAM
Pfam:7tm_1	41	290	9.3e-27	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000205193
AA Change: L164V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000145073
Gene: ENSMUSG00000042774
AA Change: L164V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	95	5.8e-10	PFAM
Pfam:7tm_1	41	94	3.5e-8	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219714

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

92% (49/53)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700109H08Rik	T	A	5: 3,630,442 (GRCm39)	Y119*	probably null	Het
Abcb9	C	A	5: 124,209,812 (GRCm39)	E664*	probably null	Het
Adgrl2	T	C	3: 148,564,578 (GRCm39)	D334G	probably damaging	Het
Ak9	T	G	10: 41,193,826 (GRCm39)	C57G	probably damaging	Het
Als2cl	A	G	9: 110,724,952 (GRCm39)	K809E	probably damaging	Het
Arsi	G	A	18: 61,049,723 (GRCm39)	G202E	probably benign	Het
Atp11a	A	G	8: 12,896,099 (GRCm39)	I223V	probably benign	Het
Cacna2d3	A	T	14: 28,630,278 (GRCm39)	V1022E	probably benign	Het
Cc2d1b	C	T	4: 108,490,422 (GRCm39)	R825W	probably damaging	Het
Cd37	A	G	7: 44,886,598 (GRCm39)	C85R	probably damaging	Het
Ces1g	T	C	8: 94,063,764 (GRCm39)	S7G	probably benign	Het
Cltc	T	C	11: 86,611,188 (GRCm39)	N561S	probably benign	Het
Cnbd2	A	G	2: 156,217,494 (GRCm39)	E661G	possibly damaging	Het
Col6a3	A	T	1: 90,750,063 (GRCm39)	F257Y	probably damaging	Het
Cpt1b	T	C	15: 89,309,037 (GRCm39)	Y55C	possibly damaging	Het
Csmd1	A	G	8: 15,976,611 (GRCm39)	V2869A	probably benign	Het
Dnah11	T	C	12: 118,143,482 (GRCm39)	E387G	probably benign	Het
Eny2	T	A	15: 44,292,949 (GRCm39)		probably null	Het
Fbxo10	G	T	4: 45,043,857 (GRCm39)	H655Q	probably benign	Het
Gm14403	AAACCCTA	AA	2: 177,201,448 (GRCm39)		probably benign	Het
Gpx2	C	T	12: 76,842,068 (GRCm39)	G28S	probably damaging	Het
H2-Q5	G	T	17: 35,613,918 (GRCm39)	A156S	probably benign	Het
Hoxd4	A	G	2: 74,558,807 (GRCm39)	D210G	possibly damaging	Het
Hoxd9	A	G	2: 74,529,166 (GRCm39)	Q256R	probably damaging	Het
Macf1	A	G	4: 123,346,085 (GRCm39)	V2571A	probably damaging	Het
Mtus1	A	G	8: 41,537,074 (GRCm39)	V214A	possibly damaging	Het
Myh1	C	T	11: 67,111,793 (GRCm39)	A1716V	probably benign	Het
Nbeal1	A	G	1: 60,261,287 (GRCm39)	D249G	probably damaging	Het
Nup54	TCTGCTGCTGCTGCTGCTGCTGCTG	TCTGCTGCTGCTGCTGCTGCTG	5: 92,578,663 (GRCm39)		probably benign	Het
Or10v9	G	T	19: 11,833,148 (GRCm39)	H56Q	probably damaging	Het
Or4c124	A	T	2: 89,155,677 (GRCm39)	N282K	probably damaging	Het
Or5w17	C	T	2: 87,583,696 (GRCm39)	V214I	probably benign	Het
Peg10	GC	GCTCC	6: 4,756,452 (GRCm39)		probably benign	Het
Pramel23	T	C	4: 143,423,886 (GRCm39)	Y301C	possibly damaging	Het
Prss59	A	G	6: 40,897,939 (GRCm39)	I248T	probably benign	Het
Pwwp2a	A	G	11: 43,595,423 (GRCm39)	D196G	probably benign	Het
Rarg	A	T	15: 102,150,327 (GRCm39)	C93S	possibly damaging	Het
Rcc1	T	C	4: 132,065,073 (GRCm39)	D150G	possibly damaging	Het
Ripk2	A	G	4: 16,163,330 (GRCm39)	Y23H	probably damaging	Het
Rragc	A	G	4: 123,811,340 (GRCm39)	Y5C	possibly damaging	Het
Rubcnl	G	A	14: 75,269,369 (GRCm39)	G9D	probably damaging	Het
Sephs2	A	T	7: 126,872,073 (GRCm39)	V340E	probably damaging	Het
Slc22a3	C	T	17: 12,677,438 (GRCm39)	M243I	probably benign	Het
Slco6c1	A	G	1: 97,000,518 (GRCm39)		probably null	Het
Sncaip	T	G	18: 53,039,966 (GRCm39)	I308R	probably damaging	Het
Supt16	G	A	14: 52,408,338 (GRCm39)	T869M	probably damaging	Het
Tanc1	G	A	2: 59,674,366 (GRCm39)	E1817K	possibly damaging	Het
Usp4	C	A	9: 108,248,154 (GRCm39)	Q395K	probably damaging	Het
Usp49	T	A	17: 47,984,272 (GRCm39)	S210T	possibly damaging	Het
Virma	A	G	4: 11,505,498 (GRCm39)	I124M	probably damaging	Het
Vmn1r234	G	A	17: 21,449,589 (GRCm39)	V168I	probably benign	Het
Vnn3	T	A	10: 23,732,187 (GRCm39)	C146S	probably damaging	Het
Ylpm1	A	G	12: 85,088,953 (GRCm39)	D1234G	probably damaging	Het
Zfp617	T	A	8: 72,687,098 (GRCm39)	V476E	probably benign	Het

Other mutations in Or7a37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02135:Or7a37	APN	10	78,805,940 (GRCm39)	missense	probably damaging	1.00
IGL02159:Or7a37	APN	10	78,805,735 (GRCm39)	missense	probably damaging	1.00
R0355:Or7a37	UTSW	10	78,806,267 (GRCm39)	missense	probably damaging	1.00
R0561:Or7a37	UTSW	10	78,805,729 (GRCm39)	nonsense	probably null
R1305:Or7a37	UTSW	10	78,805,933 (GRCm39)	missense	probably benign	0.03
R1921:Or7a37	UTSW	10	78,805,975 (GRCm39)	nonsense	probably null
R1922:Or7a37	UTSW	10	78,805,975 (GRCm39)	nonsense	probably null
R2382:Or7a37	UTSW	10	78,805,990 (GRCm39)	missense	probably damaging	0.99
R2920:Or7a37	UTSW	10	78,805,846 (GRCm39)	missense	probably damaging	1.00
R4491:Or7a37	UTSW	10	78,806,151 (GRCm39)	missense	probably damaging	1.00
R5113:Or7a37	UTSW	10	78,806,037 (GRCm39)	missense	probably benign
R5305:Or7a37	UTSW	10	78,806,390 (GRCm39)	missense	possibly damaging	0.68
R5744:Or7a37	UTSW	10	78,806,017 (GRCm39)	missense	probably damaging	1.00
R5861:Or7a37	UTSW	10	78,805,765 (GRCm39)	missense	probably damaging	1.00
R6314:Or7a37	UTSW	10	78,806,179 (GRCm39)	missense	probably benign
R7693:Or7a37	UTSW	10	78,806,137 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTGGAATTGGACAACTTCTTGC -3'
(R):5'- AGGTGGAGAATGCTTTGTACTTCC -3'

Sequencing Primer
(F):5'- GGACAACTTCTTGCTCACTATCATGG -3'
(R):5'- CATTGCACGTATGGAGGACACTATC -3'

Posted On

2018-02-27