|Institutional Source||Beutler Lab|
|Gene Name||ribonucleotide reductase M1|
|Essential gene?||Probably essential (E-score: 0.971)|
|Stock #||R6198 (G1)|
|Chromosomal Location||102441695-102469771 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to G at 102446729 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000033283 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000033283] [ENSMUST00000211720]|
|Coding Region Coverage||
|Validation Efficiency||99% (68/69)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic letahlity before E3.5. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Rrm1||
(F):5'- CTGTTGTTTCTCGGGAAAGCTC -3'
(R):5'- ATGCTCTTTCACTCAGTAGCTCAG -3'
(F):5'- TTGTAGGCTCAGATCACCATG -3'
(R):5'- TAGCTCAGCTACATGGAGAAAC -3'