Mutagenetix > Incidental Mutation

Incidental Mutation 'R6198:Gm9573'

503070

Institutional Source

Beutler Lab

Gene Symbol

Gm9573

Ensembl Gene

ENSMUSG00000090588

Gene Name

predicted gene 9573

Synonyms

Muc21, epiglycanin

MMRRC Submission

044338-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

R6198 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

35617923-35626637 bp(-) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

T to A at 35620916 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000134221 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164502] [ENSMUST00000174521]

AlphaFold

F7C950

Predicted Effect

unknown
Transcript: ENSMUST00000164502
AA Change: T793S

SMART Domains

Protein: ENSMUSP00000130987
Gene: ENSMUSG00000090588
AA Change: T793S

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
low complexity region	26	39	N/A	INTRINSIC
low complexity region	42	59	N/A	INTRINSIC
low complexity region	76	144	N/A	INTRINSIC
low complexity region	149	578	N/A	INTRINSIC
low complexity region	580	653	N/A	INTRINSIC
low complexity region	655	1179	N/A	INTRINSIC
low complexity region	1183	1373	N/A	INTRINSIC
low complexity region	1383	1436	N/A	INTRINSIC
low complexity region	1438	1479	N/A	INTRINSIC
Pfam:Epiglycanin_C	1518	1605	3.8e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173759

Predicted Effect

probably benign
Transcript: ENSMUST00000174521

SMART Domains

Protein: ENSMUSP00000134221
Gene: ENSMUSG00000090509

Domain	Start	End	E-Value	Type
Pfam:SFTA2	80	117	9.2e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000174534

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

99% (68/69)

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	A	T	3: 124,416,850		probably null	Het
1700061G19Rik	A	G	17: 56,882,679	S265G	probably damaging	Het
2610318N02Rik	A	G	16: 17,118,369	S164P	probably damaging	Het
Acyp2	C	T	11: 30,506,354	E98K	possibly damaging	Het
Adam19	A	C	11: 46,121,502	N275T	probably damaging	Het
Adgrg7	T	A	16: 56,777,193	T84S	possibly damaging	Het
Asl	C	T	5: 130,018,916	V70I	probably benign	Het
Atp2c1	A	G	9: 105,521,072	S26P	probably benign	Het
Bcas3	A	T	11: 85,509,435	D410V	probably damaging	Het
Cc2d1b	C	T	4: 108,633,225	R825W	probably damaging	Het
Ccdc15	A	C	9: 37,314,285		probably null	Het
Cfh	A	G	1: 140,105,440	S789P	probably damaging	Het
Cltc	T	C	11: 86,720,362	N561S	probably benign	Het
Cnst	A	G	1: 179,592,865	Q187R	probably damaging	Het
Csmd3	T	C	15: 48,313,877	T422A	probably benign	Het
Cyp2c55	A	T	19: 39,007,121	R26*	probably null	Het
Dgkb	A	T	12: 38,173,823	M414L	probably benign	Het
Dgkd	A	G	1: 87,924,208	D444G	probably damaging	Het
Dnmt3c	T	C	2: 153,720,009	V544A	noncoding transcript	Het
Dus3l	A	T	17: 56,767,858	T327S	possibly damaging	Het
Elf2	A	T	3: 51,277,249	L5Q	probably damaging	Het
Fam69b	A	G	2: 26,635,698	K215E	probably damaging	Het
Fxyd6	A	G	9: 45,390,670	Y30C	probably damaging	Het
Gcc2	A	T	10: 58,292,590	T1375S	probably benign	Het
Git2	A	T	5: 114,745,495	Y393*	probably null	Het
Gm14403	AAACCCTA	AA	2: 177,509,655		probably benign	Het
Golgb1	T	C	16: 36,893,395	L246P	probably damaging	Het
Grp	G	T	18: 65,879,986	Q74H	possibly damaging	Het
Ifi203	A	T	1: 173,924,082	M391K	probably damaging	Het
Itih2	A	G	2: 10,098,541	Y712H	probably benign	Het
Kdm5a	T	A	6: 120,438,997	V1626E	probably benign	Het
Klhl40	A	G	9: 121,778,767	Y331C	probably damaging	Het
Kprp	T	A	3: 92,824,687	Y352F	probably damaging	Het
Lama2	G	T	10: 27,188,022	H1286Q	probably damaging	Het
Lgi4	T	A	7: 31,069,122		probably null	Het
Lrrc47	A	T	4: 154,015,672	N235I	probably damaging	Het
Lrrc74b	T	A	16: 17,548,786	I308F	probably damaging	Het
Map7d1	T	A	4: 126,241,843	K135M	probably damaging	Het
March5	A	G	19: 37,210,741	R36G	probably damaging	Het
Mtx3	C	A	13: 92,852,851	P299Q	probably benign	Het
Ncapd2	C	A	6: 125,179,323	E500*	probably null	Het
Nckap5l	T	C	15: 99,425,988	K878R	probably damaging	Het
Nphs1	T	C	7: 30,467,915	I756T	probably damaging	Het
Olfm4	T	G	14: 80,000,373	S17A	probably benign	Het
Olfr1270	A	T	2: 90,149,438	D189E	probably damaging	Het
Olfr344	A	G	2: 36,568,951	M118V	probably damaging	Het
Pak1ip1	G	T	13: 41,001,410	Q27H	probably benign	Het
Piezo2	A	T	18: 63,157,210	C159*	probably null	Het
Pkn2	G	T	3: 142,810,404	T538K	probably benign	Het
Ppp3cc	A	T	14: 70,247,611	M198K	probably benign	Het
Rrm1	T	G	7: 102,446,729		probably null	Het
Setd3	T	C	12: 108,165,168	K7E	possibly damaging	Het
Shc1	A	G	3: 89,422,107	K86R	probably benign	Het
Slc16a7	T	C	10: 125,228,215	T418A	probably benign	Het
Spocd1	C	T	4: 129,955,415	P676S	probably damaging	Het
Spp1	A	G	5: 104,439,508		probably null	Het
Syne1	A	G	10: 5,302,269	Y2462H	probably damaging	Het
Tiam2	T	C	17: 3,414,121	S42P	probably benign	Het
Tmem63b	C	T	17: 45,661,516	V722I	probably benign	Het
Ubqln1	A	G	13: 58,196,590	S130P	probably benign	Het
Usp34	G	T	11: 23,484,127	L3215F	probably damaging	Het
Uvssa	A	G	5: 33,409,510	Y517C	probably damaging	Het
Vps13d	A	T	4: 145,148,990	F1649Y	probably benign	Het
Zfp236	A	G	18: 82,657,153	S405P	probably damaging	Het
Zfp9	T	C	6: 118,477,321	M1V	probably null	Het
Zfp946	A	T	17: 22,454,915	S217C	probably damaging	Het
Zfp970	T	A	2: 177,475,460	C276S	probably damaging	Het
Zswim5	T	A	4: 116,878,007	F183Y	probably benign	Het

Other mutations in Gm9573

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
BB009:Gm9573	UTSW	17	35622633	intron	probably benign
FR4304:Gm9573	UTSW	17	35622121	intron	probably benign
R0334:Gm9573	UTSW	17	35622722	intron	probably benign
R0946:Gm9573	UTSW	17	35618213	missense	probably benign	0.32
R1117:Gm9573	UTSW	17	35620028	intron	probably benign
R1345:Gm9573	UTSW	17	35621597	intron	probably benign
R1697:Gm9573	UTSW	17	35620648	intron	probably benign
R1750:Gm9573	UTSW	17	35621048	intron	probably benign
R1756:Gm9573	UTSW	17	35619239	intron	probably benign
R1946:Gm9573	UTSW	17	35622524	intron	probably benign
R1978:Gm9573	UTSW	17	35622965	intron	probably benign
R1991:Gm9573	UTSW	17	35618708	missense	probably benign	0.32
R1992:Gm9573	UTSW	17	35618708	missense	probably benign	0.32
R2063:Gm9573	UTSW	17	35621405	intron	probably benign
R2356:Gm9573	UTSW	17	35621671	intron	probably benign
R2866:Gm9573	UTSW	17	35619707	intron	probably benign
R3826:Gm9573	UTSW	17	35621612	intron	probably benign
R4020:Gm9573	UTSW	17	35620061	intron	probably benign
R4474:Gm9573	UTSW	17	35620604	intron	probably benign
R4677:Gm9573	UTSW	17	35619707	intron	probably benign
R4786:Gm9573	UTSW	17	35619329	intron	probably benign
R5071:Gm9573	UTSW	17	35620552	intron	probably benign
R5173:Gm9573	UTSW	17	35620741	intron	probably benign
R5283:Gm9573	UTSW	17	35621332	intron	probably benign
R5446:Gm9573	UTSW	17	35622503	intron	probably benign
R5542:Gm9573	UTSW	17	35622503	intron	probably benign
R5716:Gm9573	UTSW	17	35620783	intron	probably benign
R5913:Gm9573	UTSW	17	35623231	intron	probably benign
R6011:Gm9573	UTSW	17	35622182	intron	probably benign
R6394:Gm9573	UTSW	17	35620166	intron	probably benign
R6786:Gm9573	UTSW	17	35623165	intron	probably benign
R6940:Gm9573	UTSW	17	35623226	intron	probably benign
R7082:Gm9573	UTSW	17	35621201	missense	unknown
R7103:Gm9573	UTSW	17	35621540	missense	unknown
R7110:Gm9573	UTSW	17	35622618	intron	probably benign
R7139:Gm9573	UTSW	17	35622633	intron	probably benign
R7165:Gm9573	UTSW	17	35621978	missense	unknown
R7200:Gm9573	UTSW	17	35622633	intron	probably benign
R7204:Gm9573	UTSW	17	35621213	intron	probably benign
R7289:Gm9573	UTSW	17	35618869	missense	unknown
R7290:Gm9573	UTSW	17	35618869	missense	unknown
R7295:Gm9573	UTSW	17	35618869	missense	unknown
R7319:Gm9573	UTSW	17	35622043	intron	probably benign
R7462:Gm9573	UTSW	17	35620676	missense	unknown
R7529:Gm9573	UTSW	17	35619231	missense	unknown
R7718:Gm9573	UTSW	17	35622836	missense	unknown
R7762:Gm9573	UTSW	17	35622085	missense	unknown
R7788:Gm9573	UTSW	17	35618906	missense	unknown
R7798:Gm9573	UTSW	17	35621254	missense	unknown
R7831:Gm9573	UTSW	17	35618759	missense	unknown
R7896:Gm9573	UTSW	17	35620025	missense	unknown
R7899:Gm9573	UTSW	17	35620601	intron	probably benign
R7932:Gm9573	UTSW	17	35622633	intron	probably benign
R8025:Gm9573	UTSW	17	35620987	intron	probably benign
R8077:Gm9573	UTSW	17	35619736	intron	probably benign
R8090:Gm9573	UTSW	17	35621725	missense	unknown
R8169:Gm9573	UTSW	17	35621180	missense	unknown
R8184:Gm9573	UTSW	17	35622830	missense	unknown
R8209:Gm9573	UTSW	17	35619707	intron	probably benign
R8226:Gm9573	UTSW	17	35619707	intron	probably benign
R8464:Gm9573	UTSW	17	35622206	intron	probably benign
R8670:Gm9573	UTSW	17	35621648	missense	unknown
R8783:Gm9573	UTSW	17	35619983	missense	unknown
R8856:Gm9573	UTSW	17	35620973	missense	unknown
R9155:Gm9573	UTSW	17	35621239	missense	unknown
R9214:Gm9573	UTSW	17	35620946	missense	unknown
R9353:Gm9573	UTSW	17	35619653	missense	unknown
R9618:Gm9573	UTSW	17	35622043	intron	probably benign
R9621:Gm9573	UTSW	17	35621828	missense	unknown
R9679:Gm9573	UTSW	17	35619599	missense	unknown
RF025:Gm9573	UTSW	17	35622879	intron	probably benign
Z1176:Gm9573	UTSW	17	35621245	missense	unknown
Z1177:Gm9573	UTSW	17	35621059	missense	unknown
Z1177:Gm9573	UTSW	17	35620925	missense	unknown

Predicted Primers

PCR Primer
(F):5'- GATCCTGAGGCAGTGCTAGATG -3'
(R):5'- CTCTGCCTCAGGATCTATGC -3'

Sequencing Primer
(F):5'- GCTAGATGCAGTGGTGGTAG -3'
(R):5'- AGCTCTGCCTCAGGATCTG -3'

Posted On

2018-02-27