Incidental Mutation 'R6199:Gpr75'
ID 503110
Institutional Source Beutler Lab
Gene Symbol Gpr75
Ensembl Gene ENSMUSG00000043999
Gene Name G protein-coupled receptor 75
Synonyms
MMRRC Submission 044339-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R6199 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 30835358-30843729 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 30841527 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 144 (L144P)
Ref Sequence ENSEMBL: ENSMUSP00000105057 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109430] [ENSMUST00000203878]
AlphaFold Q6X632
Predicted Effect probably damaging
Transcript: ENSMUST00000109430
AA Change: L144P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105057
Gene: ENSMUSG00000043999
AA Change: L144P

DomainStartEndE-ValueType
Pfam:7tm_1 59 376 1.6e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203878
SMART Domains Protein: ENSMUSP00000144900
Gene: ENSMUSG00000020305

DomainStartEndE-ValueType
low complexity region 20 36 N/A INTRINSIC
ANK 48 77 3.5e-2 SMART
ANK 81 110 8e-3 SMART
ANK 117 146 4.8e-5 SMART
ANK 150 179 1.7e-7 SMART
ANK 184 213 1.8e-4 SMART
ANK 217 246 1.8e-6 SMART
ANK 250 279 1.2e-7 SMART
ANK 285 315 1.1e0 SMART
ANK 318 347 1.2e-3 SMART
ANK 354 385 7.7e-1 SMART
SOCS 493 542 2.8e-4 SMART
SOCS_box 499 541 1.6e-17 SMART
Meta Mutation Damage Score 0.5195 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck1 A T 12: 88,407,887 (GRCm39) D206V possibly damaging Het
Ank2 T A 3: 126,797,655 (GRCm39) D685V probably damaging Het
Baz2b A G 2: 59,809,019 (GRCm39) S77P probably benign Het
Ccdc194 T C 8: 71,978,109 (GRCm39) N83D probably benign Het
Ceacam5 A T 7: 17,448,810 (GRCm39) T59S probably benign Het
Cemip2 G A 19: 21,822,186 (GRCm39) G1194S probably benign Het
Ces1e A C 8: 93,944,163 (GRCm39) F218L probably damaging Het
Cilk1 T C 9: 78,071,921 (GRCm39) V531A probably benign Het
Cps1 TGTCCATTGGTC TGTC 1: 67,201,774 (GRCm39) probably null Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Eftud2 A T 11: 102,730,883 (GRCm39) V843E probably damaging Het
Fuca2 G T 10: 13,381,783 (GRCm39) W232L probably damaging Het
Gdf7 T C 12: 8,348,832 (GRCm39) D155G unknown Het
Ggcx G T 6: 72,407,122 (GRCm39) V753F possibly damaging Het
Ghrhr A T 6: 55,356,173 (GRCm39) T89S probably benign Het
Gpr151 T C 18: 42,711,619 (GRCm39) K353R probably benign Het
Gsdmc2 A G 15: 63,696,962 (GRCm39) I403T probably benign Het
H2-M1 A G 17: 36,982,059 (GRCm39) S181P probably benign Het
Igsf5 C T 16: 96,222,939 (GRCm39) S61L possibly damaging Het
Insc A T 7: 114,390,401 (GRCm39) probably null Het
Izumo4 G A 10: 80,538,707 (GRCm39) G53D probably damaging Het
Ksr1 G A 11: 78,911,267 (GRCm39) P693S possibly damaging Het
Lgals4 G A 7: 28,535,317 (GRCm39) R27H probably damaging Het
Lpcat2b A G 5: 107,581,171 (GRCm39) R167G probably benign Het
Man1a C T 10: 53,890,552 (GRCm39) V288I possibly damaging Het
Map2 T G 1: 66,464,637 (GRCm39) S1676A probably damaging Het
Mbl1 G T 14: 40,875,572 (GRCm39) V9F unknown Het
Mrgprb8 T A 7: 48,039,051 (GRCm39) C241S probably benign Het
Mrpl2 T C 17: 46,960,012 (GRCm39) L227P probably damaging Het
Mthfd1 T A 12: 76,335,685 (GRCm39) V253E probably damaging Het
Mthfd1 A G 12: 76,350,454 (GRCm39) H464R probably damaging Het
Mug2 T A 6: 122,024,398 (GRCm39) M490K probably benign Het
Naip6 C T 13: 100,437,108 (GRCm39) A472T probably benign Het
Notch1 A G 2: 26,359,911 (GRCm39) V1268A probably damaging Het
Or6b2b A T 1: 92,419,264 (GRCm39) I71N possibly damaging Het
Or8b12c C A 9: 37,716,177 (GRCm39) probably null Het
Pgm1 A T 4: 99,836,151 (GRCm39) I412F probably damaging Het
Plaur A T 7: 24,164,628 (GRCm39) Q44L possibly damaging Het
Ppara T C 15: 85,671,434 (GRCm39) Y112H probably damaging Het
Ppm1h G A 10: 122,756,644 (GRCm39) V430M probably damaging Het
Prpf40a T C 2: 53,047,927 (GRCm39) M197V probably benign Het
Prph A G 15: 98,954,713 (GRCm39) T35A probably benign Het
Prrc2c C T 1: 162,510,085 (GRCm39) G780S probably damaging Het
Ptchd3 T A 11: 121,721,908 (GRCm39) N260K probably benign Het
Ptprz1 A G 6: 23,002,470 (GRCm39) D1520G probably benign Het
Samd9l T A 6: 3,376,686 (GRCm39) I192L probably benign Het
Slc39a10 T C 1: 46,874,993 (GRCm39) D103G probably damaging Het
Smndc1 G A 19: 53,372,063 (GRCm39) T117M probably benign Het
Tesk2 A G 4: 116,649,367 (GRCm39) D159G probably damaging Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Vmn2r108 A T 17: 20,682,644 (GRCm39) N853K probably benign Het
Wdfy3 C T 5: 102,020,831 (GRCm39) R2491Q possibly damaging Het
Other mutations in Gpr75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00332:Gpr75 APN 11 30,841,590 (GRCm39) missense probably damaging 1.00
IGL00787:Gpr75 APN 11 30,842,290 (GRCm39) missense probably benign 0.00
IGL01102:Gpr75 APN 11 30,841,755 (GRCm39) missense probably benign 0.41
IGL01790:Gpr75 APN 11 30,841,132 (GRCm39) missense probably damaging 0.97
IGL01975:Gpr75 APN 11 30,841,835 (GRCm39) missense probably benign 0.09
IGL02266:Gpr75 APN 11 30,841,977 (GRCm39) missense probably benign 0.01
IGL02338:Gpr75 APN 11 30,841,730 (GRCm39) missense probably benign 0.00
IGL02394:Gpr75 APN 11 30,842,190 (GRCm39) missense possibly damaging 0.92
IGL03208:Gpr75 APN 11 30,842,699 (GRCm39) missense probably damaging 1.00
Thinner UTSW 11 30,841,527 (GRCm39) missense probably damaging 1.00
R0053:Gpr75 UTSW 11 30,842,571 (GRCm39) missense possibly damaging 0.71
R0053:Gpr75 UTSW 11 30,842,571 (GRCm39) missense possibly damaging 0.71
R0449:Gpr75 UTSW 11 30,842,456 (GRCm39) missense probably damaging 0.99
R1289:Gpr75 UTSW 11 30,842,706 (GRCm39) missense probably benign 0.23
R1760:Gpr75 UTSW 11 30,841,527 (GRCm39) missense probably damaging 1.00
R3123:Gpr75 UTSW 11 30,841,709 (GRCm39) missense possibly damaging 0.82
R4669:Gpr75 UTSW 11 30,842,072 (GRCm39) missense probably damaging 1.00
R4704:Gpr75 UTSW 11 30,841,110 (GRCm39) missense probably benign
R4809:Gpr75 UTSW 11 30,842,154 (GRCm39) missense possibly damaging 0.74
R4913:Gpr75 UTSW 11 30,841,808 (GRCm39) missense possibly damaging 0.85
R4982:Gpr75 UTSW 11 30,841,463 (GRCm39) missense possibly damaging 0.96
R4982:Gpr75 UTSW 11 30,841,462 (GRCm39) missense probably damaging 1.00
R5071:Gpr75 UTSW 11 30,842,380 (GRCm39) missense probably damaging 1.00
R5318:Gpr75 UTSW 11 30,842,459 (GRCm39) missense probably benign 0.00
R6019:Gpr75 UTSW 11 30,841,640 (GRCm39) missense probably benign 0.39
R6455:Gpr75 UTSW 11 30,841,529 (GRCm39) missense probably damaging 1.00
R7188:Gpr75 UTSW 11 30,842,687 (GRCm39) missense probably damaging 1.00
R7826:Gpr75 UTSW 11 30,841,209 (GRCm39) missense probably damaging 0.99
R8053:Gpr75 UTSW 11 30,841,559 (GRCm39) missense probably benign 0.25
R8703:Gpr75 UTSW 11 30,841,890 (GRCm39) missense probably damaging 0.99
R8870:Gpr75 UTSW 11 30,841,860 (GRCm39) missense probably benign 0.00
R8930:Gpr75 UTSW 11 30,842,571 (GRCm39) missense possibly damaging 0.71
R8932:Gpr75 UTSW 11 30,842,571 (GRCm39) missense possibly damaging 0.71
Z1088:Gpr75 UTSW 11 30,841,139 (GRCm39) missense probably benign 0.11
Predicted Primers PCR Primer
(F):5'- TCAGGAAGTTCAGAACCAACTTTG -3'
(R):5'- GACAGAATGGCTTTCCCTTCC -3'

Sequencing Primer
(F):5'- GGAAGTTCAGAACCAACTTTGATTTC -3'
(R):5'- CTTCCCCATCCATAAGACTGG -3'
Posted On 2018-02-27