|Institutional Source||Beutler Lab|
|Gene Name||C-type lectin domain family 4, member d|
|Synonyms||Clecsf8, mcl, Mpcl, mMCL|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6209 (G1)|
|Chromosomal Location||123262111-123275265 bp(+) (GRCm38)|
|Type of Mutation||splice site (133 bp from exon)|
|DNA Base Change (assembly)||T to G at 123270529 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000032240 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000032240] [ENSMUST00000204826]|
|Predicted Effect||probably null
|Predicted Effect||noncoding transcript
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased sensitivity to trehalose-6,60'-dimycolate treatment. Mice homozygous for a different knock-out allele exhibit increased susceptibility to pneumonia infection. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Clec4d||
(F):5'- GTATGCAGAATTTTGTGACCCAGC -3'
(R):5'- CACATGACTTCTAGGAAATTCAACC -3'
(F):5'- CAGAATTTTGTGACCCAGCTTTTG -3'
(R):5'- AATCTTAAGAAGCCCTTGTT -3'