Incidental Mutation 'R6209:Fbxw26'
ID 503341
Institutional Source Beutler Lab
Gene Symbol Fbxw26
Ensembl Gene ENSMUSG00000059547
Gene Name F-box and WD-40 domain protein 26
Synonyms Gm5163
MMRRC Submission 044343-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6209 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 109546634-109575157 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 109547033 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 464 (I464T)
Ref Sequence ENSEMBL: ENSMUSP00000071811 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071917]
AlphaFold Q8BI58
Predicted Effect possibly damaging
Transcript: ENSMUST00000071917
AA Change: I464T

PolyPhen 2 Score 0.491 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000071811
Gene: ENSMUSG00000059547
AA Change: I464T

DomainStartEndE-ValueType
FBOX 5 45 2.54e-6 SMART
SCOP:d1tbga_ 128 249 1e-5 SMART
Blast:WD40 137 176 4e-7 BLAST
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff3 T A 1: 38,232,670 (GRCm39) M990L probably benign Het
Agl A T 3: 116,578,845 (GRCm39) Y429* probably null Het
Ahnak A T 19: 8,989,930 (GRCm39) K3738M probably damaging Het
Amn G T 12: 111,241,845 (GRCm39) V304L probably damaging Het
Ap3s1 G A 18: 46,912,318 (GRCm39) V113I probably benign Het
Arhgef28 A T 13: 98,065,917 (GRCm39) probably null Het
Atad2 A G 15: 57,981,811 (GRCm39) S18P probably damaging Het
Bhmt1b C T 18: 87,775,341 (GRCm39) A288V probably damaging Het
C4b T A 17: 34,960,061 (GRCm39) E305V possibly damaging Het
Caskin1 T C 17: 24,726,095 (GRCm39) S1401P possibly damaging Het
Cblc A T 7: 19,519,230 (GRCm39) V366D possibly damaging Het
Cdk17 A T 10: 93,044,093 (GRCm39) T11S probably benign Het
Cenpc1 A G 5: 86,181,509 (GRCm39) S619P probably benign Het
Clec4d T G 6: 123,247,488 (GRCm39) probably null Het
Disp2 T C 2: 118,617,402 (GRCm39) L132P probably damaging Het
Dync2h1 T C 9: 7,165,677 (GRCm39) K528R probably benign Het
Gaa C A 11: 119,171,997 (GRCm39) A700D probably benign Het
Gabbr2 A G 4: 46,804,069 (GRCm39) V262A probably damaging Het
Galnt17 T A 5: 131,110,434 (GRCm39) M302L probably benign Het
Gpn3 T C 5: 122,520,175 (GRCm39) I243T probably benign Het
Gpr160 T C 3: 30,950,141 (GRCm39) V71A possibly damaging Het
Gramd1b G T 9: 40,244,946 (GRCm39) A154D probably damaging Het
Grid2ip G A 5: 143,366,184 (GRCm39) S379N probably damaging Het
H60b C A 10: 22,163,043 (GRCm39) T206N probably benign Het
Hydin A T 8: 111,320,434 (GRCm39) I4493F probably benign Het
Il19 C T 1: 130,866,852 (GRCm39) E43K possibly damaging Het
Ints2 A G 11: 86,115,884 (GRCm39) Y782H probably damaging Het
Itprid1 T A 6: 55,851,306 (GRCm39) I62N probably damaging Het
Jph1 C A 1: 17,167,810 (GRCm39) D7Y probably damaging Het
Lipo2 T C 19: 33,726,852 (GRCm39) I62V probably damaging Het
Map7 G A 10: 20,152,026 (GRCm39) probably null Het
Matk T G 10: 81,095,422 (GRCm39) W81G probably damaging Het
Matn4 T C 2: 164,242,735 (GRCm39) Y121C probably damaging Het
Mical2 G A 7: 111,923,293 (GRCm39) probably null Het
Miga2 T G 2: 30,271,674 (GRCm39) Y399D probably damaging Het
Mocos A T 18: 24,799,672 (GRCm39) E302V probably benign Het
Mrpl11 C T 19: 5,014,743 (GRCm39) A172V probably damaging Het
Mrpl48 A C 7: 100,209,001 (GRCm39) Y108D probably damaging Het
Mtr A G 13: 12,205,278 (GRCm39) S1061P probably benign Het
Myh11 T A 16: 14,026,155 (GRCm39) K1309* probably null Het
Myom2 G A 8: 15,154,173 (GRCm39) V704I possibly damaging Het
Nars2 A G 7: 96,706,728 (GRCm39) H413R probably benign Het
Nckap1 A G 2: 80,355,946 (GRCm39) L619P probably damaging Het
Notch1 T C 2: 26,362,817 (GRCm39) N983S probably damaging Het
Nup210 A G 6: 91,002,337 (GRCm39) V717A probably benign Het
P4ha3 G T 7: 99,966,292 (GRCm39) G479V probably benign Het
Pcdhb18 G A 18: 37,623,537 (GRCm39) R289Q probably benign Het
Phf11a A G 14: 59,525,028 (GRCm39) S59P probably damaging Het
Phyhip G A 14: 70,700,798 (GRCm39) S95N probably benign Het
Ppat A G 5: 77,065,993 (GRCm39) V375A probably benign Het
Prkdc A G 16: 15,608,456 (GRCm39) E3086G probably damaging Het
Psg22 A G 7: 18,453,599 (GRCm39) E98G probably damaging Het
Rabgap1 A T 2: 37,453,610 (GRCm39) K1013* probably null Het
Retreg3 C T 11: 101,010,526 (GRCm39) G27D probably benign Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Rptn C G 3: 93,305,437 (GRCm39) H923Q possibly damaging Het
Sema6a A T 18: 47,431,369 (GRCm39) probably null Het
Septin10 T C 10: 59,006,670 (GRCm39) E349G probably damaging Het
Serpina1c A G 12: 103,863,429 (GRCm39) V257A probably damaging Het
Sgpp2 T A 1: 78,367,119 (GRCm39) M84K probably damaging Het
Shoc1 A G 4: 59,043,869 (GRCm39) *1482R probably null Het
Skint11 A G 4: 114,101,907 (GRCm39) S116G possibly damaging Het
Slc2a5 G A 4: 150,227,557 (GRCm39) V459I probably benign Het
Smarca2 T G 19: 26,748,404 (GRCm39) Y126* probably null Het
Stab2 T G 10: 86,758,867 (GRCm39) N1024H possibly damaging Het
Sting1 A T 18: 35,869,155 (GRCm39) I178N probably damaging Het
Svep1 A C 4: 58,128,869 (GRCm39) F609L probably benign Het
Tbc1d2 G A 4: 46,614,068 (GRCm39) T671I probably damaging Het
Thoc5 T C 11: 4,855,697 (GRCm39) I82T probably damaging Het
Tmem213 G T 6: 38,092,517 (GRCm39) C83F probably damaging Het
Topaz1 G A 9: 122,579,570 (GRCm39) D827N possibly damaging Het
Trappc10 C A 10: 78,050,646 (GRCm39) G265V possibly damaging Het
Ttn A G 2: 76,539,808 (GRCm39) S26066P probably damaging Het
Zfp292 G T 4: 34,809,442 (GRCm39) Q1201K probably benign Het
Zfp354a T A 11: 50,951,815 (GRCm39) probably null Het
Zfp418 T C 7: 7,185,096 (GRCm39) V353A possibly damaging Het
Zfp444 G A 7: 6,192,948 (GRCm39) probably benign Het
Zfp503 C A 14: 22,035,778 (GRCm39) Q379H probably damaging Het
Zfp804a A G 2: 82,088,462 (GRCm39) K764E probably damaging Het
Other mutations in Fbxw26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00589:Fbxw26 APN 9 109,547,016 (GRCm39) utr 3 prime probably benign
IGL01072:Fbxw26 APN 9 109,552,905 (GRCm39) missense probably damaging 1.00
IGL01151:Fbxw26 APN 9 109,550,848 (GRCm39) missense possibly damaging 0.50
IGL01394:Fbxw26 APN 9 109,547,057 (GRCm39) missense probably benign 0.00
IGL01432:Fbxw26 APN 9 109,547,043 (GRCm39) missense probably benign 0.32
IGL02559:Fbxw26 APN 9 109,551,232 (GRCm39) missense probably benign 0.34
IGL02981:Fbxw26 APN 9 109,573,862 (GRCm39) missense probably benign 0.09
IGL03370:Fbxw26 APN 9 109,575,087 (GRCm39) missense probably damaging 1.00
R0023:Fbxw26 UTSW 9 109,547,079 (GRCm39) missense probably benign 0.01
R0087:Fbxw26 UTSW 9 109,554,006 (GRCm39) missense probably benign
R0369:Fbxw26 UTSW 9 109,552,780 (GRCm39) critical splice donor site probably null
R0446:Fbxw26 UTSW 9 109,572,788 (GRCm39) missense probably benign 0.03
R1844:Fbxw26 UTSW 9 109,553,946 (GRCm39) missense probably benign 0.42
R1891:Fbxw26 UTSW 9 109,551,232 (GRCm39) missense probably benign 0.34
R2042:Fbxw26 UTSW 9 109,561,772 (GRCm39) missense probably damaging 1.00
R3615:Fbxw26 UTSW 9 109,572,828 (GRCm39) nonsense probably null
R3616:Fbxw26 UTSW 9 109,572,828 (GRCm39) nonsense probably null
R4659:Fbxw26 UTSW 9 109,573,939 (GRCm39) missense probably damaging 0.97
R4785:Fbxw26 UTSW 9 109,553,868 (GRCm39) missense possibly damaging 0.50
R4898:Fbxw26 UTSW 9 109,547,037 (GRCm39) missense possibly damaging 0.95
R5791:Fbxw26 UTSW 9 109,574,221 (GRCm39) missense probably damaging 1.00
R5818:Fbxw26 UTSW 9 109,561,634 (GRCm39) missense probably benign
R5921:Fbxw26 UTSW 9 109,575,086 (GRCm39) missense probably damaging 1.00
R5983:Fbxw26 UTSW 9 109,547,033 (GRCm39) missense possibly damaging 0.49
R6145:Fbxw26 UTSW 9 109,561,691 (GRCm39) missense probably benign 0.09
R6412:Fbxw26 UTSW 9 109,561,715 (GRCm39) missense probably damaging 0.97
R6842:Fbxw26 UTSW 9 109,553,988 (GRCm39) missense probably damaging 1.00
R7228:Fbxw26 UTSW 9 109,554,012 (GRCm39) missense possibly damaging 0.93
R7451:Fbxw26 UTSW 9 109,561,691 (GRCm39) missense probably benign 0.03
R7467:Fbxw26 UTSW 9 109,561,765 (GRCm39) missense probably benign 0.00
R8397:Fbxw26 UTSW 9 109,561,715 (GRCm39) missense probably damaging 0.99
R8912:Fbxw26 UTSW 9 109,561,717 (GRCm39) missense probably damaging 1.00
R9284:Fbxw26 UTSW 9 109,550,962 (GRCm39) intron probably benign
R9479:Fbxw26 UTSW 9 109,561,625 (GRCm39) missense probably damaging 0.99
R9694:Fbxw26 UTSW 9 109,575,135 (GRCm39) start gained probably benign
X0020:Fbxw26 UTSW 9 109,561,700 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCAAATGATTTGTACATCTAGCC -3'
(R):5'- CTCAGATAGGTACACACAGGC -3'

Sequencing Primer
(F):5'- TAGATCAGGCTGGTCTCAGAACTC -3'
(R):5'- TATGAACTCGGCATCTCTGGAAG -3'
Posted On 2018-02-27