Incidental Mutation 'R6211:Armc3'
ID 503434
Institutional Source Beutler Lab
Gene Symbol Armc3
Ensembl Gene ENSMUSG00000037683
Gene Name armadillo repeat containing 3
Synonyms 4921513G22Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R6211 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 19204113-19315052 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) G to A at 19301614 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000048784 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049255] [ENSMUST00000049255] [ENSMUST00000114640]
AlphaFold A2AU72
Predicted Effect probably null
Transcript: ENSMUST00000049255
SMART Domains Protein: ENSMUSP00000048784
Gene: ENSMUSG00000037683

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
low complexity region 544 557 N/A INTRINSIC
low complexity region 583 595 N/A INTRINSIC
low complexity region 620 639 N/A INTRINSIC
low complexity region 675 696 N/A INTRINSIC
Pfam:EDR1 723 857 3.1e-28 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000049255
SMART Domains Protein: ENSMUSP00000048784
Gene: ENSMUSG00000037683

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
low complexity region 544 557 N/A INTRINSIC
low complexity region 583 595 N/A INTRINSIC
low complexity region 620 639 N/A INTRINSIC
low complexity region 675 696 N/A INTRINSIC
Pfam:EDR1 723 857 3.1e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114640
SMART Domains Protein: ENSMUSP00000110287
Gene: ENSMUSG00000037683

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
Pfam:EDR1 549 868 1.4e-41 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.6%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 [PubMed 16915934]).[supplied by OMIM, Mar 2008]
Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acin1 A T 14: 54,881,503 (GRCm39) W391R probably damaging Het
Arl6ip1 A T 7: 117,726,473 (GRCm39) S18R probably benign Het
Ccdc162 G T 10: 41,506,141 (GRCm39) S883* probably null Het
Cd300lg A G 11: 101,944,995 (GRCm39) M358V possibly damaging Het
Cdh23 A G 10: 60,246,600 (GRCm39) V949A possibly damaging Het
Cenpo C T 12: 4,266,733 (GRCm39) S126N probably benign Het
Chd3 A T 11: 69,243,503 (GRCm39) D1366E probably damaging Het
Chd4 A G 6: 125,078,248 (GRCm39) E169G possibly damaging Het
Clec1b A G 6: 129,378,440 (GRCm39) T24A possibly damaging Het
Clhc1 A G 11: 29,528,145 (GRCm39) I558V probably damaging Het
Col5a2 T A 1: 45,415,826 (GRCm39) R1440S probably damaging Het
Cops3 A G 11: 59,708,727 (GRCm39) probably benign Het
Cxcr4 A G 1: 128,517,187 (GRCm39) V158A probably damaging Het
Dnah7a A G 1: 53,458,795 (GRCm39) M3781T probably damaging Het
Dnai7 C T 6: 145,146,217 (GRCm39) R95Q probably damaging Het
Elovl5 C A 9: 77,888,784 (GRCm39) T217K probably damaging Het
Fbln7 G T 2: 128,737,260 (GRCm39) M358I probably damaging Het
Fbxl13 C T 5: 21,689,019 (GRCm39) R763Q possibly damaging Het
Gabrr3 C A 16: 59,268,471 (GRCm39) N361K probably benign Het
Garre1 A T 7: 33,938,429 (GRCm39) H1035Q possibly damaging Het
Gbp7 A G 3: 142,251,754 (GRCm39) M534V probably benign Het
Hcar2 G A 5: 124,003,017 (GRCm39) T162I probably benign Het
Hdc A T 2: 126,435,897 (GRCm39) L658Q probably damaging Het
Hivep3 A G 4: 119,955,602 (GRCm39) Y1306C probably damaging Het
Homer3 C T 8: 70,738,174 (GRCm39) R49C probably damaging Het
Hspa4 C T 11: 53,153,766 (GRCm39) E702K probably benign Het
Iqgap3 A G 3: 87,998,822 (GRCm39) N308D probably benign Het
Itga8 G A 2: 12,198,320 (GRCm39) T555M probably damaging Het
Lrfn5 G T 12: 61,886,256 (GRCm39) V15L probably benign Het
Lrrk1 T C 7: 65,952,458 (GRCm39) K493E possibly damaging Het
Lyzl6 A G 11: 103,525,889 (GRCm39) I77T probably damaging Het
Mavs G T 2: 131,082,311 (GRCm39) R65L probably damaging Het
Mdn1 T G 4: 32,696,269 (GRCm39) D1217E probably benign Het
Or12d13 A T 17: 37,647,599 (GRCm39) F175I possibly damaging Het
Or52h1 A T 7: 103,828,954 (GRCm39) Y220* probably null Het
Or9i1 A G 19: 13,839,938 (GRCm39) I260M probably benign Het
Otof C A 5: 30,529,244 (GRCm39) V1762L probably damaging Het
Pcdha12 T C 18: 37,153,374 (GRCm39) L31P probably damaging Het
Pxk C A 14: 8,163,952 (GRCm38) P515T probably damaging Het
Qrich2 A T 11: 116,344,368 (GRCm39) D1759E probably benign Het
Rps6ka1 A T 4: 133,596,617 (GRCm39) F33Y probably damaging Het
Rxfp2 G A 5: 149,967,591 (GRCm39) probably null Het
Slc23a4 A T 6: 34,933,896 (GRCm39) I202N probably damaging Het
Slc24a5 A T 2: 124,930,171 (GRCm39) I491F probably benign Het
Slco1a1 T A 6: 141,854,775 (GRCm39) K625N probably benign Het
Snx31 A G 15: 36,547,030 (GRCm39) V51A probably damaging Het
Sox6 G T 7: 115,400,697 (GRCm39) H48Q probably damaging Het
Tas2r109 A T 6: 132,957,587 (GRCm39) Y114* probably null Het
Tbc1d2 C T 4: 46,629,912 (GRCm39) G252R probably benign Het
Timm13 A C 10: 80,736,314 (GRCm39) probably null Het
Tpsb2 G A 17: 25,586,737 (GRCm39) A250T possibly damaging Het
Trpm6 T C 19: 18,760,492 (GRCm39) I131T probably damaging Het
Vars2 A T 17: 35,976,554 (GRCm39) probably null Het
Vmn2r35 T A 7: 7,789,527 (GRCm39) I737F probably damaging Het
Wdr46 C A 17: 34,163,459 (GRCm39) T339K probably damaging Het
Other mutations in Armc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00535:Armc3 APN 2 19,308,669 (GRCm39) missense possibly damaging 0.48
IGL01123:Armc3 APN 2 19,206,616 (GRCm39) missense possibly damaging 0.87
IGL01142:Armc3 APN 2 19,302,709 (GRCm39) splice site probably benign
IGL01556:Armc3 APN 2 19,273,957 (GRCm39) missense probably damaging 1.00
IGL02145:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02145:Armc3 APN 2 19,301,671 (GRCm39) missense possibly damaging 0.81
IGL02152:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02154:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02243:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02244:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02516:Armc3 APN 2 19,305,317 (GRCm39) missense possibly damaging 0.94
IGL02691:Armc3 APN 2 19,240,295 (GRCm39) missense probably damaging 1.00
IGL03151:Armc3 APN 2 19,243,509 (GRCm39) missense probably damaging 1.00
IGL03190:Armc3 APN 2 19,293,761 (GRCm39) missense probably damaging 0.99
IGL03288:Armc3 APN 2 19,240,293 (GRCm39) missense probably damaging 1.00
IGL03338:Armc3 APN 2 19,253,512 (GRCm39) missense possibly damaging 0.88
R0015:Armc3 UTSW 2 19,301,132 (GRCm39) critical splice acceptor site probably null
R0015:Armc3 UTSW 2 19,301,132 (GRCm39) critical splice acceptor site probably null
R0256:Armc3 UTSW 2 19,274,027 (GRCm39) missense probably damaging 1.00
R0621:Armc3 UTSW 2 19,300,204 (GRCm39) missense probably damaging 0.96
R1326:Armc3 UTSW 2 19,314,935 (GRCm39) makesense probably null
R1470:Armc3 UTSW 2 19,243,547 (GRCm39) missense probably benign
R1470:Armc3 UTSW 2 19,243,547 (GRCm39) missense probably benign
R1489:Armc3 UTSW 2 19,314,858 (GRCm39) missense probably benign 0.01
R1990:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R1991:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R1992:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R2002:Armc3 UTSW 2 19,293,747 (GRCm39) missense probably benign 0.01
R2095:Armc3 UTSW 2 19,293,740 (GRCm39) missense possibly damaging 0.65
R2127:Armc3 UTSW 2 19,206,622 (GRCm39) missense probably damaging 1.00
R2158:Armc3 UTSW 2 19,253,444 (GRCm39) missense probably damaging 0.99
R2697:Armc3 UTSW 2 19,308,746 (GRCm39) missense probably damaging 1.00
R3809:Armc3 UTSW 2 19,305,476 (GRCm39) missense probably damaging 1.00
R3897:Armc3 UTSW 2 19,273,988 (GRCm39) missense probably damaging 1.00
R4107:Armc3 UTSW 2 19,293,720 (GRCm39) missense probably benign 0.13
R4326:Armc3 UTSW 2 19,305,284 (GRCm39) missense probably damaging 0.97
R4464:Armc3 UTSW 2 19,253,470 (GRCm39) missense probably damaging 0.99
R4702:Armc3 UTSW 2 19,314,792 (GRCm39) missense probably damaging 1.00
R4923:Armc3 UTSW 2 19,297,791 (GRCm39) critical splice acceptor site probably null
R5370:Armc3 UTSW 2 19,290,873 (GRCm39) missense probably benign 0.00
R5518:Armc3 UTSW 2 19,302,739 (GRCm39) missense probably benign 0.28
R5718:Armc3 UTSW 2 19,308,610 (GRCm39) nonsense probably null
R5739:Armc3 UTSW 2 19,258,728 (GRCm39) missense possibly damaging 0.67
R5913:Armc3 UTSW 2 19,314,858 (GRCm39) missense possibly damaging 0.65
R6245:Armc3 UTSW 2 19,253,516 (GRCm39) missense probably damaging 1.00
R6841:Armc3 UTSW 2 19,206,630 (GRCm39) splice site probably null
R7003:Armc3 UTSW 2 19,274,839 (GRCm39) missense probably damaging 1.00
R7190:Armc3 UTSW 2 19,297,947 (GRCm39) missense probably damaging 1.00
R7499:Armc3 UTSW 2 19,290,790 (GRCm39) missense probably benign 0.03
R7738:Armc3 UTSW 2 19,293,761 (GRCm39) missense probably damaging 0.99
R7844:Armc3 UTSW 2 19,258,829 (GRCm39) missense possibly damaging 0.90
R7919:Armc3 UTSW 2 19,290,906 (GRCm39) missense probably benign 0.00
R8060:Armc3 UTSW 2 19,293,720 (GRCm39) missense probably benign 0.08
R8111:Armc3 UTSW 2 19,301,674 (GRCm39) missense probably benign
R8406:Armc3 UTSW 2 19,240,365 (GRCm39) missense probably damaging 0.98
R8485:Armc3 UTSW 2 19,297,945 (GRCm39) missense probably damaging 1.00
R8773:Armc3 UTSW 2 19,293,667 (GRCm39) missense probably benign 0.01
R8940:Armc3 UTSW 2 19,240,393 (GRCm39) missense probably damaging 1.00
R9441:Armc3 UTSW 2 19,253,426 (GRCm39) missense possibly damaging 0.89
Z1177:Armc3 UTSW 2 19,290,802 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGCTGATGTGGCAAAGTTGTC -3'
(R):5'- TGCTGCATAATCACAAGTTGTC -3'

Sequencing Primer
(F):5'- CGGTAGAGGTTGAGTTTCCCTAAAC -3'
(R):5'- CACAAGTTGTCACGATTATAACTAGG -3'
Posted On 2018-02-27