Mutagenetix > Incidental Mutation

Incidental Mutation 'R6211:Vmn2r35'

503455

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r35

Ensembl Gene

ENSMUSG00000096399

Gene Name

vomeronasal 2, receptor 35

Synonyms

EG625353

Accession Numbers

Essential gene?

Not available question?

Stock #

R6211 (G1)

Quality Score

127.008

Status

Not validated

Chromosome

Chromosomal Location

7786151-7819867 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 7786528 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 737 (I737F)

Ref Sequence

ENSEMBL: ENSMUSP00000133007 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169683]

AlphaFold

E9Q7U8

Predicted Effect

probably damaging
Transcript: ENSMUST00000169683
AA Change: I737F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000133007
Gene: ENSMUSG00000096399
AA Change: I737F

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	1.8e-32	PFAM
Pfam:NCD3G	512	565	1.2e-18	PFAM
Pfam:7tm_3	595	833	2.4e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.2%
20x: 97.6%

Validation Efficiency

100% (54/54)

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931406P16Rik	A	T	7: 34,239,004	H1035Q	possibly damaging	Het
Acin1	A	T	14: 54,644,046	W391R	probably damaging	Het
Arl6ip1	A	T	7: 118,127,250	S18R	probably benign	Het
Armc3	G	A	2: 19,296,803		probably null	Het
Casc1	C	T	6: 145,200,491	R95Q	probably damaging	Het
Ccdc162	G	T	10: 41,630,145	S883*	probably null	Het
Cd300lg	A	G	11: 102,054,169	M358V	possibly damaging	Het
Cdh23	A	G	10: 60,410,821	V949A	possibly damaging	Het
Cenpo	C	T	12: 4,216,733	S126N	probably benign	Het
Chd3	A	T	11: 69,352,677	D1366E	probably damaging	Het
Chd4	A	G	6: 125,101,285	E169G	possibly damaging	Het
Clec1b	A	G	6: 129,401,477	T24A	possibly damaging	Het
Clhc1	A	G	11: 29,578,145	I558V	probably damaging	Het
Col5a2	T	A	1: 45,376,666	R1440S	probably damaging	Het
Cops3	A	G	11: 59,817,901		probably benign	Het
Cxcr4	A	G	1: 128,589,450	V158A	probably damaging	Het
Dnah7a	A	G	1: 53,419,636	M3781T	probably damaging	Het
Elovl5	C	A	9: 77,981,502	T217K	probably damaging	Het
Fbln7	G	T	2: 128,895,340	M358I	probably damaging	Het
Fbxl13	C	T	5: 21,484,021	R763Q	possibly damaging	Het
Gabrr3	C	A	16: 59,448,108	N361K	probably benign	Het
Gbp7	A	G	3: 142,545,993	M534V	probably benign	Het
Hcar2	G	A	5: 123,864,954	T162I	probably benign	Het
Hdc	A	T	2: 126,593,977	L658Q	probably damaging	Het
Hivep3	A	G	4: 120,098,405	Y1306C	probably damaging	Het
Homer3	C	T	8: 70,285,524	R49C	probably damaging	Het
Hspa4	C	T	11: 53,262,939	E702K	probably benign	Het
Iqgap3	A	G	3: 88,091,515	N308D	probably benign	Het
Itga8	G	A	2: 12,193,509	T555M	probably damaging	Het
Lrfn5	G	T	12: 61,839,470	V15L	probably benign	Het
Lrrk1	T	C	7: 66,302,710	K493E	possibly damaging	Het
Lyzl6	A	G	11: 103,635,063	I77T	probably damaging	Het
Mavs	G	T	2: 131,240,391	R65L	probably damaging	Het
Mdn1	T	G	4: 32,696,269	D1217E	probably benign	Het
Olfr103	A	T	17: 37,336,708	F175I	possibly damaging	Het
Olfr1502	A	G	19: 13,862,574	I260M	probably benign	Het
Olfr648	A	T	7: 104,179,747	Y220*	probably null	Het
Otof	C	A	5: 30,371,900	V1762L	probably damaging	Het
Pcdha12	T	C	18: 37,020,321	L31P	probably damaging	Het
Pxk	C	A	14: 8,163,952	P515T	probably damaging	Het
Qrich2	A	T	11: 116,453,542	D1759E	probably benign	Het
Rps6ka1	A	T	4: 133,869,306	F33Y	probably damaging	Het
Rxfp2	G	A	5: 150,044,126		probably null	Het
Slc23a4	A	T	6: 34,956,961	I202N	probably damaging	Het
Slc24a5	A	T	2: 125,088,251	I491F	probably benign	Het
Slco1a1	T	A	6: 141,909,049	K625N	probably benign	Het
Snx31	A	G	15: 36,546,885	V51A	probably damaging	Het
Sox6	G	T	7: 115,801,462	H48Q	probably damaging	Het
Tas2r109	A	T	6: 132,980,624	Y114*	probably null	Het
Tbc1d2	C	T	4: 46,629,912	G252R	probably benign	Het
Timm13	A	C	10: 80,900,480		probably null	Het
Tpsb2	G	A	17: 25,367,763	A250T	possibly damaging	Het
Trpm6	T	C	19: 18,783,128	I131T	probably damaging	Het
Vars2	A	T	17: 35,665,662		probably null	Het
Wdr46	C	A	17: 33,944,485	T339K	probably damaging	Het

Other mutations in Vmn2r35

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01875:Vmn2r35	APN	7	7816773	splice site	probably benign
IGL03334:Vmn2r35	APN	7	7786494	missense	probably damaging	1.00
R1858:Vmn2r35	UTSW	7	7816806	missense	possibly damaging	0.46
R5505:Vmn2r35	UTSW	7	7786480	missense	probably damaging	1.00
R6150:Vmn2r35	UTSW	7	7786556	missense	probably damaging	1.00
R7439:Vmn2r35	UTSW	7	7817014	missense	probably damaging	1.00
R8399:Vmn2r35	UTSW	7	7816898	missense	probably benign	0.00
R9628:Vmn2r35	UTSW	7	7812703	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- CCTTGGTGCTATGGTAGACAGG -3'
(R):5'- GGCTAAAACAGTCACTGTGGTTC -3'

Sequencing Primer
(F):5'- GGAGGAAGGTGACCCAGACAC -3'
(R):5'- GTGGTTCTCGCCTTCAAAATCACAG -3'

Posted On

2018-02-27