Mutagenetix > Incidental Mutation

Incidental Mutation 'R6213:Csmd3'

503587

Institutional Source

Beutler Lab

Gene Symbol

Csmd3

Ensembl Gene

ENSMUSG00000022311

Gene Name

CUB and Sushi multiple domains 3

Synonyms

4930500N14Rik

MMRRC Submission

044346-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6213 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

47444033-48655459 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 47492656 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 3162 (S3162P)

Ref Sequence

ENSEMBL: ENSMUSP00000124775 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100670] [ENSMUST00000160658] [ENSMUST00000162830]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000100670
AA Change: S3162P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000098235
Gene: ENSMUSG00000022311
AA Change: S3162P

Domain	Start	End	E-Value	Type
CUB	65	173	8.79e-30	SMART
CCP	178	235	1.77e-11	SMART
CUB	241	345	2.29e-28	SMART
low complexity region	370	387	N/A	INTRINSIC
CCP	486	543	6.9e-14	SMART
CUB	548	659	9.22e-24	SMART
CCP	664	717	1.29e-13	SMART
CUB	721	829	6.87e-32	SMART
CCP	834	891	5.19e-9	SMART
CUB	895	1003	3.23e-37	SMART
CCP	1010	1063	1.82e-13	SMART
CUB	1067	1177	4.87e-23	SMART
CCP	1182	1237	1.82e-13	SMART
CUB	1241	1349	5.02e-25	SMART
CCP	1354	1410	2.5e-11	SMART
CUB	1414	1523	6.27e-26	SMART
CCP	1528	1584	4.41e-12	SMART
CUB	1588	1696	5.37e-34	SMART
CCP	1701	1758	1.18e-12	SMART
CUB	1762	1870	2.27e-23	SMART
CCP	1878	1935	1.84e-9	SMART
CUB	1939	2047	1.8e-35	SMART
CCP	2052	2107	4.48e-13	SMART
CUB	2111	2219	3.95e-32	SMART
CCP	2224	2279	4.02e-15	SMART
CUB	2283	2390	1.74e-33	SMART
CCP	2395	2452	5.82e-12	SMART
CUB	2457	2567	5.3e-24	SMART
CCP	2569	2627	2.11e-9	SMART
CCP	2632	2689	8.23e-12	SMART
CCP	2694	2754	8.56e-10	SMART
CCP	2759	2812	1.14e-14	SMART
CCP	2817	2870	4.76e-17	SMART
CCP	2875	2928	1.85e-14	SMART
CCP	2933	2990	9.9e-15	SMART
CCP	2995	3048	1.79e-12	SMART
CCP	3056	3109	1.72e-14	SMART
CCP	3114	3168	3.17e-13	SMART
CCP	3173	3228	1.25e-11	SMART
CCP	3233	3286	1.25e-11	SMART
CCP	3291	3344	8.23e-12	SMART
CCP	3352	3406	5.6e-14	SMART
CCP	3411	3466	1.89e-11	SMART
transmembrane domain	3630	3652	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000160658
AA Change: S2993P

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000124753
Gene: ENSMUSG00000022311
AA Change: S2993P

Domain	Start	End	E-Value	Type
CUB	65	173	8.79e-30	SMART
CCP	178	235	1.77e-11	SMART
CUB	241	345	2.29e-28	SMART
CCP	382	439	6.9e-14	SMART
CUB	444	555	9.22e-24	SMART
CCP	560	613	1.29e-13	SMART
CUB	617	725	6.87e-32	SMART
CCP	730	787	5.19e-9	SMART
CUB	791	899	3.23e-37	SMART
CCP	906	959	1.82e-13	SMART
CUB	963	1073	4.87e-23	SMART
CCP	1078	1133	1.82e-13	SMART
CUB	1137	1245	5.02e-25	SMART
CCP	1250	1306	2.5e-11	SMART
CUB	1310	1419	6.27e-26	SMART
CCP	1424	1480	4.41e-12	SMART
CUB	1484	1592	5.37e-34	SMART
CCP	1597	1654	1.18e-12	SMART
CUB	1658	1766	2.27e-23	SMART
CCP	1774	1831	1.84e-9	SMART
CUB	1835	1943	1.8e-35	SMART
CCP	1948	2003	4.48e-13	SMART
CUB	2007	2115	3.95e-32	SMART
CCP	2120	2175	4.02e-15	SMART
CUB	2179	2286	1.74e-33	SMART
CCP	2291	2348	5.82e-12	SMART
CUB	2353	2463	5.3e-24	SMART
CCP	2465	2523	2.11e-9	SMART
CCP	2528	2585	8.23e-12	SMART
CCP	2590	2643	1.14e-14	SMART
CCP	2648	2701	4.76e-17	SMART
CCP	2706	2759	1.85e-14	SMART
CCP	2764	2821	9.9e-15	SMART
CCP	2826	2879	1.79e-12	SMART
CCP	2887	2940	1.72e-14	SMART
CCP	2945	2999	3.17e-13	SMART
CCP	3004	3059	1.25e-11	SMART
CCP	3064	3117	1.25e-11	SMART
CCP	3122	3175	8.23e-12	SMART
CCP	3183	3237	5.6e-14	SMART
CCP	3242	3297	1.89e-11	SMART
transmembrane domain	3461	3483	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161173

Predicted Effect

unknown
Transcript: ENSMUST00000161653
AA Change: S2251P

SMART Domains

Protein: ENSMUSP00000124195
Gene: ENSMUSG00000022311
AA Change: S2251P

Domain	Start	End	E-Value	Type
CCP	1	51	6.59e-1	SMART
CUB	55	163	3.23e-37	SMART
CCP	170	223	1.82e-13	SMART
CUB	227	337	4.87e-23	SMART
CCP	342	397	1.82e-13	SMART
CUB	401	509	5.02e-25	SMART
CCP	514	570	2.5e-11	SMART
CUB	574	683	6.27e-26	SMART
CCP	688	744	4.41e-12	SMART
CUB	748	856	5.37e-34	SMART
CCP	861	918	1.18e-12	SMART
Pfam:CUB	922	964	9.7e-8	PFAM
CCP	968	1025	1.84e-9	SMART
CUB	1029	1137	1.8e-35	SMART
CCP	1142	1197	4.48e-13	SMART
CUB	1201	1309	3.95e-32	SMART
CCP	1314	1369	4.02e-15	SMART
CUB	1373	1480	1.74e-33	SMART
CCP	1485	1542	5.82e-12	SMART
CUB	1547	1657	5.3e-24	SMART
CCP	1659	1717	2.11e-9	SMART
CCP	1722	1779	8.23e-12	SMART
CCP	1784	1844	8.56e-10	SMART
CCP	1849	1902	1.14e-14	SMART
CCP	1907	1960	4.76e-17	SMART
CCP	1965	2018	1.85e-14	SMART
CCP	2023	2080	9.9e-15	SMART
CCP	2085	2138	1.79e-12	SMART
CCP	2146	2199	1.72e-14	SMART
CCP	2204	2258	3.17e-13	SMART
CCP	2263	2318	1.25e-11	SMART
CCP	2323	2376	1.25e-11	SMART
CCP	2381	2434	8.23e-12	SMART
CCP	2442	2496	5.6e-14	SMART
CCP	2501	2556	1.89e-11	SMART
transmembrane domain	2720	2742	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000162830
AA Change: S3162P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000124775
Gene: ENSMUSG00000022311
AA Change: S3162P

Domain	Start	End	E-Value	Type
CUB	65	173	8.79e-30	SMART
CCP	178	235	1.77e-11	SMART
CUB	241	345	2.29e-28	SMART
low complexity region	370	387	N/A	INTRINSIC
CCP	486	543	6.9e-14	SMART
CUB	548	659	9.22e-24	SMART
CCP	664	717	1.29e-13	SMART
CUB	721	829	6.87e-32	SMART
CCP	834	891	5.19e-9	SMART
CUB	895	1003	3.23e-37	SMART
CCP	1010	1063	1.82e-13	SMART
CUB	1067	1177	4.87e-23	SMART
CCP	1182	1237	1.82e-13	SMART
CUB	1241	1349	5.02e-25	SMART
CCP	1354	1410	2.5e-11	SMART
CUB	1414	1523	6.27e-26	SMART
CCP	1528	1584	4.41e-12	SMART
CUB	1588	1696	5.37e-34	SMART
CCP	1701	1758	1.18e-12	SMART
CUB	1762	1870	2.27e-23	SMART
CCP	1878	1935	1.84e-9	SMART
CUB	1939	2047	1.8e-35	SMART
CCP	2052	2107	4.48e-13	SMART
CUB	2111	2219	3.95e-32	SMART
CCP	2224	2279	4.02e-15	SMART
CUB	2283	2390	1.74e-33	SMART
CCP	2395	2452	5.82e-12	SMART
CUB	2457	2567	5.3e-24	SMART
CCP	2569	2627	2.11e-9	SMART
CCP	2632	2689	8.23e-12	SMART
CCP	2694	2754	8.56e-10	SMART
CCP	2759	2812	1.14e-14	SMART
CCP	2817	2870	4.76e-17	SMART
CCP	2875	2928	1.85e-14	SMART
CCP	2933	2990	9.9e-15	SMART
CCP	2995	3048	1.79e-12	SMART
CCP	3056	3109	1.72e-14	SMART
CCP	3114	3168	3.17e-13	SMART
CCP	3173	3228	1.25e-11	SMART
CCP	3233	3286	1.25e-11	SMART
CCP	3291	3344	8.23e-12	SMART
CCP	3352	3406	5.6e-14	SMART
CCP	3411	3466	1.89e-11	SMART
transmembrane domain	3630	3652	N/A	INTRINSIC

Meta Mutation Damage Score

0.2741

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.2%
20x: 97.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc5	A	G	16: 20,218,762 (GRCm39)	Y207H	probably damaging	Het
Adcy7	G	A	8: 89,040,765 (GRCm39)	V335M	probably damaging	Het
Apol11b	A	C	15: 77,522,200 (GRCm39)	D32E	possibly damaging	Het
Ccdc13	A	G	9: 121,627,975 (GRCm39)		probably benign	Het
Cdkn1b	T	A	6: 134,898,206 (GRCm39)	D108E	probably benign	Het
Cep290	A	G	10: 100,359,222 (GRCm39)	D984G	probably benign	Het
Csde1	T	C	3: 102,947,830 (GRCm39)	V128A	probably damaging	Het
D5Ertd579e	G	A	5: 36,759,978 (GRCm39)	T1394I	probably damaging	Het
Ddx6	T	A	9: 44,539,990 (GRCm39)	L306Q	probably damaging	Het
Dmxl1	T	A	18: 49,996,082 (GRCm39)	S403T	possibly damaging	Het
F11	G	T	8: 45,694,537 (GRCm39)	T608K	probably damaging	Het
Flrt3	C	T	2: 140,503,085 (GRCm39)	R181H	probably damaging	Het
Hs3st1	A	T	5: 39,771,864 (GRCm39)	C260S	probably damaging	Het
Ighv7-1	A	T	12: 113,860,141 (GRCm39)	S84T	probably damaging	Het
Inpp4b	A	G	8: 82,724,019 (GRCm39)	D332G	probably damaging	Het
Irf2bpl	T	C	12: 86,930,367 (GRCm39)	Q102R	probably benign	Het
Itpr3	T	A	17: 27,330,174 (GRCm39)	D1597E	probably benign	Het
Kcnd1	G	C	X: 7,690,148 (GRCm39)	A23P	probably damaging	Homo
Lypd8	A	G	11: 58,281,160 (GRCm39)	T241A	probably benign	Het
Map1lc3a	T	C	2: 155,118,935 (GRCm39)		probably null	Het
Mast1	G	A	8: 85,642,198 (GRCm39)	T1052I	probably damaging	Het
Muc2	T	C	7: 141,305,151 (GRCm39)	C152R	probably damaging	Het
Muc5b	A	T	7: 141,415,903 (GRCm39)	M2950L	probably benign	Het
Muc5b	A	G	7: 141,421,356 (GRCm39)	D4282G	possibly damaging	Het
Myo16	G	T	8: 10,420,963 (GRCm39)		probably null	Het
Myo9a	T	A	9: 59,734,541 (GRCm39)	F708I	probably damaging	Het
Nadsyn1	A	T	7: 143,353,549 (GRCm39)	F558Y	probably benign	Het
Nat9	A	T	11: 115,075,932 (GRCm39)	W30R	probably damaging	Het
Nipbl	A	G	15: 8,364,390 (GRCm39)	L1338S	probably damaging	Het
Nipsnap3b	A	G	4: 53,017,066 (GRCm39)	T97A	probably benign	Het
Npepps	A	T	11: 97,132,823 (GRCm39)	Y301*	probably null	Het
Nrcam	C	T	12: 44,609,215 (GRCm39)	P447S	possibly damaging	Het
Or14c41	A	G	7: 86,234,485 (GRCm39)	M1V	probably null	Het
Or1o4	T	C	17: 37,591,264 (GRCm39)	S16G	probably benign	Het
Or2a14	A	G	6: 43,130,821 (GRCm39)	N194S	possibly damaging	Het
Or52b4	T	C	7: 102,184,139 (GRCm39)	Y62H	probably damaging	Het
Pacsin3	G	T	2: 91,090,779 (GRCm39)	V29F	probably damaging	Het
Pdzrn3	A	C	6: 101,354,805 (GRCm39)	D15E	probably damaging	Het
Phf20l1	T	C	15: 66,504,752 (GRCm39)		probably null	Het
Pign	A	C	1: 105,516,991 (GRCm39)	V545G	possibly damaging	Het
Pkhd1	T	C	1: 20,593,994 (GRCm39)	N1373S	possibly damaging	Het
Ptchd4	T	A	17: 42,688,251 (GRCm39)	H264Q	probably benign	Het
Ptpn3	G	T	4: 57,265,012 (GRCm39)	Q73K	probably damaging	Het
Ptrh1	G	A	2: 32,666,757 (GRCm39)	V109I	probably benign	Het
Reg1	A	T	6: 78,404,386 (GRCm39)	I87F	possibly damaging	Het
Rrp12	C	A	19: 41,857,217 (GRCm39)	V1186L	probably benign	Het
Sall1	AGTGGTGGTGGTGGTGGTGGTGG	AGTGGTGGTGGTGGTGGTGG	8: 89,759,686 (GRCm39)		probably benign	Het
Slc23a3	A	C	1: 75,108,392 (GRCm39)	F279V	probably benign	Het
Smtnl2	G	A	11: 72,292,225 (GRCm39)	A274V	probably damaging	Het
Suds3	A	G	5: 117,244,727 (GRCm39)	L115P	probably damaging	Het
Tekt2	G	A	4: 126,216,989 (GRCm39)	A260V	probably damaging	Het
Tgfb3	T	A	12: 86,104,621 (GRCm39)	Y391F	probably damaging	Het
Topbp1	T	C	9: 103,209,950 (GRCm39)	S866P	probably benign	Het
Tspan14	A	G	14: 40,635,372 (GRCm39)	Y175H	probably benign	Het
Vars2	T	C	17: 35,971,332 (GRCm39)	T568A	probably benign	Het
Vmn1r216	T	G	13: 23,283,339 (GRCm39)	D7E	probably benign	Het
Vmn2r115	ATCTTCT	ATCT	17: 23,578,962 (GRCm39)		probably benign	Het
Zfp281	T	C	1: 136,553,250 (GRCm39)	V76A	probably benign	Het
Zfp36l2	T	C	17: 84,493,980 (GRCm39)	N219S	probably damaging	Het
Zfp626	T	C	7: 27,507,717 (GRCm39)	M42T	probably benign	Het
Zscan21	C	T	5: 138,123,359 (GRCm39)	P13S	probably benign	Het

Other mutations in Csmd3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Csmd3	APN	15	48,150,891 (GRCm39)	missense	possibly damaging	0.61
IGL00591:Csmd3	APN	15	47,868,279 (GRCm39)	missense	probably damaging	1.00
IGL00668:Csmd3	APN	15	47,777,341 (GRCm39)	missense	probably damaging	1.00
IGL00753:Csmd3	APN	15	47,507,631 (GRCm39)	missense	probably damaging	1.00
IGL00773:Csmd3	APN	15	47,454,115 (GRCm39)	missense	probably damaging	0.96
IGL00926:Csmd3	APN	15	47,574,360 (GRCm39)	missense	possibly damaging	0.87
IGL00942:Csmd3	APN	15	47,710,502 (GRCm39)	critical splice donor site	probably null
IGL01080:Csmd3	APN	15	47,744,799 (GRCm39)	missense	probably benign	0.12
IGL01314:Csmd3	APN	15	47,713,151 (GRCm39)	missense	probably damaging	1.00
IGL01326:Csmd3	APN	15	47,713,181 (GRCm39)	missense	probably benign	0.06
IGL01393:Csmd3	APN	15	48,320,995 (GRCm39)	missense	possibly damaging	0.88
IGL01432:Csmd3	APN	15	47,596,895 (GRCm39)	missense	probably damaging	1.00
IGL01519:Csmd3	APN	15	47,460,246 (GRCm39)	missense	probably benign	0.31
IGL01530:Csmd3	APN	15	47,533,013 (GRCm39)	missense	probably damaging	1.00
IGL01530:Csmd3	APN	15	47,701,833 (GRCm39)	missense	possibly damaging	0.95
IGL01547:Csmd3	APN	15	47,747,013 (GRCm39)	missense	probably benign	0.41
IGL01594:Csmd3	APN	15	47,492,635 (GRCm39)	missense	probably benign	0.01
IGL01618:Csmd3	APN	15	47,874,479 (GRCm39)	missense	probably benign	0.05
IGL01670:Csmd3	APN	15	47,475,225 (GRCm39)	missense	probably damaging	1.00
IGL01680:Csmd3	APN	15	47,833,426 (GRCm39)	missense	probably damaging	1.00
IGL01734:Csmd3	APN	15	48,048,700 (GRCm39)	missense	probably damaging	1.00
IGL01777:Csmd3	APN	15	47,561,594 (GRCm39)	missense	probably benign	0.06
IGL01779:Csmd3	APN	15	47,721,290 (GRCm39)	missense	probably benign	0.10
IGL01820:Csmd3	APN	15	47,470,538 (GRCm39)	nonsense	probably null
IGL01843:Csmd3	APN	15	47,522,395 (GRCm39)	splice site	probably benign
IGL01919:Csmd3	APN	15	47,539,168 (GRCm39)	missense	possibly damaging	0.62
IGL01986:Csmd3	APN	15	47,522,591 (GRCm39)	missense	possibly damaging	0.82
IGL02049:Csmd3	APN	15	47,864,870 (GRCm39)	missense	possibly damaging	0.91
IGL02065:Csmd3	APN	15	47,530,024 (GRCm39)	missense	probably damaging	1.00
IGL02112:Csmd3	APN	15	48,177,265 (GRCm39)	missense	possibly damaging	0.95
IGL02133:Csmd3	APN	15	47,721,338 (GRCm39)	missense	possibly damaging	0.86
IGL02203:Csmd3	APN	15	47,713,073 (GRCm39)	splice site	probably null
IGL02215:Csmd3	APN	15	47,449,084 (GRCm39)	missense	probably damaging	1.00
IGL02234:Csmd3	APN	15	47,811,512 (GRCm39)	missense	probably damaging	1.00
IGL02326:Csmd3	APN	15	47,619,359 (GRCm39)	splice site	probably benign
IGL02478:Csmd3	APN	15	47,701,794 (GRCm39)	splice site	probably benign
IGL02491:Csmd3	APN	15	47,777,511 (GRCm39)	splice site	probably benign
IGL02598:Csmd3	APN	15	47,533,086 (GRCm39)	missense	probably damaging	0.98
IGL02626:Csmd3	APN	15	47,567,503 (GRCm39)	splice site	probably benign
IGL02696:Csmd3	APN	15	47,533,065 (GRCm39)	missense	probably benign	0.33
IGL02876:Csmd3	APN	15	47,469,492 (GRCm39)	splice site	probably benign
IGL02971:Csmd3	APN	15	47,777,325 (GRCm39)	splice site	probably benign
IGL03068:Csmd3	APN	15	47,710,517 (GRCm39)	missense	possibly damaging	0.69
IGL03087:Csmd3	APN	15	47,840,429 (GRCm39)	missense	probably damaging	1.00
IGL03114:Csmd3	APN	15	47,683,847 (GRCm39)	missense	probably damaging	0.99
IGL03146:Csmd3	APN	15	47,744,873 (GRCm39)	missense	probably benign	0.25
IGL03193:Csmd3	APN	15	47,492,626 (GRCm39)	splice site	probably benign
IGL03274:Csmd3	APN	15	47,508,900 (GRCm39)	missense	probably damaging	1.00
R0040:Csmd3	UTSW	15	47,497,212 (GRCm39)	missense	probably damaging	1.00
R0071:Csmd3	UTSW	15	47,460,217 (GRCm39)	missense	probably benign	0.04
R0071:Csmd3	UTSW	15	47,460,217 (GRCm39)	missense	probably benign	0.04
R0119:Csmd3	UTSW	15	47,710,527 (GRCm39)	missense	probably benign	0.08
R0124:Csmd3	UTSW	15	47,454,112 (GRCm39)	missense	probably damaging	1.00
R0127:Csmd3	UTSW	15	47,845,326 (GRCm39)	missense	probably benign	0.45
R0136:Csmd3	UTSW	15	47,710,527 (GRCm39)	missense	probably benign	0.08
R0201:Csmd3	UTSW	15	47,483,125 (GRCm39)	splice site	probably benign
R0240:Csmd3	UTSW	15	47,492,635 (GRCm39)	missense	probably benign	0.05
R0240:Csmd3	UTSW	15	47,492,635 (GRCm39)	missense	probably benign	0.05
R0318:Csmd3	UTSW	15	47,522,549 (GRCm39)	missense	probably damaging	1.00
R0369:Csmd3	UTSW	15	47,833,543 (GRCm39)	missense	probably damaging	1.00
R0391:Csmd3	UTSW	15	47,520,969 (GRCm39)	missense	probably damaging	1.00
R0499:Csmd3	UTSW	15	47,710,527 (GRCm39)	missense	probably benign	0.08
R0506:Csmd3	UTSW	15	48,320,907 (GRCm39)	missense	probably benign	0.00
R0606:Csmd3	UTSW	15	48,321,058 (GRCm39)	missense	probably benign
R0639:Csmd3	UTSW	15	47,777,336 (GRCm39)	missense	probably damaging	1.00
R0658:Csmd3	UTSW	15	47,874,543 (GRCm39)	missense	possibly damaging	0.66
R0673:Csmd3	UTSW	15	47,777,336 (GRCm39)	missense	probably damaging	1.00
R0689:Csmd3	UTSW	15	47,619,421 (GRCm39)	missense	probably benign	0.19
R0696:Csmd3	UTSW	15	47,710,569 (GRCm39)	missense	probably benign	0.01
R0799:Csmd3	UTSW	15	48,048,780 (GRCm39)	splice site	probably benign
R0834:Csmd3	UTSW	15	47,747,073 (GRCm39)	intron	probably benign
R0894:Csmd3	UTSW	15	47,721,316 (GRCm39)	missense	possibly damaging	0.95
R0926:Csmd3	UTSW	15	47,840,429 (GRCm39)	missense	probably damaging	1.00
R0943:Csmd3	UTSW	15	47,539,135 (GRCm39)	missense	probably damaging	0.99
R0944:Csmd3	UTSW	15	47,475,227 (GRCm39)	missense	probably damaging	1.00
R0967:Csmd3	UTSW	15	47,721,227 (GRCm39)	missense	probably null	0.89
R0973:Csmd3	UTSW	15	47,522,485 (GRCm39)	missense	probably damaging	1.00
R1055:Csmd3	UTSW	15	47,744,933 (GRCm39)	missense	probably damaging	1.00
R1066:Csmd3	UTSW	15	47,777,361 (GRCm39)	missense	probably damaging	1.00
R1086:Csmd3	UTSW	15	47,559,151 (GRCm39)	missense	probably damaging	0.99
R1103:Csmd3	UTSW	15	47,811,402 (GRCm39)	missense	probably damaging	1.00
R1136:Csmd3	UTSW	15	47,539,213 (GRCm39)	missense	probably damaging	1.00
R1139:Csmd3	UTSW	15	47,559,232 (GRCm39)	missense	probably damaging	1.00
R1158:Csmd3	UTSW	15	48,156,170 (GRCm39)	splice site	probably null
R1215:Csmd3	UTSW	15	47,868,227 (GRCm39)	splice site	probably null
R1233:Csmd3	UTSW	15	48,536,927 (GRCm39)	missense	probably damaging	1.00
R1271:Csmd3	UTSW	15	47,874,455 (GRCm39)	missense	probably benign	0.11
R1469:Csmd3	UTSW	15	47,532,598 (GRCm39)	nonsense	probably null
R1469:Csmd3	UTSW	15	47,532,598 (GRCm39)	nonsense	probably null
R1479:Csmd3	UTSW	15	47,721,282 (GRCm39)	missense	probably damaging	1.00
R1480:Csmd3	UTSW	15	47,595,325 (GRCm39)	missense	possibly damaging	0.90
R1526:Csmd3	UTSW	15	47,449,028 (GRCm39)	critical splice donor site	probably null
R1527:Csmd3	UTSW	15	47,811,483 (GRCm39)	missense	probably benign	0.08
R1539:Csmd3	UTSW	15	47,683,794 (GRCm39)	missense	probably benign	0.24
R1544:Csmd3	UTSW	15	47,475,294 (GRCm39)	splice site	probably null
R1548:Csmd3	UTSW	15	47,845,371 (GRCm39)	missense	possibly damaging	0.91
R1574:Csmd3	UTSW	15	47,559,257 (GRCm39)	splice site	probably null
R1574:Csmd3	UTSW	15	47,559,257 (GRCm39)	splice site	probably null
R1619:Csmd3	UTSW	15	47,813,346 (GRCm39)	missense	probably damaging	1.00
R1630:Csmd3	UTSW	15	47,701,918 (GRCm39)	missense	possibly damaging	0.66
R1665:Csmd3	UTSW	15	47,560,185 (GRCm39)	missense	probably damaging	1.00
R1680:Csmd3	UTSW	15	47,604,566 (GRCm39)	missense	probably damaging	1.00
R1725:Csmd3	UTSW	15	47,460,203 (GRCm39)	missense	probably damaging	1.00
R1743:Csmd3	UTSW	15	48,485,485 (GRCm39)	missense	probably damaging	1.00
R1749:Csmd3	UTSW	15	47,449,056 (GRCm39)	missense	probably damaging	1.00
R1752:Csmd3	UTSW	15	47,523,669 (GRCm39)	missense	probably benign	0.15
R1769:Csmd3	UTSW	15	47,567,505 (GRCm39)	splice site	probably benign
R1775:Csmd3	UTSW	15	47,763,135 (GRCm39)	missense	probably damaging	0.99
R1795:Csmd3	UTSW	15	47,721,316 (GRCm39)	missense	possibly damaging	0.95
R1819:Csmd3	UTSW	15	47,617,131 (GRCm39)	missense	possibly damaging	0.56
R1840:Csmd3	UTSW	15	47,470,560 (GRCm39)	missense	probably damaging	1.00
R1860:Csmd3	UTSW	15	47,522,588 (GRCm39)	missense	probably damaging	1.00
R1861:Csmd3	UTSW	15	47,522,588 (GRCm39)	missense	probably damaging	1.00
R1879:Csmd3	UTSW	15	47,520,915 (GRCm39)	missense	possibly damaging	0.90
R1958:Csmd3	UTSW	15	47,868,035 (GRCm39)	critical splice donor site	probably null
R1965:Csmd3	UTSW	15	47,713,144 (GRCm39)	missense	probably benign	0.15
R1970:Csmd3	UTSW	15	48,536,927 (GRCm39)	missense	probably damaging	1.00
R2029:Csmd3	UTSW	15	47,701,975 (GRCm39)	missense	probably damaging	1.00
R2051:Csmd3	UTSW	15	48,485,389 (GRCm39)	critical splice donor site	probably null
R2108:Csmd3	UTSW	15	47,868,257 (GRCm39)	missense	possibly damaging	0.81
R2132:Csmd3	UTSW	15	48,320,899 (GRCm39)	missense	probably benign	0.06
R2146:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2147:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2148:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2157:Csmd3	UTSW	15	47,559,183 (GRCm39)	missense	probably damaging	0.99
R2159:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2160:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2161:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2162:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2164:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2213:Csmd3	UTSW	15	47,683,843 (GRCm39)	missense	possibly damaging	0.92
R2301:Csmd3	UTSW	15	47,595,394 (GRCm39)	missense	probably damaging	1.00
R2302:Csmd3	UTSW	15	48,177,447 (GRCm39)	missense	probably benign
R2355:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2497:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2509:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2566:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2567:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2568:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2570:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2571:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2870:Csmd3	UTSW	15	47,721,320 (GRCm39)	missense	probably damaging	1.00
R2870:Csmd3	UTSW	15	47,721,320 (GRCm39)	missense	probably damaging	1.00
R2907:Csmd3	UTSW	15	47,874,449 (GRCm39)	missense	probably damaging	0.99
R3116:Csmd3	UTSW	15	47,520,995 (GRCm39)	missense	probably damaging	1.00
R3423:Csmd3	UTSW	15	47,710,648 (GRCm39)	missense	probably damaging	0.98
R3425:Csmd3	UTSW	15	47,710,648 (GRCm39)	missense	probably damaging	0.98
R3508:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R3746:Csmd3	UTSW	15	47,713,162 (GRCm39)	missense	probably benign	0.04
R3813:Csmd3	UTSW	15	48,655,209 (GRCm39)	missense	possibly damaging	0.82
R3832:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R3959:Csmd3	UTSW	15	47,507,585 (GRCm39)	missense	probably benign	0.18
R4042:Csmd3	UTSW	15	47,477,480 (GRCm39)	missense	probably damaging	1.00
R4043:Csmd3	UTSW	15	47,619,362 (GRCm39)	critical splice donor site	probably null
R4191:Csmd3	UTSW	15	47,710,667 (GRCm39)	missense	probably damaging	0.99
R4192:Csmd3	UTSW	15	47,710,667 (GRCm39)	missense	probably damaging	0.99
R4419:Csmd3	UTSW	15	47,567,707 (GRCm39)	missense	probably damaging	1.00
R4426:Csmd3	UTSW	15	47,532,581 (GRCm39)	missense	possibly damaging	0.51
R4434:Csmd3	UTSW	15	47,763,191 (GRCm39)	missense	possibly damaging	0.68
R4438:Csmd3	UTSW	15	47,763,191 (GRCm39)	missense	possibly damaging	0.68
R4490:Csmd3	UTSW	15	48,177,429 (GRCm39)	missense	possibly damaging	0.83
R4562:Csmd3	UTSW	15	47,763,240 (GRCm39)	missense	probably benign	0.32
R4604:Csmd3	UTSW	15	47,868,211 (GRCm39)	missense	possibly damaging	0.90
R4620:Csmd3	UTSW	15	47,449,149 (GRCm39)	missense	probably benign	0.09
R4632:Csmd3	UTSW	15	47,874,605 (GRCm39)	missense	probably damaging	0.99
R4679:Csmd3	UTSW	15	48,024,479 (GRCm39)	nonsense	probably null
R4696:Csmd3	UTSW	15	47,777,364 (GRCm39)	missense	probably benign	0.24
R4718:Csmd3	UTSW	15	47,561,546 (GRCm39)	nonsense	probably null
R4723:Csmd3	UTSW	15	47,532,556 (GRCm39)	missense	probably benign	0.29
R4801:Csmd3	UTSW	15	47,484,688 (GRCm39)	missense	probably damaging	1.00
R4802:Csmd3	UTSW	15	47,484,688 (GRCm39)	missense	probably damaging	1.00
R4806:Csmd3	UTSW	15	48,177,464 (GRCm39)	missense	probably benign
R4816:Csmd3	UTSW	15	47,721,330 (GRCm39)	missense	possibly damaging	0.68
R4935:Csmd3	UTSW	15	48,024,480 (GRCm39)	missense	probably damaging	1.00
R4955:Csmd3	UTSW	15	48,536,914 (GRCm39)	missense	probably damaging	0.99
R4991:Csmd3	UTSW	15	47,864,874 (GRCm39)	missense	probably damaging	1.00
R5031:Csmd3	UTSW	15	47,522,588 (GRCm39)	missense	probably damaging	1.00
R5034:Csmd3	UTSW	15	47,492,683 (GRCm39)	missense	possibly damaging	0.94
R5035:Csmd3	UTSW	15	47,454,175 (GRCm39)	missense	probably damaging	1.00
R5120:Csmd3	UTSW	15	48,536,891 (GRCm39)	nonsense	probably null
R5224:Csmd3	UTSW	15	47,752,080 (GRCm39)	missense	possibly damaging	0.91
R5235:Csmd3	UTSW	15	47,492,674 (GRCm39)	missense	probably benign	0.20
R5279:Csmd3	UTSW	15	48,655,340 (GRCm39)	splice site	probably null
R5360:Csmd3	UTSW	15	47,532,599 (GRCm39)	missense	probably damaging	0.99
R5365:Csmd3	UTSW	15	47,868,145 (GRCm39)	missense	possibly damaging	0.68
R5379:Csmd3	UTSW	15	47,499,846 (GRCm39)	nonsense	probably null
R5381:Csmd3	UTSW	15	47,604,611 (GRCm39)	missense	probably benign	0.21
R5393:Csmd3	UTSW	15	47,497,099 (GRCm39)	missense	probably damaging	1.00
R5413:Csmd3	UTSW	15	47,701,831 (GRCm39)	missense	probably damaging	1.00
R5549:Csmd3	UTSW	15	48,048,753 (GRCm39)	missense	probably damaging	0.98
R5550:Csmd3	UTSW	15	48,048,753 (GRCm39)	missense	probably damaging	0.98
R5551:Csmd3	UTSW	15	48,177,492 (GRCm39)	missense	probably benign	0.13
R5567:Csmd3	UTSW	15	47,508,864 (GRCm39)	missense	possibly damaging	0.92
R5621:Csmd3	UTSW	15	48,177,374 (GRCm39)	missense	possibly damaging	0.84
R5668:Csmd3	UTSW	15	47,559,151 (GRCm39)	missense	possibly damaging	0.48
R5677:Csmd3	UTSW	15	48,485,447 (GRCm39)	missense	probably damaging	0.98
R5701:Csmd3	UTSW	15	48,403,729 (GRCm39)	missense	probably damaging	0.99
R5701:Csmd3	UTSW	15	47,513,617 (GRCm39)	missense	probably damaging	1.00
R5871:Csmd3	UTSW	15	47,752,112 (GRCm39)	missense	probably damaging	0.98
R5872:Csmd3	UTSW	15	47,445,923 (GRCm39)	missense	probably damaging	1.00
R5874:Csmd3	UTSW	15	47,507,666 (GRCm39)	missense	probably damaging	1.00
R5952:Csmd3	UTSW	15	47,596,901 (GRCm39)	missense	probably damaging	0.98
R5956:Csmd3	UTSW	15	48,655,278 (GRCm39)	missense	possibly damaging	0.84
R5966:Csmd3	UTSW	15	47,713,135 (GRCm39)	missense	probably damaging	0.96
R5969:Csmd3	UTSW	15	47,811,386 (GRCm39)	missense	probably damaging	1.00
R5989:Csmd3	UTSW	15	47,454,160 (GRCm39)	missense	possibly damaging	0.69
R6017:Csmd3	UTSW	15	48,177,408 (GRCm39)	missense	possibly damaging	0.95
R6057:Csmd3	UTSW	15	47,618,787 (GRCm39)	missense	probably damaging	1.00
R6127:Csmd3	UTSW	15	47,513,624 (GRCm39)	missense	probably damaging	1.00
R6178:Csmd3	UTSW	15	48,536,854 (GRCm39)	missense	probably damaging	1.00
R6198:Csmd3	UTSW	15	48,177,273 (GRCm39)	missense	probably benign	0.28
R6256:Csmd3	UTSW	15	47,533,125 (GRCm39)	missense	probably damaging	1.00
R6274:Csmd3	UTSW	15	47,484,833 (GRCm39)	missense	probably benign
R6327:Csmd3	UTSW	15	47,744,783 (GRCm39)	missense	probably damaging	1.00
R6354:Csmd3	UTSW	15	47,744,885 (GRCm39)	missense	probably damaging	1.00
R6405:Csmd3	UTSW	15	47,683,767 (GRCm39)	missense	probably damaging	0.99
R6410:Csmd3	UTSW	15	48,536,803 (GRCm39)	missense	probably damaging	1.00
R6416:Csmd3	UTSW	15	48,536,956 (GRCm39)	missense	probably damaging	1.00
R6463:Csmd3	UTSW	15	47,539,875 (GRCm39)	missense	probably damaging	1.00
R6536:Csmd3	UTSW	15	47,701,863 (GRCm39)	missense	probably damaging	1.00
R6625:Csmd3	UTSW	15	47,470,471 (GRCm39)	missense	probably benign	0.02
R6695:Csmd3	UTSW	15	47,721,230 (GRCm39)	missense	probably damaging	0.99
R6895:Csmd3	UTSW	15	47,529,910 (GRCm39)	splice site	probably null
R6906:Csmd3	UTSW	15	47,710,569 (GRCm39)	missense	probably benign	0.01
R6914:Csmd3	UTSW	15	47,874,534 (GRCm39)	missense	possibly damaging	0.53
R6920:Csmd3	UTSW	15	47,507,601 (GRCm39)	missense	probably damaging	1.00
R7024:Csmd3	UTSW	15	47,574,387 (GRCm39)	missense	probably damaging	1.00
R7178:Csmd3	UTSW	15	47,454,170 (GRCm39)	missense
R7192:Csmd3	UTSW	15	47,567,633 (GRCm39)	missense
R7220:Csmd3	UTSW	15	48,320,994 (GRCm39)	missense	probably damaging	0.99
R7362:Csmd3	UTSW	15	47,619,388 (GRCm39)	missense	possibly damaging	0.65
R7380:Csmd3	UTSW	15	47,450,361 (GRCm39)	missense
R7397:Csmd3	UTSW	15	47,559,130 (GRCm39)	missense
R7467:Csmd3	UTSW	15	47,492,640 (GRCm39)	missense
R7585:Csmd3	UTSW	15	48,485,471 (GRCm39)	missense	possibly damaging	0.76
R7623:Csmd3	UTSW	15	47,813,334 (GRCm39)	missense
R7649:Csmd3	UTSW	15	47,532,539 (GRCm39)	missense
R7691:Csmd3	UTSW	15	47,604,569 (GRCm39)	missense
R7695:Csmd3	UTSW	15	47,683,777 (GRCm39)	missense
R7759:Csmd3	UTSW	15	47,561,569 (GRCm39)	missense
R7817:Csmd3	UTSW	15	47,721,356 (GRCm39)	missense	probably damaging	0.99
R8052:Csmd3	UTSW	15	47,569,783 (GRCm39)	missense
R8089:Csmd3	UTSW	15	47,532,603 (GRCm39)	missense
R8110:Csmd3	UTSW	15	47,507,666 (GRCm39)	missense	probably damaging	1.00
R8152:Csmd3	UTSW	15	47,532,860 (GRCm39)	splice site	probably null
R8323:Csmd3	UTSW	15	47,561,547 (GRCm39)	missense
R8341:Csmd3	UTSW	15	47,561,547 (GRCm39)	missense
R8353:Csmd3	UTSW	15	47,813,349 (GRCm39)	missense	probably damaging	1.00
R8364:Csmd3	UTSW	15	48,536,837 (GRCm39)	missense	probably damaging	1.00
R8405:Csmd3	UTSW	15	47,619,379 (GRCm39)	missense	probably damaging	1.00
R8412:Csmd3	UTSW	15	47,499,794 (GRCm39)	missense
R8436:Csmd3	UTSW	15	47,868,218 (GRCm39)	missense	probably damaging	0.97
R8516:Csmd3	UTSW	15	47,492,761 (GRCm39)	nonsense	probably null
R8553:Csmd3	UTSW	15	47,484,724 (GRCm39)	missense	possibly damaging	0.52
R8554:Csmd3	UTSW	15	47,507,538 (GRCm39)	missense	probably benign	0.32
R8678:Csmd3	UTSW	15	47,499,849 (GRCm39)	missense
R8751:Csmd3	UTSW	15	47,845,402 (GRCm39)	missense
R8758:Csmd3	UTSW	15	47,469,593 (GRCm39)	missense
R8768:Csmd3	UTSW	15	47,561,572 (GRCm39)	missense
R8785:Csmd3	UTSW	15	48,177,482 (GRCm39)	missense	probably benign	0.00
R8788:Csmd3	UTSW	15	47,470,513 (GRCm39)	missense
R8798:Csmd3	UTSW	15	47,595,382 (GRCm39)	missense
R8801:Csmd3	UTSW	15	48,321,024 (GRCm39)	missense	possibly damaging	0.70
R8811:Csmd3	UTSW	15	47,560,139 (GRCm39)	missense
R8844:Csmd3	UTSW	15	48,536,815 (GRCm39)	missense	probably damaging	0.98
R8844:Csmd3	UTSW	15	47,604,590 (GRCm39)	missense	probably damaging	0.96
R8892:Csmd3	UTSW	15	47,604,634 (GRCm39)	missense
R8897:Csmd3	UTSW	15	48,222,739 (GRCm39)	missense	probably benign	0.06
R9001:Csmd3	UTSW	15	47,596,901 (GRCm39)	missense
R9007:Csmd3	UTSW	15	47,751,892 (GRCm39)	intron	probably benign
R9016:Csmd3	UTSW	15	47,522,438 (GRCm39)	missense
R9039:Csmd3	UTSW	15	47,483,308 (GRCm39)	splice site	probably benign
R9109:Csmd3	UTSW	15	47,617,187 (GRCm39)	missense
R9121:Csmd3	UTSW	15	47,683,774 (GRCm39)	missense
R9155:Csmd3	UTSW	15	47,449,051 (GRCm39)	missense
R9176:Csmd3	UTSW	15	47,864,937 (GRCm39)	missense
R9281:Csmd3	UTSW	15	47,460,272 (GRCm39)	missense
R9298:Csmd3	UTSW	15	47,617,187 (GRCm39)	missense
R9304:Csmd3	UTSW	15	47,569,805 (GRCm39)	missense
R9343:Csmd3	UTSW	15	48,015,001 (GRCm39)	missense	probably damaging	1.00
R9367:Csmd3	UTSW	15	47,567,564 (GRCm39)	missense
R9405:Csmd3	UTSW	15	47,539,187 (GRCm39)	missense
R9448:Csmd3	UTSW	15	47,460,315 (GRCm39)	missense
R9460:Csmd3	UTSW	15	47,617,130 (GRCm39)	missense
R9481:Csmd3	UTSW	15	47,470,459 (GRCm39)	missense
R9520:Csmd3	UTSW	15	47,561,608 (GRCm39)	missense
R9551:Csmd3	UTSW	15	48,655,356 (GRCm39)	start gained	probably benign
R9552:Csmd3	UTSW	15	48,655,356 (GRCm39)	start gained	probably benign
R9568:Csmd3	UTSW	15	48,150,942 (GRCm39)	missense	probably damaging	0.97
R9571:Csmd3	UTSW	15	48,655,398 (GRCm39)	start gained	probably benign
R9607:Csmd3	UTSW	15	47,618,811 (GRCm39)	missense	probably damaging	0.98
R9621:Csmd3	UTSW	15	47,713,116 (GRCm39)	missense
R9671:Csmd3	UTSW	15	47,845,299 (GRCm39)	missense
R9718:Csmd3	UTSW	15	47,560,083 (GRCm39)	missense
U24488:Csmd3	UTSW	15	47,573,795 (GRCm39)	missense	probably damaging	1.00
V8831:Csmd3	UTSW	15	48,321,092 (GRCm39)	missense	probably damaging	0.96
X0021:Csmd3	UTSW	15	47,833,489 (GRCm39)	nonsense	probably null
Z1088:Csmd3	UTSW	15	47,710,677 (GRCm39)	missense	probably damaging	0.98
Z1088:Csmd3	UTSW	15	47,499,789 (GRCm39)	missense	probably damaging	1.00
Z1177:Csmd3	UTSW	15	47,596,813 (GRCm39)	missense
Z1177:Csmd3	UTSW	15	47,539,130 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- AGGGCTTCGAATTCTTGAAATC -3'
(R):5'- CAAGGTGTTTCACTGCTAAATTTGG -3'

Sequencing Primer
(F):5'- GGGCTTCGAATTCTTGAAATCATCAG -3'
(R):5'- GTGTTTCACTGCTAAATTTGGAGAAG -3'

Posted On

2018-02-27