Incidental Mutation 'IGL01154:Tram1'
ID 50368
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tram1
Ensembl Gene ENSMUSG00000025935
Gene Name translocating chain-associating membrane protein 1
Synonyms TRAMP, 1810049E02Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.578) question?
Stock # IGL01154
Quality Score
Chromosome 1
Chromosomal Location 13634922-13660134 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 13649673 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000027068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027068] [ENSMUST00000188377]
AlphaFold Q91V04
Predicted Effect probably null
Transcript: ENSMUST00000027068
SMART Domains Protein: ENSMUSP00000027068
Gene: ENSMUSG00000025935

Pfam:TRAM1 47 115 6.1e-24 PFAM
TLC 117 326 2.36e-54 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185447
Predicted Effect probably benign
Transcript: ENSMUST00000188377
SMART Domains Protein: ENSMUSP00000140499
Gene: ENSMUSG00000025935

Blast:TLC 9 58 5e-24 BLAST
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a multi-pass transmembrane protein of the endoplasmic reticulum (ER). It is involved in the process of cotranslational translocation of secretory proteins into the ER. [provided by RefSeq, Dec 2014]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
2210408I21Rik T G 13: 77,429,213 (GRCm39) F767V probably benign Het
A2m C A 6: 121,650,501 (GRCm39) S1203* probably null Het
Abcc3 T C 11: 94,250,058 (GRCm39) probably benign Het
Adamts13 T C 2: 26,896,206 (GRCm39) Y1200H probably benign Het
Aldh1l2 T C 10: 83,356,237 (GRCm39) D51G probably damaging Het
Apc2 A G 10: 80,148,903 (GRCm39) E1319G possibly damaging Het
Arap3 A T 18: 38,129,787 (GRCm39) S125T probably benign Het
Atp2b1 T A 10: 98,832,750 (GRCm39) V417E probably damaging Het
Bpifa1 T A 2: 153,985,920 (GRCm39) D78E probably benign Het
Catsperb C A 12: 101,591,940 (GRCm39) A1090E possibly damaging Het
Ceacam9 C A 7: 16,457,886 (GRCm39) T138K probably damaging Het
Cenpf T A 1: 189,412,530 (GRCm39) E244D probably benign Het
Cep135 A T 5: 76,754,643 (GRCm39) probably benign Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Col15a1 A C 4: 47,208,450 (GRCm39) T6P possibly damaging Het
Cyp11b1 T A 15: 74,710,383 (GRCm39) Q306L probably benign Het
Defa22 T A 8: 21,653,053 (GRCm39) probably null Het
Dnah5 A T 15: 28,458,802 (GRCm39) T4480S possibly damaging Het
Fastkd1 T C 2: 69,520,404 (GRCm39) probably null Het
Flt1 A G 5: 147,512,966 (GRCm39) Y1124H possibly damaging Het
Fsd1l A G 4: 53,701,074 (GRCm39) M469V probably benign Het
Fxr2 T C 11: 69,532,259 (GRCm39) probably benign Het
Gm10801 A T 2: 98,494,328 (GRCm39) Y135F probably benign Het
Grm4 A T 17: 27,653,711 (GRCm39) C699* probably null Het
Hcn4 A G 9: 58,766,362 (GRCm39) T677A unknown Het
Igkv9-123 G T 6: 67,931,518 (GRCm39) probably benign Het
Irf4 T A 13: 30,941,404 (GRCm39) H253Q possibly damaging Het
Jakmip2 T C 18: 43,723,744 (GRCm39) probably benign Het
Kmt2c A G 5: 25,489,397 (GRCm39) V1134A probably damaging Het
Limch1 G T 5: 66,903,301 (GRCm39) E17* probably null Het
Nap1l1 T A 10: 111,322,536 (GRCm39) N72K probably damaging Het
Or4x11 T C 2: 89,867,812 (GRCm39) L183P probably damaging Het
Or51t4 T C 7: 102,598,046 (GRCm39) S115P probably damaging Het
Otud6b A T 4: 14,811,732 (GRCm39) Y304N probably damaging Het
Pdcd10 A C 3: 75,448,540 (GRCm39) M8R probably damaging Het
Ppip5k1 T C 2: 121,173,660 (GRCm39) T404A probably damaging Het
Ppp2r2d C T 7: 138,483,940 (GRCm39) A197V probably benign Het
Psg25 C T 7: 18,258,624 (GRCm39) D351N probably benign Het
Sbno1 A T 5: 124,548,312 (GRCm39) I87N probably damaging Het
Stfa2l1 C T 16: 35,980,307 (GRCm39) probably benign Het
Sugp2 T A 8: 70,695,349 (GRCm39) D107E probably damaging Het
Syne1 G T 10: 5,310,848 (GRCm39) F576L probably damaging Het
Syne3 A G 12: 104,924,328 (GRCm39) F357S probably benign Het
Tenm2 A G 11: 35,932,371 (GRCm39) L1741P probably damaging Het
Tgs1 A T 4: 3,585,473 (GRCm39) K117* probably null Het
Trank1 T A 9: 111,215,468 (GRCm39) D1799E probably benign Het
Ttc14 A T 3: 33,857,248 (GRCm39) Y198F probably benign Het
Ube3b A G 5: 114,544,313 (GRCm39) N570S probably null Het
Ube4b A G 4: 149,449,927 (GRCm39) F412S probably benign Het
Vac14 T C 8: 111,380,239 (GRCm39) probably benign Het
Vmn2r65 T C 7: 84,592,729 (GRCm39) T493A probably benign Het
Zfp408 T C 2: 91,478,351 (GRCm39) probably benign Het
Zfp580 C T 7: 5,056,267 (GRCm39) T209I possibly damaging Het
Other mutations in Tram1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03071:Tram1 APN 1 13,649,998 (GRCm39) nonsense probably null
IGL03123:Tram1 APN 1 13,659,829 (GRCm39) missense probably benign 0.01
R0764:Tram1 UTSW 1 13,649,933 (GRCm39) missense probably damaging 1.00
R1229:Tram1 UTSW 1 13,639,776 (GRCm39) missense probably damaging 0.98
R1775:Tram1 UTSW 1 13,646,680 (GRCm39) unclassified probably benign
R3877:Tram1 UTSW 1 13,639,827 (GRCm39) missense probably benign 0.01
R4077:Tram1 UTSW 1 13,636,599 (GRCm39) missense probably benign
R4747:Tram1 UTSW 1 13,659,870 (GRCm39) missense probably damaging 1.00
R5197:Tram1 UTSW 1 13,642,126 (GRCm39) missense probably benign 0.19
R5213:Tram1 UTSW 1 13,649,966 (GRCm39) missense probably damaging 1.00
R5224:Tram1 UTSW 1 13,648,349 (GRCm39) missense probably benign 0.10
R7362:Tram1 UTSW 1 13,659,832 (GRCm39) missense probably benign 0.04
R7587:Tram1 UTSW 1 13,649,771 (GRCm39) missense probably damaging 0.99
R7671:Tram1 UTSW 1 13,659,868 (GRCm39) missense probably damaging 0.96
R7988:Tram1 UTSW 1 13,640,199 (GRCm39) missense probably benign 0.04
R9047:Tram1 UTSW 1 13,639,830 (GRCm39) missense probably benign
R9749:Tram1 UTSW 1 13,640,238 (GRCm39) missense possibly damaging 0.95
RF015:Tram1 UTSW 1 13,649,966 (GRCm39) missense probably damaging 1.00
Posted On 2013-06-21