Incidental Mutation 'R6216:Vmn2r101'
| ID |
503748 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r101
|
| Ensembl Gene |
ENSMUSG00000094892 |
| Gene Name |
vomeronasal 2, receptor 101 |
| Synonyms |
EG627576 |
| MMRRC Submission |
044349-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.102)
|
| Stock # |
R6216 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19797493-19832579 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 19811267 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Arginine
at position 450
(S450R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131583
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171914]
|
| AlphaFold |
E9PZS9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171914
AA Change: S450R
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892
AA Change: S450R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
466 |
1.6e-36 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
6.4e-22 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.5%
|
| Validation Efficiency |
97% (67/69) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017B05Rik |
T |
C |
9: 57,164,910 (GRCm39) |
D488G |
probably benign |
Het |
| Adgrv1 |
C |
A |
13: 81,672,590 (GRCm39) |
|
probably null |
Het |
| Afg3l2 |
G |
T |
18: 67,554,329 (GRCm39) |
L458M |
probably damaging |
Het |
| Alkbh3 |
G |
A |
2: 93,838,881 (GRCm39) |
|
probably benign |
Het |
| Ankrd22 |
A |
T |
19: 34,101,569 (GRCm39) |
|
probably null |
Het |
| Anks1b |
A |
G |
10: 90,096,618 (GRCm39) |
D425G |
probably damaging |
Het |
| Arid2 |
A |
G |
15: 96,254,790 (GRCm39) |
D212G |
probably benign |
Het |
| Bbx |
A |
T |
16: 50,071,751 (GRCm39) |
S225T |
probably benign |
Het |
| Bivm |
T |
A |
1: 44,166,028 (GRCm39) |
|
probably null |
Het |
| Bpifb3 |
A |
G |
2: 153,767,773 (GRCm39) |
Y282C |
probably benign |
Het |
| Cacna1h |
A |
T |
17: 25,597,793 (GRCm39) |
I1767N |
probably damaging |
Het |
| Ccdc28a |
G |
T |
10: 18,100,719 (GRCm39) |
S36* |
probably null |
Het |
| Ccser2 |
A |
G |
14: 36,662,465 (GRCm39) |
S240P |
probably damaging |
Het |
| Ceacam1 |
A |
T |
7: 25,171,421 (GRCm39) |
S348T |
probably benign |
Het |
| Ddx49 |
C |
T |
8: 70,749,934 (GRCm39) |
G161D |
probably damaging |
Het |
| Dhx16 |
A |
G |
17: 36,193,864 (GRCm39) |
E353G |
possibly damaging |
Het |
| Dnaaf6rt |
A |
T |
1: 31,262,432 (GRCm39) |
D138V |
probably damaging |
Het |
| Etv2 |
A |
G |
7: 30,334,036 (GRCm39) |
|
probably null |
Het |
| Extl1 |
T |
C |
4: 134,090,441 (GRCm39) |
T345A |
probably benign |
Het |
| Fam163a |
A |
T |
1: 155,954,741 (GRCm39) |
S137T |
probably benign |
Het |
| Fermt2 |
A |
T |
14: 45,697,338 (GRCm39) |
M671K |
possibly damaging |
Het |
| Fsd1l |
T |
C |
4: 53,694,742 (GRCm39) |
C388R |
probably damaging |
Het |
| Galnt18 |
A |
C |
7: 111,112,757 (GRCm39) |
V470G |
probably benign |
Het |
| Grin2b |
T |
A |
6: 135,749,397 (GRCm39) |
I602F |
probably damaging |
Het |
| Gucy1b1 |
G |
T |
3: 81,954,020 (GRCm39) |
|
probably null |
Het |
| Hace1 |
T |
C |
10: 45,494,643 (GRCm39) |
V151A |
probably benign |
Het |
| Hadhb |
T |
A |
5: 30,379,929 (GRCm39) |
D258E |
probably benign |
Het |
| Heatr1 |
C |
T |
13: 12,447,545 (GRCm39) |
T1746I |
probably benign |
Het |
| Hrnr |
T |
C |
3: 93,239,469 (GRCm39) |
S3236P |
unknown |
Het |
| Kcnd1 |
G |
C |
X: 7,690,148 (GRCm39) |
A23P |
probably damaging |
Homo |
| Kiz |
C |
A |
2: 146,731,417 (GRCm39) |
D302E |
probably damaging |
Het |
| Kng2 |
A |
T |
16: 22,806,343 (GRCm39) |
W619R |
probably damaging |
Het |
| Mfap3l |
C |
A |
8: 61,124,841 (GRCm39) |
T361K |
probably damaging |
Het |
| Mlec |
T |
C |
5: 115,288,376 (GRCm39) |
H160R |
probably benign |
Het |
| Myo16 |
T |
C |
8: 10,365,494 (GRCm39) |
L89P |
probably benign |
Het |
| Neb |
T |
C |
2: 52,114,564 (GRCm39) |
I4232V |
probably benign |
Het |
| Nf1 |
A |
G |
11: 79,302,433 (GRCm39) |
I334V |
possibly damaging |
Het |
| Nipbl |
A |
C |
15: 8,347,867 (GRCm39) |
F1942V |
probably damaging |
Het |
| Or2ag17 |
A |
T |
7: 106,389,665 (GRCm39) |
I181N |
probably benign |
Het |
| Or4a70 |
C |
A |
2: 89,324,066 (GRCm39) |
V197F |
probably damaging |
Het |
| Or4c11c |
T |
C |
2: 88,661,655 (GRCm39) |
S65P |
probably damaging |
Het |
| Or51a10 |
A |
G |
7: 103,698,902 (GRCm39) |
Y220H |
probably damaging |
Het |
| Pabpc2 |
G |
T |
18: 39,907,772 (GRCm39) |
A346S |
probably damaging |
Het |
| Paxip1 |
T |
C |
5: 27,971,171 (GRCm39) |
T393A |
unknown |
Het |
| Pcdhgb5 |
A |
T |
18: 37,864,981 (GRCm39) |
T259S |
probably benign |
Het |
| Pfkp |
A |
T |
13: 6,669,224 (GRCm39) |
L253H |
probably benign |
Het |
| Piezo1 |
T |
C |
8: 123,215,869 (GRCm39) |
D1428G |
probably benign |
Het |
| Pkd1l2 |
T |
G |
8: 117,808,209 (GRCm39) |
D105A |
probably damaging |
Het |
| Pou2f1 |
G |
T |
1: 165,707,889 (GRCm39) |
|
probably benign |
Het |
| Ppfia4 |
T |
C |
1: 134,256,921 (GRCm39) |
E100G |
probably damaging |
Het |
| Ppp1r15a |
G |
T |
7: 45,173,446 (GRCm39) |
T454K |
probably damaging |
Het |
| Prpsap1 |
A |
T |
11: 116,362,239 (GRCm39) |
I381N |
probably damaging |
Het |
| Ptx3 |
T |
A |
3: 66,132,265 (GRCm39) |
V262E |
probably damaging |
Het |
| Rab21 |
A |
T |
10: 115,130,831 (GRCm39) |
H158Q |
probably benign |
Het |
| Rasa2 |
A |
G |
9: 96,426,357 (GRCm39) |
S830P |
probably damaging |
Het |
| Rdh1 |
G |
A |
10: 127,600,622 (GRCm39) |
S215N |
probably benign |
Het |
| Rhot1 |
G |
A |
11: 80,141,885 (GRCm39) |
R463H |
probably benign |
Het |
| Rsf1 |
CG |
CGACGGCGGGG |
7: 97,229,115 (GRCm39) |
|
probably benign |
Het |
| Sart3 |
C |
T |
5: 113,881,267 (GRCm39) |
A938T |
probably benign |
Het |
| Selenom |
A |
T |
11: 3,464,915 (GRCm39) |
|
probably benign |
Het |
| Selenop |
T |
C |
15: 3,308,947 (GRCm39) |
C300R |
probably damaging |
Het |
| Skint1 |
T |
A |
4: 111,878,679 (GRCm39) |
S204T |
probably benign |
Het |
| Ss18l1 |
A |
G |
2: 179,703,706 (GRCm39) |
N313S |
unknown |
Het |
| Sycp2l |
A |
G |
13: 41,295,200 (GRCm39) |
D289G |
probably damaging |
Het |
| Terf1 |
C |
T |
1: 15,889,221 (GRCm39) |
H188Y |
probably benign |
Het |
| Tmem116 |
C |
T |
5: 121,629,171 (GRCm39) |
T188M |
probably benign |
Het |
| Trdn |
A |
G |
10: 33,181,065 (GRCm39) |
T357A |
probably damaging |
Het |
| Trip11 |
A |
C |
12: 101,856,859 (GRCm39) |
M401R |
probably benign |
Het |
| Ubald2 |
A |
C |
11: 116,325,211 (GRCm39) |
D26A |
probably benign |
Het |
| Ube2w |
C |
G |
1: 16,689,508 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Vmn2r101 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01121:Vmn2r101
|
APN |
17 |
19,809,936 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02125:Vmn2r101
|
APN |
17 |
19,809,963 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02300:Vmn2r101
|
APN |
17 |
19,832,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02682:Vmn2r101
|
APN |
17 |
19,832,507 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02825:Vmn2r101
|
APN |
17 |
19,810,132 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02862:Vmn2r101
|
APN |
17 |
19,831,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02943:Vmn2r101
|
APN |
17 |
19,831,666 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0371:Vmn2r101
|
UTSW |
17 |
19,810,394 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0462:Vmn2r101
|
UTSW |
17 |
19,810,431 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0492:Vmn2r101
|
UTSW |
17 |
19,809,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0654:Vmn2r101
|
UTSW |
17 |
19,810,373 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1120:Vmn2r101
|
UTSW |
17 |
19,797,723 (GRCm39) |
splice site |
probably benign |
|
|
R1323:Vmn2r101
|
UTSW |
17 |
19,832,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1323:Vmn2r101
|
UTSW |
17 |
19,832,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1676:Vmn2r101
|
UTSW |
17 |
19,832,184 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2023:Vmn2r101
|
UTSW |
17 |
19,810,368 (GRCm39) |
nonsense |
probably null |
|
|
R2149:Vmn2r101
|
UTSW |
17 |
19,809,225 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2350:Vmn2r101
|
UTSW |
17 |
19,810,045 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2760:Vmn2r101
|
UTSW |
17 |
19,809,901 (GRCm39) |
missense |
probably benign |
0.14 |
|
R3085:Vmn2r101
|
UTSW |
17 |
19,809,077 (GRCm39) |
splice site |
probably null |
|
|
R3086:Vmn2r101
|
UTSW |
17 |
19,809,077 (GRCm39) |
splice site |
probably null |
|
|
R3719:Vmn2r101
|
UTSW |
17 |
19,809,811 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R3771:Vmn2r101
|
UTSW |
17 |
19,809,919 (GRCm39) |
missense |
probably benign |
|
|
R3773:Vmn2r101
|
UTSW |
17 |
19,809,919 (GRCm39) |
missense |
probably benign |
|
|
R4225:Vmn2r101
|
UTSW |
17 |
19,831,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4248:Vmn2r101
|
UTSW |
17 |
19,809,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4290:Vmn2r101
|
UTSW |
17 |
19,832,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4291:Vmn2r101
|
UTSW |
17 |
19,832,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4293:Vmn2r101
|
UTSW |
17 |
19,832,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4307:Vmn2r101
|
UTSW |
17 |
19,810,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4721:Vmn2r101
|
UTSW |
17 |
19,832,287 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4829:Vmn2r101
|
UTSW |
17 |
19,832,229 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5022:Vmn2r101
|
UTSW |
17 |
19,831,649 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5110:Vmn2r101
|
UTSW |
17 |
19,831,897 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5244:Vmn2r101
|
UTSW |
17 |
19,831,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5397:Vmn2r101
|
UTSW |
17 |
19,809,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5875:Vmn2r101
|
UTSW |
17 |
19,809,092 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5944:Vmn2r101
|
UTSW |
17 |
19,809,769 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6334:Vmn2r101
|
UTSW |
17 |
19,810,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6512:Vmn2r101
|
UTSW |
17 |
19,809,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6607:Vmn2r101
|
UTSW |
17 |
19,832,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6965:Vmn2r101
|
UTSW |
17 |
19,811,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7101:Vmn2r101
|
UTSW |
17 |
19,809,350 (GRCm39) |
missense |
probably null |
0.14 |
|
R7183:Vmn2r101
|
UTSW |
17 |
19,832,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7344:Vmn2r101
|
UTSW |
17 |
19,832,059 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7375:Vmn2r101
|
UTSW |
17 |
19,831,652 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7574:Vmn2r101
|
UTSW |
17 |
19,831,899 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7575:Vmn2r101
|
UTSW |
17 |
19,831,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7592:Vmn2r101
|
UTSW |
17 |
19,811,443 (GRCm39) |
splice site |
probably null |
|
|
R7626:Vmn2r101
|
UTSW |
17 |
19,832,192 (GRCm39) |
nonsense |
probably null |
|
|
R7715:Vmn2r101
|
UTSW |
17 |
19,832,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7730:Vmn2r101
|
UTSW |
17 |
19,831,950 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8078:Vmn2r101
|
UTSW |
17 |
19,810,507 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8228:Vmn2r101
|
UTSW |
17 |
19,811,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8283:Vmn2r101
|
UTSW |
17 |
19,832,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8712:Vmn2r101
|
UTSW |
17 |
19,811,397 (GRCm39) |
missense |
probably benign |
0.24 |
|
R8765:Vmn2r101
|
UTSW |
17 |
19,809,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9091:Vmn2r101
|
UTSW |
17 |
19,810,244 (GRCm39) |
missense |
probably benign |
|
|
R9092:Vmn2r101
|
UTSW |
17 |
19,809,807 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9113:Vmn2r101
|
UTSW |
17 |
19,811,288 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9158:Vmn2r101
|
UTSW |
17 |
19,809,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9168:Vmn2r101
|
UTSW |
17 |
19,809,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9235:Vmn2r101
|
UTSW |
17 |
19,810,238 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9270:Vmn2r101
|
UTSW |
17 |
19,810,244 (GRCm39) |
missense |
probably benign |
|
|
R9290:Vmn2r101
|
UTSW |
17 |
19,811,395 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9296:Vmn2r101
|
UTSW |
17 |
19,810,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9602:Vmn2r101
|
UTSW |
17 |
19,831,780 (GRCm39) |
nonsense |
probably null |
|
|
R9706:Vmn2r101
|
UTSW |
17 |
19,809,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r101
|
UTSW |
17 |
19,809,237 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAAGCTTGGCTCTCAGTTTTCACTG -3'
(R):5'- CCACCTCTGAAAATGTTTCTGGC -3'
Sequencing Primer
(F):5'- TCGAACACTTAGGTTTTTACTTAGTC -3'
(R):5'- ACCTCTGAAAATGTTTCTGGCCATTG -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation