Incidental Mutation 'R6217:Vmn2r106'
| ID |
503807 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r106
|
| Ensembl Gene |
ENSMUSG00000091656 |
| Gene Name |
vomeronasal 2, receptor 106 |
| Synonyms |
EG224576 |
| MMRRC Submission |
044350-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.163)
|
| Stock # |
R6217 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20487809-20505692 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 20488501 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 633
(T633A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126534
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167464]
|
| AlphaFold |
E9PY92 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167464
AA Change: T633A
PolyPhen 2
Score 0.105 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: T633A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
471 |
3.8e-37 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.7e-22 |
PFAM |
|
Pfam:7tm_3
|
596 |
835 |
1.3e-49 |
PFAM |
|
| Meta Mutation Damage Score |
0.0846 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 98.2%
|
| Validation Efficiency |
97% (59/61) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abraxas2 |
G |
A |
7: 132,476,694 (GRCm39) |
A145T |
probably damaging |
Het |
| Adamts20 |
T |
C |
15: 94,236,596 (GRCm39) |
D808G |
probably benign |
Het |
| Ankdd1a |
C |
T |
9: 65,415,343 (GRCm39) |
A227T |
possibly damaging |
Het |
| Arsk |
T |
A |
13: 76,239,935 (GRCm39) |
Q46L |
unknown |
Het |
| Asnsd1 |
A |
G |
1: 53,387,187 (GRCm39) |
F147L |
probably benign |
Het |
| Atp5f1a |
T |
A |
18: 77,869,056 (GRCm39) |
S427T |
probably benign |
Het |
| Atp6v1b2 |
A |
C |
8: 69,562,530 (GRCm39) |
|
probably null |
Het |
| AU021092 |
T |
A |
16: 5,030,050 (GRCm39) |
T322S |
possibly damaging |
Het |
| Bcl7c |
A |
T |
7: 127,307,698 (GRCm39) |
M1K |
probably null |
Het |
| Cacna1i |
T |
C |
15: 80,273,333 (GRCm39) |
V1673A |
probably damaging |
Het |
| Ccdc146 |
A |
T |
5: 21,522,900 (GRCm39) |
|
probably null |
Het |
| Cdc7 |
A |
G |
5: 107,120,660 (GRCm39) |
D122G |
probably damaging |
Het |
| Cfap46 |
CCTTCTTCT |
CCTTCT |
7: 139,218,816 (GRCm39) |
|
probably benign |
Het |
| Chd3 |
T |
A |
11: 69,236,361 (GRCm39) |
Q1950L |
probably damaging |
Het |
| Cutc |
T |
C |
19: 43,748,436 (GRCm39) |
L111S |
probably damaging |
Het |
| Cyp2j6 |
A |
G |
4: 96,406,398 (GRCm39) |
F458L |
probably damaging |
Het |
| Ddhd1 |
T |
C |
14: 45,856,971 (GRCm39) |
|
probably null |
Het |
| Dstyk |
T |
C |
1: 132,387,677 (GRCm39) |
S804P |
probably damaging |
Het |
| Ech1 |
A |
G |
7: 28,531,261 (GRCm39) |
D283G |
possibly damaging |
Het |
| Exosc10 |
A |
G |
4: 148,666,768 (GRCm39) |
|
probably null |
Het |
| Fancg |
A |
C |
4: 43,010,084 (GRCm39) |
V5G |
probably benign |
Het |
| Fbxo11 |
A |
G |
17: 88,316,332 (GRCm39) |
V394A |
probably benign |
Het |
| Fcmr |
C |
T |
1: 130,806,060 (GRCm39) |
R339W |
probably damaging |
Het |
| Fhip2b |
T |
C |
14: 70,829,198 (GRCm39) |
|
probably null |
Het |
| Fsip2 |
T |
A |
2: 82,818,762 (GRCm39) |
L4832M |
possibly damaging |
Het |
| Gab1 |
A |
G |
8: 81,518,237 (GRCm39) |
V125A |
possibly damaging |
Het |
| Gabrr1 |
A |
T |
4: 33,149,026 (GRCm39) |
|
probably null |
Het |
| Gon4l |
T |
C |
3: 88,799,968 (GRCm39) |
V871A |
possibly damaging |
Het |
| Hspg2 |
A |
G |
4: 137,267,559 (GRCm39) |
T2056A |
probably damaging |
Het |
| Lrrc3 |
T |
A |
10: 77,736,843 (GRCm39) |
T198S |
probably benign |
Het |
| Lsamp |
A |
T |
16: 41,954,675 (GRCm39) |
E174V |
possibly damaging |
Het |
| Ltbr |
C |
T |
6: 125,284,417 (GRCm39) |
V342M |
probably damaging |
Het |
| Muc16 |
A |
T |
9: 18,566,742 (GRCm39) |
S1926T |
unknown |
Het |
| Ntn1 |
C |
A |
11: 68,104,158 (GRCm39) |
V497F |
possibly damaging |
Het |
| Or2ag18 |
A |
T |
7: 106,405,279 (GRCm39) |
L130Q |
probably damaging |
Het |
| Or5k17 |
T |
C |
16: 58,746,877 (GRCm39) |
D19G |
probably benign |
Het |
| Or8g22 |
A |
T |
9: 38,958,039 (GRCm39) |
*270R |
probably null |
Het |
| Osmr |
T |
C |
15: 6,853,047 (GRCm39) |
Y615C |
probably damaging |
Het |
| Pcdhgb2 |
T |
C |
18: 37,823,054 (GRCm39) |
V15A |
possibly damaging |
Het |
| Pkd2l2 |
A |
G |
18: 34,547,733 (GRCm39) |
N162S |
probably benign |
Het |
| Ppp1r12a |
G |
A |
10: 108,076,045 (GRCm39) |
|
probably null |
Het |
| Prss59 |
G |
A |
6: 40,903,019 (GRCm39) |
P118S |
possibly damaging |
Het |
| Prtg |
C |
T |
9: 72,812,076 (GRCm39) |
P899S |
probably damaging |
Het |
| Ptprn |
A |
T |
1: 75,224,810 (GRCm39) |
S912R |
probably damaging |
Het |
| Rex2 |
A |
G |
4: 147,141,931 (GRCm39) |
T140A |
possibly damaging |
Het |
| Ryr2 |
T |
G |
13: 11,848,964 (GRCm39) |
D339A |
probably damaging |
Het |
| Sf3b1 |
C |
T |
1: 55,046,677 (GRCm39) |
R289H |
probably damaging |
Het |
| Slc17a9 |
A |
G |
2: 180,379,455 (GRCm39) |
D309G |
probably benign |
Het |
| Slc4a10 |
A |
G |
2: 62,134,295 (GRCm39) |
R1004G |
probably benign |
Het |
| Sprr2f |
A |
T |
3: 92,273,366 (GRCm39) |
Q55L |
unknown |
Het |
| Syne1 |
C |
T |
10: 5,243,761 (GRCm39) |
G2801D |
probably benign |
Het |
| Tenm3 |
A |
T |
8: 48,746,700 (GRCm39) |
V1026D |
probably damaging |
Het |
| Ticam1 |
A |
T |
17: 56,577,730 (GRCm39) |
I455N |
probably damaging |
Het |
| Tmem161b |
A |
G |
13: 84,399,363 (GRCm39) |
I6M |
possibly damaging |
Het |
| Ubn1 |
A |
G |
16: 4,895,096 (GRCm39) |
E714G |
probably damaging |
Het |
| Ush2a |
T |
G |
1: 188,475,651 (GRCm39) |
|
probably null |
Het |
| Usp19 |
G |
A |
9: 108,377,343 (GRCm39) |
V874M |
probably damaging |
Het |
| Vmn2r75 |
A |
T |
7: 85,815,375 (GRCm39) |
|
probably benign |
Het |
| Zfyve27 |
T |
C |
19: 42,178,016 (GRCm39) |
V386A |
probably damaging |
Het |
| Zscan20 |
A |
T |
4: 128,498,327 (GRCm39) |
W24R |
probably damaging |
Het |
|
| Other mutations in Vmn2r106 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00979:Vmn2r106
|
APN |
17 |
20,497,837 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01313:Vmn2r106
|
APN |
17 |
20,498,651 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01419:Vmn2r106
|
APN |
17 |
20,499,807 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01574:Vmn2r106
|
APN |
17 |
20,488,572 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01796:Vmn2r106
|
APN |
17 |
20,488,314 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01893:Vmn2r106
|
APN |
17 |
20,497,730 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01895:Vmn2r106
|
APN |
17 |
20,499,227 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02378:Vmn2r106
|
APN |
17 |
20,497,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02430:Vmn2r106
|
APN |
17 |
20,499,158 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02664:Vmn2r106
|
APN |
17 |
20,488,344 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03308:Vmn2r106
|
APN |
17 |
20,498,785 (GRCm39) |
nonsense |
probably null |
|
|
IGL03384:Vmn2r106
|
APN |
17 |
20,488,405 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0401:Vmn2r106
|
UTSW |
17 |
20,499,281 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0842:Vmn2r106
|
UTSW |
17 |
20,488,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0964:Vmn2r106
|
UTSW |
17 |
20,487,859 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1235:Vmn2r106
|
UTSW |
17 |
20,499,741 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1709:Vmn2r106
|
UTSW |
17 |
20,499,373 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1712:Vmn2r106
|
UTSW |
17 |
20,498,997 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1770:Vmn2r106
|
UTSW |
17 |
20,488,560 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2049:Vmn2r106
|
UTSW |
17 |
20,488,566 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2245:Vmn2r106
|
UTSW |
17 |
20,488,423 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2336:Vmn2r106
|
UTSW |
17 |
20,488,470 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2910:Vmn2r106
|
UTSW |
17 |
20,498,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3025:Vmn2r106
|
UTSW |
17 |
20,499,147 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3944:Vmn2r106
|
UTSW |
17 |
20,487,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4081:Vmn2r106
|
UTSW |
17 |
20,487,818 (GRCm39) |
nonsense |
probably null |
|
|
R4153:Vmn2r106
|
UTSW |
17 |
20,488,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4356:Vmn2r106
|
UTSW |
17 |
20,499,910 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4426:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4590:Vmn2r106
|
UTSW |
17 |
20,497,728 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4661:Vmn2r106
|
UTSW |
17 |
20,487,885 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5106:Vmn2r106
|
UTSW |
17 |
20,499,395 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5341:Vmn2r106
|
UTSW |
17 |
20,497,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5509:Vmn2r106
|
UTSW |
17 |
20,498,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5826:Vmn2r106
|
UTSW |
17 |
20,499,133 (GRCm39) |
missense |
probably benign |
|
|
R5859:Vmn2r106
|
UTSW |
17 |
20,505,583 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5937:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
nonsense |
probably null |
|
|
R5972:Vmn2r106
|
UTSW |
17 |
20,498,738 (GRCm39) |
missense |
probably benign |
|
|
R6056:Vmn2r106
|
UTSW |
17 |
20,487,806 (GRCm39) |
splice site |
probably null |
|
|
R6108:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6114:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6115:Vmn2r106
|
UTSW |
17 |
20,488,638 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6132:Vmn2r106
|
UTSW |
17 |
20,488,666 (GRCm39) |
missense |
probably benign |
|
|
R6208:Vmn2r106
|
UTSW |
17 |
20,488,591 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6289:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Vmn2r106
|
UTSW |
17 |
20,498,667 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6390:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6391:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6392:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6405:Vmn2r106
|
UTSW |
17 |
20,499,361 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6427:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6435:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6436:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6437:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6511:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6512:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6587:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6703:Vmn2r106
|
UTSW |
17 |
20,488,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6730:Vmn2r106
|
UTSW |
17 |
20,499,096 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6961:Vmn2r106
|
UTSW |
17 |
20,488,646 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Vmn2r106
|
UTSW |
17 |
20,499,182 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7379:Vmn2r106
|
UTSW |
17 |
20,488,037 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7402:Vmn2r106
|
UTSW |
17 |
20,487,883 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7497:Vmn2r106
|
UTSW |
17 |
20,488,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7692:Vmn2r106
|
UTSW |
17 |
20,505,490 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8539:Vmn2r106
|
UTSW |
17 |
20,499,271 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8827:Vmn2r106
|
UTSW |
17 |
20,487,868 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8872:Vmn2r106
|
UTSW |
17 |
20,488,401 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9118:Vmn2r106
|
UTSW |
17 |
20,505,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9254:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9379:Vmn2r106
|
UTSW |
17 |
20,496,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r106
|
UTSW |
17 |
20,505,641 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATTCTCCCTGGAAAAGTGGC -3'
(R):5'- AATGTGTGAAGTGTCCAGAGAGTC -3'
Sequencing Primer
(F):5'- TCCCTGGAAAAGTGGCTCTGAATG -3'
(R):5'- TCACTGCTTCCAGAAAACTGTG -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation