Incidental Mutation 'R6219:Lcn10'
ID 503886
Institutional Source Beutler Lab
Gene Symbol Lcn10
Ensembl Gene ENSMUSG00000047356
Gene Name lipocalin 10
Synonyms 9230112J07Rik
MMRRC Submission 044351-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6219 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 25572738-25576093 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 25573587 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 55 (R55*)
Ref Sequence ENSEMBL: ENSMUSP00000059353 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058912] [ENSMUST00000059693] [ENSMUST00000114197] [ENSMUST00000114199]
AlphaFold Q810Z1
Predicted Effect probably null
Transcript: ENSMUST00000058912
AA Change: R55*
SMART Domains Protein: ENSMUSP00000059353
Gene: ENSMUSG00000047356
AA Change: R55*

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:Lipocalin 36 169 1.6e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000059693
SMART Domains Protein: ENSMUSP00000055660
Gene: ENSMUSG00000045684

DomainStartEndE-ValueType
Pfam:Lipocalin 7 106 1.4e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114197
SMART Domains Protein: ENSMUSP00000109835
Gene: ENSMUSG00000045684

DomainStartEndE-ValueType
Pfam:Lipocalin 7 106 4.8e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114199
SMART Domains Protein: ENSMUSP00000109837
Gene: ENSMUSG00000045684

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:Lipocalin 33 172 2.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139441
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030445D17Rik T C 4: 136,190,059 (GRCm39) S147P unknown Het
Acat2 T C 17: 13,179,604 (GRCm39) probably benign Het
Ano2 A G 6: 125,792,553 (GRCm39) D349G probably damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Ccnf C A 17: 24,445,678 (GRCm39) E523* probably null Het
Ccr10 C T 11: 101,065,375 (GRCm39) A52T possibly damaging Het
Cdc14b C T 13: 64,353,338 (GRCm39) probably benign Het
Cirop G T 14: 54,933,116 (GRCm39) Q356K noncoding transcript Het
Cmya5 T C 13: 93,230,951 (GRCm39) E1379G probably damaging Het
Cyfip1 A G 7: 55,558,189 (GRCm39) D822G possibly damaging Het
Cyp4a29 A C 4: 115,106,927 (GRCm39) T195P probably damaging Het
Dmxl1 A T 18: 50,035,434 (GRCm39) T2283S probably damaging Het
Dnah7b A G 1: 46,272,745 (GRCm39) D2291G probably benign Het
Dock3 T A 9: 106,872,080 (GRCm39) L493F probably damaging Het
Fbxw7 G A 3: 84,876,520 (GRCm39) G227D probably damaging Het
Fmo2 A T 1: 162,708,085 (GRCm39) V350D probably damaging Het
Glis1 C T 4: 107,489,102 (GRCm39) P487S probably benign Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Gm35315 G T 5: 110,226,410 (GRCm39) T343K probably benign Het
Gpr141 A G 13: 19,936,697 (GRCm39) I26T probably benign Het
Hectd4 T G 5: 121,446,941 (GRCm39) V311G possibly damaging Het
Ino80d C T 1: 63,118,206 (GRCm39) E322K possibly damaging Het
Irs2 A G 8: 11,055,121 (GRCm39) S1104P probably damaging Het
Lama1 T C 17: 68,097,851 (GRCm39) F1744L probably benign Het
Lrp2 A T 2: 69,299,822 (GRCm39) C3077S probably damaging Het
Mdc1 T A 17: 36,161,566 (GRCm39) S826R probably benign Het
Nr2c1 G T 10: 93,999,648 (GRCm39) V103L probably benign Het
Nup133 A T 8: 124,663,612 (GRCm39) D310E possibly damaging Het
Or7c70 A G 10: 78,683,093 (GRCm39) S219P possibly damaging Het
Pip5k1b T A 19: 24,359,187 (GRCm39) E112D probably damaging Het
Pira12 A T 7: 3,897,640 (GRCm39) V485E probably damaging Het
Reln T C 5: 22,153,594 (GRCm39) K2237E probably damaging Het
Sirt2 A G 7: 28,466,940 (GRCm39) probably benign Het
Slit2 A T 5: 48,459,770 (GRCm39) H1350L possibly damaging Het
Snx15 A G 19: 6,171,538 (GRCm39) S179P probably damaging Het
Sp8 T G 12: 118,812,402 (GRCm39) S86A probably benign Het
Sptbn5 T C 2: 119,907,803 (GRCm39) probably benign Het
Tfap4 A G 16: 4,365,175 (GRCm39) S196P probably damaging Het
Tgm3 T C 2: 129,880,530 (GRCm39) probably null Het
Tnks2 T C 19: 36,843,604 (GRCm39) probably benign Het
Ttll11 A T 2: 35,642,511 (GRCm39) probably null Het
Vwa3b C A 1: 37,139,779 (GRCm39) Q367K possibly damaging Het
Zdhhc20 A T 14: 58,078,340 (GRCm39) V312E probably damaging Het
Other mutations in Lcn10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02738:Lcn10 APN 2 25,574,032 (GRCm39) unclassified probably benign
R0030:Lcn10 UTSW 2 25,575,093 (GRCm39) missense probably damaging 1.00
R1832:Lcn10 UTSW 2 25,575,151 (GRCm39) missense probably damaging 1.00
R1931:Lcn10 UTSW 2 25,574,347 (GRCm39) missense probably damaging 1.00
R2890:Lcn10 UTSW 2 25,573,642 (GRCm39) missense probably damaging 1.00
R4364:Lcn10 UTSW 2 25,574,052 (GRCm39) missense probably damaging 1.00
R5511:Lcn10 UTSW 2 25,572,841 (GRCm39) missense probably benign 0.00
R8837:Lcn10 UTSW 2 25,575,298 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- CTGGATCCTCTTCATTCTAGTCAGG -3'
(R):5'- GTGGAAGCACCTAACAAGGC -3'

Sequencing Primer
(F):5'- GGGTAGAACTCCCCTGTAGATAC -3'
(R):5'- GGCTACTCTCAGAACTCCACAGTTTC -3'
Posted On 2018-02-27