Incidental Mutation 'R6220:Teddm1b'
ID503927
Institutional Source Beutler Lab
Gene Symbol Teddm1b
Ensembl Gene ENSMUSG00000043282
Gene Nametransmembrane epididymal protein 1B
SynonymsGm5531
MMRRC Submission 044352-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.231) question?
Stock #R6220 (G1)
Quality Score225.009
Status Validated
Chromosome1
Chromosomal Location153874345-153876871 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 153875201 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Stop codon at position 252 (W252*)
Ref Sequence ENSEMBL: ENSMUSP00000058437 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055314] [ENSMUST00000123490]
Predicted Effect probably null
Transcript: ENSMUST00000055314
AA Change: W252*
SMART Domains Protein: ENSMUSP00000058437
Gene: ENSMUSG00000043282
AA Change: W252*

DomainStartEndE-ValueType
transmembrane domain 10 32 N/A INTRINSIC
transmembrane domain 53 75 N/A INTRINSIC
transmembrane domain 99 121 N/A INTRINSIC
Pfam:DUF716 127 247 3.6e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000123490
SMART Domains Protein: ENSMUSP00000115023
Gene: ENSMUSG00000045968

DomainStartEndE-ValueType
Pfam:DUF716 71 195 6.1e-36 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency 100% (65/65)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130011E15Rik T C 19: 45,846,115 E618G possibly damaging Het
Abhd16b A G 2: 181,493,785 D160G probably damaging Het
Acap1 A G 11: 69,889,679 F15S probably damaging Het
Adam30 A T 3: 98,161,309 S153C probably damaging Het
Afp A T 5: 90,504,410 D420V possibly damaging Het
Ak9 T A 10: 41,370,099 H729Q unknown Het
Arsi G A 18: 60,916,651 G202E probably benign Het
Bcr A G 10: 75,062,292 T423A probably benign Het
Cc2d1b C T 4: 108,633,225 R825W probably damaging Het
Ctns T C 11: 73,193,128 T23A probably benign Het
Ddx54 T A 5: 120,620,689 N332K probably benign Het
Dysf T A 6: 84,149,745 I1344N probably damaging Het
Elovl3 A T 19: 46,134,500 M172L probably benign Het
Fbxo6 A T 4: 148,149,522 I39N probably damaging Het
Filip1l T A 16: 57,569,989 N313K probably benign Het
Foxp2 C A 6: 15,437,948 T716K probably damaging Het
Gm10549 C A 18: 33,464,305 probably benign Het
Gm10645 A G 8: 83,165,757 probably benign Het
Gm10735 T C 13: 113,041,496 probably benign Het
Gm4847 A T 1: 166,634,972 D316E probably damaging Het
Gorasp2 T C 2: 70,690,790 L388P probably damaging Het
Heatr5b A G 17: 78,773,677 L1382P probably damaging Het
Herc1 A G 9: 66,433,788 Y1729C probably damaging Het
Ifi207 A T 1: 173,729,546 L542H probably damaging Het
Ighv3-5 T A 12: 114,262,718 N96I probably damaging Het
Isl1 T C 13: 116,303,267 T182A probably benign Het
Jph4 T C 14: 55,110,085 E421G probably benign Het
Lrrc45 T C 11: 120,719,527 I488T probably benign Het
Mroh8 A G 2: 157,233,163 I471T probably benign Het
Ms4a2 A T 19: 11,617,563 D96E probably damaging Het
Mst1r T A 9: 107,907,348 N68K probably benign Het
Myo18b A G 5: 112,757,507 M2075T possibly damaging Het
Neb T C 2: 52,270,972 K2229R probably null Het
Nkx6-3 T A 8: 23,153,971 probably null Het
Nlrp1a C A 11: 71,142,338 S10I probably benign Het
Npas2 A T 1: 39,336,061 T487S probably benign Het
Nrxn1 G C 17: 91,088,476 T84R probably benign Het
Olfr730 C A 14: 50,186,678 D180Y probably damaging Het
Otx1 C A 11: 21,997,037 A91S probably damaging Het
Pcdh18 A G 3: 49,745,251 C921R probably damaging Het
Pcdha9 A G 18: 36,998,478 Y200C probably damaging Het
Pknox1 A T 17: 31,603,203 R315* probably null Het
Rasgrp1 C T 2: 117,284,929 W726* probably null Het
Rassf8 G A 6: 145,817,133 R402H probably damaging Het
Rev3l T A 10: 39,822,779 Y1091N probably damaging Het
Riok3 T G 18: 12,149,551 V349G probably damaging Het
Rps18 A T 17: 33,955,136 V15E probably damaging Het
Rptor A T 11: 119,897,442 Y1323F possibly damaging Het
Rspry1 T C 8: 94,658,750 C437R probably damaging Het
Sema5a T A 15: 32,686,729 Y996N probably damaging Het
Smarcad1 A G 6: 65,114,329 I1011M probably benign Het
Supv3l1 A T 10: 62,439,021 M295K possibly damaging Het
Sv2c T C 13: 95,976,626 D605G probably damaging Het
Tes T A 6: 17,086,196 C29* probably null Het
Thsd4 A G 9: 59,982,747 W856R probably damaging Het
Treml4 A T 17: 48,264,848 D93V possibly damaging Het
Trim66 T C 7: 109,483,093 T218A probably damaging Het
Tssk5 T C 15: 76,373,773 D128G probably damaging Het
Ubr3 T A 2: 70,020,475 W1746R probably damaging Het
Vmn2r11 T C 5: 109,053,568 I357V probably benign Het
Vmn2r87 A T 10: 130,479,938 D86E probably benign Het
Zfp184 T G 13: 21,960,207 H694Q probably damaging Het
Zranb3 A C 1: 127,999,404 F341L probably benign Het
Other mutations in Teddm1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00771:Teddm1b APN 1 153874594 missense possibly damaging 0.65
IGL00909:Teddm1b APN 1 153874645 missense probably damaging 0.99
IGL02601:Teddm1b APN 1 153874616 missense probably damaging 0.99
R0551:Teddm1b UTSW 1 153875344 missense possibly damaging 0.66
R0815:Teddm1b UTSW 1 153874892 missense possibly damaging 0.83
R3441:Teddm1b UTSW 1 153875261 missense probably benign 0.00
R6351:Teddm1b UTSW 1 153874759 missense probably benign 0.01
R6900:Teddm1b UTSW 1 153875210 missense probably benign 0.03
R7135:Teddm1b UTSW 1 153875166 missense probably damaging 1.00
R7171:Teddm1b UTSW 1 153874933 missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGGGCTCCTGAAATGTTTCAC -3'
(R):5'- TGTACCCAGGTTTCTAGGCC -3'

Sequencing Primer
(F):5'- CAGGATGATAGAGACCTTCCTGTTC -3'
(R):5'- AGGTTTCTAGGCCCTGTCACAG -3'
Posted On2018-02-27