Incidental Mutation 'IGL01069:Or5m3'
ID 50410
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5m3
Ensembl Gene ENSMUSG00000042796
Gene Name olfactory receptor family 5 subfamily M member 3
Synonyms Olfr1032, MOR199-1, GA_x6K02T2Q125-47485813-47486745
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # IGL01069
Quality Score
Status
Chromosome 2
Chromosomal Location 85838122-85839054 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85838891 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 257 (Y257C)
Ref Sequence ENSEMBL: ENSMUSP00000107216 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062166] [ENSMUST00000079298] [ENSMUST00000111589]
AlphaFold A2ATE5
Predicted Effect probably damaging
Transcript: ENSMUST00000062166
AA Change: Y257C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000054494
Gene: ENSMUSG00000042796
AA Change: Y257C

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5.6e-50 PFAM
Pfam:7tm_1 39 288 1.1e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000079298
AA Change: Y257C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078279
Gene: ENSMUSG00000042796
AA Change: Y257C

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.3e-50 PFAM
Pfam:7tm_1 39 288 9.9e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111589
AA Change: Y257C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000107216
Gene: ENSMUSG00000042796
AA Change: Y257C

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.4e-50 PFAM
Pfam:7tm_1 39 288 3.5e-21 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
1700123K08Rik C T 5: 138,560,751 (GRCm39) A215T probably benign Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Apc2 G A 10: 80,147,820 (GRCm39) C929Y probably damaging Het
Arap2 T C 5: 62,807,199 (GRCm39) H1156R probably benign Het
Arhgap9 A G 10: 127,164,821 (GRCm39) T582A probably damaging Het
Ccdc57 T A 11: 120,752,085 (GRCm39) H832L probably benign Het
Ces3b T C 8: 105,818,206 (GRCm39) S92P probably benign Het
Ces5a A G 8: 94,252,172 (GRCm39) probably null Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Cpb2 T A 14: 75,508,215 (GRCm39) D225E probably damaging Het
Cpne8 C T 15: 90,499,313 (GRCm39) probably null Het
Cux2 G A 5: 122,005,414 (GRCm39) T924M possibly damaging Het
Dtl T A 1: 191,293,651 (GRCm39) probably null Het
Dysf T A 6: 84,176,767 (GRCm39) I1912N possibly damaging Het
Edc4 T A 8: 106,613,766 (GRCm39) F369I probably benign Het
Fibcd1 T C 2: 31,711,531 (GRCm39) E298G probably benign Het
Focad C A 4: 88,244,383 (GRCm39) H788N unknown Het
Frem1 C T 4: 82,932,104 (GRCm39) R199H probably benign Het
Gadl1 T C 9: 115,783,907 (GRCm39) probably null Het
Hipk1 G A 3: 103,685,015 (GRCm39) T200I possibly damaging Het
Ighv14-2 C T 12: 113,958,379 (GRCm39) V21I possibly damaging Het
Kank4 A T 4: 98,666,632 (GRCm39) I605N probably damaging Het
Krt88 T G 15: 101,351,508 (GRCm39) *172G probably null Het
Lmf2 C A 15: 89,237,091 (GRCm39) A408S probably benign Het
Lsm12 T C 11: 102,054,896 (GRCm39) probably benign Het
Myo3b A G 2: 70,075,735 (GRCm39) I580V probably benign Het
Myt1 T C 2: 181,467,749 (GRCm39) M1061T probably damaging Het
Nup133 G A 8: 124,657,721 (GRCm39) R405* probably null Het
Or1ad1 A T 11: 50,875,830 (GRCm39) I101F possibly damaging Het
Or8g2 A T 9: 39,821,902 (GRCm39) M268L possibly damaging Het
Pcnx1 A G 12: 81,964,918 (GRCm39) R362G probably benign Het
Pomt2 G T 12: 87,157,078 (GRCm39) T747K probably damaging Het
Rgma G A 7: 73,067,239 (GRCm39) A165T probably damaging Het
Rhbdf2 T C 11: 116,492,577 (GRCm39) D437G possibly damaging Het
Rpl5 T C 5: 108,055,145 (GRCm39) probably null Het
Rtkn2 A G 10: 67,877,494 (GRCm39) D518G probably benign Het
Sclt1 T C 3: 41,696,426 (GRCm39) probably benign Het
Sidt2 C T 9: 45,854,375 (GRCm39) V616I possibly damaging Het
Ska2 A G 11: 87,000,091 (GRCm39) probably benign Het
Slc13a4 C A 6: 35,245,817 (GRCm39) L609F probably damaging Het
Sorbs3 T C 14: 70,428,604 (GRCm39) E390G probably damaging Het
Syt15 T C 14: 33,946,881 (GRCm39) V220A possibly damaging Het
Tob1 T C 11: 94,104,881 (GRCm39) F139S probably damaging Het
Yars2 C T 16: 16,124,406 (GRCm39) R338* probably null Het
Other mutations in Or5m3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03110:Or5m3 APN 2 85,838,942 (GRCm39) missense probably damaging 0.99
IGL03167:Or5m3 APN 2 85,838,511 (GRCm39) nonsense probably null
R0206:Or5m3 UTSW 2 85,838,636 (GRCm39) missense probably damaging 1.00
R0206:Or5m3 UTSW 2 85,838,636 (GRCm39) missense probably damaging 1.00
R0919:Or5m3 UTSW 2 85,838,984 (GRCm39) missense possibly damaging 0.52
R2018:Or5m3 UTSW 2 85,838,567 (GRCm39) missense probably damaging 1.00
R2019:Or5m3 UTSW 2 85,838,567 (GRCm39) missense probably damaging 1.00
R2938:Or5m3 UTSW 2 85,838,357 (GRCm39) missense probably damaging 0.97
R3843:Or5m3 UTSW 2 85,838,548 (GRCm39) missense probably benign 0.09
R4295:Or5m3 UTSW 2 85,838,614 (GRCm39) missense probably benign 0.01
R5813:Or5m3 UTSW 2 85,838,636 (GRCm39) missense probably damaging 1.00
R6283:Or5m3 UTSW 2 85,838,443 (GRCm39) missense possibly damaging 0.73
R7031:Or5m3 UTSW 2 85,838,939 (GRCm39) missense probably benign 0.26
R7427:Or5m3 UTSW 2 85,838,563 (GRCm39) missense probably benign 0.00
R7428:Or5m3 UTSW 2 85,838,563 (GRCm39) missense probably benign 0.00
R7856:Or5m3 UTSW 2 85,838,640 (GRCm39) missense probably damaging 0.99
R8048:Or5m3 UTSW 2 85,838,524 (GRCm39) missense probably damaging 0.96
R8504:Or5m3 UTSW 2 85,838,149 (GRCm39) missense probably damaging 0.99
R9129:Or5m3 UTSW 2 85,838,356 (GRCm39) missense
R9150:Or5m3 UTSW 2 85,838,626 (GRCm39) nonsense probably null
R9180:Or5m3 UTSW 2 85,838,325 (GRCm39) missense probably damaging 1.00
Posted On 2013-06-21