Incidental Mutation 'R6223:Vmn2r45'
ID 504140
Institutional Source Beutler Lab
Gene Symbol Vmn2r45
Ensembl Gene ENSMUSG00000090662
Gene Name vomeronasal 2, receptor 45
Synonyms
MMRRC Submission 044354-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R6223 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 8474468-8491958 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 8486301 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 329 (V329E)
Ref Sequence ENSEMBL: ENSMUSP00000129466 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164845]
AlphaFold L7N2B5
Predicted Effect probably benign
Transcript: ENSMUST00000164845
AA Change: V329E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: V329E

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 154 469 4.5e-26 PFAM
Pfam:NCD3G 512 565 6.4e-21 PFAM
Pfam:7tm_3 598 833 2.1e-54 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A C 2: 152,269,873 (GRCm39) R8S probably benign Het
Abca8b A G 11: 109,868,672 (GRCm39) V164A probably benign Het
Acadm C A 3: 153,644,186 (GRCm39) probably null Het
Ap3b2 G A 7: 81,123,210 (GRCm39) R435* probably null Het
Art2b A G 7: 101,229,158 (GRCm39) F247S possibly damaging Het
C1rb T A 6: 124,551,539 (GRCm39) D216E probably benign Het
Casz1 C A 4: 149,017,840 (GRCm39) D90E probably damaging Het
Ccdc13 A G 9: 121,627,975 (GRCm39) probably benign Het
Cdc25a C A 9: 109,718,842 (GRCm39) P409T possibly damaging Het
Cidea A C 18: 67,491,809 (GRCm39) K23T possibly damaging Het
Clspn T A 4: 126,479,961 (GRCm39) D1101E probably damaging Het
Col10a1 A T 10: 34,271,183 (GRCm39) D385V probably damaging Het
Crat C T 2: 30,297,042 (GRCm39) V304I probably benign Het
Cyp2d26 A T 15: 82,675,918 (GRCm39) W265R probably benign Het
Dock8 A T 19: 25,138,416 (GRCm39) Y1247F probably benign Het
Dync2i1 T C 12: 116,221,078 (GRCm39) D11G possibly damaging Het
Eed A G 7: 89,605,495 (GRCm39) Y365H probably damaging Het
Fabp5 T A 3: 10,080,170 (GRCm39) F73L probably benign Het
Fbn1 C T 2: 125,254,591 (GRCm39) C224Y possibly damaging Het
Ggcx T C 6: 72,406,588 (GRCm39) F684L probably damaging Het
Glrp1 G A 1: 88,431,164 (GRCm39) Q69* probably null Het
Gm29797 T C 2: 181,300,850 (GRCm39) V115A possibly damaging Het
Gtf3c1 C T 7: 125,275,797 (GRCm39) R543K probably benign Het
Ifih1 T C 2: 62,428,603 (GRCm39) I891V probably benign Het
Ifnar2 C T 16: 91,184,876 (GRCm39) T89M probably damaging Het
Kat6a C A 8: 23,430,442 (GRCm39) N1932K unknown Het
Mgat5 A T 1: 127,310,716 (GRCm39) D210V possibly damaging Het
Mmel1 A G 4: 154,956,159 (GRCm39) probably null Het
Myh3 G T 11: 66,988,843 (GRCm39) V1499L probably benign Het
Ncan A C 8: 70,562,604 (GRCm39) D551E probably benign Het
Nol11 G T 11: 107,062,442 (GRCm39) T598K possibly damaging Het
Olfml3 G A 3: 103,643,776 (GRCm39) R202W probably damaging Het
Or2w4 G A 13: 21,795,536 (GRCm39) T201I probably benign Het
Or4e2 A G 14: 52,688,136 (GRCm39) R89G probably benign Het
Pcdh9 T C 14: 93,253,169 (GRCm39) K1131E probably benign Het
Pcolce A G 5: 137,603,561 (GRCm39) M424T probably damaging Het
Pi16 C A 17: 29,546,413 (GRCm39) S397* probably null Het
Pi4ka A T 16: 17,175,435 (GRCm39) Y464* probably null Het
Pik3c2b T A 1: 132,998,095 (GRCm39) L324M probably damaging Het
Prdm2 T C 4: 142,868,777 (GRCm39) N179S probably benign Het
Prss56 C T 1: 87,113,134 (GRCm39) P183S probably benign Het
Prx T G 7: 27,216,261 (GRCm39) M393R probably damaging Het
Qpctl T C 7: 18,877,134 (GRCm39) D328G probably damaging Het
Qser1 A G 2: 104,617,993 (GRCm39) S940P probably benign Het
Rchy1 G A 5: 92,105,826 (GRCm39) R41W probably damaging Het
Scp2d1 T C 2: 144,665,868 (GRCm39) I69T possibly damaging Het
Sirpb1a A G 3: 15,444,086 (GRCm39) V388A probably benign Het
Ssu2 G T 6: 112,353,409 (GRCm39) C238* probably null Het
Stub1 C T 17: 26,051,787 (GRCm39) G14D probably damaging Het
Tab1 T A 15: 80,032,464 (GRCm39) C24S probably damaging Het
Tdrd1 T C 19: 56,854,282 (GRCm39) V1076A probably damaging Het
Tex10 T C 4: 48,468,525 (GRCm39) R134G probably damaging Het
Tg T A 15: 66,579,771 (GRCm39) N1525K probably benign Het
Tll2 G A 19: 41,124,391 (GRCm39) T208I possibly damaging Het
Tmem232 T C 17: 65,807,191 (GRCm39) M1V probably null Het
Ttc7b A G 12: 100,353,368 (GRCm39) probably null Het
Ubb A G 11: 62,443,351 (GRCm39) E127G possibly damaging Het
Ulk2 A T 11: 61,678,330 (GRCm39) Y796* probably null Het
Vdac2 G A 14: 21,895,246 (GRCm39) G265R possibly damaging Het
Zbtb47 G A 9: 121,592,853 (GRCm39) R391Q possibly damaging Het
Other mutations in Vmn2r45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Vmn2r45 APN 7 8,488,622 (GRCm39) missense probably benign 0.00
IGL01322:Vmn2r45 APN 7 8,484,332 (GRCm39) missense possibly damaging 0.49
IGL01402:Vmn2r45 APN 7 8,484,467 (GRCm39) missense probably damaging 0.98
IGL01404:Vmn2r45 APN 7 8,484,467 (GRCm39) missense probably damaging 0.98
IGL01529:Vmn2r45 APN 7 8,486,493 (GRCm39) missense probably benign
IGL01596:Vmn2r45 APN 7 8,486,272 (GRCm39) missense probably damaging 0.98
IGL01646:Vmn2r45 APN 7 8,486,337 (GRCm39) missense probably benign 0.18
IGL01819:Vmn2r45 APN 7 8,488,556 (GRCm39) missense probably benign 0.00
IGL02096:Vmn2r45 APN 7 8,484,443 (GRCm39) missense probably damaging 0.99
IGL02130:Vmn2r45 APN 7 8,486,556 (GRCm39) missense possibly damaging 0.46
IGL02409:Vmn2r45 APN 7 8,488,727 (GRCm39) missense probably benign 0.03
IGL02517:Vmn2r45 APN 7 8,486,185 (GRCm39) nonsense probably null
IGL02633:Vmn2r45 APN 7 8,488,728 (GRCm39) missense probably benign 0.01
IGL02940:Vmn2r45 APN 7 8,475,369 (GRCm39) missense probably damaging 0.99
IGL03281:Vmn2r45 APN 7 8,486,603 (GRCm39) missense probably damaging 1.00
IGL03358:Vmn2r45 APN 7 8,474,715 (GRCm39) missense probably damaging 1.00
BB004:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
BB014:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
R0382:Vmn2r45 UTSW 7 8,486,098 (GRCm39) missense probably benign 0.06
R0532:Vmn2r45 UTSW 7 8,474,820 (GRCm39) missense probably damaging 0.99
R0932:Vmn2r45 UTSW 7 8,478,380 (GRCm39) missense probably damaging 1.00
R1125:Vmn2r45 UTSW 7 8,488,542 (GRCm39) missense probably benign 0.00
R1580:Vmn2r45 UTSW 7 8,474,746 (GRCm39) missense possibly damaging 0.95
R1817:Vmn2r45 UTSW 7 8,475,372 (GRCm39) missense probably damaging 1.00
R1996:Vmn2r45 UTSW 7 8,475,024 (GRCm39) missense probably damaging 1.00
R2050:Vmn2r45 UTSW 7 8,475,021 (GRCm39) missense probably damaging 1.00
R2284:Vmn2r45 UTSW 7 8,488,765 (GRCm39) missense probably benign 0.02
R4019:Vmn2r45 UTSW 7 8,474,580 (GRCm39) nonsense probably null
R4227:Vmn2r45 UTSW 7 8,486,277 (GRCm39) missense probably damaging 0.98
R4381:Vmn2r45 UTSW 7 8,474,912 (GRCm39) nonsense probably null
R4618:Vmn2r45 UTSW 7 8,486,436 (GRCm39) missense probably benign 0.00
R4624:Vmn2r45 UTSW 7 8,484,341 (GRCm39) missense probably damaging 1.00
R4704:Vmn2r45 UTSW 7 8,486,535 (GRCm39) nonsense probably null
R4735:Vmn2r45 UTSW 7 8,486,472 (GRCm39) missense probably damaging 1.00
R4868:Vmn2r45 UTSW 7 8,484,480 (GRCm39) missense probably benign 0.06
R4983:Vmn2r45 UTSW 7 8,486,116 (GRCm39) missense probably damaging 0.99
R5246:Vmn2r45 UTSW 7 8,486,251 (GRCm39) missense probably benign 0.00
R5430:Vmn2r45 UTSW 7 8,486,333 (GRCm39) nonsense probably null
R5504:Vmn2r45 UTSW 7 8,486,176 (GRCm39) missense probably benign 0.03
R5511:Vmn2r45 UTSW 7 8,474,832 (GRCm39) missense probably benign 0.19
R5745:Vmn2r45 UTSW 7 8,486,074 (GRCm39) missense probably benign 0.00
R5814:Vmn2r45 UTSW 7 8,474,475 (GRCm39) missense probably benign 0.00
R6267:Vmn2r45 UTSW 7 8,475,207 (GRCm39) missense probably benign 0.26
R6623:Vmn2r45 UTSW 7 8,474,500 (GRCm39) missense probably benign 0.09
R6999:Vmn2r45 UTSW 7 8,486,219 (GRCm39) missense probably benign
R7242:Vmn2r45 UTSW 7 8,488,612 (GRCm39) nonsense probably null
R7491:Vmn2r45 UTSW 7 8,484,342 (GRCm39) missense probably benign 0.27
R7620:Vmn2r45 UTSW 7 8,486,222 (GRCm39) nonsense probably null
R7719:Vmn2r45 UTSW 7 8,486,460 (GRCm39) missense probably damaging 0.99
R7720:Vmn2r45 UTSW 7 8,486,460 (GRCm39) missense probably damaging 0.99
R7853:Vmn2r45 UTSW 7 8,485,987 (GRCm39) missense possibly damaging 0.90
R7873:Vmn2r45 UTSW 7 8,486,074 (GRCm39) missense probably benign 0.00
R7882:Vmn2r45 UTSW 7 8,486,409 (GRCm39) missense possibly damaging 0.82
R7927:Vmn2r45 UTSW 7 8,486,513 (GRCm39) missense probably benign
R8684:Vmn2r45 UTSW 7 8,486,511 (GRCm39) missense probably damaging 0.99
R8780:Vmn2r45 UTSW 7 8,484,371 (GRCm39) missense possibly damaging 0.94
R8811:Vmn2r45 UTSW 7 8,474,881 (GRCm39) missense probably damaging 1.00
R8893:Vmn2r45 UTSW 7 8,488,619 (GRCm39) missense probably damaging 1.00
R9043:Vmn2r45 UTSW 7 8,474,904 (GRCm39) missense possibly damaging 0.92
R9208:Vmn2r45 UTSW 7 8,486,298 (GRCm39) missense probably damaging 1.00
R9327:Vmn2r45 UTSW 7 8,474,532 (GRCm39) missense probably damaging 1.00
R9586:Vmn2r45 UTSW 7 8,486,050 (GRCm39) missense probably benign 0.01
R9599:Vmn2r45 UTSW 7 8,478,457 (GRCm39) critical splice acceptor site probably null
U24488:Vmn2r45 UTSW 7 8,475,361 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r45 UTSW 7 8,474,484 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- GACTATTCTCACTAAAGGTCATGTC -3'
(R):5'- CAACCAAATTGTGATGTCATCCAC -3'

Sequencing Primer
(F):5'- AGGTCATGTCAAATTTCTGTTCC -3'
(R):5'- CCAAATTGTGATGTCATCCACAAATG -3'
Posted On 2018-02-28