Incidental Mutation 'R6223:Ulk2'
ID 504153
Institutional Source Beutler Lab
Gene Symbol Ulk2
Ensembl Gene ENSMUSG00000004798
Gene Name unc-51 like kinase 2
Synonyms A830085I22Rik, Unc51.2
MMRRC Submission 044354-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.219) question?
Stock # R6223 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 61666475-61745899 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 61678330 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 796 (Y796*)
Ref Sequence ENSEMBL: ENSMUSP00000004920 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004920]
AlphaFold Q9QY01
Predicted Effect probably null
Transcript: ENSMUST00000004920
AA Change: Y796*
SMART Domains Protein: ENSMUSP00000004920
Gene: ENSMUSG00000004798
AA Change: Y796*

DomainStartEndE-ValueType
S_TKc 9 271 1.1e-93 SMART
low complexity region 274 309 N/A INTRINSIC
Blast:S_TKc 310 413 9e-28 BLAST
Blast:S_TKc 433 738 1e-29 BLAST
low complexity region 751 766 N/A INTRINSIC
low complexity region 771 791 N/A INTRINSIC
Pfam:DUF3543 821 1032 1.8e-31 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129025
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
PHENOTYPE: Homozygous mutation of this gene results in an increased anxiety-like response in males. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A C 2: 152,269,873 (GRCm39) R8S probably benign Het
Abca8b A G 11: 109,868,672 (GRCm39) V164A probably benign Het
Acadm C A 3: 153,644,186 (GRCm39) probably null Het
Ap3b2 G A 7: 81,123,210 (GRCm39) R435* probably null Het
Art2b A G 7: 101,229,158 (GRCm39) F247S possibly damaging Het
C1rb T A 6: 124,551,539 (GRCm39) D216E probably benign Het
Casz1 C A 4: 149,017,840 (GRCm39) D90E probably damaging Het
Ccdc13 A G 9: 121,627,975 (GRCm39) probably benign Het
Cdc25a C A 9: 109,718,842 (GRCm39) P409T possibly damaging Het
Cidea A C 18: 67,491,809 (GRCm39) K23T possibly damaging Het
Clspn T A 4: 126,479,961 (GRCm39) D1101E probably damaging Het
Col10a1 A T 10: 34,271,183 (GRCm39) D385V probably damaging Het
Crat C T 2: 30,297,042 (GRCm39) V304I probably benign Het
Cyp2d26 A T 15: 82,675,918 (GRCm39) W265R probably benign Het
Dock8 A T 19: 25,138,416 (GRCm39) Y1247F probably benign Het
Dync2i1 T C 12: 116,221,078 (GRCm39) D11G possibly damaging Het
Eed A G 7: 89,605,495 (GRCm39) Y365H probably damaging Het
Fabp5 T A 3: 10,080,170 (GRCm39) F73L probably benign Het
Fbn1 C T 2: 125,254,591 (GRCm39) C224Y possibly damaging Het
Ggcx T C 6: 72,406,588 (GRCm39) F684L probably damaging Het
Glrp1 G A 1: 88,431,164 (GRCm39) Q69* probably null Het
Gm29797 T C 2: 181,300,850 (GRCm39) V115A possibly damaging Het
Gtf3c1 C T 7: 125,275,797 (GRCm39) R543K probably benign Het
Ifih1 T C 2: 62,428,603 (GRCm39) I891V probably benign Het
Ifnar2 C T 16: 91,184,876 (GRCm39) T89M probably damaging Het
Kat6a C A 8: 23,430,442 (GRCm39) N1932K unknown Het
Mgat5 A T 1: 127,310,716 (GRCm39) D210V possibly damaging Het
Mmel1 A G 4: 154,956,159 (GRCm39) probably null Het
Myh3 G T 11: 66,988,843 (GRCm39) V1499L probably benign Het
Ncan A C 8: 70,562,604 (GRCm39) D551E probably benign Het
Nol11 G T 11: 107,062,442 (GRCm39) T598K possibly damaging Het
Olfml3 G A 3: 103,643,776 (GRCm39) R202W probably damaging Het
Or2w4 G A 13: 21,795,536 (GRCm39) T201I probably benign Het
Or4e2 A G 14: 52,688,136 (GRCm39) R89G probably benign Het
Pcdh9 T C 14: 93,253,169 (GRCm39) K1131E probably benign Het
Pcolce A G 5: 137,603,561 (GRCm39) M424T probably damaging Het
Pi16 C A 17: 29,546,413 (GRCm39) S397* probably null Het
Pi4ka A T 16: 17,175,435 (GRCm39) Y464* probably null Het
Pik3c2b T A 1: 132,998,095 (GRCm39) L324M probably damaging Het
Prdm2 T C 4: 142,868,777 (GRCm39) N179S probably benign Het
Prss56 C T 1: 87,113,134 (GRCm39) P183S probably benign Het
Prx T G 7: 27,216,261 (GRCm39) M393R probably damaging Het
Qpctl T C 7: 18,877,134 (GRCm39) D328G probably damaging Het
Qser1 A G 2: 104,617,993 (GRCm39) S940P probably benign Het
Rchy1 G A 5: 92,105,826 (GRCm39) R41W probably damaging Het
Scp2d1 T C 2: 144,665,868 (GRCm39) I69T possibly damaging Het
Sirpb1a A G 3: 15,444,086 (GRCm39) V388A probably benign Het
Ssu2 G T 6: 112,353,409 (GRCm39) C238* probably null Het
Stub1 C T 17: 26,051,787 (GRCm39) G14D probably damaging Het
Tab1 T A 15: 80,032,464 (GRCm39) C24S probably damaging Het
Tdrd1 T C 19: 56,854,282 (GRCm39) V1076A probably damaging Het
Tex10 T C 4: 48,468,525 (GRCm39) R134G probably damaging Het
Tg T A 15: 66,579,771 (GRCm39) N1525K probably benign Het
Tll2 G A 19: 41,124,391 (GRCm39) T208I possibly damaging Het
Tmem232 T C 17: 65,807,191 (GRCm39) M1V probably null Het
Ttc7b A G 12: 100,353,368 (GRCm39) probably null Het
Ubb A G 11: 62,443,351 (GRCm39) E127G possibly damaging Het
Vdac2 G A 14: 21,895,246 (GRCm39) G265R possibly damaging Het
Vmn2r45 A T 7: 8,486,301 (GRCm39) V329E probably benign Het
Zbtb47 G A 9: 121,592,853 (GRCm39) R391Q possibly damaging Het
Other mutations in Ulk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01599:Ulk2 APN 11 61,682,262 (GRCm39) nonsense probably null
IGL02044:Ulk2 APN 11 61,672,465 (GRCm39) missense probably damaging 1.00
IGL02185:Ulk2 APN 11 61,672,886 (GRCm39) missense probably damaging 1.00
IGL03036:Ulk2 APN 11 61,725,660 (GRCm39) missense probably damaging 1.00
BB007:Ulk2 UTSW 11 61,682,258 (GRCm39) critical splice donor site probably null
BB009:Ulk2 UTSW 11 61,698,916 (GRCm39) missense probably benign
BB017:Ulk2 UTSW 11 61,682,258 (GRCm39) critical splice donor site probably null
BB019:Ulk2 UTSW 11 61,698,916 (GRCm39) missense probably benign
R0207:Ulk2 UTSW 11 61,668,611 (GRCm39) missense probably benign 0.42
R0362:Ulk2 UTSW 11 61,678,412 (GRCm39) missense probably benign
R0657:Ulk2 UTSW 11 61,698,880 (GRCm39) splice site probably benign
R1076:Ulk2 UTSW 11 61,710,135 (GRCm39) missense probably damaging 1.00
R1144:Ulk2 UTSW 11 61,690,886 (GRCm39) missense possibly damaging 0.80
R1573:Ulk2 UTSW 11 61,670,581 (GRCm39) missense probably damaging 1.00
R1583:Ulk2 UTSW 11 61,674,371 (GRCm39) missense possibly damaging 0.95
R1619:Ulk2 UTSW 11 61,672,572 (GRCm39) missense probably damaging 1.00
R1757:Ulk2 UTSW 11 61,732,165 (GRCm39) splice site probably benign
R1845:Ulk2 UTSW 11 61,703,564 (GRCm39) missense probably benign 0.04
R1883:Ulk2 UTSW 11 61,721,438 (GRCm39) missense probably damaging 1.00
R1966:Ulk2 UTSW 11 61,710,297 (GRCm39) splice site probably null
R2177:Ulk2 UTSW 11 61,682,335 (GRCm39) missense probably benign 0.01
R2416:Ulk2 UTSW 11 61,672,865 (GRCm39) missense probably damaging 1.00
R2509:Ulk2 UTSW 11 61,678,340 (GRCm39) missense probably benign 0.00
R2847:Ulk2 UTSW 11 61,715,555 (GRCm39) critical splice acceptor site probably null
R4736:Ulk2 UTSW 11 61,724,261 (GRCm39) missense probably damaging 1.00
R4997:Ulk2 UTSW 11 61,689,982 (GRCm39) missense probably benign 0.00
R5081:Ulk2 UTSW 11 61,694,488 (GRCm39) missense probably damaging 1.00
R5190:Ulk2 UTSW 11 61,672,537 (GRCm39) missense probably benign
R5346:Ulk2 UTSW 11 61,725,740 (GRCm39) missense probably damaging 1.00
R5348:Ulk2 UTSW 11 61,674,439 (GRCm39) missense probably benign
R5520:Ulk2 UTSW 11 61,698,970 (GRCm39) missense probably damaging 1.00
R5954:Ulk2 UTSW 11 61,694,622 (GRCm39) splice site probably benign
R6153:Ulk2 UTSW 11 61,672,572 (GRCm39) missense probably damaging 1.00
R7204:Ulk2 UTSW 11 61,674,457 (GRCm39) missense probably benign 0.11
R7205:Ulk2 UTSW 11 61,725,657 (GRCm39) missense possibly damaging 0.84
R7259:Ulk2 UTSW 11 61,672,909 (GRCm39) missense probably damaging 1.00
R7353:Ulk2 UTSW 11 61,710,174 (GRCm39) missense probably damaging 1.00
R7734:Ulk2 UTSW 11 61,744,127 (GRCm39) nonsense probably null
R7797:Ulk2 UTSW 11 61,672,928 (GRCm39) missense probably benign 0.06
R7808:Ulk2 UTSW 11 61,745,378 (GRCm39) missense probably damaging 1.00
R7930:Ulk2 UTSW 11 61,682,258 (GRCm39) critical splice donor site probably null
R7932:Ulk2 UTSW 11 61,698,916 (GRCm39) missense probably benign
R8882:Ulk2 UTSW 11 61,698,887 (GRCm39) critical splice donor site probably null
R8909:Ulk2 UTSW 11 61,690,380 (GRCm39) missense probably benign
R9704:Ulk2 UTSW 11 61,716,694 (GRCm39) missense probably damaging 1.00
X0028:Ulk2 UTSW 11 61,690,394 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGGAATTTGAAGTCGGAAATACTTG -3'
(R):5'- GTCACTTGAGTAGCTTATGTTCAG -3'

Sequencing Primer
(F):5'- TCGGAAATACTTGATATAGTGTGTTC -3'
(R):5'- GAGTGTGAAAGTCCCTTCTGCC -3'
Posted On 2018-02-28