Incidental Mutation 'R6223:Or2w4'
ID 504160
Institutional Source Beutler Lab
Gene Symbol Or2w4
Ensembl Gene ENSMUSG00000051258
Gene Name olfactory receptor family 2 subfamily W member 4
Synonyms Olfr1363-ps1, Olfr1362, GA_x6K02T2QHY8-11617756-11618682, GA_x6K02T2QHY8-11628399-11628868, MOR256-8
MMRRC Submission 044354-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # R6223 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 21795190-21796174 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 21795536 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 201 (T201I)
Ref Sequence ENSEMBL: ENSMUSP00000061660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051874]
AlphaFold Q5SZZ8
Predicted Effect probably benign
Transcript: ENSMUST00000051874
AA Change: T201I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000061660
Gene: ENSMUSG00000051258
AA Change: T201I

DomainStartEndE-ValueType
Pfam:7tm_4 32 307 3.5e-51 PFAM
Pfam:7tm_1 41 290 9e-24 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A C 2: 152,269,873 (GRCm39) R8S probably benign Het
Abca8b A G 11: 109,868,672 (GRCm39) V164A probably benign Het
Acadm C A 3: 153,644,186 (GRCm39) probably null Het
Ap3b2 G A 7: 81,123,210 (GRCm39) R435* probably null Het
Art2b A G 7: 101,229,158 (GRCm39) F247S possibly damaging Het
C1rb T A 6: 124,551,539 (GRCm39) D216E probably benign Het
Casz1 C A 4: 149,017,840 (GRCm39) D90E probably damaging Het
Ccdc13 A G 9: 121,627,975 (GRCm39) probably benign Het
Cdc25a C A 9: 109,718,842 (GRCm39) P409T possibly damaging Het
Cidea A C 18: 67,491,809 (GRCm39) K23T possibly damaging Het
Clspn T A 4: 126,479,961 (GRCm39) D1101E probably damaging Het
Col10a1 A T 10: 34,271,183 (GRCm39) D385V probably damaging Het
Crat C T 2: 30,297,042 (GRCm39) V304I probably benign Het
Cyp2d26 A T 15: 82,675,918 (GRCm39) W265R probably benign Het
Dock8 A T 19: 25,138,416 (GRCm39) Y1247F probably benign Het
Dync2i1 T C 12: 116,221,078 (GRCm39) D11G possibly damaging Het
Eed A G 7: 89,605,495 (GRCm39) Y365H probably damaging Het
Fabp5 T A 3: 10,080,170 (GRCm39) F73L probably benign Het
Fbn1 C T 2: 125,254,591 (GRCm39) C224Y possibly damaging Het
Ggcx T C 6: 72,406,588 (GRCm39) F684L probably damaging Het
Glrp1 G A 1: 88,431,164 (GRCm39) Q69* probably null Het
Gm29797 T C 2: 181,300,850 (GRCm39) V115A possibly damaging Het
Gtf3c1 C T 7: 125,275,797 (GRCm39) R543K probably benign Het
Ifih1 T C 2: 62,428,603 (GRCm39) I891V probably benign Het
Ifnar2 C T 16: 91,184,876 (GRCm39) T89M probably damaging Het
Kat6a C A 8: 23,430,442 (GRCm39) N1932K unknown Het
Mgat5 A T 1: 127,310,716 (GRCm39) D210V possibly damaging Het
Mmel1 A G 4: 154,956,159 (GRCm39) probably null Het
Myh3 G T 11: 66,988,843 (GRCm39) V1499L probably benign Het
Ncan A C 8: 70,562,604 (GRCm39) D551E probably benign Het
Nol11 G T 11: 107,062,442 (GRCm39) T598K possibly damaging Het
Olfml3 G A 3: 103,643,776 (GRCm39) R202W probably damaging Het
Or4e2 A G 14: 52,688,136 (GRCm39) R89G probably benign Het
Pcdh9 T C 14: 93,253,169 (GRCm39) K1131E probably benign Het
Pcolce A G 5: 137,603,561 (GRCm39) M424T probably damaging Het
Pi16 C A 17: 29,546,413 (GRCm39) S397* probably null Het
Pi4ka A T 16: 17,175,435 (GRCm39) Y464* probably null Het
Pik3c2b T A 1: 132,998,095 (GRCm39) L324M probably damaging Het
Prdm2 T C 4: 142,868,777 (GRCm39) N179S probably benign Het
Prss56 C T 1: 87,113,134 (GRCm39) P183S probably benign Het
Prx T G 7: 27,216,261 (GRCm39) M393R probably damaging Het
Qpctl T C 7: 18,877,134 (GRCm39) D328G probably damaging Het
Qser1 A G 2: 104,617,993 (GRCm39) S940P probably benign Het
Rchy1 G A 5: 92,105,826 (GRCm39) R41W probably damaging Het
Scp2d1 T C 2: 144,665,868 (GRCm39) I69T possibly damaging Het
Sirpb1a A G 3: 15,444,086 (GRCm39) V388A probably benign Het
Ssu2 G T 6: 112,353,409 (GRCm39) C238* probably null Het
Stub1 C T 17: 26,051,787 (GRCm39) G14D probably damaging Het
Tab1 T A 15: 80,032,464 (GRCm39) C24S probably damaging Het
Tdrd1 T C 19: 56,854,282 (GRCm39) V1076A probably damaging Het
Tex10 T C 4: 48,468,525 (GRCm39) R134G probably damaging Het
Tg T A 15: 66,579,771 (GRCm39) N1525K probably benign Het
Tll2 G A 19: 41,124,391 (GRCm39) T208I possibly damaging Het
Tmem232 T C 17: 65,807,191 (GRCm39) M1V probably null Het
Ttc7b A G 12: 100,353,368 (GRCm39) probably null Het
Ubb A G 11: 62,443,351 (GRCm39) E127G possibly damaging Het
Ulk2 A T 11: 61,678,330 (GRCm39) Y796* probably null Het
Vdac2 G A 14: 21,895,246 (GRCm39) G265R possibly damaging Het
Vmn2r45 A T 7: 8,486,301 (GRCm39) V329E probably benign Het
Zbtb47 G A 9: 121,592,853 (GRCm39) R391Q possibly damaging Het
Other mutations in Or2w4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00949:Or2w4 APN 13 21,795,521 (GRCm39) missense probably damaging 0.99
R0070:Or2w4 UTSW 13 21,795,431 (GRCm39) missense possibly damaging 0.60
R0070:Or2w4 UTSW 13 21,795,431 (GRCm39) missense possibly damaging 0.60
R1458:Or2w4 UTSW 13 21,795,992 (GRCm39) missense probably benign 0.37
R1587:Or2w4 UTSW 13 21,796,083 (GRCm39) missense probably benign 0.01
R1588:Or2w4 UTSW 13 21,796,083 (GRCm39) missense probably benign 0.01
R1607:Or2w4 UTSW 13 21,795,934 (GRCm39) missense probably benign 0.04
R1708:Or2w4 UTSW 13 21,795,240 (GRCm39) missense probably damaging 0.98
R4633:Or2w4 UTSW 13 21,795,398 (GRCm39) missense probably damaging 0.99
R6229:Or2w4 UTSW 13 21,795,819 (GRCm39) missense probably benign
R7140:Or2w4 UTSW 13 21,795,297 (GRCm39) missense possibly damaging 0.87
R8385:Or2w4 UTSW 13 21,795,522 (GRCm39) missense probably benign 0.12
R9433:Or2w4 UTSW 13 21,795,224 (GRCm39) missense probably benign 0.04
R9654:Or2w4 UTSW 13 21,795,915 (GRCm39) missense possibly damaging 0.93
R9744:Or2w4 UTSW 13 21,795,827 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- GCTGTTTCCAGGCTGCATATAC -3'
(R):5'- TATGGTCATTATGCACCCACAG -3'

Sequencing Primer
(F):5'- TTCCAGGCTGCATATACATATAAATG -3'
(R):5'- ATTATGCACCCACAGCTGTG -3'
Posted On 2018-02-28