Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01072:Lzts3'

50420

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lzts3

Ensembl Gene

ENSMUSG00000037703

Gene Name

leucine zipper, putative tumor suppressor family member 3

Synonyms

Prosapip1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.206) question?

Stock #

IGL01072

Quality Score

Status

Chromosome

Chromosomal Location

130474759-130484723 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 130477365 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 475 (E475G)

Ref Sequence

ENSEMBL: ENSMUSP00000086990 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045761] [ENSMUST00000089561] [ENSMUST00000110260]

AlphaFold

A2AHG0

Predicted Effect

probably damaging
Transcript: ENSMUST00000045761
AA Change: E475G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000037109
Gene: ENSMUSG00000037703
AA Change: E475G

Domain	Start	End	E-Value	Type
low complexity region	86	107	N/A	INTRINSIC
low complexity region	147	158	N/A	INTRINSIC
low complexity region	240	250	N/A	INTRINSIC
low complexity region	253	265	N/A	INTRINSIC
low complexity region	285	297	N/A	INTRINSIC
low complexity region	301	333	N/A	INTRINSIC
low complexity region	337	346	N/A	INTRINSIC
low complexity region	349	361	N/A	INTRINSIC
low complexity region	402	436	N/A	INTRINSIC
Pfam:Fez1	465	665	1.4e-62	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000089561
AA Change: E475G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000086990
Gene: ENSMUSG00000037703
AA Change: E475G

Domain	Start	End	E-Value	Type
low complexity region	86	107	N/A	INTRINSIC
low complexity region	147	158	N/A	INTRINSIC
low complexity region	240	250	N/A	INTRINSIC
low complexity region	253	265	N/A	INTRINSIC
low complexity region	285	297	N/A	INTRINSIC
low complexity region	301	333	N/A	INTRINSIC
low complexity region	337	346	N/A	INTRINSIC
low complexity region	349	361	N/A	INTRINSIC
low complexity region	402	436	N/A	INTRINSIC
Pfam:Fez1	465	666	2.1e-74	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000110260
AA Change: E361G

PolyPhen 2 Score 0.719 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000105889
Gene: ENSMUSG00000037703
AA Change: E361G

Domain	Start	End	E-Value	Type
low complexity region	126	136	N/A	INTRINSIC
low complexity region	139	151	N/A	INTRINSIC
low complexity region	171	183	N/A	INTRINSIC
low complexity region	187	219	N/A	INTRINSIC
low complexity region	223	232	N/A	INTRINSIC
low complexity region	235	247	N/A	INTRINSIC
low complexity region	288	322	N/A	INTRINSIC
Pfam:Fez1	351	552	1.5e-74	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ccdc65	A	T	15: 98,606,277 (GRCm39)	M1L	unknown	Het
Cyp3a44	T	C	5: 145,728,438 (GRCm39)	D262G	probably benign	Het
Dmbt1	C	T	7: 130,687,098 (GRCm39)		probably benign	Het
Dnmt3l	A	G	10: 77,888,605 (GRCm39)	N169S	probably benign	Het
Fbxw26	A	T	9: 109,552,905 (GRCm39)	F290I	probably damaging	Het
Foxj3	A	G	4: 119,467,226 (GRCm39)	M190V	probably benign	Het
Gm7275	T	C	16: 47,894,519 (GRCm39)		noncoding transcript	Het
Ly75	T	A	2: 60,184,840 (GRCm39)	D438V	probably damaging	Het
Mon2	A	T	10: 122,846,444 (GRCm39)	Y1375*	probably null	Het
Ndufc2	T	A	7: 97,049,490 (GRCm39)	V32D	probably damaging	Het
Nf2	A	C	11: 4,739,713 (GRCm39)	L431R	probably null	Het
Niban2	T	C	2: 32,802,427 (GRCm39)		probably benign	Het
Ptpn9	C	T	9: 56,943,987 (GRCm39)	T287I	possibly damaging	Het
Rictor	A	G	15: 6,819,043 (GRCm39)	D1422G	probably damaging	Het
Rpp40	C	A	13: 36,086,017 (GRCm39)	G115C	probably damaging	Het
Rps6ka5	A	G	12: 100,540,157 (GRCm39)	V522A	probably benign	Het
Scgb1b24	A	T	7: 33,443,434 (GRCm39)	D31V	probably damaging	Het
Trrap	C	A	5: 144,721,065 (GRCm39)		probably benign	Het
Vmn1r214	T	C	13: 23,219,300 (GRCm39)	Y265H	possibly damaging	Het

Other mutations in Lzts3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01541:Lzts3	APN	2	130,478,126 (GRCm39)	missense	probably damaging	0.99
IGL01649:Lzts3	APN	2	130,477,351 (GRCm39)	missense	probably damaging	0.98
IGL02746:Lzts3	APN	2	130,478,261 (GRCm39)	missense	probably damaging	0.98
IGL02927:Lzts3	APN	2	130,479,877 (GRCm39)	utr 5 prime	probably benign
R0069:Lzts3	UTSW	2	130,478,460 (GRCm39)	missense	probably benign	0.16
R0069:Lzts3	UTSW	2	130,478,460 (GRCm39)	missense	probably benign	0.16
R0173:Lzts3	UTSW	2	130,476,688 (GRCm39)	makesense	probably null
R1381:Lzts3	UTSW	2	130,477,219 (GRCm39)	missense	probably damaging	0.99
R4127:Lzts3	UTSW	2	130,477,285 (GRCm39)	missense	probably damaging	0.99
R4301:Lzts3	UTSW	2	130,478,358 (GRCm39)	missense	probably damaging	0.99
R4588:Lzts3	UTSW	2	130,476,686 (GRCm39)	makesense	probably null
R5289:Lzts3	UTSW	2	130,478,021 (GRCm39)	missense	probably benign	0.18
R5878:Lzts3	UTSW	2	130,478,459 (GRCm39)	missense	probably damaging	1.00
R5964:Lzts3	UTSW	2	130,478,208 (GRCm39)	missense	probably damaging	0.99
R6193:Lzts3	UTSW	2	130,479,306 (GRCm39)	missense	probably damaging	0.97
R7692:Lzts3	UTSW	2	130,477,306 (GRCm39)	missense	probably benign	0.27
R8195:Lzts3	UTSW	2	130,477,105 (GRCm39)	missense	probably benign	0.01
R8273:Lzts3	UTSW	2	130,476,801 (GRCm39)	missense	possibly damaging	0.66
R9126:Lzts3	UTSW	2	130,477,248 (GRCm39)	missense	possibly damaging	0.66
R9129:Lzts3	UTSW	2	130,476,865 (GRCm39)	missense	possibly damaging	0.92

Posted On

2013-06-21