Incidental Mutation 'R6225:Slitrk5'
ID 504291
Institutional Source Beutler Lab
Gene Symbol Slitrk5
Ensembl Gene ENSMUSG00000033214
Gene Name SLIT and NTRK-like family, member 5
Synonyms 2610019D03Rik
MMRRC Submission 044356-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.472) question?
Stock # R6225 (G1)
Quality Score 217.468
Status Validated
Chromosome 14
Chromosomal Location 111912547-111920576 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) GACTAC to GACTACTAC at 111917248 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000154387 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042767] [ENSMUST00000227891]
AlphaFold Q810B7
Predicted Effect probably benign
Transcript: ENSMUST00000042767
SMART Domains Protein: ENSMUSP00000041499
Gene: ENSMUSG00000033214

DomainStartEndE-ValueType
Blast:LRRNT 47 85 3e-18 BLAST
low complexity region 86 96 N/A INTRINSIC
LRR 108 127 2.76e2 SMART
LRR_TYP 128 151 1.67e-2 SMART
LRR 152 175 2.67e-1 SMART
LRR 176 199 1.08e-1 SMART
LRR 202 223 7.38e1 SMART
LRRCT 235 285 2.13e-5 SMART
low complexity region 308 323 N/A INTRINSIC
LRRNT 373 410 9.53e-2 SMART
LRR 433 455 1.45e1 SMART
LRR_TYP 456 479 4.94e-5 SMART
LRR_TYP 480 503 7.78e-3 SMART
LRR_TYP 504 527 2.43e-4 SMART
LRR 528 551 1.86e2 SMART
LRRCT 563 613 3.59e-3 SMART
low complexity region 618 632 N/A INTRINSIC
transmembrane domain 666 688 N/A INTRINSIC
low complexity region 794 816 N/A INTRINSIC
low complexity region 818 823 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000227891
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency 100% (74/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a null allele have abnormal medium spiny neuron morphology and exhibit behavioral abnormalities. [provided by MGI curators]
Allele List at MGI

All alleles(3) : Targeted(3)

Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace A G 11: 105,870,445 (GRCm39) H288R possibly damaging Het
Adh1 T C 3: 137,995,565 (GRCm39) F323L probably benign Het
Adss1 A C 12: 112,600,837 (GRCm39) H226P probably damaging Het
Ahrr A G 13: 74,371,031 (GRCm39) S230P possibly damaging Het
Akap9 T C 5: 4,012,105 (GRCm39) V936A probably damaging Het
B4galnt2 A G 11: 95,759,268 (GRCm39) Y339H probably damaging Het
Bltp1 T C 3: 37,002,453 (GRCm39) V1466A probably damaging Het
C4b C A 17: 34,957,848 (GRCm39) G611V possibly damaging Het
Cacna1i A G 15: 80,205,427 (GRCm39) M128V probably damaging Het
Chia1 T C 3: 106,038,213 (GRCm39) S370P possibly damaging Het
Cops6 T C 5: 138,159,673 (GRCm39) V9A possibly damaging Het
D630003M21Rik A T 2: 158,059,321 (GRCm39) I193K probably benign Het
Daam2 T C 17: 49,801,467 (GRCm39) D90G probably damaging Het
Fads3 A G 19: 10,019,202 (GRCm39) D36G probably benign Het
Fam185a T C 5: 21,630,554 (GRCm39) V130A probably damaging Het
Fbn1 A T 2: 125,172,463 (GRCm39) N1928K probably damaging Het
Fstl3 A G 10: 79,615,843 (GRCm39) M110V probably benign Het
G2e3 A G 12: 51,415,919 (GRCm39) T552A possibly damaging Het
Gfra1 G A 19: 58,226,830 (GRCm39) T462I probably damaging Het
Glrx2 T A 1: 143,621,121 (GRCm39) probably benign Het
Gm10100 G T 10: 77,562,498 (GRCm39) C60F possibly damaging Het
Gm43302 T A 5: 105,425,605 (GRCm39) K275* probably null Het
Gm6569 A G 15: 73,711,640 (GRCm39) probably benign Het
Herc6 G T 6: 57,639,139 (GRCm39) V867L possibly damaging Het
Hhipl2 T A 1: 183,209,459 (GRCm39) probably null Het
Kcnj16 A T 11: 110,916,378 (GRCm39) K347* probably null Het
Kcnt2 T A 1: 140,354,661 (GRCm39) C305* probably null Het
Large2 A G 2: 92,196,825 (GRCm39) L477P probably damaging Het
Lnpep T C 17: 17,799,245 (GRCm39) T137A possibly damaging Het
Mettl3 T C 14: 52,534,215 (GRCm39) probably null Het
Mical3 C T 6: 120,935,684 (GRCm39) S1614N probably damaging Het
Mmut T A 17: 41,249,622 (GRCm39) V199E possibly damaging Het
Morc3 C A 16: 93,642,082 (GRCm39) Y100* probably null Het
Mrc2 A G 11: 105,237,646 (GRCm39) K1108R probably benign Het
Mrpl2 T C 17: 46,960,835 (GRCm39) V243A probably damaging Het
Mtor T A 4: 148,605,794 (GRCm39) N1505K probably benign Het
Myo1g A T 11: 6,469,168 (GRCm39) Y45N probably damaging Het
Nckap5l C A 15: 99,325,905 (GRCm39) L199F possibly damaging Het
Ndufc2 A G 7: 97,056,099 (GRCm39) T66A probably damaging Het
Nos1 T A 5: 118,050,917 (GRCm39) H779Q probably damaging Het
Or12e13 A G 2: 87,663,661 (GRCm39) T93A probably benign Het
Or13j1 T C 4: 43,705,698 (GRCm39) Y290C probably damaging Het
Or1e23 T C 11: 73,407,831 (GRCm39) N65D probably damaging Het
Or4c3 A G 2: 89,851,573 (GRCm39) probably null Het
Or51ah3 A T 7: 103,210,489 (GRCm39) R268S probably benign Het
Or5au1 C A 14: 52,272,825 (GRCm39) V248L possibly damaging Het
Or5k16 T C 16: 58,736,545 (GRCm39) N153S probably benign Het
Otog C T 7: 45,898,458 (GRCm39) T192I possibly damaging Het
Oxct1 T C 15: 4,064,812 (GRCm39) V50A probably benign Het
P3h2 T A 16: 25,784,493 (GRCm39) D667V probably damaging Het
Pcdhb20 A G 18: 37,638,047 (GRCm39) Y191C probably damaging Het
Pds5b T G 5: 150,670,083 (GRCm39) V357G probably damaging Het
Pggt1b A G 18: 46,407,674 (GRCm39) V81A possibly damaging Het
Phxr2 A G 10: 98,962,043 (GRCm39) probably benign Het
Pnpt1 T C 11: 29,095,469 (GRCm39) I406T probably benign Het
Ppat T C 5: 77,070,202 (GRCm39) I173V probably damaging Het
Proser3 T C 7: 30,243,153 (GRCm39) S167G probably damaging Het
Rnf135 A C 11: 80,080,053 (GRCm39) T115P possibly damaging Het
Rpl22 C T 4: 152,414,536 (GRCm39) R65C probably benign Het
Scel T C 14: 103,829,420 (GRCm39) F405L probably benign Het
Serinc3 A G 2: 163,469,799 (GRCm39) Y350H probably damaging Het
Slc25a16 C A 10: 62,764,102 (GRCm39) T53K probably damaging Het
Slco1a1 A T 6: 141,870,215 (GRCm39) F308I possibly damaging Het
Smok3c T C 5: 138,063,314 (GRCm39) V267A probably benign Het
Ssrp1 A G 2: 84,873,158 (GRCm39) D473G probably benign Het
Svs6 A G 2: 164,159,405 (GRCm39) E56G possibly damaging Het
Tas2r130 TCATTTC T 6: 131,607,547 (GRCm39) probably benign Het
Thoc3 T C 13: 54,615,785 (GRCm39) N93S probably benign Het
Tle6 A G 10: 81,428,600 (GRCm39) C443R probably damaging Het
Tmed6 A G 8: 107,788,371 (GRCm39) F192S probably damaging Het
Tpx2 A G 2: 152,718,548 (GRCm39) N184D probably benign Het
Vmn2r31 T A 7: 7,397,638 (GRCm39) N207Y probably benign Het
Zfp267 T C 3: 36,220,352 (GRCm39) F792L probably benign Het
Zfp709 TCGACG TCG 8: 72,644,552 (GRCm39) probably benign Het
Zfp972 A T 2: 177,549,117 (GRCm39) probably null Het
Zzef1 G A 11: 72,760,631 (GRCm39) C1318Y possibly damaging Het
Other mutations in Slitrk5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Slitrk5 APN 14 111,918,097 (GRCm39) missense probably benign 0.05
IGL01624:Slitrk5 APN 14 111,918,526 (GRCm39) missense probably damaging 1.00
IGL01680:Slitrk5 APN 14 111,916,432 (GRCm39) missense probably benign 0.23
IGL03234:Slitrk5 APN 14 111,916,717 (GRCm39) missense probably benign 0.00
P0019:Slitrk5 UTSW 14 111,918,026 (GRCm39) missense possibly damaging 0.88
R0323:Slitrk5 UTSW 14 111,919,055 (GRCm39) missense probably damaging 0.99
R0334:Slitrk5 UTSW 14 111,918,256 (GRCm39) missense probably benign
R0392:Slitrk5 UTSW 14 111,916,465 (GRCm39) missense probably benign 0.06
R0659:Slitrk5 UTSW 14 111,918,121 (GRCm39) missense probably benign 0.00
R1344:Slitrk5 UTSW 14 111,917,821 (GRCm39) missense probably benign 0.04
R1754:Slitrk5 UTSW 14 111,917,951 (GRCm39) missense probably damaging 1.00
R1983:Slitrk5 UTSW 14 111,917,821 (GRCm39) missense probably benign 0.04
R2070:Slitrk5 UTSW 14 111,917,621 (GRCm39) missense probably damaging 0.99
R2071:Slitrk5 UTSW 14 111,917,621 (GRCm39) missense probably damaging 0.99
R3001:Slitrk5 UTSW 14 111,917,014 (GRCm39) missense probably damaging 1.00
R3002:Slitrk5 UTSW 14 111,917,014 (GRCm39) missense probably damaging 1.00
R3003:Slitrk5 UTSW 14 111,917,014 (GRCm39) missense probably damaging 1.00
R3885:Slitrk5 UTSW 14 111,917,229 (GRCm39) nonsense probably null
R3886:Slitrk5 UTSW 14 111,917,229 (GRCm39) nonsense probably null
R3888:Slitrk5 UTSW 14 111,917,229 (GRCm39) nonsense probably null
R4962:Slitrk5 UTSW 14 111,918,679 (GRCm39) missense probably benign 0.02
R4999:Slitrk5 UTSW 14 111,917,648 (GRCm39) missense probably damaging 0.99
R5036:Slitrk5 UTSW 14 111,918,316 (GRCm39) missense possibly damaging 0.87
R5190:Slitrk5 UTSW 14 111,916,852 (GRCm39) missense probably damaging 1.00
R5237:Slitrk5 UTSW 14 111,919,118 (GRCm39) missense possibly damaging 0.94
R5669:Slitrk5 UTSW 14 111,919,055 (GRCm39) missense probably damaging 0.99
R5793:Slitrk5 UTSW 14 111,917,345 (GRCm39) missense probably damaging 1.00
R5839:Slitrk5 UTSW 14 111,917,030 (GRCm39) missense probably benign 0.00
R6083:Slitrk5 UTSW 14 111,919,157 (GRCm39) missense probably benign 0.01
R6224:Slitrk5 UTSW 14 111,917,248 (GRCm39) unclassified probably benign
R6230:Slitrk5 UTSW 14 111,917,248 (GRCm39) unclassified probably benign
R6337:Slitrk5 UTSW 14 111,917,684 (GRCm39) missense probably damaging 0.96
R6666:Slitrk5 UTSW 14 111,917,534 (GRCm39) missense probably damaging 0.96
R6818:Slitrk5 UTSW 14 111,917,726 (GRCm39) missense probably benign 0.32
R6895:Slitrk5 UTSW 14 111,919,085 (GRCm39) missense probably damaging 1.00
R7094:Slitrk5 UTSW 14 111,918,268 (GRCm39) missense probably benign 0.02
R7385:Slitrk5 UTSW 14 111,918,131 (GRCm39) missense probably benign 0.32
R8532:Slitrk5 UTSW 14 111,916,909 (GRCm39) missense probably benign
R8994:Slitrk5 UTSW 14 111,918,227 (GRCm39) missense probably benign 0.00
R9344:Slitrk5 UTSW 14 111,916,702 (GRCm39) missense probably damaging 0.97
R9374:Slitrk5 UTSW 14 111,916,496 (GRCm39) missense probably benign 0.23
R9499:Slitrk5 UTSW 14 111,916,496 (GRCm39) missense probably benign 0.23
R9500:Slitrk5 UTSW 14 111,916,726 (GRCm39) missense possibly damaging 0.89
R9512:Slitrk5 UTSW 14 111,917,252 (GRCm39) missense probably damaging 1.00
R9552:Slitrk5 UTSW 14 111,916,496 (GRCm39) missense probably benign 0.23
Z1177:Slitrk5 UTSW 14 111,917,285 (GRCm39) missense probably benign 0.37
Predicted Primers PCR Primer
(F):5'- TTACAGCTGGAGGAAAACCCC -3'
(R):5'- GCTATGCTGGGGCCATAGTTAC -3'

Sequencing Primer
(F):5'- GAGGAAAACCCCTGGAATTGCTC -3'
(R):5'- GGCCATAGTTACTGTAGCCCAAGTC -3'
Posted On 2018-02-28