Incidental Mutation 'IGL01080:Wfdc16'
ID50435
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wfdc16
Ensembl Gene ENSMUSG00000070530
Gene NameWAP four-disulfide core domain 16
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #IGL01080
Quality Score
Status
Chromosome2
Chromosomal Location164634707-164638796 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 164638486 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Arginine at position 30 (W30R)
Ref Sequence ENSEMBL: ENSMUSP00000104960 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109336]
Predicted Effect probably damaging
Transcript: ENSMUST00000109336
AA Change: W30R

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000104960
Gene: ENSMUSG00000070530
AA Change: W30R

DomainStartEndE-ValueType
transmembrane domain 10 28 N/A INTRINSIC
WAP 51 91 3.41e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121070
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A T 5: 8,934,258 R663W probably damaging Het
Cacng5 A T 11: 107,877,928 F179L probably damaging Het
Cacng5 C T 11: 107,881,705 V106I probably benign Het
Cd96 T C 16: 46,049,693 E471G possibly damaging Het
Cpt1c T C 7: 44,960,909 D621G probably damaging Het
Csmd3 T C 15: 47,881,403 I1503V probably benign Het
Dmgdh T C 13: 93,703,778 probably benign Het
Flg A T 3: 93,279,599 K119N probably benign Het
Gale T C 4: 135,966,078 Y104H probably damaging Het
Gm8005 T C 14: 42,437,014 D119G unknown Het
Gstk1 A T 6: 42,246,626 D50V possibly damaging Het
Kmt2a T C 9: 44,809,092 D3866G unknown Het
Mastl A G 2: 23,146,148 S119P probably damaging Het
Olfr169 A T 16: 19,566,208 V225E probably damaging Het
Phf11c G A 14: 59,393,199 T19I probably benign Het
Ppp1r16b A G 2: 158,757,172 T355A probably damaging Het
Prmt7 T G 8: 106,237,214 probably benign Het
Rad50 T C 11: 53,706,068 T44A probably damaging Het
Rangap1 C T 15: 81,705,752 probably benign Het
Slc27a3 A T 3: 90,385,460 V634E probably benign Het
Tbxas1 T A 6: 39,021,181 L228I probably damaging Het
Tnfaip3 T C 10: 19,011,655 K41E probably benign Het
Tti1 C T 2: 157,982,459 V1025I probably damaging Het
Tyrobp T C 7: 30,417,416 probably null Het
Zyg11b A T 4: 108,237,416 L657Q probably damaging Het
Other mutations in Wfdc16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02627:Wfdc16 APN 2 164638463 missense possibly damaging 0.46
IGL03267:Wfdc16 APN 2 164638542 missense possibly damaging 0.46
R0541:Wfdc16 UTSW 2 164635853 missense possibly damaging 0.73
R1171:Wfdc16 UTSW 2 164638483 missense possibly damaging 0.66
R1579:Wfdc16 UTSW 2 164635923 missense possibly damaging 0.46
R1598:Wfdc16 UTSW 2 164635430 missense probably benign 0.00
R7584:Wfdc16 UTSW 2 164638627 splice site probably null
R7780:Wfdc16 UTSW 2 164635865 missense probably benign 0.04
Posted On2013-06-21