Incidental Mutation 'IGL01082:Olfr1201'
ID50442
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1201
Ensembl Gene ENSMUSG00000059023
Gene Nameolfactory receptor 1201
SynonymsGA_x6K02T2Q125-50268830-50269753, MOR230-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #IGL01082
Quality Score
Status
Chromosome2
Chromosomal Location88793036-88796827 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 88795293 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 304 (F304L)
Ref Sequence ENSEMBL: ENSMUSP00000150454 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073458] [ENSMUST00000216213]
Predicted Effect probably benign
Transcript: ENSMUST00000073458
AA Change: F304L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000073163
Gene: ENSMUSG00000059023
AA Change: F304L

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.4e-46 PFAM
Pfam:7TM_GPCR_Srsx 32 300 3.3e-5 PFAM
Pfam:7tm_1 39 285 3e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214018
Predicted Effect probably benign
Transcript: ENSMUST00000216213
AA Change: F304L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 G A 1: 71,314,114 S723F probably damaging Het
Cacng5 C T 11: 107,881,705 V106I probably benign Het
Ccdc116 A G 16: 17,141,992 S278P probably damaging Het
Cep152 A T 2: 125,569,545 probably benign Het
Cftr T C 6: 18,226,103 V350A probably damaging Het
Dsc2 A T 18: 20,043,792 N399K probably damaging Het
Eif3d T C 15: 77,959,743 T468A probably damaging Het
Fam110b C T 4: 5,799,461 A293V possibly damaging Het
Flrt1 T C 19: 7,095,974 T403A probably benign Het
Hist1h3e A G 13: 23,562,374 probably benign Het
Ift140 T A 17: 25,048,455 V609E possibly damaging Het
Klb G A 5: 65,375,940 V531I possibly damaging Het
Krt73 T C 15: 101,798,937 probably null Het
Mcm2 A G 6: 88,887,877 V539A probably benign Het
Myb A G 10: 21,152,944 V85A probably damaging Het
Ndufs1 T C 1: 63,164,817 E102G probably damaging Het
Nr5a2 C A 1: 136,845,468 A499S probably benign Het
Olfr1256 A T 2: 89,844,063 probably benign Het
Olfr126 T A 17: 37,850,623 S10R probably benign Het
Opa1 A T 16: 29,618,115 probably benign Het
Pcnx G A 12: 81,990,598 E1877K possibly damaging Het
Sel1l A G 12: 91,811,908 V711A probably benign Het
Slc22a16 A G 10: 40,573,864 T120A probably benign Het
Slc26a1 G T 5: 108,671,878 T485N possibly damaging Het
Sp100 T C 1: 85,670,020 V201A possibly damaging Het
Spz1 T G 13: 92,575,521 K149T probably damaging Het
Stxbp5l A G 16: 37,204,578 S553P possibly damaging Het
Szt2 A G 4: 118,397,624 S290P probably damaging Het
Tbc1d10c A G 19: 4,189,027 Y165H probably damaging Het
Tnxb C A 17: 34,714,610 Q2335K probably damaging Het
Trim33 T C 3: 103,326,859 I471T possibly damaging Het
Vsig10 A G 5: 117,334,905 I188V probably benign Het
Zfp109 A T 7: 24,234,359 L45Q probably damaging Het
Other mutations in Olfr1201
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02292:Olfr1201 APN 2 88795287 missense probably benign
IGL03037:Olfr1201 APN 2 88794955 missense probably damaging 1.00
R2341:Olfr1201 UTSW 2 88794645 missense probably benign 0.16
R3900:Olfr1201 UTSW 2 88794929 missense possibly damaging 0.88
R6394:Olfr1201 UTSW 2 88794952 missense probably benign 0.22
R7276:Olfr1201 UTSW 2 88794681 missense probably damaging 1.00
Posted On2013-06-21