Incidental Mutation 'R6228:Caskin1'
| ID |
504511 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Caskin1
|
| Ensembl Gene |
ENSMUSG00000033597 |
| Gene Name |
CASK interacting protein 1 |
| Synonyms |
3300002N10Rik, C630036E02Rik |
| MMRRC Submission |
044357-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.114)
|
| Stock # |
R6228 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
24707575-24727645 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to G
at 24726154 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 1420
(D1420E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000024958
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000024958]
[ENSMUST00000070777]
[ENSMUST00000088464]
[ENSMUST00000176086]
[ENSMUST00000176353]
[ENSMUST00000176652]
[ENSMUST00000176668]
|
| AlphaFold |
Q6P9K8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000024958
AA Change: D1420E
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000024958
Gene: ENSMUSG00000033597
AA Change: D1420E
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
48 |
77 |
9.93e-5 |
SMART |
|
ANK
|
81 |
110 |
1.9e-1 |
SMART |
|
ANK
|
114 |
143 |
1.51e-4 |
SMART |
|
ANK
|
147 |
176 |
1.15e0 |
SMART |
|
ANK
|
188 |
217 |
2.6e-8 |
SMART |
|
ANK
|
220 |
249 |
3.31e-1 |
SMART |
|
SH3
|
284 |
346 |
3.62e-5 |
SMART |
|
Pfam:Caskin1-CID
|
373 |
421 |
3e-26 |
PFAM |
|
SAM
|
473 |
539 |
3.63e-15 |
SMART |
|
SAM
|
542 |
609 |
5.41e-14 |
SMART |
|
low complexity region
|
631 |
647 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
679 |
N/A |
INTRINSIC |
|
low complexity region
|
715 |
724 |
N/A |
INTRINSIC |
|
low complexity region
|
841 |
863 |
N/A |
INTRINSIC |
|
Pfam:Caskin-Pro-rich
|
878 |
966 |
3e-37 |
PFAM |
|
low complexity region
|
1163 |
1168 |
N/A |
INTRINSIC |
|
low complexity region
|
1190 |
1216 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1232 |
N/A |
INTRINSIC |
|
low complexity region
|
1269 |
1288 |
N/A |
INTRINSIC |
|
low complexity region
|
1294 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1315 |
1333 |
N/A |
INTRINSIC |
|
low complexity region
|
1344 |
1359 |
N/A |
INTRINSIC |
|
Pfam:Caskin-tail
|
1369 |
1431 |
7.2e-33 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000070777
|
| SMART Domains |
Protein: ENSMUSP00000069334
Gene: ENSMUSG00000052752
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
44 |
N/A |
INTRINSIC |
|
RING
|
92 |
125 |
4.73e-6 |
SMART |
|
coiled coil region
|
264 |
332 |
N/A |
INTRINSIC |
|
WD40
|
344 |
383 |
8.35e-11 |
SMART |
|
WD40
|
387 |
424 |
8.42e-7 |
SMART |
|
WD40
|
427 |
463 |
2.09e-2 |
SMART |
|
WD40
|
468 |
504 |
1.92e0 |
SMART |
|
WD40
|
507 |
544 |
5.15e-2 |
SMART |
|
WD40
|
547 |
588 |
1.78e-5 |
SMART |
|
WD40
|
591 |
628 |
1.63e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088464
|
| SMART Domains |
Protein: ENSMUSP00000085812
Gene: ENSMUSG00000052752
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
44 |
N/A |
INTRINSIC |
|
low complexity region
|
90 |
104 |
N/A |
INTRINSIC |
|
low complexity region
|
109 |
117 |
N/A |
INTRINSIC |
|
RING
|
130 |
163 |
4.73e-6 |
SMART |
|
Pfam:zf-TRAF
|
221 |
277 |
3.4e-8 |
PFAM |
|
coiled coil region
|
304 |
372 |
N/A |
INTRINSIC |
|
WD40
|
384 |
423 |
8.35e-11 |
SMART |
|
WD40
|
427 |
464 |
8.42e-7 |
SMART |
|
WD40
|
467 |
503 |
2.09e-2 |
SMART |
|
WD40
|
508 |
544 |
1.92e0 |
SMART |
|
WD40
|
547 |
584 |
5.15e-2 |
SMART |
|
WD40
|
587 |
628 |
1.78e-5 |
SMART |
|
WD40
|
631 |
668 |
1.63e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175698
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175732
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176086
|
| SMART Domains |
Protein: ENSMUSP00000135845
Gene: ENSMUSG00000052752
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
103 |
132 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176353
|
| SMART Domains |
Protein: ENSMUSP00000135267
Gene: ENSMUSG00000052752
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
44 |
N/A |
INTRINSIC |
|
RING
|
92 |
125 |
4.73e-6 |
SMART |
|
coiled coil region
|
264 |
332 |
N/A |
INTRINSIC |
|
WD40
|
344 |
383 |
8.35e-11 |
SMART |
|
WD40
|
387 |
424 |
8.42e-7 |
SMART |
|
WD40
|
427 |
463 |
2.09e-2 |
SMART |
|
WD40
|
468 |
504 |
1.92e0 |
SMART |
|
WD40
|
507 |
544 |
5.15e-2 |
SMART |
|
WD40
|
547 |
588 |
1.78e-5 |
SMART |
|
WD40
|
591 |
628 |
1.63e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000177024
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176652
|
| SMART Domains |
Protein: ENSMUSP00000134759
Gene: ENSMUSG00000052752
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
44 |
N/A |
INTRINSIC |
|
low complexity region
|
90 |
104 |
N/A |
INTRINSIC |
|
low complexity region
|
109 |
117 |
N/A |
INTRINSIC |
|
RING
|
130 |
163 |
4.73e-6 |
SMART |
|
coiled coil region
|
304 |
372 |
N/A |
INTRINSIC |
|
WD40
|
384 |
423 |
8.35e-11 |
SMART |
|
WD40
|
427 |
464 |
8.42e-7 |
SMART |
|
WD40
|
467 |
503 |
2.09e-2 |
SMART |
|
WD40
|
508 |
544 |
1.92e0 |
SMART |
|
WD40
|
547 |
584 |
5.15e-2 |
SMART |
|
WD40
|
587 |
628 |
1.78e-5 |
SMART |
|
WD40
|
631 |
668 |
1.63e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176805
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176900
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176530
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177502
|
| SMART Domains |
Protein: ENSMUSP00000134970
Gene: ENSMUSG00000052752
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
11 |
N/A |
INTRINSIC |
|
RING
|
24 |
68 |
4.24e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176668
|
| SMART Domains |
Protein: ENSMUSP00000135586
Gene: ENSMUSG00000052752
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
44 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.6%
- 20x: 95.9%
|
| Validation Efficiency |
100% (93/93) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc6 |
G |
T |
7: 45,679,680 (GRCm39) |
T9K |
probably benign |
Het |
| Ankrd28 |
T |
C |
14: 31,429,177 (GRCm39) |
H925R |
probably damaging |
Het |
| Antxrl |
A |
T |
14: 33,778,556 (GRCm39) |
T128S |
probably damaging |
Het |
| Atosa |
A |
G |
9: 74,913,645 (GRCm39) |
M100V |
possibly damaging |
Het |
| Atp8b5 |
T |
C |
4: 43,304,674 (GRCm39) |
Y62H |
probably damaging |
Het |
| Bmpr2 |
G |
T |
1: 59,906,595 (GRCm39) |
V563L |
probably benign |
Het |
| Btn1a1 |
A |
T |
13: 23,648,521 (GRCm39) |
L104Q |
probably damaging |
Het |
| Cdc14a |
A |
T |
3: 116,144,862 (GRCm39) |
I150N |
probably damaging |
Het |
| Cdc26 |
C |
T |
4: 62,321,031 (GRCm39) |
R4Q |
probably damaging |
Het |
| Cfap46 |
T |
C |
7: 139,236,496 (GRCm39) |
D160G |
probably damaging |
Het |
| Cxcr4 |
A |
C |
1: 128,519,920 (GRCm39) |
|
probably null |
Het |
| Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
| Dgat1 |
T |
C |
15: 76,387,493 (GRCm39) |
N317S |
possibly damaging |
Het |
| Disp1 |
G |
A |
1: 182,880,589 (GRCm39) |
T228M |
possibly damaging |
Het |
| Dixdc1 |
A |
C |
9: 50,614,656 (GRCm39) |
|
probably null |
Het |
| Dnase1l2 |
C |
A |
17: 24,661,492 (GRCm39) |
|
probably benign |
Het |
| Dsg2 |
T |
C |
18: 20,727,350 (GRCm39) |
|
probably null |
Het |
| Duox2 |
A |
T |
2: 122,117,674 (GRCm39) |
F887I |
probably benign |
Het |
| Duxf4 |
A |
G |
10: 58,071,344 (GRCm39) |
M290T |
probably benign |
Het |
| Efcab6 |
T |
C |
15: 83,851,825 (GRCm39) |
D351G |
possibly damaging |
Het |
| Ep400 |
A |
G |
5: 110,818,808 (GRCm39) |
V2621A |
probably damaging |
Het |
| Epg5 |
G |
T |
18: 77,991,677 (GRCm39) |
V125F |
possibly damaging |
Het |
| Ephb1 |
T |
C |
9: 101,800,783 (GRCm39) |
R953G |
probably damaging |
Het |
| Etfdh |
G |
T |
3: 79,519,336 (GRCm39) |
Y272* |
probably null |
Het |
| Fam117b |
A |
G |
1: 60,008,207 (GRCm39) |
E347G |
probably damaging |
Het |
| Gfra3 |
A |
T |
18: 34,828,846 (GRCm39) |
C183S |
probably damaging |
Het |
| Gmip |
A |
G |
8: 70,268,773 (GRCm39) |
D466G |
probably damaging |
Het |
| Golga5 |
G |
A |
12: 102,450,740 (GRCm39) |
M464I |
probably benign |
Het |
| Gpd1 |
A |
T |
15: 99,621,146 (GRCm39) |
Q320L |
possibly damaging |
Het |
| H2-Oa |
G |
T |
17: 34,312,851 (GRCm39) |
D43Y |
probably damaging |
Het |
| Hecw1 |
T |
A |
13: 14,520,623 (GRCm39) |
I205F |
probably damaging |
Het |
| Ighv8-13 |
A |
G |
12: 115,728,973 (GRCm39) |
Y95H |
probably damaging |
Het |
| Igkv6-20 |
T |
C |
6: 70,313,081 (GRCm39) |
M31V |
possibly damaging |
Het |
| Itih1 |
T |
C |
14: 30,653,217 (GRCm39) |
D737G |
probably benign |
Het |
| Kcnc4 |
G |
C |
3: 107,355,693 (GRCm39) |
H252D |
probably damaging |
Het |
| Kcnj14 |
T |
A |
7: 45,468,921 (GRCm39) |
T195S |
probably damaging |
Het |
| Limch1 |
A |
T |
5: 67,173,845 (GRCm39) |
D642V |
probably damaging |
Het |
| Lrp2 |
T |
G |
2: 69,312,710 (GRCm39) |
D2526A |
possibly damaging |
Het |
| Lrrc8a |
A |
G |
2: 30,146,565 (GRCm39) |
T460A |
possibly damaging |
Het |
| Lrrn4cl |
A |
G |
19: 8,829,135 (GRCm39) |
T38A |
probably benign |
Het |
| Lypd8 |
A |
T |
11: 58,277,629 (GRCm39) |
Q137L |
possibly damaging |
Het |
| Mapkapk3 |
A |
G |
9: 107,137,262 (GRCm39) |
Y206H |
probably damaging |
Het |
| Mrc1 |
G |
A |
2: 14,276,115 (GRCm39) |
G483D |
probably benign |
Het |
| Mrpl35 |
C |
A |
6: 71,800,661 (GRCm39) |
|
probably benign |
Het |
| Mycbp2 |
T |
A |
14: 103,497,665 (GRCm39) |
H936L |
probably benign |
Het |
| Myh3 |
A |
T |
11: 66,978,312 (GRCm39) |
Y433F |
probably benign |
Het |
| Napb |
C |
T |
2: 148,540,098 (GRCm39) |
|
probably null |
Het |
| Nbeal1 |
C |
A |
1: 60,335,083 (GRCm39) |
Q2288K |
probably benign |
Het |
| Ndst3 |
G |
A |
3: 123,465,301 (GRCm39) |
Q224* |
probably null |
Het |
| Nkapd1 |
A |
G |
9: 50,518,971 (GRCm39) |
S214P |
possibly damaging |
Het |
| Nkd2 |
A |
G |
13: 73,969,579 (GRCm39) |
S284P |
probably benign |
Het |
| Or10a2 |
T |
C |
7: 106,673,343 (GRCm39) |
Y103H |
probably damaging |
Het |
| Or5b12 |
A |
T |
19: 12,897,301 (GRCm39) |
V124E |
probably damaging |
Het |
| Or6k2 |
G |
A |
1: 173,979,712 (GRCm39) |
S210N |
probably benign |
Het |
| Or8h10 |
T |
C |
2: 86,809,035 (GRCm39) |
Y35C |
probably damaging |
Het |
| Pcdhb8 |
A |
G |
18: 37,490,037 (GRCm39) |
T572A |
probably benign |
Het |
| Pcdhb9 |
A |
G |
18: 37,535,115 (GRCm39) |
I370V |
probably benign |
Het |
| Pcsk5 |
T |
G |
19: 17,558,631 (GRCm39) |
E592A |
possibly damaging |
Het |
| Pigc |
T |
C |
1: 161,798,036 (GRCm39) |
V6A |
probably benign |
Het |
| Pla2g6 |
T |
G |
15: 79,189,924 (GRCm39) |
I389L |
probably benign |
Het |
| Pnliprp2 |
T |
C |
19: 58,751,874 (GRCm39) |
|
probably null |
Het |
| Psmb11 |
T |
C |
14: 54,863,646 (GRCm39) |
V288A |
probably benign |
Het |
| Rapgef5 |
A |
G |
12: 117,685,398 (GRCm39) |
|
probably null |
Het |
| Rcn3 |
T |
C |
7: 44,732,720 (GRCm39) |
N316S |
probably damaging |
Het |
| Rgs6 |
A |
G |
12: 83,112,738 (GRCm39) |
K183E |
probably damaging |
Het |
| Rhoc |
A |
G |
3: 104,700,297 (GRCm39) |
|
probably null |
Het |
| Serinc5 |
T |
C |
13: 92,844,616 (GRCm39) |
C453R |
probably damaging |
Het |
| Slc14a1 |
A |
C |
18: 78,159,614 (GRCm39) |
M93R |
probably damaging |
Het |
| Slc25a3 |
A |
T |
10: 90,958,090 (GRCm39) |
D83E |
probably damaging |
Het |
| Slc36a3 |
T |
C |
11: 55,015,777 (GRCm39) |
Y459C |
probably benign |
Het |
| Slc44a5 |
A |
T |
3: 153,944,800 (GRCm39) |
Y139F |
probably benign |
Het |
| Spag17 |
A |
T |
3: 99,929,918 (GRCm39) |
Q539L |
probably benign |
Het |
| Stap2 |
C |
T |
17: 56,306,976 (GRCm39) |
V234M |
probably damaging |
Het |
| Stard9 |
A |
G |
2: 120,544,231 (GRCm39) |
Y4450C |
probably damaging |
Het |
| Taf6l |
C |
T |
19: 8,756,030 (GRCm39) |
R206Q |
probably benign |
Het |
| Tbc1d23 |
C |
T |
16: 57,003,266 (GRCm39) |
V501I |
probably damaging |
Het |
| Thap2 |
T |
C |
10: 115,208,751 (GRCm39) |
H123R |
probably damaging |
Het |
| Tlx3 |
C |
A |
11: 33,152,432 (GRCm39) |
W221L |
probably benign |
Het |
| Tmem262 |
T |
A |
19: 6,130,567 (GRCm39) |
|
probably null |
Het |
| Tpmt |
C |
A |
13: 47,180,735 (GRCm39) |
R201S |
probably benign |
Het |
| Trpm6 |
T |
C |
19: 18,831,655 (GRCm39) |
S1507P |
probably damaging |
Het |
| Ttc9c |
T |
C |
19: 8,795,847 (GRCm39) |
E64G |
possibly damaging |
Het |
| Ttn |
A |
T |
2: 76,640,790 (GRCm39) |
S13653T |
probably damaging |
Het |
| Ugt3a1 |
G |
T |
15: 9,310,726 (GRCm39) |
W336L |
possibly damaging |
Het |
| Vmn1r215 |
C |
A |
13: 23,260,633 (GRCm39) |
N224K |
probably benign |
Het |
| Vmn2r59 |
C |
T |
7: 41,691,835 (GRCm39) |
|
probably null |
Het |
| Wdfy3 |
A |
G |
5: 102,046,295 (GRCm39) |
S1853P |
possibly damaging |
Het |
| Wdr36 |
A |
T |
18: 32,975,059 (GRCm39) |
Y137F |
possibly damaging |
Het |
| Zdhhc17 |
T |
C |
10: 110,792,216 (GRCm39) |
D324G |
probably benign |
Het |
| Zfp217 |
T |
C |
2: 169,961,497 (GRCm39) |
T277A |
probably benign |
Het |
| Zfp451 |
A |
G |
1: 33,842,219 (GRCm39) |
|
probably benign |
Het |
| Zfp709 |
TCGACG |
TCG |
8: 72,644,552 (GRCm39) |
|
probably benign |
Het |
| Zfp871 |
T |
C |
17: 32,994,858 (GRCm39) |
S106G |
possibly damaging |
Het |
|
| Other mutations in Caskin1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00402:Caskin1
|
APN |
17 |
24,722,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00846:Caskin1
|
APN |
17 |
24,718,323 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01120:Caskin1
|
APN |
17 |
24,724,343 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL01543:Caskin1
|
APN |
17 |
24,723,522 (GRCm39) |
missense |
probably benign |
|
|
IGL01622:Caskin1
|
APN |
17 |
24,722,914 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01623:Caskin1
|
APN |
17 |
24,722,914 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02120:Caskin1
|
APN |
17 |
24,719,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02816:Caskin1
|
APN |
17 |
24,721,144 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02898:Caskin1
|
APN |
17 |
24,721,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03353:Caskin1
|
APN |
17 |
24,718,331 (GRCm39) |
splice site |
probably benign |
|
|
PIT4151001:Caskin1
|
UTSW |
17 |
24,721,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4453001:Caskin1
|
UTSW |
17 |
24,718,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0057:Caskin1
|
UTSW |
17 |
24,723,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0057:Caskin1
|
UTSW |
17 |
24,723,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0190:Caskin1
|
UTSW |
17 |
24,723,596 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0443:Caskin1
|
UTSW |
17 |
24,724,374 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0885:Caskin1
|
UTSW |
17 |
24,724,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1035:Caskin1
|
UTSW |
17 |
24,724,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1253:Caskin1
|
UTSW |
17 |
24,724,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1497:Caskin1
|
UTSW |
17 |
24,723,515 (GRCm39) |
nonsense |
probably null |
|
|
R1589:Caskin1
|
UTSW |
17 |
24,724,452 (GRCm39) |
splice site |
probably null |
|
|
R1651:Caskin1
|
UTSW |
17 |
24,721,186 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1944:Caskin1
|
UTSW |
17 |
24,719,745 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1969:Caskin1
|
UTSW |
17 |
24,725,824 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2057:Caskin1
|
UTSW |
17 |
24,715,433 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2127:Caskin1
|
UTSW |
17 |
24,715,970 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2158:Caskin1
|
UTSW |
17 |
24,724,128 (GRCm39) |
missense |
probably benign |
|
|
R2402:Caskin1
|
UTSW |
17 |
24,722,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2895:Caskin1
|
UTSW |
17 |
24,708,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3423:Caskin1
|
UTSW |
17 |
24,718,539 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3800:Caskin1
|
UTSW |
17 |
24,720,246 (GRCm39) |
missense |
probably benign |
|
|
R4108:Caskin1
|
UTSW |
17 |
24,721,121 (GRCm39) |
missense |
probably benign |
|
|
R4419:Caskin1
|
UTSW |
17 |
24,723,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Caskin1
|
UTSW |
17 |
24,725,602 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4511:Caskin1
|
UTSW |
17 |
24,725,602 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4552:Caskin1
|
UTSW |
17 |
24,725,602 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4638:Caskin1
|
UTSW |
17 |
24,725,602 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4642:Caskin1
|
UTSW |
17 |
24,725,602 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4644:Caskin1
|
UTSW |
17 |
24,725,602 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4824:Caskin1
|
UTSW |
17 |
24,720,103 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4882:Caskin1
|
UTSW |
17 |
24,723,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4964:Caskin1
|
UTSW |
17 |
24,726,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4966:Caskin1
|
UTSW |
17 |
24,726,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5809:Caskin1
|
UTSW |
17 |
24,723,521 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5841:Caskin1
|
UTSW |
17 |
24,715,183 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5877:Caskin1
|
UTSW |
17 |
24,724,239 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5960:Caskin1
|
UTSW |
17 |
24,717,869 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5994:Caskin1
|
UTSW |
17 |
24,715,935 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6022:Caskin1
|
UTSW |
17 |
24,715,709 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6209:Caskin1
|
UTSW |
17 |
24,726,095 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6287:Caskin1
|
UTSW |
17 |
24,715,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6497:Caskin1
|
UTSW |
17 |
24,723,522 (GRCm39) |
missense |
probably benign |
|
|
R6873:Caskin1
|
UTSW |
17 |
24,723,153 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7079:Caskin1
|
UTSW |
17 |
24,717,858 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7156:Caskin1
|
UTSW |
17 |
24,719,657 (GRCm39) |
splice site |
probably null |
|
|
R7385:Caskin1
|
UTSW |
17 |
24,722,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7953:Caskin1
|
UTSW |
17 |
24,723,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7993:Caskin1
|
UTSW |
17 |
24,718,279 (GRCm39) |
nonsense |
probably null |
|
|
R8410:Caskin1
|
UTSW |
17 |
24,721,123 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8511:Caskin1
|
UTSW |
17 |
24,724,910 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8749:Caskin1
|
UTSW |
17 |
24,723,774 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8881:Caskin1
|
UTSW |
17 |
24,718,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8979:Caskin1
|
UTSW |
17 |
24,717,899 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9005:Caskin1
|
UTSW |
17 |
24,718,111 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9341:Caskin1
|
UTSW |
17 |
24,723,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9343:Caskin1
|
UTSW |
17 |
24,723,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0022:Caskin1
|
UTSW |
17 |
24,724,140 (GRCm39) |
missense |
probably benign |
0.34 |
|
X0063:Caskin1
|
UTSW |
17 |
24,726,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Caskin1
|
UTSW |
17 |
24,724,012 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Caskin1
|
UTSW |
17 |
24,715,661 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGCCAGTGGACTGCTATG -3'
(R):5'- AGTTGTTGCACAGGGAGCAG -3'
Sequencing Primer
(F):5'- CCAGTGGACTGCTATGGGTAG -3'
(R):5'- ATCTGCTCAGAGCCCTTGGAG -3'
|
| Posted On |
2018-02-28 |
Incidental Mutation