Incidental Mutation 'R6232:Or4a66'
ID 504655
Institutional Source Beutler Lab
Gene Symbol Or4a66
Ensembl Gene ENSMUSG00000075120
Gene Name olfactory receptor family 4 subfamily A member 66
Synonyms Olfr1196, GA_x6K02T2Q125-50181139-50180195, MOR225-5
MMRRC Submission 044360-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R6232 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88530727-88531671 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 88531161 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Asparagine at position 171 (H171N)
Ref Sequence ENSEMBL: ENSMUSP00000149902 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104892] [ENSMUST00000216928] [ENSMUST00000216977]
AlphaFold Q7TR14
Predicted Effect probably benign
Transcript: ENSMUST00000104892
AA Change: H171N

PolyPhen 2 Score 0.213 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000100488
Gene: ENSMUSG00000075120
AA Change: H171N

DomainStartEndE-ValueType
Pfam:7tm_4 29 302 7.2e-47 PFAM
Pfam:7tm_1 39 285 1.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216928
AA Change: H171N

PolyPhen 2 Score 0.213 (Sensitivity: 0.92; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000216977
AA Change: H171N

PolyPhen 2 Score 0.213 (Sensitivity: 0.92; Specificity: 0.88)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.7%
Validation Efficiency 94% (64/68)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl5 T C 19: 55,268,933 (GRCm39) V198A possibly damaging Het
Adam34l T G 8: 44,078,949 (GRCm39) N425T probably benign Het
Adgra2 A T 8: 27,609,193 (GRCm39) M805L probably benign Het
Arhgap39 T C 15: 76,620,712 (GRCm39) S630G probably damaging Het
Bcl3 T A 7: 19,546,409 (GRCm39) N142I probably damaging Het
Cfap210 C T 2: 69,602,398 (GRCm39) E338K possibly damaging Het
Chuk A T 19: 44,085,431 (GRCm39) D238E probably benign Het
Cnga4 T G 7: 105,056,906 (GRCm39) Y336* probably null Het
Cyp2j8 A T 4: 96,395,427 (GRCm39) L66Q possibly damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Homo
Dst T A 1: 34,227,253 (GRCm39) D1290E probably damaging Het
Dysf T C 6: 84,075,235 (GRCm39) I583T probably benign Het
Eif1ad13 A T 12: 87,762,351 (GRCm39) R24* probably null Het
Fbxl2 T A 9: 113,815,516 (GRCm39) D249V probably damaging Het
Fbxo30 A T 10: 11,165,602 (GRCm39) Y108F possibly damaging Het
Fibin G T 2: 110,193,041 (GRCm39) H34N probably damaging Het
Gabrr1 A G 4: 33,161,632 (GRCm39) I319V probably benign Het
Gfm1 G T 3: 67,375,215 (GRCm39) L559F possibly damaging Het
Gm5134 T A 10: 75,821,859 (GRCm39) L231Q possibly damaging Het
Grm5 A G 7: 87,251,638 (GRCm39) probably benign Het
Hbs1l T A 10: 21,183,657 (GRCm39) probably null Het
Hsf5 C G 11: 87,508,120 (GRCm39) T8S probably benign Het
Hspa4 C T 11: 53,153,766 (GRCm39) E702K probably benign Het
Inpp4b A G 8: 82,678,813 (GRCm39) Q281R probably damaging Het
Krt40 G A 11: 99,433,920 (GRCm39) A22V possibly damaging Het
Ldlrap1 C T 4: 134,486,345 (GRCm39) R38Q possibly damaging Het
Lepr A G 4: 101,671,588 (GRCm39) probably null Het
Map3k12 A G 15: 102,412,081 (GRCm39) S328P probably damaging Het
Mrpl2 T C 17: 46,958,356 (GRCm39) V46A probably benign Het
Muc16 A T 9: 18,568,294 (GRCm39) N1408K unknown Het
Myh7 T A 14: 55,226,753 (GRCm39) Q366L probably benign Het
Nbeal2 A G 9: 110,467,802 (GRCm39) V462A probably damaging Het
Nradd G T 9: 110,450,655 (GRCm39) T174N probably damaging Het
Nup155 T C 15: 8,138,963 (GRCm39) S12P probably benign Het
Obscn C A 11: 58,943,337 (GRCm39) E4832* probably null Het
Opn3 G A 1: 175,490,669 (GRCm39) R331W probably damaging Het
Or2ag15 A T 7: 106,340,761 (GRCm39) C127S probably damaging Het
Or2w3 T A 11: 58,556,757 (GRCm39) V124E possibly damaging Het
Or52ae9 T A 7: 103,389,661 (GRCm39) H262L probably damaging Het
Or5b120 G A 19: 13,480,427 (GRCm39) C240Y probably damaging Het
Or6b2 T C 1: 92,408,305 (GRCm39) I13V probably benign Het
Phip A G 9: 82,785,234 (GRCm39) V827A probably benign Het
Phldb1 G A 9: 44,607,414 (GRCm39) R1264W probably damaging Het
Pibf1 T G 14: 99,424,014 (GRCm39) I529S probably benign Het
Pkp1 T A 1: 135,814,599 (GRCm39) I241F probably benign Het
Pla2g4f G T 2: 120,132,702 (GRCm39) D711E possibly damaging Het
Pold1 A G 7: 44,190,266 (GRCm39) probably null Het
Pold2 T C 11: 5,823,691 (GRCm39) S287G probably benign Het
Prg4 T C 1: 150,331,567 (GRCm39) probably benign Het
Prl8a1 T C 13: 27,759,557 (GRCm39) E160G possibly damaging Het
Rfc4 C T 16: 22,932,840 (GRCm39) probably benign Het
Robo3 T G 9: 37,332,225 (GRCm39) Y891S probably damaging Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Homo
Rsph14 G A 10: 74,797,520 (GRCm39) R156W probably benign Het
Sec61a1 T C 6: 88,482,150 (GRCm39) Y457C probably benign Het
Sec63 T A 10: 42,704,861 (GRCm39) probably null Het
Spen T C 4: 141,244,333 (GRCm39) E234G unknown Het
Sphkap T A 1: 83,258,200 (GRCm39) E181V probably damaging Het
Stau2 C T 1: 16,445,035 (GRCm39) A298T probably benign Het
Tbc1d2 C T 4: 46,629,912 (GRCm39) G252R probably benign Het
Tbc1d23 T C 16: 56,990,796 (GRCm39) I661V probably benign Het
Thoc6 A C 17: 23,889,295 (GRCm39) probably null Het
Trpv1 T A 11: 73,141,636 (GRCm39) M553K possibly damaging Het
Ttn T C 2: 76,641,579 (GRCm39) I11760V probably benign Het
Vmn1r61 G A 7: 5,613,850 (GRCm39) H155Y probably damaging Het
Vmn2r41 A G 7: 8,153,214 (GRCm39) probably null Het
Vmn2r74 A G 7: 85,607,498 (GRCm39) I75T possibly damaging Het
Wwp2 C A 8: 108,232,977 (GRCm39) T205K probably benign Het
Zfp1003 A T 2: 177,546,195 (GRCm39) T40S probably benign Het
Zfp747 C T 7: 126,973,306 (GRCm39) G288D probably damaging Het
Zfp871 CCACAC CC 17: 32,994,494 (GRCm39) probably null Het
Zfp953 G A 13: 67,491,161 (GRCm39) L264F possibly damaging Het
Other mutations in Or4a66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01309:Or4a66 APN 2 88,531,310 (GRCm39) missense probably damaging 1.00
R0269:Or4a66 UTSW 2 88,531,040 (GRCm39) missense probably damaging 0.99
R0556:Or4a66 UTSW 2 88,531,115 (GRCm39) missense possibly damaging 0.83
R0561:Or4a66 UTSW 2 88,530,914 (GRCm39) missense possibly damaging 0.91
R0617:Or4a66 UTSW 2 88,531,040 (GRCm39) missense probably damaging 0.99
R1497:Or4a66 UTSW 2 88,531,106 (GRCm39) missense probably damaging 1.00
R1676:Or4a66 UTSW 2 88,531,661 (GRCm39) missense probably benign 0.00
R3979:Or4a66 UTSW 2 88,530,792 (GRCm39) missense probably benign 0.08
R4791:Or4a66 UTSW 2 88,531,242 (GRCm39) missense probably benign 0.00
R4836:Or4a66 UTSW 2 88,531,544 (GRCm39) missense probably damaging 1.00
R5917:Or4a66 UTSW 2 88,531,049 (GRCm39) missense possibly damaging 0.94
R6392:Or4a66 UTSW 2 88,531,011 (GRCm39) missense probably damaging 1.00
R7033:Or4a66 UTSW 2 88,531,164 (GRCm39) missense probably damaging 1.00
R7360:Or4a66 UTSW 2 88,531,331 (GRCm39) missense probably damaging 1.00
R7640:Or4a66 UTSW 2 88,531,230 (GRCm39) missense probably benign
R8968:Or4a66 UTSW 2 88,531,137 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CTACAGGTAGAGAGTGCTTTGC -3'
(R):5'- GCAGGTGTGGAAATCTTCATCC -3'

Sequencing Primer
(F):5'- GCGCTTCCCTGCAGATGATC -3'
(R):5'- GGAAATCTTCATCCTGGTGTCCATG -3'
Posted On 2018-02-28