Incidental Mutation 'IGL01089:Olfr338'
ID50470
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr338
Ensembl Gene ENSMUSG00000068950
Gene Nameolfactory receptor 338
SynonymsMOR136-5, GA_x6K02T2NLDC-33070879-33071799
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock #IGL01089
Quality Score
Status
Chromosome2
Chromosomal Location36373519-36382433 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 36377166 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 130 (Y130F)
Ref Sequence ENSEMBL: ENSMUSP00000149146 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072114] [ENSMUST00000091006] [ENSMUST00000217511]
Predicted Effect probably damaging
Transcript: ENSMUST00000072114
AA Change: Y130F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071985
Gene: ENSMUSG00000068950
AA Change: Y130F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.3e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.8e-8 PFAM
Pfam:7tm_1 41 290 1.1e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000091006
AA Change: Y130F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000088528
Gene: ENSMUSG00000068950
AA Change: Y130F

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 3.9e-56 PFAM
Pfam:7tm_1 39 288 4.5e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217511
AA Change: Y130F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016K19Rik A G 11: 76,003,337 E180G possibly damaging Het
Actr8 T C 14: 29,988,335 L353S probably damaging Het
Adgrf2 G A 17: 42,710,158 P592S probably damaging Het
Aen G A 7: 78,907,302 M299I probably damaging Het
Afap1l2 A C 19: 56,913,411 probably null Het
Asnsd1 G A 1: 53,348,277 P64S probably damaging Het
Bmt2 A G 6: 13,663,271 M76T probably damaging Het
Clca3b A T 3: 144,823,522 V797D probably benign Het
Cog2 T C 8: 124,545,243 S499P probably benign Het
Cyp27a1 A T 1: 74,731,938 Y94F possibly damaging Het
D430042O09Rik A G 7: 125,795,313 E187G probably damaging Het
D630045J12Rik A G 6: 38,136,963 S1765P probably benign Het
Fam149a A G 8: 45,348,527 L519P possibly damaging Het
Fam171a2 G A 11: 102,437,848 A695V possibly damaging Het
Fat1 T A 8: 45,017,857 V1566E probably damaging Het
Flvcr1 T G 1: 191,013,390 N361H probably damaging Het
Gm1110 T C 9: 26,881,860 N540S probably benign Het
Kcns3 T A 12: 11,091,571 T376S possibly damaging Het
Krt32 A G 11: 100,087,779 S150P probably benign Het
Lrtm2 C T 6: 119,320,792 R96Q possibly damaging Het
Mctp1 A G 13: 77,020,798 E838G probably damaging Het
Mios T C 6: 8,234,363 probably null Het
Phldb1 T A 9: 44,707,887 K167* probably null Het
Pkhd1l1 A G 15: 44,483,869 probably benign Het
Plaa A G 4: 94,574,047 V531A probably benign Het
Psmb2 A G 4: 126,684,206 Y59C probably damaging Het
Ptprg A G 14: 12,215,286 H1091R probably damaging Het
Rbm44 T A 1: 91,168,697 V926D possibly damaging Het
Rgma G T 7: 73,409,714 V189L possibly damaging Het
Sbf2 A T 7: 110,348,962 I1227K probably damaging Het
Slc8a1 T C 17: 81,648,281 T443A probably damaging Het
Slc8a1 A G 17: 81,388,881 V896A probably damaging Het
Taf2 T C 15: 55,016,581 M1120V probably benign Het
Ugt2b34 C T 5: 86,906,326 V199I probably benign Het
Unc5c C A 3: 141,818,202 probably benign Het
Usp37 G A 1: 74,493,046 R63* probably null Het
Other mutations in Olfr338
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Olfr338 APN 2 36376916 missense probably damaging 0.99
IGL01298:Olfr338 APN 2 36377448 missense probably benign 0.01
IGL01300:Olfr338 APN 2 36377042 missense probably benign 0.13
IGL01632:Olfr338 APN 2 36377564 missense probably benign 0.02
IGL02480:Olfr338 APN 2 36377492 missense probably damaging 0.98
IGL02519:Olfr338 APN 2 36377313 missense possibly damaging 0.84
IGL02658:Olfr338 APN 2 36377060 missense probably damaging 0.97
IGL02716:Olfr338 APN 2 36377343 missense possibly damaging 0.88
IGL02983:Olfr338 APN 2 36377637 missense probably damaging 1.00
IGL03334:Olfr338 APN 2 36377051 missense possibly damaging 0.66
IGL03054:Olfr338 UTSW 2 36376932 missense possibly damaging 0.65
R0469:Olfr338 UTSW 2 36377462 missense probably benign 0.02
R1263:Olfr338 UTSW 2 36376994 missense probably damaging 0.99
R1500:Olfr338 UTSW 2 36377621 missense probably benign 0.04
R2444:Olfr338 UTSW 2 36377613 missense possibly damaging 0.59
R5571:Olfr338 UTSW 2 36377117 missense probably benign 0.01
R5999:Olfr338 UTSW 2 36377310 missense probably damaging 1.00
R6030:Olfr338 UTSW 2 36377544 missense probably damaging 0.97
R6030:Olfr338 UTSW 2 36377544 missense probably damaging 0.97
R6351:Olfr338 UTSW 2 36377196 missense possibly damaging 0.78
R6695:Olfr338 UTSW 2 36377105 missense probably benign 0.28
R6785:Olfr338 UTSW 2 36376842 missense probably benign 0.12
R6785:Olfr338 UTSW 2 36376951 nonsense probably null
R7795:Olfr338 UTSW 2 36377441 missense probably benign 0.05
R7814:Olfr338 UTSW 2 36376809 missense possibly damaging 0.48
R7878:Olfr338 UTSW 2 36377133 missense probably damaging 1.00
Posted On2013-06-21