Incidental Mutation 'R6235:Vsig10l'
ID 504870
Institutional Source Beutler Lab
Gene Symbol Vsig10l
Ensembl Gene ENSMUSG00000070604
Gene Name V-set and immunoglobulin domain containing 10 like
Synonyms
MMRRC Submission 044433-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.198) question?
Stock # R6235 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 43463151-43472019 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 43468972 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 798 (V798E)
Ref Sequence ENSEMBL: ENSMUSP00000103611 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107974] [ENSMUST00000107977] [ENSMUST00000203042] [ENSMUST00000203769]
AlphaFold D3YZF7
Predicted Effect probably benign
Transcript: ENSMUST00000107974
SMART Domains Protein: ENSMUSP00000103608
Gene: ENSMUSG00000013367

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
IG 39 130 1.7e-6 SMART
IGc2 145 202 4.45e-10 SMART
IGc2 229 298 1.69e-10 SMART
low complexity region 323 334 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107977
AA Change: V798E

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000103611
Gene: ENSMUSG00000070604
AA Change: V798E

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 28 52 N/A INTRINSIC
IG 183 285 1.92e0 SMART
IG 298 383 2.15e-3 SMART
IGc2 406 465 4.19e-6 SMART
Blast:IG_like 582 649 1e-13 BLAST
transmembrane domain 764 786 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000203042
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203152
Predicted Effect probably benign
Transcript: ENSMUST00000203769
AA Change: V696E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000144692
Gene: ENSMUSG00000070604
AA Change: V696E

DomainStartEndE-ValueType
IG 81 183 8.1e-3 SMART
IG 196 281 9.2e-6 SMART
IGc2 304 363 1.8e-8 SMART
Blast:IG_like 480 547 9e-14 BLAST
transmembrane domain 662 684 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205247
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.4%
Validation Efficiency 95% (73/77)
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6b T C 12: 113,491,710 (GRCm38) F716L probably benign Het
Akip1 A G 7: 109,707,413 (GRCm38) M106V probably benign Het
Aldh1l1 A T 6: 90,564,457 (GRCm38) I278F probably benign Het
Aplnr A G 2: 85,137,626 (GRCm38) T332A probably benign Het
Aqp4 A G 18: 15,398,113 (GRCm38) V197A probably damaging Het
Arid4a A T 12: 71,069,772 (GRCm38) probably null Het
Baiap2 A T 11: 119,981,408 (GRCm38) N99Y probably damaging Het
Ceacam1 A T 7: 25,471,792 (GRCm38) probably null Het
Cep78 T C 19: 15,976,486 (GRCm38) probably null Het
Cldn3 T C 5: 134,986,719 (GRCm38) F92S possibly damaging Het
Clec16a C A 16: 10,694,635 (GRCm38) P812Q probably damaging Het
Cnga4 T G 7: 105,407,699 (GRCm38) Y336* probably null Het
Copg2 A G 6: 30,816,071 (GRCm38) I443T probably damaging Het
Crhbp C A 13: 95,443,850 (GRCm38) A81S probably damaging Het
Csad A T 15: 102,178,606 (GRCm38) V410D probably damaging Het
Ctps G A 4: 120,558,806 (GRCm38) L207F probably benign Het
Dab2ip A G 2: 35,723,087 (GRCm38) E1003G probably damaging Het
Ddx31 C G 2: 28,844,842 (GRCm38) A5G probably benign Het
Dnah12 A T 14: 26,854,804 (GRCm38) I3004F probably damaging Het
Fbxo15 A G 18: 84,980,904 (GRCm38) probably benign Het
Fbxw28 C A 9: 109,326,190 (GRCm38) W356C probably damaging Het
Gimap6 G T 6: 48,702,457 (GRCm38) T215K probably benign Het
Gm5346 T G 8: 43,625,912 (GRCm38) N425T probably benign Het
Hspa4 C T 11: 53,262,939 (GRCm38) E702K probably benign Het
Hunk A G 16: 90,432,706 (GRCm38) I152V probably damaging Het
Itk T C 11: 46,336,428 (GRCm38) E456G probably benign Het
Krt40 G A 11: 99,543,094 (GRCm38) A22V possibly damaging Het
Lars2 T C 9: 123,411,880 (GRCm38) V204A probably damaging Het
Lipo1 A G 19: 33,783,563 (GRCm38) Y140H probably damaging Het
Lrp1 G A 10: 127,588,177 (GRCm38) R809W probably damaging Het
Magi3 C T 3: 104,016,068 (GRCm38) G1111D probably damaging Het
Mis18bp1 A T 12: 65,158,408 (GRCm38) V47E probably damaging Het
Mpdz T C 4: 81,385,281 (GRCm38) E140G probably damaging Het
Myo1d T C 11: 80,692,944 (GRCm38) I81V probably benign Het
Nek10 T A 14: 14,821,113 (GRCm38) Y26* probably null Het
Ntng2 C A 2: 29,227,979 (GRCm38) E152D probably damaging Het
Olfr1036 T C 2: 86,075,166 (GRCm38) L142P possibly damaging Het
Olfr1490 C A 19: 13,654,781 (GRCm38) C117* probably null Het
Otud3 A T 4: 138,901,901 (GRCm38) V185D probably damaging Het
Parp6 C T 9: 59,630,815 (GRCm38) R248W probably benign Het
Pcdhga7 A G 18: 37,716,430 (GRCm38) T497A probably benign Het
Ppp1r18 A G 17: 35,873,877 (GRCm38) E140G probably damaging Het
Prl3b1 T C 13: 27,247,945 (GRCm38) L151P probably damaging Het
Pth1r C T 9: 110,722,316 (GRCm38) E572K possibly damaging Het
Ptprq T A 10: 107,635,338 (GRCm38) T1401S possibly damaging Het
Rad51ap2 A G 12: 11,457,516 (GRCm38) T480A possibly damaging Het
Rax T A 18: 65,935,161 (GRCm38) Q291L unknown Het
Reck T C 4: 43,937,450 (GRCm38) L734P probably damaging Het
Rgmb A G 17: 15,820,819 (GRCm38) F169L probably damaging Het
Rhobtb3 T C 13: 75,892,910 (GRCm38) I426M probably damaging Het
Ring1 C A 17: 34,023,306 (GRCm38) A76S probably damaging Het
Robo3 T G 9: 37,420,929 (GRCm38) Y891S probably damaging Het
Rpusd2 A G 2: 119,034,857 (GRCm38) I12V probably benign Het
Rragd T C 4: 32,995,985 (GRCm38) V165A possibly damaging Het
Rsf1 G GACGGCGGCT 7: 97,579,909 (GRCm38) probably benign Homo
Ryr1 G T 7: 29,116,181 (GRCm38) Q95K probably benign Het
S1pr4 T A 10: 81,498,882 (GRCm38) N253Y possibly damaging Het
Scn3a A C 2: 65,461,335 (GRCm38) V1689G probably damaging Het
Sdhb A G 4: 140,973,673 (GRCm38) N147D probably damaging Het
Sdk1 A T 5: 142,034,426 (GRCm38) H913L possibly damaging Het
Serpina3i T A 12: 104,266,532 (GRCm38) M232K probably damaging Het
Sipa1l2 A T 8: 125,474,871 (GRCm38) V646E probably damaging Het
Slc38a1 A T 15: 96,578,792 (GRCm38) I396N probably benign Het
Slc6a13 A T 6: 121,302,794 (GRCm38) E42D probably benign Het
Stard9 G A 2: 120,713,546 (GRCm38) V4442M probably damaging Het
Sumo3 T A 10: 77,616,237 (GRCm38) probably benign Het
Syngap1 A G 17: 26,958,130 (GRCm38) I356V probably benign Het
Tcam1 C T 11: 106,284,054 (GRCm38) Q112* probably null Het
Tdp2 T A 13: 24,840,395 (GRCm38) L225* probably null Het
Tmprss7 A G 16: 45,658,122 (GRCm38) V747A probably benign Het
Ugt2b34 T A 5: 86,906,364 (GRCm38) Y186F probably benign Het
Usp37 G T 1: 74,475,133 (GRCm38) S293* probably null Het
Vmn1r36 A G 6: 66,716,246 (GRCm38) I109T probably benign Het
Zfp36l1 G T 12: 80,112,822 (GRCm38) C18* probably null Het
Zfp959 T C 17: 55,897,427 (GRCm38) Y152H probably damaging Het
Zfyve26 A T 12: 79,249,599 (GRCm38) C1949S probably damaging Het
Zswim9 T A 7: 13,261,603 (GRCm38) E209V probably damaging Het
Other mutations in Vsig10l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01319:Vsig10l APN 7 43,465,254 (GRCm38) missense probably damaging 1.00
IGL01390:Vsig10l APN 7 43,466,465 (GRCm38) missense probably damaging 0.97
IGL02401:Vsig10l APN 7 43,464,044 (GRCm38) missense probably damaging 1.00
IGL02404:Vsig10l APN 7 43,463,747 (GRCm38) missense possibly damaging 0.85
IGL02514:Vsig10l APN 7 43,463,914 (GRCm38) missense probably benign 0.02
IGL02636:Vsig10l APN 7 43,463,578 (GRCm38) missense possibly damaging 0.53
IGL02805:Vsig10l APN 7 43,465,242 (GRCm38) missense probably damaging 1.00
IGL02823:Vsig10l APN 7 43,466,464 (GRCm38) missense probably damaging 1.00
IGL02827:Vsig10l APN 7 43,464,869 (GRCm38) missense probably damaging 1.00
R0111:Vsig10l UTSW 7 43,468,101 (GRCm38) missense probably damaging 0.97
R0394:Vsig10l UTSW 7 43,465,455 (GRCm38) missense probably damaging 0.97
R0465:Vsig10l UTSW 7 43,467,442 (GRCm38) missense probably damaging 1.00
R0632:Vsig10l UTSW 7 43,464,137 (GRCm38) missense probably damaging 0.97
R1689:Vsig10l UTSW 7 43,465,368 (GRCm38) missense possibly damaging 0.93
R1991:Vsig10l UTSW 7 43,467,468 (GRCm38) missense possibly damaging 0.89
R2103:Vsig10l UTSW 7 43,467,468 (GRCm38) missense possibly damaging 0.89
R2358:Vsig10l UTSW 7 43,468,761 (GRCm38) missense probably benign 0.00
R3015:Vsig10l UTSW 7 43,467,457 (GRCm38) missense possibly damaging 0.73
R4024:Vsig10l UTSW 7 43,468,086 (GRCm38) missense probably benign 0.33
R4031:Vsig10l UTSW 7 43,465,374 (GRCm38) missense probably damaging 1.00
R4807:Vsig10l UTSW 7 43,463,749 (GRCm38) missense possibly damaging 0.53
R5020:Vsig10l UTSW 7 43,465,317 (GRCm38) nonsense probably null
R5261:Vsig10l UTSW 7 43,470,850 (GRCm38) missense probably damaging 1.00
R5317:Vsig10l UTSW 7 43,464,823 (GRCm38) missense probably damaging 1.00
R5426:Vsig10l UTSW 7 43,464,823 (GRCm38) missense probably damaging 0.97
R5656:Vsig10l UTSW 7 43,464,151 (GRCm38) nonsense probably null
R5842:Vsig10l UTSW 7 43,468,972 (GRCm38) missense probably benign 0.15
R6012:Vsig10l UTSW 7 43,468,015 (GRCm38) missense probably damaging 1.00
R6309:Vsig10l UTSW 7 43,470,973 (GRCm38) splice site probably null
R6994:Vsig10l UTSW 7 43,465,067 (GRCm38) missense possibly damaging 0.71
R7250:Vsig10l UTSW 7 43,463,675 (GRCm38) missense probably benign
R7397:Vsig10l UTSW 7 43,468,007 (GRCm38) missense probably damaging 1.00
R7767:Vsig10l UTSW 7 43,463,717 (GRCm38) missense probably damaging 0.96
R7956:Vsig10l UTSW 7 43,468,070 (GRCm38) missense probably benign
R8086:Vsig10l UTSW 7 43,465,452 (GRCm38) missense possibly damaging 0.92
R8139:Vsig10l UTSW 7 43,463,729 (GRCm38) missense probably benign 0.00
R8297:Vsig10l UTSW 7 43,464,107 (GRCm38) missense possibly damaging 0.50
R8341:Vsig10l UTSW 7 43,463,954 (GRCm38) missense probably damaging 1.00
R8519:Vsig10l UTSW 7 43,464,902 (GRCm38) missense probably benign 0.33
R8925:Vsig10l UTSW 7 43,466,596 (GRCm38) missense probably benign 0.41
R8927:Vsig10l UTSW 7 43,466,596 (GRCm38) missense probably benign 0.41
R8948:Vsig10l UTSW 7 43,468,199 (GRCm38) missense possibly damaging 0.53
R9157:Vsig10l UTSW 7 43,463,524 (GRCm38) missense
R9203:Vsig10l UTSW 7 43,463,233 (GRCm38) start codon destroyed probably null
R9481:Vsig10l UTSW 7 43,463,371 (GRCm38) nonsense probably null
X0028:Vsig10l UTSW 7 43,463,364 (GRCm38) utr 3 prime probably benign
X0067:Vsig10l UTSW 7 43,467,490 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGCGTTACCCAGGTAAGAG -3'
(R):5'- AGAAGCTACTTGTCCCGCAC -3'

Sequencing Primer
(F):5'- ATGCAACTGGGGCCAACTG -3'
(R):5'- TACTTGTCCCGCACAGTGG -3'
Posted On 2018-02-28