Incidental Mutation 'R6240:Vmn2r6'
| ID |
505159 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r6
|
| Ensembl Gene |
ENSMUSG00000090581 |
| Gene Name |
vomeronasal 2, receptor 6 |
| Synonyms |
EG620718, EG667069 |
| MMRRC Submission |
044364-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.184)
|
| Stock # |
R6240 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
64537561-64565298 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 64556805 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Cysteine
at position 203
(S203C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135148
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165012]
[ENSMUST00000176481]
|
| AlphaFold |
H3BK29 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165012
AA Change: S114C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000131831
Gene: ENSMUSG00000090581
AA Change: S114C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
1 |
416 |
1.4e-72 |
PFAM |
|
Pfam:Peripla_BP_6
|
58 |
244 |
1.2e-10 |
PFAM |
|
Pfam:NCD3G
|
458 |
511 |
1.8e-17 |
PFAM |
|
Pfam:7tm_3
|
542 |
779 |
3.9e-76 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176481
AA Change: S203C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135148
Gene: ENSMUSG00000090581
AA Change: S203C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
88 |
505 |
9.8e-77 |
PFAM |
|
Pfam:Peripla_BP_6
|
142 |
331 |
3.4e-10 |
PFAM |
|
Pfam:NCD3G
|
547 |
600 |
5.4e-17 |
PFAM |
|
Pfam:7tm_3
|
633 |
867 |
3.9e-47 |
PFAM |
|
| Meta Mutation Damage Score |
0.6329 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.5%
|
| Validation Efficiency |
98% (62/63) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930578I06Rik |
C |
A |
14: 63,986,252 (GRCm38) |
R25L |
probably damaging |
Het |
| 9930021J03Rik |
A |
T |
19: 29,717,240 (GRCm38) |
S1618T |
probably benign |
Het |
| Adamts1 |
G |
A |
16: 85,802,157 (GRCm38) |
S185L |
probably benign |
Het |
| Adamts12 |
A |
T |
15: 11,285,958 (GRCm38) |
D751V |
probably benign |
Het |
| Adgrg3 |
A |
G |
8: 95,039,916 (GRCm38) |
D405G |
probably benign |
Het |
| Ahi1 |
A |
G |
10: 20,977,081 (GRCm38) |
D516G |
probably damaging |
Het |
| Ahnak |
A |
T |
19: 9,013,583 (GRCm38) |
D4077V |
probably damaging |
Het |
| Arhgef18 |
G |
A |
8: 3,439,658 (GRCm38) |
R330Q |
probably damaging |
Het |
| Arid1a |
A |
G |
4: 133,680,686 (GRCm38) |
V2170A |
unknown |
Het |
| Asxl3 |
C |
T |
18: 22,465,508 (GRCm38) |
L227F |
probably damaging |
Het |
| B3glct |
A |
G |
5: 149,726,788 (GRCm38) |
I119V |
probably benign |
Het |
| Cad |
T |
A |
5: 31,072,978 (GRCm38) |
M1512K |
probably benign |
Het |
| Cdc25a |
A |
G |
9: 109,884,158 (GRCm38) |
T172A |
probably damaging |
Het |
| Cdh18 |
A |
G |
15: 23,226,936 (GRCm38) |
D161G |
possibly damaging |
Het |
| Clmp |
A |
G |
9: 40,782,411 (GRCm38) |
N308S |
probably damaging |
Het |
| Dlg5 |
A |
T |
14: 24,149,528 (GRCm38) |
|
probably null |
Het |
| Dscam |
G |
A |
16: 96,619,502 (GRCm38) |
T1728M |
probably damaging |
Het |
| E4f1 |
A |
G |
17: 24,444,582 (GRCm38) |
S524P |
possibly damaging |
Het |
| Epha5 |
G |
C |
5: 84,117,579 (GRCm38) |
A452G |
probably benign |
Het |
| Fzd3 |
T |
C |
14: 65,209,855 (GRCm38) |
T542A |
probably damaging |
Het |
| Glyctk |
A |
T |
9: 106,156,262 (GRCm38) |
|
probably null |
Het |
| Gm10382 |
G |
A |
5: 125,389,596 (GRCm38) |
|
probably benign |
Het |
| Gm8765 |
G |
A |
13: 50,701,417 (GRCm38) |
D364N |
probably damaging |
Het |
| Hnmt |
T |
A |
2: 24,014,269 (GRCm38) |
M127L |
probably benign |
Het |
| Hoxc10 |
T |
A |
15: 102,970,830 (GRCm38) |
W262R |
probably damaging |
Het |
| Icam5 |
T |
A |
9: 21,033,158 (GRCm38) |
W52R |
possibly damaging |
Het |
| Jazf1 |
A |
T |
6: 52,777,552 (GRCm38) |
C180S |
probably damaging |
Het |
| Kcnk2 |
A |
G |
1: 189,242,982 (GRCm38) |
W286R |
probably damaging |
Het |
| Kcnmb2 |
C |
T |
3: 32,181,896 (GRCm38) |
S98F |
probably damaging |
Het |
| Mob3a |
C |
G |
10: 80,689,864 (GRCm38) |
E204D |
possibly damaging |
Het |
| Morc3 |
C |
G |
16: 93,862,684 (GRCm38) |
H459D |
probably damaging |
Het |
| Mroh2b |
A |
T |
15: 4,934,644 (GRCm38) |
N876I |
probably benign |
Het |
| Myo16 |
A |
T |
8: 10,370,930 (GRCm38) |
T257S |
probably damaging |
Het |
| Nat1 |
A |
T |
8: 67,491,702 (GRCm38) |
R243S |
possibly damaging |
Het |
| Nudt9 |
T |
C |
5: 104,047,089 (GRCm38) |
V17A |
probably benign |
Het |
| Olfr1205 |
A |
G |
2: 88,831,363 (GRCm38) |
D82G |
probably benign |
Het |
| Olfr1216 |
A |
G |
2: 89,013,626 (GRCm38) |
I146T |
probably benign |
Het |
| Olfr1340 |
A |
G |
4: 118,726,471 (GRCm38) |
S75G |
probably benign |
Het |
| Olfr734 |
A |
G |
14: 50,320,586 (GRCm38) |
V83A |
probably benign |
Het |
| Olfr814 |
C |
A |
10: 129,874,677 (GRCm38) |
V27L |
probably benign |
Het |
| Pcdh7 |
T |
C |
5: 57,721,362 (GRCm38) |
L753P |
probably damaging |
Het |
| Pcf11 |
T |
A |
7: 92,646,502 (GRCm38) |
E1446D |
probably damaging |
Het |
| Pepd |
A |
G |
7: 35,021,751 (GRCm38) |
I267V |
probably benign |
Het |
| Plk2 |
T |
A |
13: 110,399,474 (GRCm38) |
Y571N |
probably damaging |
Het |
| Plk2 |
T |
A |
13: 110,400,034 (GRCm38) |
V620E |
probably damaging |
Het |
| Prag1 |
T |
C |
8: 36,103,352 (GRCm38) |
L363P |
probably benign |
Het |
| Psmd3 |
A |
G |
11: 98,693,653 (GRCm38) |
T387A |
probably damaging |
Het |
| Ptgs1 |
G |
A |
2: 36,237,285 (GRCm38) |
C61Y |
probably damaging |
Het |
| Rab18 |
T |
C |
18: 6,784,635 (GRCm38) |
Y109H |
probably benign |
Het |
| Robo2 |
G |
A |
16: 73,982,139 (GRCm38) |
P358L |
probably damaging |
Het |
| Smarcc2 |
C |
T |
10: 128,488,024 (GRCm38) |
|
probably benign |
Het |
| Srgap1 |
A |
G |
10: 122,047,156 (GRCm38) |
I13T |
probably benign |
Het |
| Tcf12 |
T |
A |
9: 71,944,016 (GRCm38) |
K110* |
probably null |
Het |
| Tdrd1 |
T |
C |
19: 56,841,335 (GRCm38) |
S214P |
probably benign |
Het |
| Tdrd3 |
T |
A |
14: 87,505,886 (GRCm38) |
N417K |
probably damaging |
Het |
| Tmem255b |
A |
G |
8: 13,454,216 (GRCm38) |
Y136C |
probably damaging |
Het |
| Tmem63c |
A |
T |
12: 87,076,405 (GRCm38) |
I448F |
possibly damaging |
Het |
| Tnpo1 |
T |
C |
13: 98,863,829 (GRCm38) |
I335M |
probably damaging |
Het |
| Vmn1r1 |
T |
C |
1: 182,157,621 (GRCm38) |
T160A |
probably damaging |
Het |
| Vmn1r203 |
A |
G |
13: 22,524,729 (GRCm38) |
N227D |
possibly damaging |
Het |
| Zfp628 |
A |
G |
7: 4,919,849 (GRCm38) |
T357A |
possibly damaging |
Het |
| Zfp872 |
A |
G |
9: 22,199,884 (GRCm38) |
K220E |
probably damaging |
Het |
|
| Other mutations in Vmn2r6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01547:Vmn2r6
|
APN |
3 |
64,538,104 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01968:Vmn2r6
|
APN |
3 |
64,556,345 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02009:Vmn2r6
|
APN |
3 |
64,537,902 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
IGL02039:Vmn2r6
|
APN |
3 |
64,556,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02652:Vmn2r6
|
APN |
3 |
64,556,328 (GRCm38) |
missense |
probably benign |
0.24 |
|
IGL02737:Vmn2r6
|
APN |
3 |
64,556,490 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
IGL02808:Vmn2r6
|
APN |
3 |
64,556,496 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03066:Vmn2r6
|
APN |
3 |
64,565,153 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03331:Vmn2r6
|
APN |
3 |
64,538,007 (GRCm38) |
missense |
probably damaging |
1.00 |
|
BB010:Vmn2r6
|
UTSW |
3 |
64,559,803 (GRCm38) |
missense |
probably benign |
0.02 |
|
BB020:Vmn2r6
|
UTSW |
3 |
64,559,803 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0010:Vmn2r6
|
UTSW |
3 |
64,559,545 (GRCm38) |
nonsense |
probably null |
|
|
R0206:Vmn2r6
|
UTSW |
3 |
64,539,912 (GRCm38) |
missense |
probably benign |
|
|
R0206:Vmn2r6
|
UTSW |
3 |
64,539,912 (GRCm38) |
missense |
probably benign |
|
|
R0208:Vmn2r6
|
UTSW |
3 |
64,539,912 (GRCm38) |
missense |
probably benign |
|
|
R0427:Vmn2r6
|
UTSW |
3 |
64,559,587 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0466:Vmn2r6
|
UTSW |
3 |
64,556,302 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1018:Vmn2r6
|
UTSW |
3 |
64,556,840 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1104:Vmn2r6
|
UTSW |
3 |
64,538,066 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R1186:Vmn2r6
|
UTSW |
3 |
64,565,067 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1245:Vmn2r6
|
UTSW |
3 |
64,556,790 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R1295:Vmn2r6
|
UTSW |
3 |
64,538,273 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1473:Vmn2r6
|
UTSW |
3 |
64,538,158 (GRCm38) |
nonsense |
probably null |
|
|
R1498:Vmn2r6
|
UTSW |
3 |
64,556,469 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1925:Vmn2r6
|
UTSW |
3 |
64,556,277 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R2044:Vmn2r6
|
UTSW |
3 |
64,537,841 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2069:Vmn2r6
|
UTSW |
3 |
64,556,098 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R2253:Vmn2r6
|
UTSW |
3 |
64,559,718 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2261:Vmn2r6
|
UTSW |
3 |
64,556,669 (GRCm38) |
missense |
probably benign |
0.24 |
|
R2262:Vmn2r6
|
UTSW |
3 |
64,556,669 (GRCm38) |
missense |
probably benign |
0.24 |
|
R2350:Vmn2r6
|
UTSW |
3 |
64,556,352 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2680:Vmn2r6
|
UTSW |
3 |
64,538,286 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R2846:Vmn2r6
|
UTSW |
3 |
64,556,790 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R2860:Vmn2r6
|
UTSW |
3 |
64,547,339 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2861:Vmn2r6
|
UTSW |
3 |
64,547,339 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3766:Vmn2r6
|
UTSW |
3 |
64,556,508 (GRCm38) |
missense |
probably benign |
0.19 |
|
R3870:Vmn2r6
|
UTSW |
3 |
64,556,621 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4018:Vmn2r6
|
UTSW |
3 |
64,556,472 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4024:Vmn2r6
|
UTSW |
3 |
64,538,250 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R4026:Vmn2r6
|
UTSW |
3 |
64,538,250 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R4227:Vmn2r6
|
UTSW |
3 |
64,537,948 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4526:Vmn2r6
|
UTSW |
3 |
64,537,724 (GRCm38) |
missense |
probably benign |
0.32 |
|
R4570:Vmn2r6
|
UTSW |
3 |
64,559,647 (GRCm38) |
missense |
probably benign |
0.31 |
|
R4894:Vmn2r6
|
UTSW |
3 |
64,547,408 (GRCm38) |
missense |
probably benign |
|
|
R4934:Vmn2r6
|
UTSW |
3 |
64,556,345 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5057:Vmn2r6
|
UTSW |
3 |
64,537,786 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5059:Vmn2r6
|
UTSW |
3 |
64,537,623 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R5148:Vmn2r6
|
UTSW |
3 |
64,556,594 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5155:Vmn2r6
|
UTSW |
3 |
64,538,514 (GRCm38) |
missense |
probably benign |
0.44 |
|
R5179:Vmn2r6
|
UTSW |
3 |
64,537,990 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5256:Vmn2r6
|
UTSW |
3 |
64,556,842 (GRCm38) |
missense |
probably benign |
0.33 |
|
R5861:Vmn2r6
|
UTSW |
3 |
64,556,033 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5950:Vmn2r6
|
UTSW |
3 |
64,565,231 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6081:Vmn2r6
|
UTSW |
3 |
64,556,532 (GRCm38) |
missense |
probably benign |
0.25 |
|
R6173:Vmn2r6
|
UTSW |
3 |
64,559,755 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6190:Vmn2r6
|
UTSW |
3 |
64,538,003 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6433:Vmn2r6
|
UTSW |
3 |
64,547,380 (GRCm38) |
nonsense |
probably null |
|
|
R6645:Vmn2r6
|
UTSW |
3 |
64,556,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6791:Vmn2r6
|
UTSW |
3 |
64,538,159 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7265:Vmn2r6
|
UTSW |
3 |
64,556,774 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7503:Vmn2r6
|
UTSW |
3 |
64,539,951 (GRCm38) |
nonsense |
probably null |
|
|
R7562:Vmn2r6
|
UTSW |
3 |
64,556,520 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7584:Vmn2r6
|
UTSW |
3 |
64,565,262 (GRCm38) |
missense |
probably benign |
0.07 |
|
R7611:Vmn2r6
|
UTSW |
3 |
64,565,142 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7759:Vmn2r6
|
UTSW |
3 |
64,556,570 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7834:Vmn2r6
|
UTSW |
3 |
64,538,022 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7933:Vmn2r6
|
UTSW |
3 |
64,559,803 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7982:Vmn2r6
|
UTSW |
3 |
64,559,820 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8024:Vmn2r6
|
UTSW |
3 |
64,559,824 (GRCm38) |
missense |
probably benign |
0.40 |
|
R8074:Vmn2r6
|
UTSW |
3 |
64,547,643 (GRCm38) |
intron |
probably benign |
|
|
R8169:Vmn2r6
|
UTSW |
3 |
64,539,889 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8337:Vmn2r6
|
UTSW |
3 |
64,556,105 (GRCm38) |
nonsense |
probably null |
|
|
R8736:Vmn2r6
|
UTSW |
3 |
64,559,800 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8962:Vmn2r6
|
UTSW |
3 |
64,556,155 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9139:Vmn2r6
|
UTSW |
3 |
64,556,856 (GRCm38) |
missense |
probably benign |
0.12 |
|
R9206:Vmn2r6
|
UTSW |
3 |
64,559,611 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9295:Vmn2r6
|
UTSW |
3 |
64,556,063 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9332:Vmn2r6
|
UTSW |
3 |
64,547,250 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9616:Vmn2r6
|
UTSW |
3 |
64,538,303 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9663:Vmn2r6
|
UTSW |
3 |
64,556,128 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R9685:Vmn2r6
|
UTSW |
3 |
64,556,660 (GRCm38) |
missense |
probably benign |
0.19 |
|
X0020:Vmn2r6
|
UTSW |
3 |
64,538,450 (GRCm38) |
missense |
probably benign |
|
|
X0066:Vmn2r6
|
UTSW |
3 |
64,547,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r6
|
UTSW |
3 |
64,556,325 (GRCm38) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCAGTGGAACTCTTTACTGC -3'
(R):5'- TCTACAGTAGGATGTGAGGGC -3'
Sequencing Primer
(F):5'- GTGGAACTCTTTACTGCATCAACAGC -3'
(R):5'- TGTGAGGGCAAAGGGATCCC -3'
|
| Posted On |
2018-02-28 |
Incidental Mutation