Mutagenetix > Incidental Mutation

Incidental Mutation 'R6242:Vmn2r23'

505292

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R6242 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

123702821-123742291 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 123704400 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 89 (E89G)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000172391
AA Change: E89G

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: E89G

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.5%
20x: 95.9%

Validation Efficiency

99% (75/76)

Allele List at MGI

Other mutations in this stock

Total: 76 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110032A03Rik	C	T	9: 50,763,915	E148K	probably benign	Het
1700016K19Rik	T	C	11: 76,000,155	S32P	probably damaging	Het
4933425L06Rik	T	A	13: 105,109,540	V203E	probably benign	Het
Adcy6	G	T	15: 98,604,015	C239*	probably null	Het
Akr1c6	A	G	13: 4,436,362	Q56R	probably benign	Het
Apaf1	T	A	10: 91,062,163	D244V	probably damaging	Het
Araf	G	T	X: 20,860,100	R601L	probably damaging	Homo
Arhgef11	C	A	3: 87,728,078	A898E	probably benign	Het
Asxl3	A	T	18: 22,522,376	N1148Y	probably damaging	Het
Atf6	T	A	1: 170,793,976	Q492L	possibly damaging	Het
Atrnl1	G	T	19: 57,642,478	V226F	probably benign	Het
Cntnap1	A	T	11: 101,182,538	Y615F	probably damaging	Het
Crybg3	T	C	16: 59,555,690	T1734A	probably benign	Het
Ctdp1	A	C	18: 80,459,212	V161G	probably damaging	Het
Cyp4a30b	T	A	4: 115,454,390	V85E	possibly damaging	Het
Dnase1l1	C	T	X: 74,277,038		probably null	Homo
Epha6	A	T	16: 59,682,662	W961R	probably damaging	Het
Fam114a1	A	G	5: 65,031,352	E475G	probably damaging	Het
Fam186a	A	G	15: 99,939,907	Y2819H	unknown	Het
Fancm	A	T	12: 65,116,442	Q1460L	probably benign	Het
Fancm	C	A	12: 65,116,449	N1462K	probably benign	Het
Fgf14	T	C	14: 124,676,528	K64E	probably benign	Het
Fndc5	T	C	4: 129,139,895	V152A	probably benign	Het
Garem1	C	G	18: 21,129,172	V862L	possibly damaging	Het
Grin3b	G	A	10: 79,976,179	G814R	probably damaging	Het
Hacd4	A	G	4: 88,414,287	S226P	probably benign	Het
Htt	A	G	5: 34,846,012	Y1277C	probably damaging	Het
Igkv1-131	T	A	6: 67,766,078	D107V	probably damaging	Het
Iqcc	T	C	4: 129,616,846	D292G	probably damaging	Het
Krtap13	C	T	16: 88,751,496	V35I	probably damaging	Het
Lrrc59	G	T	11: 94,634,983	L132F	possibly damaging	Het
Mcub	T	C	3: 129,915,795	S290G	probably benign	Het
Mettl4	A	G	17: 94,735,374	W345R	probably damaging	Het
Msgn1	G	A	12: 11,208,525	R142W	probably damaging	Het
Myo5c	A	G	9: 75,273,611	I761V	probably benign	Het
Neb	T	A	2: 52,176,812	K5879M	probably damaging	Het
Nkd2	C	T	13: 73,822,786	V226M	probably damaging	Het
Olfr1459	T	A	19: 13,146,086	H191L	probably benign	Het
Olfr645	T	G	7: 104,084,564	H172P	possibly damaging	Het
Parp4	T	A	14: 56,595,399	L393*	probably null	Het
Pcdhgb6	G	A	18: 37,743,555	V439I	probably benign	Het
Pde1a	T	A	2: 80,128,792	T15S	probably benign	Het
Pgr	T	A	9: 8,900,979	I171N	probably benign	Het
Podxl	T	A	6: 31,526,245	D296V	probably benign	Het
Polr3e	A	T	7: 120,940,467	E479V	possibly damaging	Het
Prdm10	A	T	9: 31,341,252	H427L	possibly damaging	Het
Prl5a1	A	T	13: 28,142,555	K5*	probably null	Het
Prph	A	G	15: 99,057,123	S325G	probably damaging	Het
Rabl2	C	A	15: 89,584,352	W49L	probably benign	Het
Rbbp8nl	T	A	2: 180,280,974	I209F	probably damaging	Het
Rsf1	ATGGCG	ATGGCGACGGTGGCG	7: 97,579,904		probably benign	Homo
Scn7a	T	C	2: 66,700,766	D589G	probably benign	Het
Sdr42e1	A	T	8: 117,663,197	L235Q	possibly damaging	Het
Serpina3a	T	C	12: 104,116,001	M11T	probably benign	Het
Slc6a4	A	T	11: 77,018,358	K399*	probably null	Het
Slco4c1	T	A	1: 96,839,283	T337S	probably damaging	Het
Spc25	A	T	2: 69,197,211	F112L	probably damaging	Het
Swt1	A	G	1: 151,407,614	S331P	probably benign	Het
Tab1	A	T	15: 80,155,770	K264*	probably null	Het
Tagln3	T	A	16: 45,724,338		probably benign	Het
Tbc1d2	C	T	4: 46,629,912	G252R	probably benign	Het
Tbck	A	G	3: 132,694,428	D80G	probably benign	Het
Tcim	A	T	8: 24,438,895	M1K	probably null	Het
Thap2	A	G	10: 115,372,926	S37P	unknown	Het
Tjp2	A	T	19: 24,099,603		probably null	Het
Tln1	G	A	4: 43,533,145	S2390L	probably damaging	Het
Trpm5	T	G	7: 143,073,182	I1101L	probably benign	Het
Ttc3	T	G	16: 94,442,695	M831R	probably benign	Het
Tulp3	A	G	6: 128,323,087	C459R	probably damaging	Het
Uaca	G	A	9: 60,870,044	R571Q	probably damaging	Het
Unc13b	A	T	4: 43,165,800	T195S	possibly damaging	Het
Urgcp	A	G	11: 5,716,691	L549P	probably benign	Het
Usp10	G	T	8: 119,941,838	A293S	probably benign	Het
Vmn2r75	A	C	7: 86,165,384	D300E	probably damaging	Het
Wif1	T	C	10: 121,034,461	I40T	possibly damaging	Het
Zmynd8	G	A	2: 165,898,947	R6C	possibly damaging	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123729725	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123729596	missense	probably benign
IGL01073:Vmn2r23	APN	6	123712800	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123704424	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123704407	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123741886	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123741860	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123741744	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123741836	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123704478	missense	probably benign
IGL02831:Vmn2r23	APN	6	123704385	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123704396	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123741619	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123741782	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123704374	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123729626	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123729721	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123742135	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123742004	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123713270	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123713427	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123729690	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123702915	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123713010	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123741499	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123704425	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123742188	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123713170	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123741389	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123729738	missense	probably benign
R4506:Vmn2r23	UTSW	6	123702925	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123741730	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123741826	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123733349	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123713002	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123733273	missense	probably benign
R5761:Vmn2r23	UTSW	6	123712759	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123712942	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123741895	missense	possibly damaging	0.94
R6416:Vmn2r23	UTSW	6	123712902	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123713425	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123733273	missense	probably benign
R6925:Vmn2r23	UTSW	6	123704553	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123713022	missense	probably benign
R7215:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123741581	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123704579	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123704541	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123741353	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123704640	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123741656	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123713472	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123703032	missense
R8966:Vmn2r23	UTSW	6	123742120	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123742079	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123741823	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123712713	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123712713	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123713116	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123713161	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123742108	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123729725	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- AATGTCCTGCTTGTTTCTTGGA -3'
(R):5'- ACTGCAACCAGCTTATCAGTC -3'

Sequencing Primer
(F):5'- ATCCAGAATTTGAGAGGGAGC -3'
(R):5'- AGTCTTCTCAGGCCTACAACTGTAG -3'

Posted On

2018-02-28