|Institutional Source||Beutler Lab|
|Gene Name||poly (ADP-ribose) polymerase family, member 4|
|Synonyms||p193, Adprtl1, E230037B21Rik, PH5P, VAULT3, VPARP, C030027K23Rik|
|Essential gene?||Probably non essential (E-score: 0.143)|
|Stock #||R6242 (G1)|
|Chromosomal Location||56575619-56659794 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||T to A at 56595399 bp (GRCm38)|
|Amino Acid Change||Leucine to Stop codon at position 393 (L393*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000124258 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000161553]|
AA Change: L393*
AA Change: L393*
|Coding Region Coverage||
|Validation Efficiency||99% (75/76)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are helathy and fertile. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Parp4||
(F):5'- AGGTGGTATCTCTAACATCTCTGT -3'
(R):5'- ACGTGCATGTACACACAGA -3'
(F):5'- GTATCATTCCACCCACAGCTGG -3'
(R):5'- CACAGAAATGTGTGTATGTGCCCAC -3'