Incidental Mutation 'R6244:Tnik'
ID |
505429 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tnik
|
Ensembl Gene |
ENSMUSG00000027692 |
Gene Name |
TRAF2 and NCK interacting kinase |
Synonyms |
C530008O15Rik, 4831440I19Rik, 1500031A17Rik, C630040K21Rik |
MMRRC Submission |
044435-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R6244 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
3 |
Chromosomal Location |
28317362-28724734 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to A
at 28704328 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Leucine to Isoleucine
at position 996
(L996I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000124387
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159236]
[ENSMUST00000159308]
[ENSMUST00000159680]
[ENSMUST00000160307]
[ENSMUST00000160518]
[ENSMUST00000161964]
[ENSMUST00000162485]
[ENSMUST00000162777]
[ENSMUST00000160934]
|
AlphaFold |
P83510 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000159236
AA Change: L1014I
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000124681 Gene: ENSMUSG00000027692 AA Change: L1014I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
low complexity region
|
793 |
812 |
N/A |
INTRINSIC |
low complexity region
|
951 |
958 |
N/A |
INTRINSIC |
CNH
|
1005 |
1303 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000159308
AA Change: L967I
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000125466 Gene: ENSMUSG00000027692 AA Change: L967I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
low complexity region
|
746 |
765 |
N/A |
INTRINSIC |
low complexity region
|
904 |
911 |
N/A |
INTRINSIC |
CNH
|
958 |
1256 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000159680
AA Change: L1043I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000124876 Gene: ENSMUSG00000027692 AA Change: L1043I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
low complexity region
|
822 |
841 |
N/A |
INTRINSIC |
low complexity region
|
980 |
987 |
N/A |
INTRINSIC |
CNH
|
1034 |
1332 |
1.92e-117 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159733
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000160307
AA Change: L1051I
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000125081 Gene: ENSMUSG00000027692 AA Change: L1051I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
low complexity region
|
720 |
755 |
N/A |
INTRINSIC |
low complexity region
|
830 |
849 |
N/A |
INTRINSIC |
low complexity region
|
988 |
995 |
N/A |
INTRINSIC |
CNH
|
1042 |
1340 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000160518
AA Change: L1022I
PolyPhen 2
Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000124011 Gene: ENSMUSG00000027692 AA Change: L1022I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
5.9e-99 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
691 |
726 |
N/A |
INTRINSIC |
low complexity region
|
801 |
820 |
N/A |
INTRINSIC |
low complexity region
|
959 |
966 |
N/A |
INTRINSIC |
CNH
|
1013 |
1311 |
9.3e-120 |
SMART |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000161964
AA Change: L959I
|
SMART Domains |
Protein: ENSMUSP00000125411 Gene: ENSMUSG00000027692 AA Change: L959I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
482 |
N/A |
INTRINSIC |
low complexity region
|
636 |
671 |
N/A |
INTRINSIC |
low complexity region
|
738 |
757 |
N/A |
INTRINSIC |
low complexity region
|
896 |
903 |
N/A |
INTRINSIC |
CNH
|
950 |
1248 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000162485
AA Change: L996I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000124387 Gene: ENSMUSG00000027692 AA Change: L996I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
low complexity region
|
775 |
794 |
N/A |
INTRINSIC |
low complexity region
|
933 |
940 |
N/A |
INTRINSIC |
CNH
|
987 |
1285 |
1.92e-117 |
SMART |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000162777
AA Change: L988I
|
SMART Domains |
Protein: ENSMUSP00000124726 Gene: ENSMUSG00000027692 AA Change: L988I
Domain | Start | End | E-Value | Type |
S_TKc
|
25 |
289 |
1.23e-96 |
SMART |
low complexity region
|
317 |
340 |
N/A |
INTRINSIC |
coiled coil region
|
360 |
511 |
N/A |
INTRINSIC |
low complexity region
|
665 |
700 |
N/A |
INTRINSIC |
low complexity region
|
767 |
786 |
N/A |
INTRINSIC |
low complexity region
|
925 |
932 |
N/A |
INTRINSIC |
CNH
|
979 |
1277 |
1.92e-117 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000160934
|
SMART Domains |
Protein: ENSMUSP00000123859 Gene: ENSMUSG00000027692
Domain | Start | End | E-Value | Type |
Pfam:Pkinase_Tyr
|
25 |
212 |
2.2e-37 |
PFAM |
Pfam:Pkinase
|
25 |
219 |
5.9e-52 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162037
|
Meta Mutation Damage Score |
0.1794 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.3%
- 20x: 95.1%
|
Validation Efficiency |
96% (82/85) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008] PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired postsynaptic signaling and cognitive function. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 84 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
6430550D23Rik |
T |
C |
2: 155,845,150 (GRCm39) |
H113R |
possibly damaging |
Het |
Adgrf3 |
A |
T |
5: 30,402,531 (GRCm39) |
M499K |
probably benign |
Het |
Adgrv1 |
G |
A |
13: 81,255,050 (GRCm39) |
T211I |
probably damaging |
Het |
Adss2 |
C |
T |
1: 177,604,395 (GRCm39) |
E153K |
probably benign |
Het |
Ago4 |
C |
A |
4: 126,405,280 (GRCm39) |
G431V |
possibly damaging |
Het |
Araf |
G |
T |
X: 20,726,339 (GRCm39) |
R601L |
probably damaging |
Homo |
Atp2b4 |
T |
A |
1: 133,654,299 (GRCm39) |
I769F |
probably damaging |
Het |
Atp9a |
T |
C |
2: 168,531,272 (GRCm39) |
|
probably null |
Het |
Bltp1 |
T |
C |
3: 37,011,148 (GRCm39) |
V1782A |
probably benign |
Het |
Brap |
C |
A |
5: 121,803,372 (GRCm39) |
D173E |
probably benign |
Het |
Brca2 |
G |
T |
5: 150,490,443 (GRCm39) |
R3035L |
probably benign |
Het |
Ccdc8 |
C |
A |
7: 16,730,176 (GRCm39) |
P555Q |
probably benign |
Het |
Ccser2 |
A |
G |
14: 36,662,675 (GRCm39) |
S170P |
probably benign |
Het |
Celsr2 |
T |
C |
3: 108,300,444 (GRCm39) |
H860R |
probably damaging |
Het |
Cenpc1 |
C |
A |
5: 86,194,244 (GRCm39) |
R174M |
probably damaging |
Het |
Cfap57 |
T |
G |
4: 118,436,607 (GRCm39) |
I930L |
probably damaging |
Het |
Cx3cr1 |
C |
T |
9: 119,880,760 (GRCm39) |
R214H |
probably damaging |
Het |
Cyp4f14 |
T |
A |
17: 33,125,291 (GRCm39) |
H429L |
probably benign |
Het |
D5Ertd579e |
A |
G |
5: 36,772,620 (GRCm39) |
F592L |
probably damaging |
Het |
Ddb1 |
A |
G |
19: 10,603,287 (GRCm39) |
E865G |
probably damaging |
Het |
Ddx50 |
A |
T |
10: 62,457,345 (GRCm39) |
|
probably null |
Het |
Dpp6 |
A |
G |
5: 27,254,626 (GRCm39) |
T14A |
probably damaging |
Het |
Echs1 |
C |
A |
7: 139,692,982 (GRCm39) |
Q51H |
possibly damaging |
Het |
Ecm2 |
A |
T |
13: 49,683,783 (GRCm39) |
D587V |
probably damaging |
Het |
Ect2l |
A |
T |
10: 18,016,145 (GRCm39) |
Y666N |
possibly damaging |
Het |
Epha2 |
G |
A |
4: 141,044,223 (GRCm39) |
G342S |
probably benign |
Het |
Fbxo33 |
C |
A |
12: 59,252,865 (GRCm39) |
K211N |
probably benign |
Het |
Fchsd2 |
A |
G |
7: 100,908,983 (GRCm39) |
|
probably null |
Het |
Fen1 |
A |
G |
19: 10,178,051 (GRCm39) |
V131A |
probably damaging |
Het |
Fetub |
C |
T |
16: 22,751,081 (GRCm39) |
R143C |
probably damaging |
Het |
Flnb |
A |
G |
14: 7,892,092 (GRCm38) |
E587G |
probably damaging |
Het |
Foxd3 |
A |
G |
4: 99,545,477 (GRCm39) |
T206A |
possibly damaging |
Het |
Fut1 |
A |
G |
7: 45,268,730 (GRCm39) |
E228G |
possibly damaging |
Het |
Galnt13 |
T |
C |
2: 54,823,560 (GRCm39) |
F379L |
probably damaging |
Het |
Gcnt2 |
A |
C |
13: 41,014,717 (GRCm39) |
E296A |
probably damaging |
Het |
Gm7145 |
T |
A |
1: 117,913,870 (GRCm39) |
C251S |
probably damaging |
Het |
Gpam |
G |
A |
19: 55,059,417 (GRCm39) |
P810L |
probably damaging |
Het |
Il1rl2 |
T |
A |
1: 40,366,726 (GRCm39) |
L87M |
possibly damaging |
Het |
Itgae |
A |
G |
11: 73,036,427 (GRCm39) |
S1122G |
probably damaging |
Het |
Kcnh7 |
T |
A |
2: 63,012,570 (GRCm39) |
D46V |
probably damaging |
Het |
Kcnn3 |
T |
G |
3: 89,552,830 (GRCm39) |
Y511* |
probably null |
Het |
Kdm3b |
T |
A |
18: 34,926,058 (GRCm39) |
I66N |
probably damaging |
Het |
Klk1b27 |
A |
T |
7: 43,703,974 (GRCm39) |
H39L |
probably benign |
Het |
Kmo |
C |
T |
1: 175,487,261 (GRCm39) |
T404I |
possibly damaging |
Het |
Krt222 |
C |
T |
11: 99,125,884 (GRCm39) |
|
probably null |
Het |
Magi3 |
G |
C |
3: 103,923,013 (GRCm39) |
H1235D |
probably benign |
Het |
Mapk8ip1 |
C |
A |
2: 92,219,589 (GRCm39) |
G81C |
probably damaging |
Het |
Med15 |
G |
A |
16: 17,470,609 (GRCm39) |
Q583* |
probably null |
Het |
Mroh2a |
T |
C |
1: 88,184,476 (GRCm39) |
V1453A |
probably benign |
Het |
Myh13 |
A |
G |
11: 67,253,327 (GRCm39) |
M1488V |
probably benign |
Het |
Naip2 |
A |
T |
13: 100,288,645 (GRCm39) |
F1193L |
probably damaging |
Het |
Nop58 |
T |
A |
1: 59,742,014 (GRCm39) |
M181K |
probably damaging |
Het |
Npepps |
A |
T |
11: 97,104,616 (GRCm39) |
V796D |
probably damaging |
Het |
Nr1d1 |
A |
G |
11: 98,661,363 (GRCm39) |
F301S |
probably damaging |
Het |
Nynrin |
G |
A |
14: 56,105,485 (GRCm39) |
V832I |
probably damaging |
Het |
Or13a28 |
C |
A |
7: 140,218,346 (GRCm39) |
S244Y |
probably damaging |
Het |
Or1j14 |
T |
A |
2: 36,418,353 (GRCm39) |
C310S |
probably benign |
Het |
Or2ak7 |
A |
T |
11: 58,574,830 (GRCm39) |
T44S |
possibly damaging |
Het |
Or4e1 |
T |
A |
14: 52,701,352 (GRCm39) |
Y38F |
probably damaging |
Het |
Or8k1 |
T |
A |
2: 86,047,566 (GRCm39) |
T163S |
possibly damaging |
Het |
Phrf1 |
T |
A |
7: 140,817,586 (GRCm39) |
C132S |
probably damaging |
Het |
Plekhn1 |
T |
C |
4: 156,315,015 (GRCm39) |
|
probably null |
Het |
Polr2a |
G |
A |
11: 69,635,052 (GRCm39) |
T569M |
probably damaging |
Het |
Prr29 |
A |
G |
11: 106,267,458 (GRCm39) |
|
probably null |
Het |
Rsf1 |
CG |
CGACGGCGGAG |
7: 97,229,115 (GRCm39) |
|
probably benign |
Homo |
Sc5d |
T |
C |
9: 42,166,717 (GRCm39) |
E274G |
probably benign |
Het |
Serpina1d |
A |
T |
12: 103,731,087 (GRCm39) |
|
probably null |
Het |
Serpinb11 |
T |
A |
1: 107,299,972 (GRCm39) |
I106N |
probably damaging |
Het |
Setd2 |
G |
A |
9: 110,377,733 (GRCm39) |
R516K |
probably damaging |
Het |
Sirt2 |
G |
T |
7: 28,487,222 (GRCm39) |
C291F |
probably damaging |
Het |
Stac3 |
T |
C |
10: 127,344,044 (GRCm39) |
V314A |
probably damaging |
Het |
Stat6 |
C |
T |
10: 127,493,581 (GRCm39) |
|
probably null |
Het |
Strn3 |
A |
G |
12: 51,656,890 (GRCm39) |
V712A |
probably damaging |
Het |
Tmc5 |
G |
T |
7: 118,233,437 (GRCm39) |
G84C |
possibly damaging |
Het |
Trim30d |
G |
T |
7: 104,136,817 (GRCm39) |
T129K |
probably damaging |
Het |
Triml1 |
G |
T |
8: 43,591,793 (GRCm39) |
Y188* |
probably null |
Het |
Trpc7 |
A |
G |
13: 56,921,705 (GRCm39) |
Y760H |
probably damaging |
Het |
Uaca |
G |
A |
9: 60,777,326 (GRCm39) |
R571Q |
probably damaging |
Het |
Ubash3a |
A |
T |
17: 31,458,246 (GRCm39) |
Q575L |
possibly damaging |
Het |
Usp49 |
T |
A |
17: 47,983,827 (GRCm39) |
C61* |
probably null |
Het |
Vmn2r18 |
A |
T |
5: 151,508,116 (GRCm39) |
V336E |
probably damaging |
Het |
Vwa8 |
T |
C |
14: 79,324,102 (GRCm39) |
V1135A |
probably benign |
Het |
Zcchc4 |
T |
C |
5: 52,940,503 (GRCm39) |
V24A |
probably benign |
Het |
Zfp354c |
A |
G |
11: 50,705,798 (GRCm39) |
Y426H |
probably benign |
Het |
|
Other mutations in Tnik |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00516:Tnik
|
APN |
3 |
28,708,367 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00726:Tnik
|
APN |
3 |
28,587,047 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01022:Tnik
|
APN |
3 |
28,679,377 (GRCm39) |
splice site |
probably null |
|
IGL01145:Tnik
|
APN |
3 |
28,658,316 (GRCm39) |
intron |
probably benign |
|
IGL01664:Tnik
|
APN |
3 |
28,692,628 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01843:Tnik
|
APN |
3 |
28,625,007 (GRCm39) |
splice site |
probably null |
|
IGL02378:Tnik
|
APN |
3 |
28,692,608 (GRCm39) |
nonsense |
probably null |
|
IGL02448:Tnik
|
APN |
3 |
28,675,226 (GRCm39) |
missense |
probably null |
0.01 |
IGL02756:Tnik
|
APN |
3 |
28,596,179 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03332:Tnik
|
APN |
3 |
28,720,304 (GRCm39) |
missense |
probably damaging |
1.00 |
delightful
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
Hottie
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
Knockout
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
Looker
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
Lovely
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
Usher
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
R0135:Tnik
|
UTSW |
3 |
28,661,394 (GRCm39) |
missense |
possibly damaging |
0.67 |
R0418:Tnik
|
UTSW |
3 |
28,625,029 (GRCm39) |
nonsense |
probably null |
|
R0540:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
R0549:Tnik
|
UTSW |
3 |
28,625,069 (GRCm39) |
missense |
possibly damaging |
0.87 |
R0556:Tnik
|
UTSW |
3 |
28,679,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
R0586:Tnik
|
UTSW |
3 |
28,631,510 (GRCm39) |
splice site |
probably benign |
|
R0607:Tnik
|
UTSW |
3 |
28,704,308 (GRCm39) |
missense |
probably damaging |
1.00 |
R0842:Tnik
|
UTSW |
3 |
28,648,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
R1068:Tnik
|
UTSW |
3 |
28,587,124 (GRCm39) |
missense |
probably damaging |
1.00 |
R1171:Tnik
|
UTSW |
3 |
28,587,089 (GRCm39) |
missense |
probably damaging |
1.00 |
R1597:Tnik
|
UTSW |
3 |
28,658,418 (GRCm39) |
missense |
probably damaging |
1.00 |
R1638:Tnik
|
UTSW |
3 |
28,719,889 (GRCm39) |
missense |
probably damaging |
0.99 |
R1652:Tnik
|
UTSW |
3 |
28,658,442 (GRCm39) |
missense |
probably benign |
0.22 |
R1996:Tnik
|
UTSW |
3 |
28,719,829 (GRCm39) |
missense |
probably damaging |
1.00 |
R2333:Tnik
|
UTSW |
3 |
28,587,145 (GRCm39) |
missense |
probably damaging |
1.00 |
R2426:Tnik
|
UTSW |
3 |
28,700,830 (GRCm39) |
missense |
probably damaging |
1.00 |
R2509:Tnik
|
UTSW |
3 |
28,722,064 (GRCm39) |
missense |
probably damaging |
1.00 |
R3774:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
R3775:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
R4007:Tnik
|
UTSW |
3 |
28,658,430 (GRCm39) |
missense |
probably damaging |
1.00 |
R4119:Tnik
|
UTSW |
3 |
28,720,324 (GRCm39) |
missense |
probably damaging |
1.00 |
R4209:Tnik
|
UTSW |
3 |
28,413,214 (GRCm39) |
splice site |
probably benign |
|
R4441:Tnik
|
UTSW |
3 |
28,618,246 (GRCm39) |
missense |
possibly damaging |
0.61 |
R4611:Tnik
|
UTSW |
3 |
28,596,249 (GRCm39) |
critical splice donor site |
probably null |
|
R4714:Tnik
|
UTSW |
3 |
28,648,226 (GRCm39) |
missense |
possibly damaging |
0.53 |
R4772:Tnik
|
UTSW |
3 |
28,661,359 (GRCm39) |
missense |
probably benign |
0.09 |
R4829:Tnik
|
UTSW |
3 |
28,593,690 (GRCm39) |
intron |
probably benign |
|
R4839:Tnik
|
UTSW |
3 |
28,650,224 (GRCm39) |
missense |
possibly damaging |
0.86 |
R4898:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
1.00 |
R5029:Tnik
|
UTSW |
3 |
28,719,993 (GRCm39) |
splice site |
probably null |
|
R5278:Tnik
|
UTSW |
3 |
28,704,209 (GRCm39) |
missense |
probably damaging |
1.00 |
R5307:Tnik
|
UTSW |
3 |
28,596,121 (GRCm39) |
missense |
probably damaging |
1.00 |
R5330:Tnik
|
UTSW |
3 |
28,596,167 (GRCm39) |
missense |
probably damaging |
1.00 |
R5375:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
R5459:Tnik
|
UTSW |
3 |
28,715,890 (GRCm39) |
missense |
probably damaging |
1.00 |
R5708:Tnik
|
UTSW |
3 |
28,666,120 (GRCm39) |
critical splice donor site |
probably null |
|
R5749:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
R5751:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
R5780:Tnik
|
UTSW |
3 |
28,648,241 (GRCm39) |
missense |
probably benign |
0.02 |
R5837:Tnik
|
UTSW |
3 |
28,722,202 (GRCm39) |
unclassified |
probably benign |
|
R5969:Tnik
|
UTSW |
3 |
28,675,097 (GRCm39) |
missense |
probably damaging |
1.00 |
R6273:Tnik
|
UTSW |
3 |
28,631,649 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6457:Tnik
|
UTSW |
3 |
28,593,597 (GRCm39) |
missense |
probably damaging |
1.00 |
R6464:Tnik
|
UTSW |
3 |
28,666,119 (GRCm39) |
critical splice donor site |
probably null |
|
R6473:Tnik
|
UTSW |
3 |
28,317,792 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
R6737:Tnik
|
UTSW |
3 |
28,650,235 (GRCm39) |
missense |
possibly damaging |
0.72 |
R7049:Tnik
|
UTSW |
3 |
28,715,853 (GRCm39) |
nonsense |
probably null |
|
R7237:Tnik
|
UTSW |
3 |
28,692,568 (GRCm39) |
missense |
probably damaging |
0.98 |
R7267:Tnik
|
UTSW |
3 |
28,700,776 (GRCm39) |
missense |
probably damaging |
0.99 |
R7445:Tnik
|
UTSW |
3 |
28,718,058 (GRCm39) |
splice site |
probably null |
|
R7499:Tnik
|
UTSW |
3 |
28,684,743 (GRCm39) |
missense |
possibly damaging |
0.47 |
R7629:Tnik
|
UTSW |
3 |
28,715,877 (GRCm39) |
missense |
probably damaging |
0.96 |
R7654:Tnik
|
UTSW |
3 |
28,658,334 (GRCm39) |
missense |
probably damaging |
1.00 |
R7886:Tnik
|
UTSW |
3 |
28,720,288 (GRCm39) |
missense |
probably damaging |
1.00 |
R8096:Tnik
|
UTSW |
3 |
28,715,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
R8210:Tnik
|
UTSW |
3 |
28,658,482 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8233:Tnik
|
UTSW |
3 |
28,609,086 (GRCm39) |
missense |
unknown |
|
R8386:Tnik
|
UTSW |
3 |
28,317,823 (GRCm39) |
missense |
unknown |
|
R8399:Tnik
|
UTSW |
3 |
28,548,159 (GRCm39) |
missense |
unknown |
|
R8490:Tnik
|
UTSW |
3 |
28,650,321 (GRCm39) |
missense |
probably damaging |
0.97 |
R8539:Tnik
|
UTSW |
3 |
28,596,152 (GRCm39) |
missense |
probably damaging |
1.00 |
R8751:Tnik
|
UTSW |
3 |
28,666,057 (GRCm39) |
missense |
probably damaging |
0.98 |
R8804:Tnik
|
UTSW |
3 |
28,648,202 (GRCm39) |
missense |
unknown |
|
R8966:Tnik
|
UTSW |
3 |
28,587,044 (GRCm39) |
missense |
unknown |
|
R8998:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
R8999:Tnik
|
UTSW |
3 |
28,719,920 (GRCm39) |
missense |
probably damaging |
1.00 |
R9016:Tnik
|
UTSW |
3 |
28,692,544 (GRCm39) |
missense |
probably damaging |
1.00 |
R9154:Tnik
|
UTSW |
3 |
28,704,235 (GRCm39) |
missense |
probably damaging |
0.99 |
R9284:Tnik
|
UTSW |
3 |
28,593,570 (GRCm39) |
missense |
unknown |
|
R9290:Tnik
|
UTSW |
3 |
28,675,124 (GRCm39) |
missense |
probably benign |
0.00 |
R9411:Tnik
|
UTSW |
3 |
28,684,754 (GRCm39) |
missense |
probably damaging |
1.00 |
R9484:Tnik
|
UTSW |
3 |
28,649,093 (GRCm39) |
missense |
unknown |
|
X0022:Tnik
|
UTSW |
3 |
28,722,100 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Tnik
|
UTSW |
3 |
28,661,477 (GRCm39) |
missense |
probably damaging |
0.96 |
Z1176:Tnik
|
UTSW |
3 |
28,658,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GGTATGGACACACCCTAAGC -3'
(R):5'- CAATCCTTAGGCAGTCCCAC -3'
Sequencing Primer
(F):5'- ATTGGCAGCCTGCTACTGAC -3'
(R):5'- AGGCAGTCCCACATCAGTTTC -3'
|
Posted On |
2018-02-28 |