Mutagenetix > Incidental Mutation

Incidental Mutation 'R6244:Celsr2'

505433

Institutional Source

Beutler Lab

Gene Symbol

Celsr2

Ensembl Gene

ENSMUSG00000068740

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 2

Synonyms

mfmi1, EGFL2, flamingo

MMRRC Submission

044435-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6244 (G1)

Quality Score

174.009

Status

Validated

Chromosome

Chromosomal Location

108390851-108415552 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 108393128 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 860 (H860R)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090558] [ENSMUST00000090561] [ENSMUST00000102629]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000090558
AA Change: H2872R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000088046
Gene: ENSMUSG00000068740
AA Change: H2872R

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
low complexity region	35	53	N/A	INTRINSIC
CA	203	287	1.36e-26	SMART
CA	311	397	1.33e-29	SMART
CA	421	503	2.59e-27	SMART
CA	527	608	3.33e-30	SMART
CA	632	710	5.18e-18	SMART
CA	734	813	1.08e-29	SMART
CA	837	919	8.08e-29	SMART
low complexity region	920	932	N/A	INTRINSIC
CA	943	1021	4.3e-24	SMART
CA	1049	1125	1.87e-1	SMART
low complexity region	1188	1198	N/A	INTRINSIC
EGF	1231	1286	1.81e-3	SMART
EGF_CA	1288	1324	2.24e-8	SMART
EGF	1331	1366	6.65e-2	SMART
LamG	1387	1554	8.4e-30	SMART
EGF	1577	1610	8e-5	SMART
LamG	1636	1770	1.56e-24	SMART
EGF	1796	1829	2.35e-2	SMART
EGF	1831	1867	3.88e-3	SMART
TNFR	1908	1943	1.35e-1	SMART
EGF_Lam	1924	1969	9.54e-12	SMART
HormR	1972	2034	1.57e-20	SMART
Pfam:GAIN	2046	2289	3e-62	PFAM
GPS	2315	2368	1.86e-25	SMART
Pfam:7tm_2	2373	2605	1.1e-48	PFAM
low complexity region	2715	2733	N/A	INTRINSIC
low complexity region	2857	2873	N/A	INTRINSIC
low complexity region	2874	2881	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000090561

SMART Domains

Protein: ENSMUSP00000088049
Gene: ENSMUSG00000068744

Domain	Start	End	E-Value	Type
Pfam:GTSE1_N	7	124	4.8e-24	PFAM
low complexity region	131	143	N/A	INTRINSIC
low complexity region	222	231	N/A	INTRINSIC
low complexity region	300	316	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000102629

SMART Domains

Protein: ENSMUSP00000099689
Gene: ENSMUSG00000068744

Domain	Start	End	E-Value	Type
Pfam:GTSE1_N	8	108	2e-12	PFAM
low complexity region	131	143	N/A	INTRINSIC
low complexity region	222	231	N/A	INTRINSIC
low complexity region	300	316	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126349

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126935

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000130941

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133216

Predicted Effect

probably damaging
Transcript: ENSMUST00000147251
AA Change: H860R

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000122329
Gene: ENSMUSG00000068740
AA Change: H860R

Domain	Start	End	E-Value	Type
Pfam:GAIN	35	278	5.1e-63	PFAM
GPS	304	357	1.86e-25	SMART
Pfam:7tm_2	362	594	2e-49	PFAM
low complexity region	704	722	N/A	INTRINSIC
low complexity region	846	862	N/A	INTRINSIC
low complexity region	863	870	N/A	INTRINSIC

Meta Mutation Damage Score

0.6329

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.3%
20x: 95.1%

Validation Efficiency

96% (82/85)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted, knock-out(1) Targeted, other(3)

Other mutations in this stock

Total: 84 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6430550D23Rik	T	C	2: 156,003,230 (GRCm38)	H113R	possibly damaging	Het
Adgrf3	A	T	5: 30,197,533 (GRCm38)	M499K	probably benign	Het
Adgrv1	G	A	13: 81,106,931 (GRCm38)	T211I	probably damaging	Het
Adss2	C	T	1: 177,776,829 (GRCm38)	E153K	probably benign	Het
Ago4	C	A	4: 126,511,487 (GRCm38)	G431V	possibly damaging	Het
Araf	G	T	X: 20,860,100 (GRCm38)	R601L	probably damaging	Homo
Atp2b4	T	A	1: 133,726,561 (GRCm38)	I769F	probably damaging	Het
Atp9a	T	C	2: 168,689,352 (GRCm38)		probably null	Het
Bltp1	T	C	3: 36,956,999 (GRCm38)	V1782A	probably benign	Het
Brap	C	A	5: 121,665,309 (GRCm38)	D173E	probably benign	Het
Brca2	G	T	5: 150,566,978 (GRCm38)	R3035L	probably benign	Het
Ccdc8	C	A	7: 16,996,251 (GRCm38)	P555Q	probably benign	Het
Ccser2	A	G	14: 36,940,718 (GRCm38)	S170P	probably benign	Het
Cenpc1	C	A	5: 86,046,385 (GRCm38)	R174M	probably damaging	Het
Cfap57	T	G	4: 118,579,410 (GRCm38)	I930L	probably damaging	Het
Cx3cr1	C	T	9: 120,051,694 (GRCm38)	R214H	probably damaging	Het
Cyp4f14	T	A	17: 32,906,317 (GRCm38)	H429L	probably benign	Het
D5Ertd579e	A	G	5: 36,615,276 (GRCm38)	F592L	probably damaging	Het
Ddb1	A	G	19: 10,625,923 (GRCm38)	E865G	probably damaging	Het
Ddx50	A	T	10: 62,621,566 (GRCm38)		probably null	Het
Dpp6	A	G	5: 27,049,628 (GRCm38)	T14A	probably damaging	Het
Echs1	C	A	7: 140,113,069 (GRCm38)	Q51H	possibly damaging	Het
Ecm2	A	T	13: 49,530,307 (GRCm38)	D587V	probably damaging	Het
Ect2l	A	T	10: 18,140,397 (GRCm38)	Y666N	possibly damaging	Het
Epha2	G	A	4: 141,316,912 (GRCm38)	G342S	probably benign	Het
Fbxo33	C	A	12: 59,206,079 (GRCm38)	K211N	probably benign	Het
Fchsd2	A	G	7: 101,259,776 (GRCm38)		probably null	Het
Fen1	A	G	19: 10,200,687 (GRCm38)	V131A	probably damaging	Het
Fetub	C	T	16: 22,932,331 (GRCm38)	R143C	probably damaging	Het
Flnb	A	G	14: 7,892,092 (GRCm38)	E587G	probably damaging	Het
Foxd3	A	G	4: 99,657,240 (GRCm38)	T206A	possibly damaging	Het
Fut1	A	G	7: 45,619,306 (GRCm38)	E228G	possibly damaging	Het
Galnt13	T	C	2: 54,933,548 (GRCm38)	F379L	probably damaging	Het
Gcnt2	A	C	13: 40,861,241 (GRCm38)	E296A	probably damaging	Het
Gm7145	T	A	1: 117,986,140 (GRCm38)	C251S	probably damaging	Het
Gpam	G	A	19: 55,070,985 (GRCm38)	P810L	probably damaging	Het
Il1rl2	T	A	1: 40,327,566 (GRCm38)	L87M	possibly damaging	Het
Itgae	A	G	11: 73,145,601 (GRCm38)	S1122G	probably damaging	Het
Kcnh7	T	A	2: 63,182,226 (GRCm38)	D46V	probably damaging	Het
Kcnn3	T	G	3: 89,645,523 (GRCm38)	Y511*	probably null	Het
Kdm3b	T	A	18: 34,793,005 (GRCm38)	I66N	probably damaging	Het
Klk1b27	A	T	7: 44,054,550 (GRCm38)	H39L	probably benign	Het
Kmo	C	T	1: 175,659,695 (GRCm38)	T404I	possibly damaging	Het
Krt222	C	T	11: 99,235,058 (GRCm38)		probably null	Het
Magi3	G	C	3: 104,015,697 (GRCm38)	H1235D	probably benign	Het
Mapk8ip1	C	A	2: 92,389,244 (GRCm38)	G81C	probably damaging	Het
Med15	G	A	16: 17,652,745 (GRCm38)	Q583*	probably null	Het
Mroh2a	T	C	1: 88,256,754 (GRCm38)	V1453A	probably benign	Het
Myh13	A	G	11: 67,362,501 (GRCm38)	M1488V	probably benign	Het
Naip2	A	T	13: 100,152,137 (GRCm38)	F1193L	probably damaging	Het
Nop58	T	A	1: 59,702,855 (GRCm38)	M181K	probably damaging	Het
Npepps	A	T	11: 97,213,790 (GRCm38)	V796D	probably damaging	Het
Nr1d1	A	G	11: 98,770,537 (GRCm38)	F301S	probably damaging	Het
Nynrin	G	A	14: 55,868,028 (GRCm38)	V832I	probably damaging	Het
Or13a28	C	A	7: 140,638,433 (GRCm38)	S244Y	probably damaging	Het
Or1j14	T	A	2: 36,528,341 (GRCm38)	C310S	probably benign	Het
Or2ak7	A	T	11: 58,684,004 (GRCm38)	T44S	possibly damaging	Het
Or4e1	T	A	14: 52,463,895 (GRCm38)	Y38F	probably damaging	Het
Or8k1	T	A	2: 86,217,222 (GRCm38)	T163S	possibly damaging	Het
Phrf1	T	A	7: 141,237,673 (GRCm38)	C132S	probably damaging	Het
Plekhn1	T	C	4: 156,230,558 (GRCm38)		probably null	Het
Polr2a	G	A	11: 69,744,226 (GRCm38)	T569M	probably damaging	Het
Prr29	A	G	11: 106,376,632 (GRCm38)		probably null	Het
Rsf1	CG	CGACGGCGGAG	7: 97,579,908 (GRCm38)		probably benign	Homo
Sc5d	T	C	9: 42,255,421 (GRCm38)	E274G	probably benign	Het
Serpina1d	A	T	12: 103,764,828 (GRCm38)		probably null	Het
Serpinb11	T	A	1: 107,372,242 (GRCm38)	I106N	probably damaging	Het
Setd2	G	A	9: 110,548,665 (GRCm38)	R516K	probably damaging	Het
Sirt2	G	T	7: 28,787,797 (GRCm38)	C291F	probably damaging	Het
Stac3	T	C	10: 127,508,175 (GRCm38)	V314A	probably damaging	Het
Stat6	C	T	10: 127,657,712 (GRCm38)		probably null	Het
Strn3	A	G	12: 51,610,107 (GRCm38)	V712A	probably damaging	Het
Tmc5	G	T	7: 118,634,214 (GRCm38)	G84C	possibly damaging	Het
Tnik	C	A	3: 28,650,179 (GRCm38)	L996I	probably damaging	Het
Trim30d	G	T	7: 104,487,610 (GRCm38)	T129K	probably damaging	Het
Triml1	G	T	8: 43,138,756 (GRCm38)	Y188*	probably null	Het
Trpc7	A	G	13: 56,773,892 (GRCm38)	Y760H	probably damaging	Het
Uaca	G	A	9: 60,870,044 (GRCm38)	R571Q	probably damaging	Het
Ubash3a	A	T	17: 31,239,272 (GRCm38)	Q575L	possibly damaging	Het
Usp49	T	A	17: 47,672,902 (GRCm38)	C61*	probably null	Het
Vmn2r18	A	T	5: 151,584,651 (GRCm38)	V336E	probably damaging	Het
Vwa8	T	C	14: 79,086,662 (GRCm38)	V1135A	probably benign	Het
Zcchc4	T	C	5: 52,783,161 (GRCm38)	V24A	probably benign	Het
Zfp354c	A	G	11: 50,814,971 (GRCm38)	Y426H	probably benign	Het

Other mutations in Celsr2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00898:Celsr2	APN	3	108,413,879 (GRCm38)	missense	possibly damaging	0.49
IGL01020:Celsr2	APN	3	108,403,270 (GRCm38)	missense	probably damaging	0.99
IGL01420:Celsr2	APN	3	108,393,763 (GRCm38)	missense	probably benign	0.13
IGL01448:Celsr2	APN	3	108,393,239 (GRCm38)	missense	probably damaging	0.99
IGL01559:Celsr2	APN	3	108,406,867 (GRCm38)	missense	possibly damaging	0.75
IGL01674:Celsr2	APN	3	108,414,843 (GRCm38)	missense	probably damaging	1.00
IGL01863:Celsr2	APN	3	108,394,022 (GRCm38)	missense	probably benign	0.00
IGL02309:Celsr2	APN	3	108,396,011 (GRCm38)	missense	probably damaging	1.00
IGL02325:Celsr2	APN	3	108,412,871 (GRCm38)	missense	probably damaging	1.00
IGL02409:Celsr2	APN	3	108,413,955 (GRCm38)	missense	probably damaging	1.00
IGL02514:Celsr2	APN	3	108,397,510 (GRCm38)	missense	probably benign	0.01
IGL02812:Celsr2	APN	3	108,414,113 (GRCm38)	missense	probably benign	0.25
IGL02894:Celsr2	APN	3	108,395,210 (GRCm38)	missense	probably damaging	1.00
IGL03281:Celsr2	APN	3	108,412,940 (GRCm38)	missense	probably damaging	1.00
barrow	UTSW	3	108,394,965 (GRCm38)	missense	possibly damaging	0.92
goldeneye	UTSW	3	108,394,919 (GRCm38)	missense	probably damaging	1.00
1mM(1):Celsr2	UTSW	3	108,400,838 (GRCm38)	missense	probably benign	0.01
ANU74:Celsr2	UTSW	3	108,412,499 (GRCm38)	missense	probably damaging	1.00
IGL02799:Celsr2	UTSW	3	108,414,062 (GRCm38)	missense	probably damaging	1.00
R0011:Celsr2	UTSW	3	108,413,402 (GRCm38)	missense	probably benign	0.19
R0031:Celsr2	UTSW	3	108,413,063 (GRCm38)	missense	probably damaging	1.00
R0049:Celsr2	UTSW	3	108,397,254 (GRCm38)	missense	probably benign	0.12
R0049:Celsr2	UTSW	3	108,397,254 (GRCm38)	missense	probably benign	0.12
R0090:Celsr2	UTSW	3	108,393,327 (GRCm38)	splice site	probably benign
R0140:Celsr2	UTSW	3	108,397,933 (GRCm38)	missense	probably benign	0.00
R0524:Celsr2	UTSW	3	108,401,587 (GRCm38)	missense	probably damaging	1.00
R0607:Celsr2	UTSW	3	108,403,895 (GRCm38)	critical splice donor site	probably null
R0662:Celsr2	UTSW	3	108,398,520 (GRCm38)	missense	probably damaging	0.99
R0690:Celsr2	UTSW	3	108,414,977 (GRCm38)	missense	probably damaging	1.00
R0691:Celsr2	UTSW	3	108,412,623 (GRCm38)	missense	probably damaging	1.00
R0710:Celsr2	UTSW	3	108,412,712 (GRCm38)	missense	probably benign	0.42
R0730:Celsr2	UTSW	3	108,398,606 (GRCm38)	missense	probably damaging	1.00
R0815:Celsr2	UTSW	3	108,401,301 (GRCm38)	missense	possibly damaging	0.56
R0848:Celsr2	UTSW	3	108,414,338 (GRCm38)	missense	probably benign
R0989:Celsr2	UTSW	3	108,403,272 (GRCm38)	missense	probably benign	0.00
R1185:Celsr2	UTSW	3	108,399,709 (GRCm38)	missense	possibly damaging	0.95
R1185:Celsr2	UTSW	3	108,399,709 (GRCm38)	missense	possibly damaging	0.95
R1185:Celsr2	UTSW	3	108,399,709 (GRCm38)	missense	possibly damaging	0.95
R1469:Celsr2	UTSW	3	108,414,108 (GRCm38)	missense	probably damaging	1.00
R1469:Celsr2	UTSW	3	108,414,108 (GRCm38)	missense	probably damaging	1.00
R1474:Celsr2	UTSW	3	108,393,739 (GRCm38)	missense	possibly damaging	0.91
R1608:Celsr2	UTSW	3	108,402,483 (GRCm38)	missense	probably damaging	1.00
R1653:Celsr2	UTSW	3	108,413,520 (GRCm38)	missense	possibly damaging	0.52
R1659:Celsr2	UTSW	3	108,414,095 (GRCm38)	missense	probably benign
R1689:Celsr2	UTSW	3	108,407,304 (GRCm38)	missense	possibly damaging	0.63
R1848:Celsr2	UTSW	3	108,401,310 (GRCm38)	missense	probably benign	0.35
R1859:Celsr2	UTSW	3	108,396,630 (GRCm38)	missense	probably damaging	1.00
R1918:Celsr2	UTSW	3	108,398,650 (GRCm38)	missense	probably benign	0.05
R1974:Celsr2	UTSW	3	108,414,214 (GRCm38)	missense	probably damaging	1.00
R2042:Celsr2	UTSW	3	108,402,495 (GRCm38)	missense	probably damaging	0.98
R2167:Celsr2	UTSW	3	108,413,193 (GRCm38)	missense	probably damaging	0.96
R2333:Celsr2	UTSW	3	108,398,605 (GRCm38)	missense	probably benign	0.16
R2434:Celsr2	UTSW	3	108,404,479 (GRCm38)	missense	probably damaging	1.00
R2504:Celsr2	UTSW	3	108,413,591 (GRCm38)	missense	probably benign	0.11
R3420:Celsr2	UTSW	3	108,414,416 (GRCm38)	missense	probably benign	0.03
R3712:Celsr2	UTSW	3	108,400,839 (GRCm38)	missense	probably benign
R3723:Celsr2	UTSW	3	108,397,415 (GRCm38)	splice site	probably benign
R3809:Celsr2	UTSW	3	108,403,239 (GRCm38)	missense	possibly damaging	0.67
R4018:Celsr2	UTSW	3	108,394,965 (GRCm38)	missense	possibly damaging	0.92
R4126:Celsr2	UTSW	3	108,402,097 (GRCm38)	missense	possibly damaging	0.71
R4177:Celsr2	UTSW	3	108,413,978 (GRCm38)	missense	probably damaging	0.96
R4232:Celsr2	UTSW	3	108,413,772 (GRCm38)	missense	probably benign	0.02
R4293:Celsr2	UTSW	3	108,393,677 (GRCm38)	missense	probably benign	0.01
R4458:Celsr2	UTSW	3	108,394,997 (GRCm38)	missense	probably damaging	0.98
R4621:Celsr2	UTSW	3	108,395,216 (GRCm38)	missense	possibly damaging	0.86
R4645:Celsr2	UTSW	3	108,395,969 (GRCm38)	missense	probably damaging	1.00
R4700:Celsr2	UTSW	3	108,397,231 (GRCm38)	missense	probably benign	0.24
R4732:Celsr2	UTSW	3	108,398,952 (GRCm38)	missense	probably damaging	0.99
R4733:Celsr2	UTSW	3	108,398,952 (GRCm38)	missense	probably damaging	0.99
R4901:Celsr2	UTSW	3	108,406,987 (GRCm38)	missense	possibly damaging	0.81
R4932:Celsr2	UTSW	3	108,402,758 (GRCm38)	missense	probably damaging	1.00
R4989:Celsr2	UTSW	3	108,412,629 (GRCm38)	missense	possibly damaging	0.62
R5052:Celsr2	UTSW	3	108,412,358 (GRCm38)	missense	probably damaging	1.00
R5093:Celsr2	UTSW	3	108,413,373 (GRCm38)	missense	possibly damaging	0.66
R5114:Celsr2	UTSW	3	108,393,996 (GRCm38)	missense	probably benign	0.05
R5120:Celsr2	UTSW	3	108,393,120 (GRCm38)	missense	probably benign	0.02
R5135:Celsr2	UTSW	3	108,398,659 (GRCm38)	missense	probably damaging	1.00
R5247:Celsr2	UTSW	3	108,397,630 (GRCm38)	missense	probably benign	0.34
R5381:Celsr2	UTSW	3	108,402,757 (GRCm38)	missense	probably damaging	1.00
R5412:Celsr2	UTSW	3	108,399,995 (GRCm38)	missense	probably damaging	1.00
R5445:Celsr2	UTSW	3	108,392,658 (GRCm38)	missense	probably benign	0.01
R5528:Celsr2	UTSW	3	108,413,294 (GRCm38)	missense	probably damaging	1.00
R5598:Celsr2	UTSW	3	108,402,803 (GRCm38)	missense	possibly damaging	0.82
R5652:Celsr2	UTSW	3	108,396,735 (GRCm38)	missense	probably null	0.49
R5697:Celsr2	UTSW	3	108,403,921 (GRCm38)	nonsense	probably null
R5718:Celsr2	UTSW	3	108,393,358 (GRCm38)	missense	probably benign
R5869:Celsr2	UTSW	3	108,413,909 (GRCm38)	missense	probably damaging	1.00
R5876:Celsr2	UTSW	3	108,413,943 (GRCm38)	missense	probably damaging	0.96
R6021:Celsr2	UTSW	3	108,401,245 (GRCm38)	missense	probably benign
R6054:Celsr2	UTSW	3	108,406,963 (GRCm38)	missense	possibly damaging	0.95
R6313:Celsr2	UTSW	3	108,401,214 (GRCm38)	missense	probably damaging	0.99
R6322:Celsr2	UTSW	3	108,412,574 (GRCm38)	missense	probably damaging	1.00
R6555:Celsr2	UTSW	3	108,394,919 (GRCm38)	missense	probably damaging	1.00
R6682:Celsr2	UTSW	3	108,400,501 (GRCm38)	critical splice donor site	probably null
R7062:Celsr2	UTSW	3	108,402,510 (GRCm38)	missense	possibly damaging	0.95
R7110:Celsr2	UTSW	3	108,397,865 (GRCm38)	missense	probably damaging	1.00
R7139:Celsr2	UTSW	3	108,415,359 (GRCm38)	missense	unknown
R7326:Celsr2	UTSW	3	108,394,995 (GRCm38)	missense	possibly damaging	0.85
R7425:Celsr2	UTSW	3	108,402,457 (GRCm38)	missense	probably damaging	1.00
R7452:Celsr2	UTSW	3	108,413,090 (GRCm38)	missense	possibly damaging	0.95
R7461:Celsr2	UTSW	3	108,395,640 (GRCm38)	missense	probably damaging	1.00
R7502:Celsr2	UTSW	3	108,398,902 (GRCm38)	missense	probably benign	0.00
R7613:Celsr2	UTSW	3	108,395,640 (GRCm38)	missense	probably damaging	1.00
R7644:Celsr2	UTSW	3	108,413,490 (GRCm38)	missense	probably damaging	0.99
R7666:Celsr2	UTSW	3	108,398,588 (GRCm38)	missense	probably benign
R7687:Celsr2	UTSW	3	108,397,769 (GRCm38)	missense	probably benign	0.27
R7695:Celsr2	UTSW	3	108,402,753 (GRCm38)	missense	probably damaging	1.00
R8002:Celsr2	UTSW	3	108,403,969 (GRCm38)	missense	probably damaging	1.00
R8052:Celsr2	UTSW	3	108,412,655 (GRCm38)	missense	probably damaging	1.00
R8283:Celsr2	UTSW	3	108,396,455 (GRCm38)	missense	probably damaging	1.00
R8356:Celsr2	UTSW	3	108,413,531 (GRCm38)	missense	possibly damaging	0.90
R8381:Celsr2	UTSW	3	108,395,636 (GRCm38)	missense	probably damaging	1.00
R8427:Celsr2	UTSW	3	108,392,633 (GRCm38)	makesense	probably null
R8435:Celsr2	UTSW	3	108,414,399 (GRCm38)	missense	probably benign
R8438:Celsr2	UTSW	3	108,393,823 (GRCm38)	missense	probably damaging	1.00
R8458:Celsr2	UTSW	3	108,398,902 (GRCm38)	missense	probably benign	0.00
R8460:Celsr2	UTSW	3	108,396,777 (GRCm38)	missense	possibly damaging	0.84
R8462:Celsr2	UTSW	3	108,412,851 (GRCm38)	nonsense	probably null
R8479:Celsr2	UTSW	3	108,398,902 (GRCm38)	missense	probably benign	0.00
R8480:Celsr2	UTSW	3	108,398,902 (GRCm38)	missense	probably benign	0.00
R8512:Celsr2	UTSW	3	108,413,838 (GRCm38)	missense	probably damaging	1.00
R8694:Celsr2	UTSW	3	108,406,860 (GRCm38)	missense	probably damaging	1.00
R8772:Celsr2	UTSW	3	108,397,073 (GRCm38)	missense	possibly damaging	0.84
R8843:Celsr2	UTSW	3	108,396,127 (GRCm38)	splice site	probably benign
R8888:Celsr2	UTSW	3	108,413,564 (GRCm38)	missense	possibly damaging	0.95
R8895:Celsr2	UTSW	3	108,413,564 (GRCm38)	missense	possibly damaging	0.95
R8917:Celsr2	UTSW	3	108,396,566 (GRCm38)	missense	probably benign	0.00
R9119:Celsr2	UTSW	3	108,401,972 (GRCm38)	missense	possibly damaging	0.90
R9169:Celsr2	UTSW	3	108,402,546 (GRCm38)	missense	probably benign	0.04
R9209:Celsr2	UTSW	3	108,414,033 (GRCm38)	missense	probably benign	0.02
R9342:Celsr2	UTSW	3	108,413,126 (GRCm38)	missense	probably damaging	1.00
R9416:Celsr2	UTSW	3	108,414,768 (GRCm38)	missense	probably damaging	0.96
R9493:Celsr2	UTSW	3	108,393,758 (GRCm38)	missense	probably damaging	1.00
R9564:Celsr2	UTSW	3	108,414,518 (GRCm38)	missense	probably damaging	1.00
R9598:Celsr2	UTSW	3	108,415,262 (GRCm38)	missense	possibly damaging	0.72
R9629:Celsr2	UTSW	3	108,401,599 (GRCm38)	missense	probably damaging	1.00
R9691:Celsr2	UTSW	3	108,394,235 (GRCm38)	missense	probably damaging	1.00
X0020:Celsr2	UTSW	3	108,396,110 (GRCm38)	missense	probably damaging	1.00
X0050:Celsr2	UTSW	3	108,401,272 (GRCm38)	missense	probably benign	0.09
Z1088:Celsr2	UTSW	3	108,414,117 (GRCm38)	missense	probably damaging	1.00
Z1176:Celsr2	UTSW	3	108,412,341 (GRCm38)	missense	probably benign	0.07
Z1176:Celsr2	UTSW	3	108,393,131 (GRCm38)	missense	probably benign	0.10
Z1177:Celsr2	UTSW	3	108,413,571 (GRCm38)	missense	probably benign	0.32
Z1177:Celsr2	UTSW	3	108,412,220 (GRCm38)	missense	probably damaging	1.00
Z1191:Celsr2	UTSW	3	108,414,549 (GRCm38)	missense	possibly damaging	0.68

Predicted Primers

PCR Primer
(F):5'- CTTGGGTTAGCAAGGACCTC -3'
(R):5'- ACAAAGGTGAGTGGAGTCTCTC -3'

Sequencing Primer
(F):5'- TTAGCAAGGACCTCAGGCAG -3'
(R):5'- GGAGTCTCTCCCATCAGCTC -3'

Posted On

2018-02-28