Incidental Mutation 'R6244:Myh13'
| ID |
505468 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh13
|
| Ensembl Gene |
ENSMUSG00000060180 |
| Gene Name |
myosin, heavy polypeptide 13, skeletal muscle |
| Synonyms |
EO Myosin, extraocular myosin, MyHC-eo |
| MMRRC Submission |
044435-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.148)
|
| Stock # |
R6244 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
67321658-67371586 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 67362501 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 1488
(M1488V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000137731
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081911]
[ENSMUST00000108684]
[ENSMUST00000180845]
|
| AlphaFold |
B1AR69 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000081911
AA Change: M1488V
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000080584
Gene: ENSMUSG00000060180
AA Change: M1488V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
74 |
8e-13 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
4.6e-1 |
SMART |
|
Pfam:Myosin_tail_1
|
847 |
1928 |
4.6e-159 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108684
AA Change: M1488V
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000104324
Gene: ENSMUSG00000060180
AA Change: M1488V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
76 |
2.8e-14 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
4.6e-1 |
SMART |
|
low complexity region
|
847 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
940 |
N/A |
INTRINSIC |
|
Pfam:Myosin_tail_1
|
1072 |
1930 |
N/A |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000122618
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000180845
AA Change: M1488V
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000137731
Gene: ENSMUSG00000060180
AA Change: M1488V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
76 |
2.8e-14 |
PFAM |
|
MYSc
|
80 |
783 |
N/A |
SMART |
|
IQ
|
784 |
806 |
4.6e-1 |
SMART |
|
low complexity region
|
847 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
940 |
N/A |
INTRINSIC |
|
Pfam:Myosin_tail_1
|
1072 |
1930 |
N/A |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000181027
|
| Meta Mutation Damage Score |
0.1025 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.3%
- 20x: 95.1%
|
| Validation Efficiency |
96% (82/85) |
| Allele List at MGI |
All alleles(4) : Gene trapped(4) |
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 6430550D23Rik |
T |
C |
2: 156,003,230 (GRCm38) |
H113R |
possibly damaging |
Het |
| Adgrf3 |
A |
T |
5: 30,197,533 (GRCm38) |
M499K |
probably benign |
Het |
| Adgrv1 |
G |
A |
13: 81,106,931 (GRCm38) |
T211I |
probably damaging |
Het |
| Adss2 |
C |
T |
1: 177,776,829 (GRCm38) |
E153K |
probably benign |
Het |
| Ago4 |
C |
A |
4: 126,511,487 (GRCm38) |
G431V |
possibly damaging |
Het |
| Araf |
G |
T |
X: 20,860,100 (GRCm38) |
R601L |
probably damaging |
Homo |
| Atp2b4 |
T |
A |
1: 133,726,561 (GRCm38) |
I769F |
probably damaging |
Het |
| Atp9a |
T |
C |
2: 168,689,352 (GRCm38) |
|
probably null |
Het |
| Bltp1 |
T |
C |
3: 36,956,999 (GRCm38) |
V1782A |
probably benign |
Het |
| Brap |
C |
A |
5: 121,665,309 (GRCm38) |
D173E |
probably benign |
Het |
| Brca2 |
G |
T |
5: 150,566,978 (GRCm38) |
R3035L |
probably benign |
Het |
| Ccdc8 |
C |
A |
7: 16,996,251 (GRCm38) |
P555Q |
probably benign |
Het |
| Ccser2 |
A |
G |
14: 36,940,718 (GRCm38) |
S170P |
probably benign |
Het |
| Celsr2 |
T |
C |
3: 108,393,128 (GRCm38) |
H860R |
probably damaging |
Het |
| Cenpc1 |
C |
A |
5: 86,046,385 (GRCm38) |
R174M |
probably damaging |
Het |
| Cfap57 |
T |
G |
4: 118,579,410 (GRCm38) |
I930L |
probably damaging |
Het |
| Cx3cr1 |
C |
T |
9: 120,051,694 (GRCm38) |
R214H |
probably damaging |
Het |
| Cyp4f14 |
T |
A |
17: 32,906,317 (GRCm38) |
H429L |
probably benign |
Het |
| D5Ertd579e |
A |
G |
5: 36,615,276 (GRCm38) |
F592L |
probably damaging |
Het |
| Ddb1 |
A |
G |
19: 10,625,923 (GRCm38) |
E865G |
probably damaging |
Het |
| Ddx50 |
A |
T |
10: 62,621,566 (GRCm38) |
|
probably null |
Het |
| Dpp6 |
A |
G |
5: 27,049,628 (GRCm38) |
T14A |
probably damaging |
Het |
| Echs1 |
C |
A |
7: 140,113,069 (GRCm38) |
Q51H |
possibly damaging |
Het |
| Ecm2 |
A |
T |
13: 49,530,307 (GRCm38) |
D587V |
probably damaging |
Het |
| Ect2l |
A |
T |
10: 18,140,397 (GRCm38) |
Y666N |
possibly damaging |
Het |
| Epha2 |
G |
A |
4: 141,316,912 (GRCm38) |
G342S |
probably benign |
Het |
| Fbxo33 |
C |
A |
12: 59,206,079 (GRCm38) |
K211N |
probably benign |
Het |
| Fchsd2 |
A |
G |
7: 101,259,776 (GRCm38) |
|
probably null |
Het |
| Fen1 |
A |
G |
19: 10,200,687 (GRCm38) |
V131A |
probably damaging |
Het |
| Fetub |
C |
T |
16: 22,932,331 (GRCm38) |
R143C |
probably damaging |
Het |
| Flnb |
A |
G |
14: 7,892,092 (GRCm38) |
E587G |
probably damaging |
Het |
| Foxd3 |
A |
G |
4: 99,657,240 (GRCm38) |
T206A |
possibly damaging |
Het |
| Fut1 |
A |
G |
7: 45,619,306 (GRCm38) |
E228G |
possibly damaging |
Het |
| Galnt13 |
T |
C |
2: 54,933,548 (GRCm38) |
F379L |
probably damaging |
Het |
| Gcnt2 |
A |
C |
13: 40,861,241 (GRCm38) |
E296A |
probably damaging |
Het |
| Gm7145 |
T |
A |
1: 117,986,140 (GRCm38) |
C251S |
probably damaging |
Het |
| Gpam |
G |
A |
19: 55,070,985 (GRCm38) |
P810L |
probably damaging |
Het |
| Il1rl2 |
T |
A |
1: 40,327,566 (GRCm38) |
L87M |
possibly damaging |
Het |
| Itgae |
A |
G |
11: 73,145,601 (GRCm38) |
S1122G |
probably damaging |
Het |
| Kcnh7 |
T |
A |
2: 63,182,226 (GRCm38) |
D46V |
probably damaging |
Het |
| Kcnn3 |
T |
G |
3: 89,645,523 (GRCm38) |
Y511* |
probably null |
Het |
| Kdm3b |
T |
A |
18: 34,793,005 (GRCm38) |
I66N |
probably damaging |
Het |
| Klk1b27 |
A |
T |
7: 44,054,550 (GRCm38) |
H39L |
probably benign |
Het |
| Kmo |
C |
T |
1: 175,659,695 (GRCm38) |
T404I |
possibly damaging |
Het |
| Krt222 |
C |
T |
11: 99,235,058 (GRCm38) |
|
probably null |
Het |
| Magi3 |
G |
C |
3: 104,015,697 (GRCm38) |
H1235D |
probably benign |
Het |
| Mapk8ip1 |
C |
A |
2: 92,389,244 (GRCm38) |
G81C |
probably damaging |
Het |
| Med15 |
G |
A |
16: 17,652,745 (GRCm38) |
Q583* |
probably null |
Het |
| Mroh2a |
T |
C |
1: 88,256,754 (GRCm38) |
V1453A |
probably benign |
Het |
| Naip2 |
A |
T |
13: 100,152,137 (GRCm38) |
F1193L |
probably damaging |
Het |
| Nop58 |
T |
A |
1: 59,702,855 (GRCm38) |
M181K |
probably damaging |
Het |
| Npepps |
A |
T |
11: 97,213,790 (GRCm38) |
V796D |
probably damaging |
Het |
| Nr1d1 |
A |
G |
11: 98,770,537 (GRCm38) |
F301S |
probably damaging |
Het |
| Nynrin |
G |
A |
14: 55,868,028 (GRCm38) |
V832I |
probably damaging |
Het |
| Or13a28 |
C |
A |
7: 140,638,433 (GRCm38) |
S244Y |
probably damaging |
Het |
| Or1j14 |
T |
A |
2: 36,528,341 (GRCm38) |
C310S |
probably benign |
Het |
| Or2ak7 |
A |
T |
11: 58,684,004 (GRCm38) |
T44S |
possibly damaging |
Het |
| Or4e1 |
T |
A |
14: 52,463,895 (GRCm38) |
Y38F |
probably damaging |
Het |
| Or8k1 |
T |
A |
2: 86,217,222 (GRCm38) |
T163S |
possibly damaging |
Het |
| Phrf1 |
T |
A |
7: 141,237,673 (GRCm38) |
C132S |
probably damaging |
Het |
| Plekhn1 |
T |
C |
4: 156,230,558 (GRCm38) |
|
probably null |
Het |
| Polr2a |
G |
A |
11: 69,744,226 (GRCm38) |
T569M |
probably damaging |
Het |
| Prr29 |
A |
G |
11: 106,376,632 (GRCm38) |
|
probably null |
Het |
| Rsf1 |
CG |
CGACGGCGGAG |
7: 97,579,908 (GRCm38) |
|
probably benign |
Homo |
| Sc5d |
T |
C |
9: 42,255,421 (GRCm38) |
E274G |
probably benign |
Het |
| Serpina1d |
A |
T |
12: 103,764,828 (GRCm38) |
|
probably null |
Het |
| Serpinb11 |
T |
A |
1: 107,372,242 (GRCm38) |
I106N |
probably damaging |
Het |
| Setd2 |
G |
A |
9: 110,548,665 (GRCm38) |
R516K |
probably damaging |
Het |
| Sirt2 |
G |
T |
7: 28,787,797 (GRCm38) |
C291F |
probably damaging |
Het |
| Stac3 |
T |
C |
10: 127,508,175 (GRCm38) |
V314A |
probably damaging |
Het |
| Stat6 |
C |
T |
10: 127,657,712 (GRCm38) |
|
probably null |
Het |
| Strn3 |
A |
G |
12: 51,610,107 (GRCm38) |
V712A |
probably damaging |
Het |
| Tmc5 |
G |
T |
7: 118,634,214 (GRCm38) |
G84C |
possibly damaging |
Het |
| Tnik |
C |
A |
3: 28,650,179 (GRCm38) |
L996I |
probably damaging |
Het |
| Trim30d |
G |
T |
7: 104,487,610 (GRCm38) |
T129K |
probably damaging |
Het |
| Triml1 |
G |
T |
8: 43,138,756 (GRCm38) |
Y188* |
probably null |
Het |
| Trpc7 |
A |
G |
13: 56,773,892 (GRCm38) |
Y760H |
probably damaging |
Het |
| Uaca |
G |
A |
9: 60,870,044 (GRCm38) |
R571Q |
probably damaging |
Het |
| Ubash3a |
A |
T |
17: 31,239,272 (GRCm38) |
Q575L |
possibly damaging |
Het |
| Usp49 |
T |
A |
17: 47,672,902 (GRCm38) |
C61* |
probably null |
Het |
| Vmn2r18 |
A |
T |
5: 151,584,651 (GRCm38) |
V336E |
probably damaging |
Het |
| Vwa8 |
T |
C |
14: 79,086,662 (GRCm38) |
V1135A |
probably benign |
Het |
| Zcchc4 |
T |
C |
5: 52,783,161 (GRCm38) |
V24A |
probably benign |
Het |
| Zfp354c |
A |
G |
11: 50,814,971 (GRCm38) |
Y426H |
probably benign |
Het |
|
| Other mutations in Myh13 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00497:Myh13
|
APN |
11 |
67,342,488 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00808:Myh13
|
APN |
11 |
67,335,004 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL00822:Myh13
|
APN |
11 |
67,361,328 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00823:Myh13
|
APN |
11 |
67,355,947 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL00945:Myh13
|
APN |
11 |
67,348,006 (GRCm38) |
missense |
probably null |
1.00 |
|
IGL01414:Myh13
|
APN |
11 |
67,342,472 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL01482:Myh13
|
APN |
11 |
67,352,068 (GRCm38) |
missense |
probably benign |
|
|
IGL01523:Myh13
|
APN |
11 |
67,347,943 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
IGL01723:Myh13
|
APN |
11 |
67,369,219 (GRCm38) |
unclassified |
probably benign |
|
|
IGL01997:Myh13
|
APN |
11 |
67,367,166 (GRCm38) |
missense |
probably benign |
0.14 |
|
IGL02369:Myh13
|
APN |
11 |
67,360,274 (GRCm38) |
unclassified |
probably benign |
|
|
IGL02478:Myh13
|
APN |
11 |
67,369,378 (GRCm38) |
missense |
probably benign |
|
|
IGL02663:Myh13
|
APN |
11 |
67,354,927 (GRCm38) |
nonsense |
probably null |
|
|
IGL02851:Myh13
|
APN |
11 |
67,348,916 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02863:Myh13
|
APN |
11 |
67,332,541 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02929:Myh13
|
APN |
11 |
67,367,165 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02979:Myh13
|
APN |
11 |
67,334,962 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
IGL03065:Myh13
|
APN |
11 |
67,344,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03214:Myh13
|
APN |
11 |
67,353,585 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
IGL03223:Myh13
|
APN |
11 |
67,350,242 (GRCm38) |
missense |
probably benign |
0.39 |
|
IGL03231:Myh13
|
APN |
11 |
67,351,991 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL03407:Myh13
|
APN |
11 |
67,352,152 (GRCm38) |
missense |
probably damaging |
1.00 |
|
3-1:Myh13
|
UTSW |
11 |
67,351,951 (GRCm38) |
splice site |
probably benign |
|
|
P0042:Myh13
|
UTSW |
11 |
67,334,991 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0047:Myh13
|
UTSW |
11 |
67,367,237 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0047:Myh13
|
UTSW |
11 |
67,367,237 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0379:Myh13
|
UTSW |
11 |
67,369,295 (GRCm38) |
unclassified |
probably benign |
|
|
R0496:Myh13
|
UTSW |
11 |
67,348,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0584:Myh13
|
UTSW |
11 |
67,360,374 (GRCm38) |
nonsense |
probably null |
|
|
R0595:Myh13
|
UTSW |
11 |
67,344,846 (GRCm38) |
missense |
probably benign |
0.03 |
|
R0621:Myh13
|
UTSW |
11 |
67,341,232 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0834:Myh13
|
UTSW |
11 |
67,349,610 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0893:Myh13
|
UTSW |
11 |
67,334,601 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0964:Myh13
|
UTSW |
11 |
67,345,002 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0973:Myh13
|
UTSW |
11 |
67,332,520 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0973:Myh13
|
UTSW |
11 |
67,332,520 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0974:Myh13
|
UTSW |
11 |
67,332,520 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1028:Myh13
|
UTSW |
11 |
67,356,181 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1112:Myh13
|
UTSW |
11 |
67,354,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1283:Myh13
|
UTSW |
11 |
67,370,921 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1288:Myh13
|
UTSW |
11 |
67,353,718 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1386:Myh13
|
UTSW |
11 |
67,370,950 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R1457:Myh13
|
UTSW |
11 |
67,331,046 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1503:Myh13
|
UTSW |
11 |
67,353,674 (GRCm38) |
missense |
probably benign |
0.43 |
|
R1574:Myh13
|
UTSW |
11 |
67,362,581 (GRCm38) |
unclassified |
probably benign |
|
|
R1673:Myh13
|
UTSW |
11 |
67,352,119 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R1693:Myh13
|
UTSW |
11 |
67,341,484 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1763:Myh13
|
UTSW |
11 |
67,334,576 (GRCm38) |
missense |
probably benign |
|
|
R2029:Myh13
|
UTSW |
11 |
67,361,289 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2030:Myh13
|
UTSW |
11 |
67,350,238 (GRCm38) |
missense |
probably benign |
|
|
R2247:Myh13
|
UTSW |
11 |
67,334,558 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2393:Myh13
|
UTSW |
11 |
67,340,358 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R2395:Myh13
|
UTSW |
11 |
67,364,922 (GRCm38) |
missense |
probably benign |
0.12 |
|
R2884:Myh13
|
UTSW |
11 |
67,337,643 (GRCm38) |
missense |
probably benign |
0.27 |
|
R3696:Myh13
|
UTSW |
11 |
67,345,044 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R3786:Myh13
|
UTSW |
11 |
67,327,188 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3875:Myh13
|
UTSW |
11 |
67,358,194 (GRCm38) |
missense |
probably benign |
0.26 |
|
R3918:Myh13
|
UTSW |
11 |
67,329,238 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4061:Myh13
|
UTSW |
11 |
67,330,889 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R4160:Myh13
|
UTSW |
11 |
67,364,810 (GRCm38) |
intron |
probably benign |
|
|
R4183:Myh13
|
UTSW |
11 |
67,349,610 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R4392:Myh13
|
UTSW |
11 |
67,344,881 (GRCm38) |
splice site |
probably null |
|
|
R4639:Myh13
|
UTSW |
11 |
67,341,551 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4670:Myh13
|
UTSW |
11 |
67,364,738 (GRCm38) |
nonsense |
probably null |
|
|
R4783:Myh13
|
UTSW |
11 |
67,341,270 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4877:Myh13
|
UTSW |
11 |
67,337,651 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5250:Myh13
|
UTSW |
11 |
67,327,259 (GRCm38) |
nonsense |
probably null |
|
|
R5278:Myh13
|
UTSW |
11 |
67,334,564 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5371:Myh13
|
UTSW |
11 |
67,344,790 (GRCm38) |
splice site |
probably null |
|
|
R5479:Myh13
|
UTSW |
11 |
67,348,822 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R5510:Myh13
|
UTSW |
11 |
67,337,723 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5690:Myh13
|
UTSW |
11 |
67,329,275 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5797:Myh13
|
UTSW |
11 |
67,335,002 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R5823:Myh13
|
UTSW |
11 |
67,360,468 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5877:Myh13
|
UTSW |
11 |
67,353,658 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R6041:Myh13
|
UTSW |
11 |
67,364,730 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6175:Myh13
|
UTSW |
11 |
67,354,762 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6454:Myh13
|
UTSW |
11 |
67,350,365 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6617:Myh13
|
UTSW |
11 |
67,361,400 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6707:Myh13
|
UTSW |
11 |
67,350,260 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6747:Myh13
|
UTSW |
11 |
67,350,419 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6823:Myh13
|
UTSW |
11 |
67,356,158 (GRCm38) |
missense |
probably benign |
|
|
R6911:Myh13
|
UTSW |
11 |
67,354,927 (GRCm38) |
nonsense |
probably null |
|
|
R6997:Myh13
|
UTSW |
11 |
67,327,154 (GRCm38) |
nonsense |
probably null |
|
|
R7033:Myh13
|
UTSW |
11 |
67,369,316 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R7145:Myh13
|
UTSW |
11 |
67,354,740 (GRCm38) |
missense |
probably benign |
0.08 |
|
R7232:Myh13
|
UTSW |
11 |
67,348,846 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7428:Myh13
|
UTSW |
11 |
67,332,564 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7448:Myh13
|
UTSW |
11 |
67,364,460 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7474:Myh13
|
UTSW |
11 |
67,367,711 (GRCm38) |
missense |
|
|
|
R7474:Myh13
|
UTSW |
11 |
67,327,164 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7766:Myh13
|
UTSW |
11 |
67,358,329 (GRCm38) |
missense |
probably benign |
0.37 |
|
R7809:Myh13
|
UTSW |
11 |
67,350,341 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7813:Myh13
|
UTSW |
11 |
67,327,230 (GRCm38) |
missense |
probably benign |
0.27 |
|
R7953:Myh13
|
UTSW |
11 |
67,340,380 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8085:Myh13
|
UTSW |
11 |
67,334,787 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8397:Myh13
|
UTSW |
11 |
67,350,287 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
R8434:Myh13
|
UTSW |
11 |
67,363,185 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R8490:Myh13
|
UTSW |
11 |
67,364,525 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8676:Myh13
|
UTSW |
11 |
67,342,485 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8681:Myh13
|
UTSW |
11 |
67,352,134 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R8777:Myh13
|
UTSW |
11 |
67,361,335 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8777-TAIL:Myh13
|
UTSW |
11 |
67,361,335 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8965:Myh13
|
UTSW |
11 |
67,364,606 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9088:Myh13
|
UTSW |
11 |
67,352,059 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9151:Myh13
|
UTSW |
11 |
67,361,323 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9154:Myh13
|
UTSW |
11 |
67,362,492 (GRCm38) |
missense |
probably benign |
|
|
R9182:Myh13
|
UTSW |
11 |
67,337,753 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9332:Myh13
|
UTSW |
11 |
67,363,283 (GRCm38) |
missense |
possibly damaging |
0.57 |
|
R9393:Myh13
|
UTSW |
11 |
67,352,068 (GRCm38) |
missense |
probably benign |
|
|
R9446:Myh13
|
UTSW |
11 |
67,364,499 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9474:Myh13
|
UTSW |
11 |
67,364,886 (GRCm38) |
missense |
|
|
|
R9690:Myh13
|
UTSW |
11 |
67,358,368 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9761:Myh13
|
UTSW |
11 |
67,360,468 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9778:Myh13
|
UTSW |
11 |
67,358,190 (GRCm38) |
missense |
probably damaging |
0.98 |
|
Z1176:Myh13
|
UTSW |
11 |
67,329,295 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
Z1177:Myh13
|
UTSW |
11 |
67,364,591 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
Z1177:Myh13
|
UTSW |
11 |
67,350,452 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTTGGATGGTCTCTCCCAAG -3'
(R):5'- ATCAGGGGCCATTGCATGAAG -3'
Sequencing Primer
(F):5'- GGTCTCTCCCAAGCCCCC -3'
(R):5'- TCTGAGCCTTAGGGAACACTAG -3'
|
| Posted On |
2018-02-28 |
Incidental Mutation