Mutagenetix > Incidental Mutation

Incidental Mutation 'R6244:Naip2'

505481

Institutional Source

Beutler Lab

Gene Symbol

Naip2

Ensembl Gene

ENSMUSG00000078945

Gene Name

NLR family, apoptosis inhibitory protein 2

Synonyms

Birc1b, Naip2, Naip-rs6

MMRRC Submission

044435-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

R6244 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

100144063-100202092 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 100152137 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 1193 (F1193L)

Ref Sequence

ENSEMBL: ENSMUSP00000125852 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067975] [ENSMUST00000117913] [ENSMUST00000167986]

AlphaFold

Q9QUK4

Predicted Effect

probably damaging
Transcript: ENSMUST00000067975
AA Change: F1249L

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000070827
Gene: ENSMUSG00000078945
AA Change: F1249L

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	1.9e-36	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000117913
AA Change: F1249L

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000113890
Gene: ENSMUSG00000078945
AA Change: F1249L

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	1.9e-36	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000167986
AA Change: F1193L

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000125852
Gene: ENSMUSG00000078945
AA Change: F1193L

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	8.6e-35	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221573

Meta Mutation Damage Score

0.1220

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.3%
20x: 95.1%

Validation Efficiency

96% (82/85)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Allele List at MGI

Other mutations in this stock

Total: 84 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	C	3: 36,956,999 (GRCm38)	V1782A	probably benign	Het
6430550D23Rik	T	C	2: 156,003,230 (GRCm38)	H113R	possibly damaging	Het
Adgrf3	A	T	5: 30,197,533 (GRCm38)	M499K	probably benign	Het
Adgrv1	G	A	13: 81,106,931 (GRCm38)	T211I	probably damaging	Het
Adss	C	T	1: 177,776,829 (GRCm38)	E153K	probably benign	Het
Ago4	C	A	4: 126,511,487 (GRCm38)	G431V	possibly damaging	Het
Araf	G	T	X: 20,860,100 (GRCm38)	R601L	probably damaging	Homo
Atp2b4	T	A	1: 133,726,561 (GRCm38)	I769F	probably damaging	Het
Atp9a	T	C	2: 168,689,352 (GRCm38)		probably null	Het
Brap	C	A	5: 121,665,309 (GRCm38)	D173E	probably benign	Het
Brca2	G	T	5: 150,566,978 (GRCm38)	R3035L	probably benign	Het
Ccdc8	C	A	7: 16,996,251 (GRCm38)	P555Q	probably benign	Het
Ccser2	A	G	14: 36,940,718 (GRCm38)	S170P	probably benign	Het
Celsr2	T	C	3: 108,393,128 (GRCm38)	H860R	probably damaging	Het
Cenpc1	C	A	5: 86,046,385 (GRCm38)	R174M	probably damaging	Het
Cfap57	T	G	4: 118,579,410 (GRCm38)	I930L	probably damaging	Het
Cx3cr1	C	T	9: 120,051,694 (GRCm38)	R214H	probably damaging	Het
Cyp4f14	T	A	17: 32,906,317 (GRCm38)	H429L	probably benign	Het
D5Ertd579e	A	G	5: 36,615,276 (GRCm38)	F592L	probably damaging	Het
Ddb1	A	G	19: 10,625,923 (GRCm38)	E865G	probably damaging	Het
Ddx50	A	T	10: 62,621,566 (GRCm38)		probably null	Het
Dpp6	A	G	5: 27,049,628 (GRCm38)	T14A	probably damaging	Het
Echs1	C	A	7: 140,113,069 (GRCm38)	Q51H	possibly damaging	Het
Ecm2	A	T	13: 49,530,307 (GRCm38)	D587V	probably damaging	Het
Ect2l	A	T	10: 18,140,397 (GRCm38)	Y666N	possibly damaging	Het
Epha2	G	A	4: 141,316,912 (GRCm38)	G342S	probably benign	Het
Fbxo33	C	A	12: 59,206,079 (GRCm38)	K211N	probably benign	Het
Fchsd2	A	G	7: 101,259,776 (GRCm38)		probably null	Het
Fen1	A	G	19: 10,200,687 (GRCm38)	V131A	probably damaging	Het
Fetub	C	T	16: 22,932,331 (GRCm38)	R143C	probably damaging	Het
Flnb	A	G	14: 7,892,092 (GRCm38)	E587G	probably damaging	Het
Foxd3	A	G	4: 99,657,240 (GRCm38)	T206A	possibly damaging	Het
Fut1	A	G	7: 45,619,306 (GRCm38)	E228G	possibly damaging	Het
Galnt13	T	C	2: 54,933,548 (GRCm38)	F379L	probably damaging	Het
Gcnt2	A	C	13: 40,861,241 (GRCm38)	E296A	probably damaging	Het
Gm7145	T	A	1: 117,986,140 (GRCm38)	C251S	probably damaging	Het
Gpam	G	A	19: 55,070,985 (GRCm38)	P810L	probably damaging	Het
Il1rl2	T	A	1: 40,327,566 (GRCm38)	L87M	possibly damaging	Het
Itgae	A	G	11: 73,145,601 (GRCm38)	S1122G	probably damaging	Het
Kcnh7	T	A	2: 63,182,226 (GRCm38)	D46V	probably damaging	Het
Kcnn3	T	G	3: 89,645,523 (GRCm38)	Y511*	probably null	Het
Kdm3b	T	A	18: 34,793,005 (GRCm38)	I66N	probably damaging	Het
Klk1b27	A	T	7: 44,054,550 (GRCm38)	H39L	probably benign	Het
Kmo	C	T	1: 175,659,695 (GRCm38)	T404I	possibly damaging	Het
Krt222	C	T	11: 99,235,058 (GRCm38)		probably null	Het
Magi3	G	C	3: 104,015,697 (GRCm38)	H1235D	probably benign	Het
Mapk8ip1	C	A	2: 92,389,244 (GRCm38)	G81C	probably damaging	Het
Med15	G	A	16: 17,652,745 (GRCm38)	Q583*	probably null	Het
Mroh2a	T	C	1: 88,256,754 (GRCm38)	V1453A	probably benign	Het
Myh13	A	G	11: 67,362,501 (GRCm38)	M1488V	probably benign	Het
Nop58	T	A	1: 59,702,855 (GRCm38)	M181K	probably damaging	Het
Npepps	A	T	11: 97,213,790 (GRCm38)	V796D	probably damaging	Het
Nr1d1	A	G	11: 98,770,537 (GRCm38)	F301S	probably damaging	Het
Nynrin	G	A	14: 55,868,028 (GRCm38)	V832I	probably damaging	Het
Olfr1046	T	A	2: 86,217,222 (GRCm38)	T163S	possibly damaging	Het
Olfr1508	T	A	14: 52,463,895 (GRCm38)	Y38F	probably damaging	Het
Olfr320	A	T	11: 58,684,004 (GRCm38)	T44S	possibly damaging	Het
Olfr342	T	A	2: 36,528,341 (GRCm38)	C310S	probably benign	Het
Olfr61	C	A	7: 140,638,433 (GRCm38)	S244Y	probably damaging	Het
Phrf1	T	A	7: 141,237,673 (GRCm38)	C132S	probably damaging	Het
Plekhn1	T	C	4: 156,230,558 (GRCm38)		probably null	Het
Polr2a	G	A	11: 69,744,226 (GRCm38)	T569M	probably damaging	Het
Prr29	A	G	11: 106,376,632 (GRCm38)		probably null	Het
Rsf1	CG	CGACGGCGGAG	7: 97,579,908 (GRCm38)		probably benign	Homo
Sc5d	T	C	9: 42,255,421 (GRCm38)	E274G	probably benign	Het
Serpina1d	A	T	12: 103,764,828 (GRCm38)		probably null	Het
Serpinb11	T	A	1: 107,372,242 (GRCm38)	I106N	probably damaging	Het
Setd2	G	A	9: 110,548,665 (GRCm38)	R516K	probably damaging	Het
Sirt2	G	T	7: 28,787,797 (GRCm38)	C291F	probably damaging	Het
Stac3	T	C	10: 127,508,175 (GRCm38)	V314A	probably damaging	Het
Stat6	C	T	10: 127,657,712 (GRCm38)		probably null	Het
Strn3	A	G	12: 51,610,107 (GRCm38)	V712A	probably damaging	Het
Tmc5	G	T	7: 118,634,214 (GRCm38)	G84C	possibly damaging	Het
Tnik	C	A	3: 28,650,179 (GRCm38)	L996I	probably damaging	Het
Trim30d	G	T	7: 104,487,610 (GRCm38)	T129K	probably damaging	Het
Triml1	G	T	8: 43,138,756 (GRCm38)	Y188*	probably null	Het
Trpc7	A	G	13: 56,773,892 (GRCm38)	Y760H	probably damaging	Het
Uaca	G	A	9: 60,870,044 (GRCm38)	R571Q	probably damaging	Het
Ubash3a	A	T	17: 31,239,272 (GRCm38)	Q575L	possibly damaging	Het
Usp49	T	A	17: 47,672,902 (GRCm38)	C61*	probably null	Het
Vmn2r18	A	T	5: 151,584,651 (GRCm38)	V336E	probably damaging	Het
Vwa8	T	C	14: 79,086,662 (GRCm38)	V1135A	probably benign	Het
Zcchc4	T	C	5: 52,783,161 (GRCm38)	V24A	probably benign	Het
Zfp354c	A	G	11: 50,814,971 (GRCm38)	Y426H	probably benign	Het

Other mutations in Naip2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00515:Naip2	APN	13	100,154,887 (GRCm38)	missense	probably benign	0.00
IGL00676:Naip2	APN	13	100,152,632 (GRCm38)	missense	probably damaging	1.00
IGL00870:Naip2	APN	13	100,152,060 (GRCm38)	splice site	probably benign
IGL00908:Naip2	APN	13	100,160,649 (GRCm38)	missense	probably benign	0.01
IGL00916:Naip2	APN	13	100,161,431 (GRCm38)	missense	probably damaging	0.97
IGL00949:Naip2	APN	13	100,161,591 (GRCm38)	missense	probably damaging	1.00
IGL01010:Naip2	APN	13	100,154,938 (GRCm38)	missense	probably damaging	0.99
IGL01642:Naip2	APN	13	100,160,937 (GRCm38)	missense	probably damaging	0.97
IGL01884:Naip2	APN	13	100,188,821 (GRCm38)	splice site	probably benign
IGL01917:Naip2	APN	13	100,162,083 (GRCm38)	missense	probably benign	0.00
IGL02015:Naip2	APN	13	100,161,607 (GRCm38)	missense	possibly damaging	0.57
IGL02315:Naip2	APN	13	100,161,236 (GRCm38)	missense	probably damaging	1.00
IGL02328:Naip2	APN	13	100,161,369 (GRCm38)	missense	probably damaging	1.00
IGL02735:Naip2	APN	13	100,160,214 (GRCm38)	missense	probably damaging	0.99
IGL02738:Naip2	APN	13	100,189,177 (GRCm38)	missense	probably benign	0.01
IGL02887:Naip2	APN	13	100,161,512 (GRCm38)	missense	possibly damaging	0.90
IGL02894:Naip2	APN	13	100,183,789 (GRCm38)	missense	probably benign
IGL02894:Naip2	APN	13	100,160,997 (GRCm38)	missense	probably damaging	1.00
IGL02974:Naip2	APN	13	100,161,678 (GRCm38)	missense	probably damaging	1.00
IGL03024:Naip2	APN	13	100,189,354 (GRCm38)	missense	possibly damaging	0.50
IGL03056:Naip2	APN	13	100,162,287 (GRCm38)	missense	possibly damaging	0.90
IGL03281:Naip2	APN	13	100,161,620 (GRCm38)	missense	probably damaging	0.99
R0131:Naip2	UTSW	13	100,183,788 (GRCm38)	missense	probably benign	0.01
R0131:Naip2	UTSW	13	100,183,788 (GRCm38)	missense	probably benign	0.01
R0132:Naip2	UTSW	13	100,183,788 (GRCm38)	missense	probably benign	0.01
R0310:Naip2	UTSW	13	100,148,842 (GRCm38)	missense	probably damaging	1.00
R0367:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0368:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0422:Naip2	UTSW	13	100,161,113 (GRCm38)	missense	probably benign	0.10
R0441:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0445:Naip2	UTSW	13	100,161,887 (GRCm38)	missense	possibly damaging	0.91
R0446:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0464:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0466:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0467:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0486:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0533:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0853:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R0853:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R0855:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R0855:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R0904:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R0904:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R0906:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R0906:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R0908:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R0908:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R0959:Naip2	UTSW	13	100,154,911 (GRCm38)	missense	probably benign	0.03
R0959:Naip2	UTSW	13	100,154,878 (GRCm38)	missense	probably benign	0.01
R0962:Naip2	UTSW	13	100,179,385 (GRCm38)	missense	probably damaging	1.00
R1024:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1024:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1186:Naip2	UTSW	13	100,162,037 (GRCm38)	frame shift	probably null
R1186:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1217:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1217:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1340:Naip2	UTSW	13	100,189,122 (GRCm38)	missense	possibly damaging	0.80
R1342:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1342:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1404:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1423:Naip2	UTSW	13	100,154,847 (GRCm38)	intron	probably benign
R1423:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1423:Naip2	UTSW	13	100,154,878 (GRCm38)	missense	probably benign	0.01
R1423:Naip2	UTSW	13	100,154,872 (GRCm38)	missense	possibly damaging	0.59
R1426:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1426:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1472:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1575:Naip2	UTSW	13	100,155,029 (GRCm38)	intron	probably benign
R1575:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
R1576:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
R1576:Naip2	UTSW	13	100,155,029 (GRCm38)	intron	probably benign
R1599:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1640:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1641:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1642:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1643:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1644:Naip2	UTSW	13	100,182,929 (GRCm38)	missense	possibly damaging	0.83
R1681:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1681:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1891:Naip2	UTSW	13	100,154,887 (GRCm38)	missense	probably benign	0.00
R1913:Naip2	UTSW	13	100,152,157 (GRCm38)	critical splice acceptor site	probably null
R1937:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1937:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1993:Naip2	UTSW	13	100,162,007 (GRCm38)	missense	probably benign	0.03
R2001:Naip2	UTSW	13	100,144,588 (GRCm38)	missense	probably damaging	1.00
R2055:Naip2	UTSW	13	100,179,372 (GRCm38)	missense	probably benign	0.07
R2198:Naip2	UTSW	13	100,152,592 (GRCm38)	missense	probably damaging	1.00
R2906:Naip2	UTSW	13	100,161,996 (GRCm38)	missense	probably damaging	1.00
R2931:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
R3014:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R3016:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R3037:Naip2	UTSW	13	100,154,949 (GRCm38)	missense	probably benign	0.08
R3414:Naip2	UTSW	13	100,189,263 (GRCm38)	nonsense	probably null
R3437:Naip2	UTSW	13	100,154,911 (GRCm38)	missense	probably benign	0.03
R3713:Naip2	UTSW	13	100,161,902 (GRCm38)	missense	probably damaging	1.00
R3806:Naip2	UTSW	13	100,152,634 (GRCm38)	missense	possibly damaging	0.92
R3847:Naip2	UTSW	13	100,179,432 (GRCm38)	missense	probably damaging	1.00
R3847:Naip2	UTSW	13	100,179,433 (GRCm38)	missense	probably damaging	1.00
R3848:Naip2	UTSW	13	100,179,432 (GRCm38)	missense	probably damaging	1.00
R3848:Naip2	UTSW	13	100,179,433 (GRCm38)	missense	probably damaging	1.00
R3849:Naip2	UTSW	13	100,179,432 (GRCm38)	missense	probably damaging	1.00
R3849:Naip2	UTSW	13	100,179,433 (GRCm38)	missense	probably damaging	1.00
R3850:Naip2	UTSW	13	100,179,432 (GRCm38)	missense	probably damaging	1.00
R3850:Naip2	UTSW	13	100,179,433 (GRCm38)	missense	probably damaging	1.00
R3891:Naip2	UTSW	13	100,161,098 (GRCm38)	missense	probably damaging	0.99
R4419:Naip2	UTSW	13	100,160,625 (GRCm38)	missense	probably benign	0.03
R4456:Naip2	UTSW	13	100,154,911 (GRCm38)	missense	probably benign	0.03
R4458:Naip2	UTSW	13	100,154,911 (GRCm38)	missense	probably benign	0.03
R4689:Naip2	UTSW	13	100,148,812 (GRCm38)	missense	probably damaging	1.00
R4797:Naip2	UTSW	13	100,161,735 (GRCm38)	missense	probably damaging	1.00
R4852:Naip2	UTSW	13	100,161,536 (GRCm38)	missense	probably benign
R4922:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R5135:Naip2	UTSW	13	100,179,440 (GRCm38)	missense	probably damaging	0.98
R5185:Naip2	UTSW	13	100,189,351 (GRCm38)	missense	probably damaging	1.00
R5265:Naip2	UTSW	13	100,152,560 (GRCm38)	missense	probably damaging	1.00
R5451:Naip2	UTSW	13	100,188,860 (GRCm38)	missense	probably benign	0.12
R5521:Naip2	UTSW	13	100,154,914 (GRCm38)	missense	probably damaging	1.00
R5737:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign	0.38
R6478:Naip2	UTSW	13	100,162,041 (GRCm38)	missense	probably benign
R6480:Naip2	UTSW	13	100,162,041 (GRCm38)	missense	probably benign
R6481:Naip2	UTSW	13	100,162,041 (GRCm38)	missense	probably benign
R6490:Naip2	UTSW	13	100,160,685 (GRCm38)	missense	probably benign
R6653:Naip2	UTSW	13	100,152,136 (GRCm38)	missense	probably benign	0.00
R6653:Naip2	UTSW	13	100,161,844 (GRCm38)	missense	probably benign
R6768:Naip2	UTSW	13	100,178,324 (GRCm38)	nonsense	probably null
R6791:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R6793:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R6890:Naip2	UTSW	13	100,162,041 (GRCm38)	missense	probably benign
R7036:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
R7213:Naip2	UTSW	13	100,187,483 (GRCm38)	missense	probably damaging	1.00
R7342:Naip2	UTSW	13	100,189,356 (GRCm38)	missense	probably benign	0.09
R7445:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R7572:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R7699:Naip2	UTSW	13	100,160,369 (GRCm38)	missense	probably benign	0.00
R7840:Naip2	UTSW	13	100,144,409 (GRCm38)	missense	probably benign	0.14
R7874:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R7874:Naip2	UTSW	13	100,154,951 (GRCm38)	missense	probably benign	0.00
R8038:Naip2	UTSW	13	100,162,062 (GRCm38)	missense	probably benign	0.00
R8065:Naip2	UTSW	13	100,189,222 (GRCm38)	missense	probably damaging	1.00
R8094:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R8166:Naip2	UTSW	13	100,162,007 (GRCm38)	missense	probably benign	0.03
R8378:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R8669:Naip2	UTSW	13	100,188,969 (GRCm38)	missense	probably benign	0.05
R8691:Naip2	UTSW	13	100,161,168 (GRCm38)	missense	probably damaging	1.00
R8716:Naip2	UTSW	13	100,144,406 (GRCm38)	missense	probably benign
R8720:Naip2	UTSW	13	100,162,122 (GRCm38)	missense	probably benign	0.04
R8888:Naip2	UTSW	13	100,189,136 (GRCm38)	missense	probably benign	0.01
R8895:Naip2	UTSW	13	100,189,136 (GRCm38)	missense	probably benign	0.01
R9031:Naip2	UTSW	13	100,178,268 (GRCm38)	missense	possibly damaging	0.55
R9072:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R9072:Naip2	UTSW	13	100,154,951 (GRCm38)	missense	probably benign	0.00
R9074:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R9074:Naip2	UTSW	13	100,154,951 (GRCm38)	missense	probably benign	0.00
R9077:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R9077:Naip2	UTSW	13	100,154,951 (GRCm38)	missense	probably benign	0.00
R9176:Naip2	UTSW	13	100,162,199 (GRCm38)	missense	probably damaging	1.00
R9219:Naip2	UTSW	13	100,160,705 (GRCm38)	missense	probably benign	0.06
R9358:Naip2	UTSW	13	100,161,572 (GRCm38)	missense	probably damaging	1.00
R9371:Naip2	UTSW	13	100,161,846 (GRCm38)	nonsense	probably null
R9414:Naip2	UTSW	13	100,161,735 (GRCm38)	missense	probably damaging	1.00
R9415:Naip2	UTSW	13	100,161,735 (GRCm38)	missense	probably damaging	1.00
R9416:Naip2	UTSW	13	100,161,735 (GRCm38)	missense	probably damaging	1.00
R9708:Naip2	UTSW	13	100,161,579 (GRCm38)	missense	probably damaging	0.99
V5622:Naip2	UTSW	13	100,155,029 (GRCm38)	intron	probably benign
V5622:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
V5622:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
X0063:Naip2	UTSW	13	100,161,758 (GRCm38)	missense	probably damaging	1.00
Y5405:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
Z1088:Naip2	UTSW	13	100,161,909 (GRCm38)	missense	probably benign
Z1176:Naip2	UTSW	13	100,161,909 (GRCm38)	missense	probably benign
Z1176:Naip2	UTSW	13	100,161,593 (GRCm38)	missense	probably benign	0.02
Z1177:Naip2	UTSW	13	100,161,909 (GRCm38)	missense	probably benign
Z1177:Naip2	UTSW	13	100,152,629 (GRCm38)	missense	possibly damaging	0.65
Z1177:Naip2	UTSW	13	100,162,865 (GRCm38)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- ATAACTTGCTTTGTTGTAGGTTCCC -3'
(R):5'- TCTCAGCGAGGCTCTCATAAG -3'

Sequencing Primer
(F):5'- CTTTGTTGTAGGTTCCCAGGAG -3'
(R):5'- CTCTCATAAGAGTGAATGAACTACAG -3'

Posted On

2018-02-28