Incidental Mutation 'R6245:Armc3'
ID 505501
Institutional Source Beutler Lab
Gene Symbol Armc3
Ensembl Gene ENSMUSG00000037683
Gene Name armadillo repeat containing 3
Synonyms 4921513G22Rik
MMRRC Submission 044403-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R6245 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 19199302-19310241 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 19248705 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 219 (T219M)
Ref Sequence ENSEMBL: ENSMUSP00000110287 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049255] [ENSMUST00000114640]
AlphaFold A2AU72
Predicted Effect probably damaging
Transcript: ENSMUST00000049255
AA Change: T219M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000048784
Gene: ENSMUSG00000037683
AA Change: T219M

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
low complexity region 544 557 N/A INTRINSIC
low complexity region 583 595 N/A INTRINSIC
low complexity region 620 639 N/A INTRINSIC
low complexity region 675 696 N/A INTRINSIC
Pfam:EDR1 723 857 3.1e-28 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000114640
AA Change: T219M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110287
Gene: ENSMUSG00000037683
AA Change: T219M

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
Pfam:EDR1 549 868 1.4e-41 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 [PubMed 16915934]).[supplied by OMIM, Mar 2008]
Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik T C 15: 8,178,418 (GRCm38) Y218H probably benign Het
Abca9 A G 11: 110,135,423 (GRCm38) I937T probably damaging Het
Adgrl3 T A 5: 81,688,556 (GRCm38) N720K probably benign Het
Akr1c21 T G 13: 4,575,232 (GRCm38) V54G possibly damaging Het
Alpi G T 1: 87,100,834 (GRCm38) D111E probably damaging Het
Bms1 T A 6: 118,396,836 (GRCm38) E780V probably damaging Het
Ccdc159 T C 9: 21,935,568 (GRCm38) S244P probably damaging Het
Cdon T C 9: 35,476,939 (GRCm38) W737R probably damaging Het
Chdh T A 14: 30,035,305 (GRCm38) V395D probably damaging Het
Col22a1 C A 15: 71,973,816 (GRCm38) D366Y probably damaging Het
Crnkl1 T A 2: 145,928,131 (GRCm38) N264I probably benign Het
Ctnnd2 T C 15: 30,905,748 (GRCm38) L847P probably damaging Het
Cyp4a31 A C 4: 115,571,348 (GRCm38) T382P possibly damaging Het
Dcaf8 A T 1: 172,165,867 (GRCm38) M1L probably benign Het
Ddx31 T A 2: 28,844,982 (GRCm38) F52I probably benign Het
Eps15 G A 4: 109,382,866 (GRCm38) S852N possibly damaging Het
Fchsd1 A T 18: 37,962,775 (GRCm38) L552Q probably damaging Het
Fetub C T 16: 22,932,331 (GRCm38) R143C probably damaging Het
Frem2 T C 3: 53,655,824 (GRCm38) M421V probably benign Het
Gm1110 T G 9: 26,920,747 (GRCm38) H36P probably benign Het
Gm11639 A T 11: 104,785,008 (GRCm38) Y1542F probably benign Het
Hadha C T 5: 30,120,044 (GRCm38) probably null Het
Hspa4 C T 11: 53,262,939 (GRCm38) E702K probably benign Het
Intu C A 3: 40,675,326 (GRCm38) T362K probably damaging Het
Jaml C T 9: 45,097,919 (GRCm38) T248I probably damaging Het
Kcnj1 A T 9: 32,396,867 (GRCm38) S176C probably damaging Het
Kcnj9 A G 1: 172,326,137 (GRCm38) L140P probably damaging Het
Kif7 T C 7: 79,702,143 (GRCm38) K957R probably damaging Het
Klc4 T A 17: 46,636,679 (GRCm38) I366F probably damaging Het
Lamb2 A G 9: 108,488,199 (GRCm38) probably null Het
Madd T C 2: 91,178,104 (GRCm38) D151G probably benign Het
Man2a1 C A 17: 64,710,826 (GRCm38) A689E probably damaging Het
Mapk8ip1 C A 2: 92,389,244 (GRCm38) G81C probably damaging Het
Msmp T C 4: 43,583,909 (GRCm38) Y48C probably damaging Het
Muc6 T C 7: 141,648,821 (GRCm38) N567S probably damaging Het
Nrap A G 19: 56,354,221 (GRCm38) Y748H probably damaging Het
Nrap C T 19: 56,379,875 (GRCm38) A192T possibly damaging Het
Olfr1138 G C 2: 87,737,896 (GRCm38) Q143E possibly damaging Het
Olfr1370 T A 13: 21,072,690 (GRCm38) T204S possibly damaging Het
Olfr1384 T A 11: 49,514,165 (GRCm38) F176I possibly damaging Het
Pcdhb8 T G 18: 37,357,169 (GRCm38) D633E possibly damaging Het
Pcdhb9 G A 18: 37,403,154 (GRCm38) V734M probably damaging Het
Plscr1 T C 9: 92,259,321 (GRCm38) Y21H unknown Het
Ptk2b G T 14: 66,163,066 (GRCm38) P767T probably damaging Het
Ptprz1 T C 6: 23,051,990 (GRCm38) Y1424H probably damaging Het
Sec31a T A 5: 100,386,184 (GRCm38) Q118L probably benign Het
Selenop A G 15: 3,274,734 (GRCm38) S21G probably damaging Het
Shank1 G A 7: 44,352,253 (GRCm38) S1132N unknown Het
Slf1 A G 13: 77,084,383 (GRCm38) L534P probably damaging Het
Sparcl1 T A 5: 104,085,147 (GRCm38) H596L probably damaging Het
Spocd1 C T 4: 129,957,108 (GRCm38) probably null Het
Tbc1d24 A T 17: 24,185,993 (GRCm38) I59N probably damaging Het
Tctex1d1 A G 4: 102,988,667 (GRCm38) N32S probably benign Het
Tjp3 G A 10: 81,277,276 (GRCm38) T580I probably benign Het
Tmem154 C T 3: 84,684,296 (GRCm38) T51M possibly damaging Het
Tmem8b G A 4: 43,690,246 (GRCm38) V894I probably benign Het
Trbv20 A T 6: 41,188,906 (GRCm38) L88F possibly damaging Het
Tssk2 A C 16: 17,898,948 (GRCm38) I72L possibly damaging Het
Tub T A 7: 109,027,058 (GRCm38) I267N probably damaging Het
Vmn2r104 A T 17: 20,041,567 (GRCm38) F434I possibly damaging Het
Vmn2r42 T C 7: 8,192,734 (GRCm38) N471S probably damaging Het
Vmn2r94 C G 17: 18,258,123 (GRCm38) G121R probably damaging Het
Wdr72 T C 9: 74,148,223 (GRCm38) S245P probably damaging Het
Zbtb42 A G 12: 112,679,535 (GRCm38) Y48C probably damaging Het
Zdbf2 T C 1: 63,304,433 (GRCm38) V657A possibly damaging Het
Zfp768 A T 7: 127,344,091 (GRCm38) C288* probably null Het
Zfp988 T A 4: 147,332,013 (GRCm38) C301* probably null Het
Other mutations in Armc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00535:Armc3 APN 2 19,303,858 (GRCm38) missense possibly damaging 0.48
IGL01123:Armc3 APN 2 19,201,805 (GRCm38) missense possibly damaging 0.87
IGL01142:Armc3 APN 2 19,297,898 (GRCm38) splice site probably benign
IGL01556:Armc3 APN 2 19,269,146 (GRCm38) missense probably damaging 1.00
IGL02145:Armc3 APN 2 19,286,137 (GRCm38) critical splice donor site probably null
IGL02145:Armc3 APN 2 19,296,860 (GRCm38) missense possibly damaging 0.81
IGL02152:Armc3 APN 2 19,286,137 (GRCm38) critical splice donor site probably null
IGL02154:Armc3 APN 2 19,286,137 (GRCm38) critical splice donor site probably null
IGL02243:Armc3 APN 2 19,286,137 (GRCm38) critical splice donor site probably null
IGL02244:Armc3 APN 2 19,286,137 (GRCm38) critical splice donor site probably null
IGL02516:Armc3 APN 2 19,300,506 (GRCm38) missense possibly damaging 0.94
IGL02691:Armc3 APN 2 19,235,484 (GRCm38) missense probably damaging 1.00
IGL03151:Armc3 APN 2 19,238,698 (GRCm38) missense probably damaging 1.00
IGL03190:Armc3 APN 2 19,288,950 (GRCm38) missense probably damaging 0.99
IGL03288:Armc3 APN 2 19,235,482 (GRCm38) missense probably damaging 1.00
IGL03338:Armc3 APN 2 19,248,701 (GRCm38) missense possibly damaging 0.88
R0015:Armc3 UTSW 2 19,296,321 (GRCm38) critical splice acceptor site probably null
R0015:Armc3 UTSW 2 19,296,321 (GRCm38) critical splice acceptor site probably null
R0256:Armc3 UTSW 2 19,269,216 (GRCm38) missense probably damaging 1.00
R0621:Armc3 UTSW 2 19,295,393 (GRCm38) missense probably damaging 0.96
R1326:Armc3 UTSW 2 19,310,124 (GRCm38) makesense probably null
R1470:Armc3 UTSW 2 19,238,736 (GRCm38) missense probably benign
R1470:Armc3 UTSW 2 19,238,736 (GRCm38) missense probably benign
R1489:Armc3 UTSW 2 19,310,047 (GRCm38) missense probably benign 0.01
R1990:Armc3 UTSW 2 19,293,142 (GRCm38) missense probably damaging 0.97
R1991:Armc3 UTSW 2 19,293,142 (GRCm38) missense probably damaging 0.97
R1992:Armc3 UTSW 2 19,293,142 (GRCm38) missense probably damaging 0.97
R2002:Armc3 UTSW 2 19,288,936 (GRCm38) missense probably benign 0.01
R2095:Armc3 UTSW 2 19,288,929 (GRCm38) missense possibly damaging 0.65
R2127:Armc3 UTSW 2 19,201,811 (GRCm38) missense probably damaging 1.00
R2158:Armc3 UTSW 2 19,248,633 (GRCm38) missense probably damaging 0.99
R2697:Armc3 UTSW 2 19,303,935 (GRCm38) missense probably damaging 1.00
R3809:Armc3 UTSW 2 19,300,665 (GRCm38) missense probably damaging 1.00
R3897:Armc3 UTSW 2 19,269,177 (GRCm38) missense probably damaging 1.00
R4107:Armc3 UTSW 2 19,288,909 (GRCm38) missense probably benign 0.13
R4326:Armc3 UTSW 2 19,300,473 (GRCm38) missense probably damaging 0.97
R4464:Armc3 UTSW 2 19,248,659 (GRCm38) missense probably damaging 0.99
R4702:Armc3 UTSW 2 19,309,981 (GRCm38) missense probably damaging 1.00
R4923:Armc3 UTSW 2 19,292,980 (GRCm38) critical splice acceptor site probably null
R5370:Armc3 UTSW 2 19,286,062 (GRCm38) missense probably benign 0.00
R5518:Armc3 UTSW 2 19,297,928 (GRCm38) missense probably benign 0.28
R5718:Armc3 UTSW 2 19,303,799 (GRCm38) nonsense probably null
R5739:Armc3 UTSW 2 19,253,917 (GRCm38) missense possibly damaging 0.67
R5913:Armc3 UTSW 2 19,310,047 (GRCm38) missense possibly damaging 0.65
R6211:Armc3 UTSW 2 19,296,803 (GRCm38) critical splice acceptor site probably null
R6841:Armc3 UTSW 2 19,201,819 (GRCm38) splice site probably null
R7003:Armc3 UTSW 2 19,270,028 (GRCm38) missense probably damaging 1.00
R7190:Armc3 UTSW 2 19,293,136 (GRCm38) missense probably damaging 1.00
R7499:Armc3 UTSW 2 19,285,979 (GRCm38) missense probably benign 0.03
R7738:Armc3 UTSW 2 19,288,950 (GRCm38) missense probably damaging 0.99
R7844:Armc3 UTSW 2 19,254,018 (GRCm38) missense possibly damaging 0.90
R7919:Armc3 UTSW 2 19,286,095 (GRCm38) missense probably benign 0.00
R8060:Armc3 UTSW 2 19,288,909 (GRCm38) missense probably benign 0.08
R8111:Armc3 UTSW 2 19,296,863 (GRCm38) missense probably benign
R8406:Armc3 UTSW 2 19,235,554 (GRCm38) missense probably damaging 0.98
R8485:Armc3 UTSW 2 19,293,134 (GRCm38) missense probably damaging 1.00
R8773:Armc3 UTSW 2 19,288,856 (GRCm38) missense probably benign 0.01
R8940:Armc3 UTSW 2 19,235,582 (GRCm38) missense probably damaging 1.00
R9441:Armc3 UTSW 2 19,248,615 (GRCm38) missense possibly damaging 0.89
Z1177:Armc3 UTSW 2 19,285,991 (GRCm38) missense probably benign
Predicted Primers PCR Primer
(F):5'- ATAATAGATGCTCCCCATTCTGG -3'
(R):5'- GTTCTAGATGGTCTCTGTAACTAGGTC -3'

Sequencing Primer
(F):5'- CCCCATTCTGGAGATTGTGTTTTG -3'
(R):5'- AAATAGCCTAATAGACTTTACACAGC -3'
Posted On 2018-02-28